PCIDB

KNApSAcK Metabolite C00025812

Metabolite

KNApSAcK Entry

id C00025812
Name Coclaurine / (S)-Coclaurine / (-)-Coclaurine
CAS RN 486-39-5
Standard InChI InChI=1S/C17H19NO3/c1-21-17-9-12-6-7-18-15(14(12)10-16(17)20)8-11-2-4-13(19)5-3-11/h2-5,9-10,15,18-20H,6-8H2,1H3/t15-/m0/s1
Standard InChI (Main Layer) InChI=1S/C17H19NO3/c1-21-17-9-12-6-7-18-15(14(12)10-16(17)20)8-11-2-4-13(19)5-3-11/h2-5,9-10,15,18-20H,6-8H2,1H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 253

Link

ChEMBL

By standard InChI CHEMBL446211
By standard InChI Main Layer CHEMBL256448 CHEMBL453291 CHEMBL446211

KEGG

By LinkDB C06161

CTD

By CAS RN C004690

Human Protein / Gene in interaction

8 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P14618 Pyruvate kinase PKM Enzyme CHEMBL446211 CHEMBL1613996 (1) CHEMBL1614428 (1)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL446211 CHEMBL1613818 (1)
6 / 4
O75496 Geminin Unclassified protein CHEMBL446211 CHEMBL2114843 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL446211 CHEMBL2114810 (1)
7 / 3
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL446211 CHEMBL1614421 (1)
4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL446211 CHEMBL1613914 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL446211 CHEMBL1738442 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL446211 CHEMBL2114738 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (10)

KEGG disease name UniProt
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)