KCF-S cluster No. 253 (25 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (25)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Magnoliophyta	33
eudicotyledons	29
Liliopsida	19
Spermatophyta	2

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Cumulative family count

class name	count
Menispermaceae	21
Lauraceae	21
Amaryllidaceae	18
Annonaceae	10
Papaveraceae	6
Ranunculaceae	2
Monimiaceae	2
Gnetaceae	2
Colchicaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Isoquinoline alkaloids	4

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Isoquinoline alkaloids	C05176	C00025268
Isoquinoline alkaloids	C05243	C00025619
Isoquinoline alkaloids	C06161	C00025812
Isoquinoline alkaloids	C06160	C00034613

Metabolite list (25)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001846	(+)-Demethylcoclaurine	CHEMBL19344 CHEMBL501778 CHEMBL470491		2 / 2 / 0
C00024372	Cheryllin / Cherylline / (-)-Cherylline / (S)-(-)-Cherylline / Crinine(C17 alkaloid)
C00024385	Crinine
C00024400	Latifine / (-)-Latifine
C00025268	(+)-N-Methylcoclaurine / (+)-(S)-N-Methylcoclaurine	CHEMBL453292 CHEMBL513109
C00025328	Norcinnamolaurine / (+)-Norcinnamolaurine
C00025619	(-)-N-Methylcoclaurine / (R)-N-Methylcoclaurine	CHEMBL453292 CHEMBL513109
C00025652	d-Coclaurine / Sanjoinine K / (R)-Coclaurine / (+)-Coclaurine / (+)-R-Coclaurine	CHEMBL256448 CHEMBL453291 CHEMBL446211		8 / 17 / 10
C00025812	Coclaurine / (S)-Coclaurine / (-)-Coclaurine	CHEMBL256448 CHEMBL453291 CHEMBL446211	C004690	8 / 17 / 10
C00025924	Juziphine / Yuziphine / (+)-Juziphine	CHEMBL462956
C00027202	Cinnamolaurine
C00027226	Norarmepavine / (-)-Norarmepavine	CHEMBL510363 CHEMBL453038		9 / 14 / 7
C00027385	Isococlaurine / R-(+)-Isococlaurine
C00027437	Norgorchacoine / (-)-Magnococline / 2,2-Didemethylpetaline
C00027440	Norjuziphine / (-)-Norjusiphine / (-)-Norjuziphine	CHEMBL462757
C00027870	Anomoline
C00028042	Cherylline
C00028076	Colchiethanamine
C00028713	Noranicanine
C00028715	Norcanelilline
C00034613	Norcoclaurine / (S)-(-)-Higenamine	CHEMBL19344 CHEMBL501778 CHEMBL470491		2 / 2 / 0
C00034979	(-)-4'-O-Methylcoclaurine	CHEMBL451723
C00047850	dl-Coclaurine	CHEMBL256448 CHEMBL453291 CHEMBL446211		8 / 17 / 10
C00049554	N-Methylhigenamine
C00049556	Higenamine	CHEMBL19344 CHEMBL501778 CHEMBL470491	C012348	2 / 2 / 0

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00025652 C00025812 C00027226 C00047850	7 / 3
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00025652 C00025812 C00027226 C00047850	0 / 0
O75496	Geminin	Unclassified protein	C00025652 C00025812 C00027226 C00047850	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00025652 C00025812 C00047850	0 / 0
P04062	Glucosylceramidase	Enzyme	C00025652 C00025812 C00047850	6 / 4
P14416	D(2) dopamine receptor	Dopamine receptor	C00001846 C00034613 C00049556	2 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00025652 C00025812 C00047850	4 / 3
P14618	Pyruvate kinase PKM	Enzyme	C00025652 C00025812 C00047850	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00025652 C00025812 C00047850	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00001846 C00034613 C00049556	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00027226	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00027226	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00027226	2 / 0
P11473	Vitamin D3 receptor	NR1I1	C00027226	2 / 3
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00027226	2 / 0
Q99700	Ataxin-2	Unclassified protein	C00027226	1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions