KCF-S cluster No. 10 (230 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (230)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
eudicotyledons	562
Magnoliophyta	42
asterids	5
Spermatophyta	1
rosids	1
Liliopsida	1

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Cumulative family count

class name	count
Menispermaceae	447
Ranunculaceae	58
Berberidaceae	56
Atherospermataceae	15
Lauraceae	10
Annonaceae	10
Aristolochiaceae	6
Plantaginaceae	3
Apiaceae	2
Hernandiaceae	1
Cupressaceae	1
Rhamnaceae	1
Buxaceae	1
Orchidaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Isoquinoline alkaloids	21

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metabolites link (23)

br08003 Category	KEGG ID	KNApSAcK ID
Isoquinoline alkaloids	C11141	C00001814
Isoquinoline alkaloids	C09352	C00001816
Isoquinoline alkaloids	C09357	C00001817
Isoquinoline alkaloids	C09369	C00001826
Isoquinoline alkaloids	C09391	C00001836
Isoquinoline alkaloids	C09415	C00001843
Isoquinoline alkaloids	C09458	C00001863
Isoquinoline alkaloids	C09461	C00001866
Isoquinoline alkaloids	C09543	C00001870
Isoquinoline alkaloids	C09580	C00001884
Isoquinoline alkaloids	C09590	C00001888
Isoquinoline alkaloids	C09596	C00001895
Isoquinoline alkaloids	C09598	C00001897
Isoquinoline alkaloids	C09615	C00001909
Isoquinoline alkaloids	C09624	C00001912
Isoquinoline alkaloids	C09654	C00001919
Isoquinoline alkaloids	C09656	C00001921
Isoquinoline alkaloids	C09659	C00001922
Isoquinoline alkaloids	C09661	C00001923
Isoquinoline alkaloids	C09667	C00001925
Isoquinoline alkaloids	C07547	C00001927
Isoquinoline alkaloids	C09654	C00025278
Isoquinoline alkaloids	C09659	C00027494

