PCIDB

KNApSAcK Metabolite C00001918

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00001918
Name	Cucoline / Kukoline / Sinomenine
CAS RN	115-53-7
Standard InChI	InChI=1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3/t12-,13+,19-/m1/s1
Standard InChI (Main Layer)	InChI=1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3

Cluster

Phytochemical cluster	No. 4
KCF-S cluster	No. 346

Link

ChEMBL

By standard InChI	CHEMBL248095
By standard InChI Main Layer	CHEMBL248095 CHEMBL1551847 CHEMBL1555036 CHEMBL1589951 CHEMBL1591798

KEGG

By LinkDB	C09643

CTD

By CAS RN	C009271

Species

Summary

Plant class

class name	count
eudicotyledons	4

Family

family name	count
Menispermaceae	4

List (4)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Cocculus laurifolius DC.	152359	Menispermaceae	eudicotyledons	Viridiplantae
Menispermum dauricum DC.	49680	Menispermaceae	eudicotyledons	Viridiplantae
Sinomenium acutum	152363	Menispermaceae	eudicotyledons	Viridiplantae
Stephania cepharantha	147243	Menispermaceae	eudicotyledons	Viridiplantae

Human Protein / Gene in interaction

9 ChEMBL Protein in interactions

accession	description	class description	compound	assay ID (# of activities)	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	CHEMBL1555036	CHEMBL1614110 (1)	1 / 0
P01375	Tumor necrosis factor	Secreted protein	CHEMBL248095	CHEMBL2343223 (1)	3 / 6
P24941	Cyclin-dependent kinase 2	Cdc2	CHEMBL248095	CHEMBL1067148 (1)	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	CHEMBL1591798	CHEMBL1738606 (1)	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	CHEMBL1589951	CHEMBL1614280 (1)	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	CHEMBL1589951	CHEMBL1738588 (1)	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	CHEMBL1551847	CHEMBL1614108 (1) CHEMBL1613886 (1)	0 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	CHEMBL1551847	CHEMBL1614250 (1)	4 / 3
B2RXH2	Lysine-specific demethylase 4E	Enzyme	CHEMBL1551847	CHEMBL1613914 (1)	0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM	preferred title	UniProt
#608902	Drug metabolism, poor, cyp2d6-related	P10635
#600274	Frontotemporal dementia; ftd	P10636
#610424	Hepatitis b virus, susceptibility to	P01375
#611162	Malaria, susceptibility to	P01375
#260540	Parkinson-dementia syndrome	P10636
#172700	Pick disease of brain	P10636
#607507	Psoriatic arthritis, susceptibility to	P01375
#601104	Supranuclear palsy, progressive, 1; psnp1	P10636

KEGG DISEASE (8)

KEGG	disease name	UniProt
H00079	Asthma	P01375 (related)
H00080	Systemic lupus erythematosus	P01375 (related) P01375 (marker)
H00083	Allograft rejection	P01375 (related)
H00084	Graft-versus-host disease	P01375 (related) P01375 (marker)
H00036	Osteosarcoma	P08684 (marker)
H00058	Amyotrophic lateral sclerosis (ALS)	P10636 (related)
H00077	Progressive supranuclear palsy (PSP)	P10636 (related)
H00078	Frontotemporal lobar degeneration (FTLD)	P10636 (related)