Cocculus laurifolius DC.

• Index
• Plant Species
• Metabolite list (31)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Cocculus laurifolius DC.
Genus	Cocculus
Family	Menispermaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Cocculus laurifolius
Linked NCBI taxonomy ID	152359
Linked level	species

Family

Family in NCBI taxonomy	Menispermaceae
ID	3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	eudicotyledons
ID	71240

Metabolite list (31)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00025653	Efirine / Cocsulin / (+)-Efirine / Trigilletine / (+)-Cocsuline / (+)-Trigilletine	CHEMBL447886 CHEMBL2063766				No. 10	No. 4
C00025313	Isotetrandrine / Isosinomenine A / O-Methylberbamine / O,O-Dimethylobamegine / O,O'-Dimethylobamegine / O,O-Dimethylstepholine / O,O'-Dimethylstepholine	CHEMBL176045 CHEMBL367260 CHEMBL445477 CHEMBL449690 CHEMBL504958 CHEMBL504757		26 / 23 / 48		No. 10	No. 4
C00025962	Norisoboldine / Laurelliptine / (+)-Norisoboldine / (+)-Laurelliptine / (+)-N-Norisoboldine / (S)-(+)-Laurelliptine	CHEMBL375902				No. 20	No. 4
C00026094	Stepholidine / (-)-Stepholidine	CHEMBL487387 CHEMBL2334890	C010513	7 / 4 / 0	0 / 1	No. 37	No. 4
C00026102	(+)-Sinactine					No. 37	No. 4
C00025812	Coclaurine / (S)-Coclaurine / (-)-Coclaurine	CHEMBL256448 CHEMBL453291 CHEMBL446211	C004690	8 / 17 / 10		No. 253	No. 4
C00025869	Erythramide					No. 273	No. 4
C00025868	Erythlaurine					No. 273	No. 4
C00025850	Dihydroerysodine					No. 273	No. 4
C00025870	Erythroculine					No. 273	No. 4
C00025807	Cocculitinine					No. 273	No. 4
C00025802	Cocculidine		C015083			No. 273	No. 4
C00025805	Kokuline / Cocculine / (+)-Coculine					No. 273	No. 4
C00025806	Cocculitine					No. 273	No. 4
C00024888	Garryfoline / Laurifoline / 15-Epiveatchine / (20S)-Garryfoline					No. 274	No. 10
C00025667	(+)-Laurifoline	CHEMBL235429				No. 286	No. 4
C00025674	N-Methylcorydine / (+)-N-Methylcorydine	CHEMBL1617951				No. 286	No. 4
C00001918	Cucoline / Kukoline / Sinomenine	CHEMBL248095 CHEMBL1551847 CHEMBL1555036 CHEMBL1589951 CHEMBL1591798	C009271	9 / 8 / 8		No. 346	No. 4
C00025988	Sebiferine / (9R)-Sebiferine / O-Methylflavinantine / (+)-O-Methylflavinanthine / (+)-O-Methylflavinantine	CHEMBL224744 CHEMBL490139	C024736			No. 426	No. 4
C00025810	Coccuvine		C013447			No. 446	No. 4
C00025811	Coccuvinine / O-Methylcoccuvine					No. 446	No. 4
C00025272	Stepharine / (+)-Stepharine	CHEMBL463957 CHEMBL1975436	C009320			No. 688
C00001905	Milthanthine / Pronuciferine / (+)-Pronuciferine / N-Methylstepharine / N,O-Dimethylcrotonosine	CHEMBL237766				No. 688
C00025799	Coccoline					No. 948
C00025800	Coccolinine / O-Methylcoccoline					No. 948
C00025925	Laurifinine					No. 2029
C00025926	Laurifonine / (+/-)-Laurifonine					No. 2029
C00025904	Isococculine					No. 3755	No. 4
C00025804	Cocculimine					No. 3755	No. 4
C00025803	Cocculidinone					No. 4375
C00025801	Coccudienone					No. 4375

Human Protein / Gene in interactions

44 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001918 C00025313	1 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001918 C00025812	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00001918 C00025812	4 / 3
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001918 C00025313	0 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001918 C00025313	0 / 0
O75496	Geminin	Unclassified protein	C00025313 C00025812	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00025313	0 / 0
P01375	Tumor necrosis factor	Secreted protein	C00001918	3 / 4
P04062	Glucosylceramidase	Enzyme	C00025812	6 / 4
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00025313	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00025313	0 / 0
P21918	D(1B) dopamine receptor	Dopamine receptor	C00026094	1 / 0
P08183	Multidrug resistance protein 1	drug	C00025313	1 / 0
P24941	Cyclin-dependent kinase 2	Cdc2	C00001918	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00025313	0 / 1
P14416	D(2) dopamine receptor	Dopamine receptor	C00026094	2 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00025313	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00025313	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00001918	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00025313	2 / 0
P14618	Pyruvate kinase PKM	Enzyme	C00025812	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00026094	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00026094	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00025812	7 / 3
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00001918	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00025313	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00025313	1 / 1
P13726	Tissue factor	Membrane receptor	C00026094	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00025313	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00025313	1 / 1
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00026094	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00025313	1 / 1
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00025313	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00025313	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00025313	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00025313	4 / 1
P08908	5-hydroxytryptamine receptor 1A	Serotonin receptor	C00026094	1 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00025313	7 / 37
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00025812	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00025313	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00025313	1 / 0
O00255	Menin	Unclassified protein	C00025313	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00025313	1 / 2
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00025812	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions