Stephania cepharantha
Species
KNApSAcK Entry
| Organism name | Stephania cepharantha |
|---|---|
| Genus | Stephania |
| Family | Menispermaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Stephania |
|---|---|
| Linked NCBI taxonomy ID | 147243 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Menispermaceae |
|---|---|
| ID | 3455 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (25)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00025265
|
Homoaromoline
/ Homothalicrine / (+)-Homoaromoline / (+)-Thalrugosamine |
CHEMBL507220
CHEMBL503522 CHEMBL509855 CHEMBL1185978 |
No. 10 | No. 4 |
|
|||
|
C00026063
|
Aromoline
/ Thalicrine / (+)-Aromoline |
CHEMBL504525
CHEMBL508781 |
C066341
|
6 / 2 / 3 | No. 10 | No. 4 |
|
|
|
C00001817
|
Berbamine
/ d-Berbamine / (+)-Berbamine |
CHEMBL504323
CHEMBL507540 CHEMBL1198334 |
C027870
|
4 / 3 / 4 | 9 / 1 | No. 10 | No. 4 |
|
|
C00001836
|
Cepharanthine
|
CHEMBL472588
CHEMBL449782 CHEMBL475273 CHEMBL1473842 |
C006947
|
22 / 19 / 17 | 1 / 1 | No. 10 | No. 4 |
|
|
C00025266
|
Isosinomenin A
/ Isotetrandrine / Isosinomenine A / O-Methylberbamine / (+)-Isotetrandrine / O,O-Dimethylobamegine / O,O'-Dimethylobamegine / O,O-Dimethylstepholine / O,O'-Dimethylstepholine |
No. 10 | No. 4 |
|
||||
|
C00025261
|
2-Norisotetrandrine
/ (+)-2-Norisotetrandrine |
No. 10 | No. 4 |
|
||||
|
C00027507
|
2-Norcepharanoline
|
No. 10 | No. 4 |
|
||||
|
C00001895
|
Obaberine
|
CHEMBL464525
|
No. 10 | No. 4 |
|
|||
|
C00001807
|
Anonaine
/ (-)-Anonaine / (R)-Annonaine |
CHEMBL401798
|
C098138
|
1 / 0 / 0 | No. 20 | No. 4 |
|
|
|
C00001872
|
Isocorydine
/ (+)-Isocorydine / L-(+)-Isocorydine / (S)-(+)-Isocorydine |
CHEMBL489525
CHEMBL1376826 |
14 / 7 / 10 | No. 20 | No. 4 |
|
||
|
C00001869
|
Isoboldine
/ (S)-Isoboldine |
CHEMBL462880
|
19 / 22 / 55 | No. 20 | No. 4 |
|
||
|
C00026120
|
Cyclanoline
/ (-)-Cissamine / alpha-Cyclanoline |
CHEMBL2008127
|
C060801
|
No. 234 |
|
|||
|
C00033389
|
Stecepharine
/ (-)-Stecepharine |
No. 234 |
|
|||||
|
C00032838
|
cis-N-Methylcapaurine
/ 9-O-Methylstecepharine |
No. 234 |
|
|||||
|
C00026148
|
Steponine
/ (-)-Steponine |
No. 234 |
|
|||||
|
C00025939
|
Menisperine
/ (+)-Menisperine / N-Methylisocorydine / (+)-N-Methylisocorydine |
CHEMBL175775
CHEMBL1186240 |
C042421
|
No. 286 | No. 4 |
|
||
|
C00001885
|
Escholin
/ Escholine / Thalictrin / Thalictrine / Magnoflorine / (+)-Magnoflorine |
CHEMBL235428
|
C001670
|
No. 286 | No. 4 |
|
||
|
C00001918
|
Cucoline
/ Kukoline / Sinomenine |
CHEMBL248095
CHEMBL1551847 CHEMBL1555036 CHEMBL1589951 CHEMBL1591798 |
C009271
|
9 / 8 / 8 | No. 346 | No. 4 |
|
|
|
C00027526
|
Cephamuline
/ (-)-Cephamuline |
No. 346 | No. 4 |
|
||||
|
C00027527
|
Cephatonine
/ (-)-Cephatonine |
No. 512 | No. 4 |
|
||||
|
C00001793
|
Aknadicine
|
CHEMBL2000216
|
No. 559 | No. 4 |
|
|||
|
C00026030
|
Secocepharanthine
|
No. 815 |
|
|||||
|
C00025982
|
Oblongine
/ (+)-Oblongine |
CHEMBL457373
|
C081049
|
No. 896 |
|
|||
|
C00033438
|
Tetradehydroreticuline
|
No. 1165 | No. 4 |
|
||||
|
C00027538
|
FK 3000
|
No. 3886 |
|
Human Protein / Gene in interactions
45 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001817 C00001836 C00001869 C00001872 C00001918 C00026063 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001869 C00001872 C00001918 C00026063 | 1 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001836 C00001869 C00001872 C00001918 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001869 C00001872 C00026063 | 0 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001817 C00001869 C00001872 | 3 / 3 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00001817 C00001836 C00026063 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001869 C00001872 C00026063 | 1 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001836 C00001869 C00001918 | 4 / 3 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00001872 C00001918 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001836 C00001872 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00001836 C00001869 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001836 C00001869 | 1 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001869 C00001872 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001869 C00001872 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001869 C00001872 | 1 / 4 |
| O75496 | Geminin | Unclassified protein | C00001836 C00001872 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001872 C00026063 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001836 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001918 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001836 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001836 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001836 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001836 | 2 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001918 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001869 | 2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00001836 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001918 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00001869 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001836 | 0 / 0 |
| Q14761 | Protein tyrosine phosphatase receptor type C-associated protein | Enzyme | C00001807 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001836 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001869 | 0 / 0 |
| P54750 | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | PDE_1A | C00001817 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001836 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001869 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00001836 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001869 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001836 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001836 | 1 / 1 |
| P29466 | Caspase-1 | C14 | C00001869 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00001836 | 6 / 4 |
| P01375 | Tumor necrosis factor | Secreted protein | C00001918 | 3 / 4 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001836 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001869 | 7 / 37 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001872 | 0 / 0 |
10 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00001836
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00001817
|
| 637 | BID, FP497 | BH3 interacting domain death agonist |
C00001817
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00001817
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001817
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00001817
|
| 1147 | CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 | conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) |
C00001817
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00001817
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00001817
|
| 7128 | TNFAIP3, A20, OTUD7C, TNFA1P2 | tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) |
C00001817
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (37)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610424 | Hepatitis b virus, susceptibility to |
P01375
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #611162 | Malaria, susceptibility to |
P01375
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607507 | Psoriatic arthritis, susceptibility to |
P01375
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (65)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00079 | Asthma |
P01375
(related)
|
| H00080 | Systemic lupus erythematosus |
P01375
(related)
P01375 (marker) |
| H00083 | Allograft rejection |
P01375
(related)
|
| H00084 | Graft-versus-host disease |
P01375
(related)
P01375 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|