KCF-S cluster No. 346 (20 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (20)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
eudicotyledons	31
Magnoliophyta	3
rosids	1

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Cumulative family count

class name	count
Menispermaceae	31
Lauraceae	3
Euphorbiaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Isoquinoline alkaloids	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Isoquinoline alkaloids	C09643	C00001918

Metabolite list (20)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001918	Cucoline / Kukoline / Sinomenine	CHEMBL248095 CHEMBL1551847 CHEMBL1555036 CHEMBL1589951 CHEMBL1591798	C009271	9 / 8 / 8
C00025596	8,14-Dihydrosalutaridine / (-)-8,14-dihydrosalutaridine
C00025661	Erromangine / (+)-Erromangine / 14-Epi-(+)-isostephodeline
C00025687	Stephodeline / (+)-Stephodeline
C00025688	Tannagine / (+)-Tannagine / 14-Epi-(+)-stephodeline
C00025691	Zippelianine / (+)-Zippelianine / 2-O-Demethyl-(+)-stephodeline
C00025692	Zippeline / (+)-Zippeline / 8-Demethoxy-(+)-stephodeline
C00025718	14-Episinomenine	CHEMBL248095 CHEMBL1551847 CHEMBL1555036 CHEMBL1589951 CHEMBL1591798		9 / 8 / 8
C00025781	Carococculine		C006918
C00025784	Cephamonine / (-)-Cephamonine / (-)-8-Methoxysinomenine
C00025786	Cephamuline / (-)-Cephamuline
C00025792	Cephasamine
C00025794	Cephatonine / (-)-Cephatonine
C00025913	Isostephodeline / (+)-Isostephodeline / (+)-14-Epierromangine
C00025944	Milonine / (+)-Milonine
C00027109	(-)-Pallidinine
C00027110	(+)-Pallidinine
C00027250	14-Hydroxyisostephodeline
C00027526	Cephamuline / (-)-Cephamuline
C00028255	Erromangine

Human Protein / Gene in interactions

9 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001918 C00025718	1 / 0
P01375	Tumor necrosis factor	Secreted protein	C00001918 C00025718	3 / 4
P24941	Cyclin-dependent kinase 2	Cdc2	C00001918 C00025718	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00001918 C00025718	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00001918 C00025718	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001918 C00025718	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001918 C00025718	0 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00001918 C00025718	4 / 3
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001918 C00025718	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions