KNApSAcK Metabolite C00001889
Metabolite
KNApSAcK Entry
| id | C00001889 |
|---|---|
| Name | Morphine / (-)-Morphine |
| CAS RN | 57-27-2 |
| Standard InChI | InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3 |
Cluster
| Phytochemical cluster | No. 4 |
|---|---|
| KCF-S cluster | No. 4235 |
Link
ChEMBL
| By standard InChI | CHEMBL70 |
|---|---|
| By standard InChI Main Layer | CHEMBL70 CHEMBL1888905 CHEMBL2133708 CHEMBL2139208 |
KEGG
| By LinkDB | C01516 |
|---|
CTD
| By CAS RN | D009020 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| eudicotyledons | 2 |
Family
| family name | count |
|---|---|
| Papaveraceae | 2 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Papaver setigerum | 215229 | Papaveraceae | eudicotyledons | Viridiplantae |
| Papaver somniferum | 3469 | Papaveraceae | eudicotyledons | Viridiplantae |
Human Protein / Gene in interaction
32 ChEMBL Protein in interactions
CTD interaction (142)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D009020 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form] |
decreases expression
/ decreases reaction |
protein |
19239323
|
| D009020 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | Morphine results in decreased expression of AKT1 protein modified form |
decreases expression
|
protein |
19239323
|
| D009020 | 338 |
APOB
FLDB LDLCQ4 |
apolipoprotein B | Morphine results in increased expression of APOB protein |
increases expression
|
protein |
18980684
|
| D009020 | 10550 |
ARL6IP5
DERP11 GTRAP3-18 JWA PRAF3 addicsin hp22 jmx |
ADP-ribosylation-like factor 6 interacting protein 5 | ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein] |
decreases reaction
/ increases expression |
mutant form |
21600884
|
| D009020 | 10550 |
ARL6IP5
DERP11 GTRAP3-18 JWA PRAF3 addicsin hp22 jmx |
ADP-ribosylation-like factor 6 interacting protein 5 | ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
mutant form |
21600884
|
| D009020 | 10550 |
ARL6IP5
DERP11 GTRAP3-18 JWA PRAF3 addicsin hp22 jmx |
ADP-ribosylation-like factor 6 interacting protein 5 | ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
mutant form |
21600884
|
| D009020 | 10550 |
ARL6IP5
DERP11 GTRAP3-18 JWA PRAF3 addicsin hp22 jmx |
ADP-ribosylation-like factor 6 interacting protein 5 | ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein] |
decreases reaction
/ increases phosphorylation |
mutant form |
21600884
|
| D009020 | 10550 |
ARL6IP5
DERP11 GTRAP3-18 JWA PRAF3 addicsin hp22 jmx |
ADP-ribosylation-like factor 6 interacting protein 5 | Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein] |
affects binding
/ increases reaction |
protein |
21600884
|
| D009020 | 409 |
ARRB2
ARB2 ARR2 BARR2 |
arrestin, beta 2 | ARRB2 gene SNP affects the susceptibility to Morphine |
affects response to substance
|
gene |
16103897
|
| D009020 | 409 |
ARRB2
ARB2 ARR2 BARR2 |
arrestin, beta 2 | ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form] |
decreases expression
/ decreases reaction |
protein |
19239323
|
| D009020 | 409 |
ARRB2
ARB2 ARR2 BARR2 |
arrestin, beta 2 | ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form] |
decreases expression
/ decreases reaction |
protein |
19239323
|
| D009020 | 409 |
ARRB2
ARB2 ARR2 BARR2 |
arrestin, beta 2 | [gp120 protein, Human immunodeficiency virus 1 co-treated with Morphine] results in decreased expression of ARRB2 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
19477204
|
| D009020 | 578 |
BAK1
BAK BAK-LIKE BCL2L7 CDN1 |
BCL2-antagonist/killer 1 | Morphine results in increased expression of BAK1 protein |
increases expression
|
protein |
19070643
|
| D009020 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein] |
decreases reaction
/ increases expression |
protein |
12927789
|
| D009020 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | Morphine inhibits the reaction [Doxorubicin results in increased expression of BAX protein] |
decreases reaction
/ increases expression |
protein |
17542780
|
| D009020 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | Morphine results in increased expression of BAX protein |
increases expression
|
protein |
10534122
19070643 21483469 |
| D009020 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | [[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein |
affects cotreatment
/ decreases expression / increases activity / increases expression |
protein |
10534122
|
| D009020 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein |
increases expression
/ increases phosphorylation / increases stability |
protein |
12702572
|
| D009020 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]] |
decreases reaction
/ increases expression |
protein |
12927789
|
| D009020 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein] |
decreases reaction
/ increases expression |
protein |
21483469
|
| D009020 | 27113 |
BBC3
JFY-1 JFY1 PUMA |
BCL2 binding component 3 | Morphine results in increased expression of BBC3 mRNA |
increases expression
|
mRNA |
19397953
|
| D009020 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein] |
affects binding
/ decreases reaction |
protein |
20190558
|
| D009020 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein] |
decreases expression
/ decreases reaction |
protein |
12927789
|
| D009020 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | Morphine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] |
decreases expression
/ decreases reaction |
protein |
17542780
|
| D009020 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | Morphine results in decreased expression of BCL2 protein |
decreases expression
|
protein |
10534122
19292871 21483469 |
| D009020 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | [[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein |
affects cotreatment
/ decreases expression / increases activity / increases expression |
protein |
10534122
|
| D009020 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]] |
decreases expression
/ decreases reaction |
protein |
12927789
|
| D009020 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein] |
decreases expression
/ decreases reaction |
protein |
21483469
|
| D009020 | 10018 |
BCL2L11
BAM BIM BOD |
BCL2-like 11 (apoptosis facilitator) | Morphine results in increased expression of BCL2L11 protein |
increases expression
|
protein |
19292871
|
| D009020 | 8678 |
BECN1
ATG6 VPS30 beclin1 |
beclin 1, autophagy related | Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein] |
affects binding
/ decreases reaction |
protein |
20190558
|
| D009020 | 8678 |
BECN1
ATG6 VPS30 beclin1 |
beclin 1, autophagy related | Morphine results in increased expression of BECN1 protein |
increases expression
|
protein |
20190558
|
| D009020 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Morphine inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity / increases cleavage |
protein |
17542780
|
| D009020 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Morphine results in increased activity of and results in increased cleavage of CASP3 protein |
increases activity
/ increases cleavage |
protein |
19292871
|
| D009020 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Morphine results in increased activity of CASP3 protein |
increases activity
|
protein |
10534122
19070643 21483469 |
| D009020 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | [[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein |
affects cotreatment
/ decreases expression / increases activity / increases expression |
protein |
10534122
|
| D009020 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
21483469
|
| D009020 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form] |
decreases expression
/ decreases reaction |
protein |
19239323
|
| D009020 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | Morphine results in decreased expression of CASP8 protein alternative form |
decreases expression
|
protein |
19239323
|
| D009020 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | Morphine results in increased activity of CASP8 protein |
increases activity
|
protein |
19070643
|
| D009020 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | Morphine results in increased activity of CASP9 protein |
increases activity
|
protein |
19292871
|
| D009020 | 6352 |
CCL5
D17S136E RANTES SCYA5 SIS-delta SISd TCP228 eoCP |
chemokine (C-C motif) ligand 5 | beta-funaltrexamine inhibits the reaction [Morphine results in decreased expression of CCL5 protein] |
decreases expression
/ decreases reaction |
protein |
11106302
|
| D009020 | 6352 |
CCL5
D17S136E RANTES SCYA5 SIS-delta SISd TCP228 eoCP |
chemokine (C-C motif) ligand 5 | Morphine results in decreased expression of CCL5 protein |
decreases expression
|
protein |
11106302
|
| D009020 | 6352 |
CCL5
D17S136E RANTES SCYA5 SIS-delta SISd TCP228 eoCP |
chemokine (C-C motif) ligand 5 | Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein] |
decreases expression
/ decreases reaction |
protein |
11106302
|
| D009020 | 6355 |
CCL8
HC14 MCP-2 MCP2 SCYA10 SCYA8 |
chemokine (C-C motif) ligand 8 | Morphine results in increased secretion of CCL8 protein |
increases secretion
|
protein |
20564181
|
| D009020 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein |
increases expression
/ increases phosphorylation / increases stability |
protein |
12702572
|
| D009020 | 8824 |
CES2
CE-2 CES2A1 PCE-2 iCE |
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) | CES2 protein results in increased chemical synthesis of Morphine |
increases chemical synthesis
|
protein |
8930175
|
| D009020 | 8824 |
CES2
CE-2 CES2A1 PCE-2 iCE |
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) | Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of Morphine] |
decreases reaction
/ increases chemical synthesis |
protein |
8930175
|
| D009020 | 1312 |
COMT
|
catechol-O-methyltransferase (EC:2.1.1.6) | [COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine |
affects cotreatment
/ affects response to substance |
gene |
21127283
|
| D009020 | 1401 |
CRP
PTX1 |
C-reactive protein, pentraxin-related | Morphine results in increased expression of CRP protein |
increases expression
|
protein |
18980684
|
| D009020 | 54205 |
CYCS
CYC HCS THC4 |
cytochrome c, somatic | Morphine inhibits the reaction [Doxorubicin affects the localization of CYCS protein] |
affects localization
/ decreases reaction |
protein |
17542780
|
| D009020 | 54205 |
CYCS
CYC HCS THC4 |
cytochrome c, somatic | Morphine results in increased secretion of CYCS protein |
increases secretion
|
protein |
19292871
|
| D009020 | 1565 |
CYP2D6
CPD6 CYP2D CYP2D7AP CYP2D7BP CYP2D7P2 CYP2D8P2 CYP2DL1 CYPIID6 P450-DB1 P450C2D P450DB1 |
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) | CYP2D6 protein affects the chemical synthesis of Morphine |
affects chemical synthesis
|
protein |
15625333
|
| D009020 | 1565 |
CYP2D6
CPD6 CYP2D CYP2D7AP CYP2D7BP CYP2D7P2 CYP2D8P2 CYP2DL1 CYPIID6 P450-DB1 P450C2D P450DB1 |
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) | [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine |
increases chemical synthesis
/ increases metabolic processing |
protein |
21241245
|
| D009020 | 1643 |
DDB2
DDBB UV-DDB2 |
damage-specific DNA binding protein 2, 48kDa | Morphine results in increased expression of DDB2 mRNA |
increases expression
|
mRNA |
19397953
|
| D009020 | 1643 |
DDB2
DDBB UV-DDB2 |
damage-specific DNA binding protein 2, 48kDa | Naloxone inhibits the reaction [Morphine results in increased expression of DDB2] |
decreases reaction
/ increases expression |
19397953
|
|
| D009020 | 1984 |
EIF5A
EIF-5A EIF5A1 eIF5AI |
eukaryotic translation initiation factor 5A | Morphine results in increased expression of EIF5A mRNA |
increases expression
|
mRNA |
19397953
|
| D009020 | 2155 |
F7
SPCA |
coagulation factor VII (serum prothrombin conversion accelerator) (EC:3.4.21.21) | Morphine results in increased expression of F7 protein |
increases expression
|
protein |
18980684
|
| D009020 | 355 |
FAS
ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6 |
Fas cell surface death receptor | [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein |
increases expression
/ increases phosphorylation / increases stability |
protein |
12702572
|
| D009020 | 2247 |
FGF2
BFGF FGF-2 FGFB HBGF-2 |
fibroblast growth factor 2 (basic) | Morphine results in decreased secretion of FGF2 protein |
decreases secretion
|
protein |
20564181
|
| D009020 | 2247 |
FGF2
BFGF FGF-2 FGFB HBGF-2 |
fibroblast growth factor 2 (basic) | Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein] |
decreases reaction
/ decreases secretion |
protein |
20564181
|
| D009020 | 2247 |
FGF2
BFGF FGF-2 FGFB HBGF-2 |
fibroblast growth factor 2 (basic) | OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein] |
affects reaction
/ decreases secretion |
protein |
20564181
|
| D009020 | 3557 |
IL1RN
DIRA ICIL-1RA IL-1RN IL-1ra IL-1ra3 IL1F3 IL1RA IRAP MVCD4 |
interleukin 1 receptor antagonist | IL1RN protein affects the susceptibility to Morphine |
affects response to substance
|
protein |
15317861
|
| D009020 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | Morphine results in increased secretion of IL6 protein |
increases secretion
|
protein |
20564181
|
| D009020 | 3725 |
JUN
AP-1 AP1 c-Jun |
jun proto-oncogene | Acetylcysteine inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein] |
decreases reaction
/ increases activity / increases phosphorylation |
protein |
19292871
|
| D009020 | 3725 |
JUN
AP-1 AP1 c-Jun |
jun proto-oncogene | anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein] |
decreases reaction
/ increases activity / increases phosphorylation |
protein |
19292871
|
| D009020 | 3725 |
JUN
AP-1 AP1 c-Jun |
jun proto-oncogene | Morphine results in increased phosphorylation of and results in increased activity of JUN protein |
increases activity
/ increases phosphorylation |
protein |
19292871
|
| D009020 | 8609 |
KLF7
UKLF |
Kruppel-like factor 7 (ubiquitous) | Morphine results in increased expression of KLF7 mRNA |
increases expression
|
mRNA |
14644156
|
| D009020 | 8609 |
KLF7
UKLF |
Kruppel-like factor 7 (ubiquitous) | Morphine results in increased expression of KLF7 protein |
increases expression
|
protein |
14644156
|
| D009020 | 8609 |
KLF7
UKLF |
Kruppel-like factor 7 (ubiquitous) | Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA] |
decreases reaction
/ increases expression |
mRNA |
14644156
|
| D009020 | 4010 |
LMX1B
LMX1.2 NPS1 |
LIM homeobox transcription factor 1, beta | Morphine results in increased expression of LMX1B mRNA |
increases expression
|
mRNA |
19397953
|
| D009020 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
21600884
|
| D009020 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein |
increases activity
/ increases phosphorylation |
protein |
21483469
|
| D009020 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein] |
increases activity
/ increases phosphorylation / increases reaction |
protein |
21483469
|
| D009020 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
21600884
|
| D009020 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
21600884
|
| D009020 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein |
increases activity
/ increases phosphorylation |
protein |
21483469
|
| D009020 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
increases activity
/ increases phosphorylation / increases reaction |
protein |
21483469
|
| D009020 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
21600884
|
| D009020 | 406901 |
MIR107
MIRN107 miR-107 |
microRNA 107 | Morphine results in decreased expression of MIR107 |
decreases expression
|
20564181
|
|
| D009020 | 406921 |
MIR132
MIRN132 miRNA132 |
microRNA 132 | Morphine results in increased expression of MIR132 |
increases expression
|
20564181
|
|
| D009020 | 100302258 |
MIR1469
MIRN1469 hsa-mir-1469 |
microRNA 1469 | Morphine results in decreased expression of MIR1469 |
decreases expression
|
20564181
|
|
| D009020 | 406938 |
MIR146A
MIRN146 MIRN146A miR-146a miRNA146A |
microRNA 146a | Morphine results in increased expression of MIR146A |
increases expression
|
20564181
|
|
| D009020 | 406942 |
MIR150
MIRN150 miRNA150 |
microRNA 150 | Morphine results in increased expression of MIR150 |
increases expression
|
20564181
|
|
| D009020 | 406947 |
MIR155
MIRN155 miRNA155 |
microRNA 155 | Morphine results in increased expression of MIR155 |
increases expression
|
20564181
|
|
| D009020 | 406949 |
MIR15B
MIRN15B hsa-mir-15b miR-15b |
microRNA 15b | Morphine results in increased expression of MIR15B |
increases expression
|
20564181
|
|
| D009020 | 406966 |
MIR191
MIRN191 miR-191 |
microRNA 191 | Morphine results in decreased expression of MIR191 |
decreases expression
|
20564181
|
|
| D009020 | 100302129 |
MIR1915
MIRN1915 hsa-mir-1915 |
microRNA 1915 | Morphine results in decreased expression of MIR1915 |
decreases expression
|
20564181
|
|
| D009020 | 406991 |
MIR21
MIRN21 hsa-mir-21 miR-21 miRNA21 |
microRNA 21 | Morphine results in decreased expression of MIR21 |
decreases expression
|
20564181
|
|
| D009020 | 407006 |
MIR221
MIRN221 miRNA221 mir-221 |
microRNA 221 | Morphine results in increased expression of MIR221 |
increases expression
|
20564181
|
|
| D009020 | 407010 |
MIR23A
MIRN23A hsa-mir-23a miRNA23A |
microRNA 23a | Morphine results in increased expression of MIR23A |
increases expression
|
20564181
|
|
| D009020 | 407011 |
MIR23B
MIRN23B hsa-mir-23b miRNA23B |
microRNA 23b | Morphine results in increased expression of MIR23B |
increases expression
|
20564181
|
|
| D009020 | 407015 |
MIR26A1
MIR26A MIRN26A1 |
microRNA 26a-1 | Morphine results in decreased expression of MIR26A1 |
decreases expression
|
20564181
|
|
| D009020 | 407017 |
MIR26B
MIRN26B hsa-mir-26b miR-26b |
microRNA 26b | Morphine results in decreased expression of MIR26B |
decreases expression
|
20564181
|
|
| D009020 | 407037 |
MIR320A
MIRN320 MIRN320A hsa-mir-320a |
microRNA 320a | Morphine results in decreased expression of MIR320A |
decreases expression
|
20564181
|
|
| D009020 | 494335 |
MIR423
MIRN423 hsa-mir-423 |
microRNA 423 | Morphine results in decreased expression of MIR423 |
decreases expression
|
20564181
|
|
| D009020 | 693223 |
MIR638
MIRN638 hsa-mir-638 |
microRNA 638 | Morphine results in decreased expression of MIR638 |
decreases expression
|
20564181
|
|
| D009020 | 407056 |
MIR99B
MIRN99B |
microRNA 99b | Morphine results in decreased expression of MIR99B |
decreases expression
|
20564181
|
|
| D009020 | 4792 |
NFKBIA
IKBA MAD-3 NFKBI |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | Morphine inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein] |
decreases reaction
/ increases degradation |
protein |
17542780
|
| D009020 | 4792 |
NFKBIA
IKBA MAD-3 NFKBI |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | Morphine results in increased phosphorylation of NFKBIA protein |
increases phosphorylation
|
protein |
19070643
|
| D009020 | 4814 |
NINJ1
NIN1 NINJURIN |
ninjurin 1 | Morphine results in increased expression of NINJ1 mRNA |
increases expression
|
mRNA |
19397953
|
| D009020 | 4985 |
OPRD1
OPRD |
opioid receptor, delta 1 | ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein] |
decreases reaction
/ increases expression |
protein |
21600884
|
| D009020 | 4985 |
OPRD1
OPRD |
opioid receptor, delta 1 | Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein] |
affects binding
/ increases reaction |
protein |
21600884
|
| D009020 | 4985 |
OPRD1
OPRD |
opioid receptor, delta 1 | OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
mutant form |
21600884
|
| D009020 | 4985 |
OPRD1
OPRD |
opioid receptor, delta 1 | OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
mutant form |
21600884
|
| D009020 | 4985 |
OPRD1
OPRD |
opioid receptor, delta 1 | OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein] |
decreases reaction
/ increases phosphorylation |
mutant form |
21600884
|
| D009020 | 4988 |
OPRM1
LMOR M-OR-1 MOP MOR MOR1 OPRM |
opioid receptor, mu 1 | [COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine |
affects cotreatment
/ affects response to substance |
gene |
21127283
|
| D009020 | 4988 |
OPRM1
LMOR M-OR-1 MOP MOR MOR1 OPRM |
opioid receptor, mu 1 | Morphine affects the activity of OPRM1 protein |
affects activity
|
protein |
11106302
|
| D009020 | 4988 |
OPRM1
LMOR M-OR-1 MOP MOR MOR1 OPRM |
opioid receptor, mu 1 | Morphine binds to and results in increased activity of OPRM1 protein |
affects binding
/ increases activity |
protein |
17656655
|
| D009020 | 4988 |
OPRM1
LMOR M-OR-1 MOP MOR MOR1 OPRM |
opioid receptor, mu 1 | [[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP |
affects binding
/ affects cotreatment / decreases activity / increases expression |
protein |
11413242
|
| D009020 | 4988 |
OPRM1
LMOR M-OR-1 MOP MOR MOR1 OPRM |
opioid receptor, mu 1 | [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP |
affects binding
/ affects cotreatment / decreases activity / increases expression |
protein |
11413242
|
| D009020 | 4988 |
OPRM1
LMOR M-OR-1 MOP MOR MOR1 OPRM |
opioid receptor, mu 1 | OPRM1 exon SNP results in decreased susceptibility to Morphine |
decreases response to substance
|
exon |
15504181
|
| D009020 | 4988 |
OPRM1
LMOR M-OR-1 MOP MOR MOR1 OPRM |
opioid receptor, mu 1 | OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein] |
affects reaction
/ decreases secretion |
protein |
20564181
|
| D009020 | 5155 |
PDGFB
IBGC5 PDGF-2 PDGF2 SIS SSV c-sis |
platelet-derived growth factor beta polypeptide | PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein] |
decreases expression
/ decreases reaction |
protein |
21483469
|
| D009020 | 5155 |
PDGFB
IBGC5 PDGF-2 PDGF2 SIS SSV c-sis |
platelet-derived growth factor beta polypeptide | PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
21483469
|
| D009020 | 5155 |
PDGFB
IBGC5 PDGF-2 PDGF2 SIS SSV c-sis |
platelet-derived growth factor beta polypeptide | PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein] |
decreases reaction
/ increases expression |
protein |
21483469
|
| D009020 | 5155 |
PDGFB
IBGC5 PDGF-2 PDGF2 SIS SSV c-sis |
platelet-derived growth factor beta polypeptide | PDGFB protein results in decreased susceptibility to Morphine |
decreases response to substance
|
protein |
21483469
|
| D009020 | 5443 |
POMC
ACTH CLIP LPH MSH NPP POC |
proopiomelanocortin | [Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form |
affects cotreatment
/ decreases expression |
protein |
20084599
|
| D009020 | 84152 |
PPP1R1B
DARPP-32 DARPP32 |
protein phosphatase 1, regulatory (inhibitor) subunit 1B (EC:3.1.3.16) | ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein] |
decreases reaction
/ increases phosphorylation |
protein |
21600884
|
| D009020 | 84152 |
PPP1R1B
DARPP-32 DARPP32 |
protein phosphatase 1, regulatory (inhibitor) subunit 1B (EC:3.1.3.16) | OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein] |
decreases reaction
/ increases phosphorylation |
protein |
21600884
|
| D009020 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | Morphine inhibits the reaction [Doxorubicin affects the localization of RELA protein] |
affects localization
/ decreases reaction |
protein |
17542780
|
| D009020 | 6648 |
SOD2
IPOB MNSOD MVCD6 |
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) | Morphine results in increased expression of SOD2 protein |
increases expression
|
protein |
20564181
|
| D009020 | 6778 |
STAT6
D12S1644 IL-4-STAT STAT6B STAT6C |
signal transducer and activator of transcription 6, interleukin-4 induced | STAT6 gene SNP affects the susceptibility to Morphine |
affects response to substance
|
gene |
16103897
|
| D009020 | 7099 |
TLR4
ARMD10 CD284 TLR-4 TOLL |
toll-like receptor 4 | Morphine binds to TLR4 protein |
affects binding
|
protein |
20178837
|
| D009020 | 7099 |
TLR4
ARMD10 CD284 TLR-4 TOLL |
toll-like receptor 4 | Naloxone affects the reaction [Morphine binds to TLR4 protein] |
affects binding
/ affects reaction |
protein |
20178837
|
| D009020 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form] |
decreases reaction
/ increases expression |
protein |
12927789
|
| D009020 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | Morphine results in increased expression of TP53 mRNA |
increases expression
|
mRNA |
19397953
|
| D009020 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | Morphine results in increased phosphorylation of and results in increased activity of TP53 protein |
increases activity
/ increases phosphorylation |
protein |
19397953
|
| D009020 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | Morphine results in increased phosphorylation of and results in increased stability of TP53 protein |
increases phosphorylation
/ increases stability |
protein |
12702572
|
| D009020 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein |
increases expression
/ increases phosphorylation / increases stability |
protein |
12702572
|
| D009020 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein |
increases expression
/ increases phosphorylation / increases stability |
protein |
12702572
|
| D009020 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein |
increases expression
/ increases phosphorylation / increases stability |
protein |
12702572
|
| D009020 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]] |
decreases reaction
/ increases expression |
protein |
12927789
|
| D009020 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | Naloxone inhibits the reaction [Morphine results in increased expression of TP53] |
decreases reaction
/ increases expression |
19397953
|
|
| D009020 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | Naloxone inhibits the reaction [Morphine results in increased phosphorylation of TP53 protein] |
decreases reaction
/ increases phosphorylation |
protein |
19397953
|
| D009020 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | UGT1A1 protein results in increased glucuronidation of Morphine |
increases glucuronidation
|
protein |
12920162
|
| D009020 | 54575 |
UGT1A10
UDPGT UGT-1J UGT1-10 UGT1.10 UGT1J |
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) | UGT1A10 protein results in increased glucuronidation of Morphine |
increases glucuronidation
|
protein |
12920162
|
| D009020 | 54659 |
UGT1A3
UDPGT UDPGT_1-3 UGT-1C UGT1-03 UGT1.3 UGT1C |
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) | UGT1A3 protein results in increased glucuronidation of Morphine |
increases glucuronidation
|
protein |
12920162
|
| D009020 | 54578 |
UGT1A6
GNT1 HLUGP HLUGP1 UDPGT UDPGT_1-6 UGT1 UGT1A6S UGT1F |
UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) | UGT1A6 protein results in increased glucuronidation of Morphine |
increases glucuronidation
|
protein |
12920162
|
| D009020 | 54576 |
UGT1A8
UDPGT UDPGT_1-8 UGT-1H UGT1-08 UGT1.8 UGT1A8S UGT1H |
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) | UGT1A8 protein results in increased glucuronidation of Morphine |
increases glucuronidation
|
protein |
12920162
|
| D009020 | 54600 |
UGT1A9
HLUGP4 LUGP4 UDPGT UDPGT_1-9 UGT-1I UGT1-09 UGT1-9 UGT1.9 UGT1AI UGT1I |
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) | UGT1A9 protein results in increased glucuronidation of Morphine |
increases glucuronidation
|
protein |
12920162
|
| D009020 | 7364 |
UGT2B7
UDPGT_2B9 UDPGT2B7 UDPGTH2 UGT2B9 |
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) | UGT2B7 protein affects the metabolism of Morphine |
affects metabolic processing
|
protein |
15286053
|
| D009020 | 7364 |
UGT2B7
UDPGT_2B9 UDPGT2B7 UDPGTH2 UGT2B9 |
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) | UGT2B7 protein results in increased glucuronidation of Morphine |
increases glucuronidation
|
protein |
11186130
12756209 12920162 15611481 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (17)
| OMIM | preferred title | UniProt |
|---|---|---|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #300615 | Brunner syndrome |
P21397
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #607208 | Dravet syndrome |
P35498
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #613721 | Epileptic encephalopathy, early infantile, 11; eiee11 |
Q99250
|
| #604403 | Generalized epilepsy with febrile seizures plus, type 2; gefsp2 |
P35498
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #609634 | Migraine, familial hemiplegic, 3; fhm3 |
P35498
|
| #607745 | Seizures, benign familial infantile, 3; bfis3 |
Q99250
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
KEGG DISEASE (11)
| KEGG | disease name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P35498
(related)
|
| H00783 | Febrile seizures |
P35498
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
Q99250
(related)
|
| H00806 | Benign familial neonatal and infantile epilepsies |
Q99250
(related)
|