Metabolite

KNApSAcK Entry

id C00025718
Name 14-Episinomenine
CAS RN 60761-53-7
Standard InChI InChI=1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3/t12-,13-,19+/m0/s1
Standard InChI (Main Layer) InChI=1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 346

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL248095 CHEMBL1551847 CHEMBL1555036 CHEMBL1589951 CHEMBL1591798

KEGG

By LinkDB

CTD

By CAS RN

Species

Summary

Plant class

class name count
eudicotyledons 1

Family

family name count
Menispermaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Stephania cepharantha Hayata 147243 Menispermaceae eudicotyledons Viridiplantae

Human Protein / Gene in interaction

9 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1555036 CHEMBL1614110 (1)
1 / 0
P01375 Tumor necrosis factor Secreted protein CHEMBL248095 CHEMBL2343223 (1)
3 / 6
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL248095 CHEMBL1067148 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1591798 CHEMBL1738606 (1)
0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL1589951 CHEMBL1614280 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1589951 CHEMBL1738588 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1551847 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1551847 CHEMBL1614250 (1)
4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1551847 CHEMBL1613914 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#610424 Hepatitis b virus, susceptibility to P01375
#611162 Malaria, susceptibility to P01375
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#607507 Psoriatic arthritis, susceptibility to P01375
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (8)

KEGG disease name UniProt
H00079 Asthma P01375 (related)
H00080 Systemic lupus erythematosus P01375 (related)
P01375 (marker)
H00083 Allograft rejection P01375 (related)
H00084 Graft-versus-host disease P01375 (related)
P01375 (marker)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)