Metabolite list (230)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001811	(+)-Aromoline	CHEMBL504525 CHEMBL508781	C066341	6 / 2 / 3
C00001814	(+)-Atherospermoline
C00001816	(+)-Bebeerine	CHEMBL1169627	C066405	13 / 6 / 5
C00001817	Berbamine / d-Berbamine / (+)-Berbamine	CHEMBL504323 CHEMBL507540 CHEMBL1198334	C027870	4 / 3 / 4	9 / 1
C00001826	Calafatimine
C00001836	Cepharanthine	CHEMBL472588 CHEMBL449782 CHEMBL475273 CHEMBL1473842	C006947	22 / 19 / 17	1 / 1
C00001843	Daphnandrine / (+)-Daphnandrine / O12'-Methyldaphnoline	CHEMBL502441 CHEMBL510612
C00001844	Daphnoline / Trilobamin / Trilobamine
C00001863	Gyrocarpine	CHEMBL463946
C00001866	Hernandezine	CHEMBL504936	C067193	5 / 4 / 8
C00001870	Isobebeerin / Isobebeerine / Isochondodendrine	CHEMBL509310 CHEMBL1169628
C00001884	Macoline
C00001888	O-Methylthalicberine / (+)-O-Methylthalicberine	CHEMBL2005418
C00001895	Obaberine	CHEMBL464525
C00001897	Oxyacanthine	CHEMBL510022 CHEMBL509999 CHEMBL1983122	C092646	5 / 4 / 1
C00001909	Pycnamine	CHEMBL504323 CHEMBL507540 CHEMBL1198334		4 / 3 / 4
C00001912	Rodiasine
C00001919	Tetrandrine / (+)-Tetrandrine	CHEMBL176045 CHEMBL367260 CHEMBL445477 CHEMBL449690 CHEMBL504958 CHEMBL504757	C009438	26 / 23 / 48	6 / 16
C00001921	Thalidasine	CHEMBL506593	C057069
C00001922	Thalmine
C00001923	Thalsimine
C00001925	Tiliacorine	CHEMBL2017489 CHEMBL2017491
C00001926	Trilobine	CHEMBL500324	C041179
C00001927	(+)-Tubocurarine	CHEMBL339427 CHEMBL1616987	D014403	5 / 2 / 0	38 / 16
C00025236	(-)-Curicycleatjenine	CHEMBL449980 CHEMBL508957
C00025237	(-)-Curicycleatjine	CHEMBL510729
C00025239	Isocuricycleatjenine / (-)-Isocuricycleatjenine	CHEMBL449980 CHEMBL508957
C00025240	Isocuricycleatjine / (-)-Isocuricycleatjine	CHEMBL510729
C00025260	2-Norberbamine / (+)-2-Norberbamine / 2-Demethylberbamine
C00025261	2-Norisotetrandrine / (+)-2-Norisotetrandrine
C00025263	Cycleatjehenine / (+)-Cycleatjehenine	CHEMBL487904
C00025264	Cycleatjehine / (+)-Cycleatjehine	CHEMBL502592
C00025265	Homoaromoline / Homothalicrine / (+)-Homoaromoline / (+)-Thalrugosamine	CHEMBL507220 CHEMBL503522 CHEMBL509855 CHEMBL1185978
C00025266	Isosinomenin A / Isotetrandrine / Isosinomenine A / O-Methylberbamine / (+)-Isotetrandrine / O,O-Dimethylobamegine / O,O'-Dimethylobamegine / O,O-Dimethylstepholine / O,O'-Dimethylstepholine
C00025270	(+)-Norstephasubine
C00025273	(+)-Stephasubine
C00025274	Stephibaberine / (+)-Stephibaberine	CHEMBL463946
C00025275	Homoaromoline / Homothalicrine / (+)-Homoaromoline / (+)-Thalrugosamine	CHEMBL507220 CHEMBL503522 CHEMBL509855 CHEMBL1185978
C00025276	Thalrugosine / (+)-Thalrugosine		C060802		0 / 1
C00025278	(+/-)-Tetrandrine	CHEMBL176045 CHEMBL367260 CHEMBL445477 CHEMBL449690 CHEMBL504958 CHEMBL504757	C009438	26 / 23 / 48	6 / 16
C00025299	Dinklacorine / O12-Demethyl-O12'-methyltiliacorine
C00025306	Fangchinoline / dl-Fangchinoline / 7-O-Demethyltetrandrine	CHEMBL504256 CHEMBL509803 CHEMBL500614		12 / 6 / 3
C00025310	Homoaromoline / (+)-Homoaromoline / (+)-Thalrugosamine	CHEMBL507220 CHEMBL503522 CHEMBL509855 CHEMBL1185978
C00025313	Isotetrandrine / Isosinomenine A / O-Methylberbamine / O,O-Dimethylobamegine / O,O'-Dimethylobamegine / O,O-Dimethylstepholine / O,O'-Dimethylstepholine	CHEMBL176045 CHEMBL367260 CHEMBL445477 CHEMBL449690 CHEMBL504958 CHEMBL504757		26 / 23 / 48
C00025320	Limacine / (-)-Limacine	CHEMBL504256 CHEMBL509803 CHEMBL500614		12 / 6 / 3
C00025321	Limacine 2'-beta-N-oxide / (-)-Limacine 2'-beta-N-oxide
C00025329	Norisoyanangine / Norisoyanangin / N'-Demethyl-1-epiyanangine
C00025330	Nortiliacorine A	CHEMBL2017490
C00025331	Nortiliacorinine A	CHEMBL2017490
C00025332	Nortiliacorinine B	CHEMBL2017490
C00025333	Noryanangine / Noryanangin / N'-Demethylyanangine
C00025346	Stephasubimine
C00025348	Tetrandrine N-2'-oxide	CHEMBL510782
C00025350	Tiliacorinine 2'-N-oxide
C00025351	Tiliageine
C00025352	Tilianangine
C00025355	Yanangcorinin / Yanangcorinine
C00025356	Yanangine
C00025571	Tetrandrine N-2'-oxide / Tetrandrine 2'beta-N-oxide / Tetrandrine mono-N-2'-oxide
C00025592	2,2'-Didemethylpheanthine / (-)-2,2'-Bisnorphaeanthine
C00025593	(-)-2-Norisocepharanthine / 2'-Nor-1-epicepharanthine	CHEMBL476777 CHEMBL505900
C00025594	2'-N-Norlimacine / (-)-2'-Norlimacine / 2'-Demethyllimacine / 2'-Demethyl-(-)-fangchinoline	CHEMBL508608	C085399
C00025595	2-Norlimacine / (-)-2-Norlimacine / (-)-2-Demethyllimacine	CHEMBL449198
C00025601	Caryolivine / (-)-Caryolivine
C00025602	l-Curine / (-)-Curine / l-Bebeerine / Aristolochine / (-)-Bebeerine / Aristolochine(C36 alkaloid)	CHEMBL1169627		13 / 6 / 5
C00025603	(-)-Cycleaneonine
C00025604	Cycleanine / (-)-Cycleanine	CHEMBL1711244 CHEMBL1983719	C037098	7 / 1 / 1
C00025605	Faralaotrine / Cycleapeltin / Cycleapeltine / (-)-Cycleapeltine	CHEMBL507220 CHEMBL503522 CHEMBL509855 CHEMBL1185978
C00025608	(-)-Epistephanine	CHEMBL2063775
C00025613	(-)-Krukovine	CHEMBL500609 CHEMBL452895 CHEMBL492604 CHEMBL1976284
C00025614	(-)-Limacine 2'-alpha-N-oxide
C00025615	(-)-Limacine, 2-beta-N-oxide
C00025621	(-)-Norcycleanine / O7-Demethylcycleanine
C00025624	Repandin / Repandine / (-)-Repandine / N-Methyldemerarine	CHEMBL510022 CHEMBL509999 CHEMBL1983122		5 / 4 / 1
C00025633	(+)-1,2-Dehydro-2'-nortelobine / (+)-1',2'-Didehydro-2-nortelobine	CHEMBL505958
C00025634	1,2-Dehydroapateline / (+)-1,2-Dehydroapateline	CHEMBL390616
C00025635	(+)-1,2-Dehydrokohatamine
C00025636	(+)-1,2-Dehydrokohatine
C00025637	1,2-Dehydrotelobine / 1',2'-Didehydrotelobine / (+)-1,2-Dehydrotelobine	CHEMBL452663
C00025638	(+)-12-O-Methyltricordatine	CHEMBL505269
C00025639	2-Norcepharanthine / (+)-2-Norcepharanthine
C00025640	(+)-2'-Norcocsoline / N-Demethylcocsoline
C00025641	(+)-2'-Norcocsuline / 12'-O-Nortrilobine / (+)-O12'-Demethyltrilobine	CHEMBL443331
C00025642	Dihydrotiliafunimine / (+)-2-Northalrugosine	CHEMBL449198
C00025643	3',4'-Dihydrostephasubine / (+)-3',4'-Dihydrostephasubine
C00025644	(+)-5'-Hydroxytelobine
C00025645	Angchibangkine / (+)-Angchibangkine	CHEMBL524668
C00025646	Apateline / (+)-Apateline / O12'-Demethyltelobine
C00025647	(+)-Bisnorobamegine / N,N'-Didemethylobamegine
C00025648	(+)-Bisnorthalrugosine / N,N'-Didemethylthalrugosine
C00025649	(+)-Candicusine / (+)-12-O-Demethyllimacusine	CHEMBL504525 CHEMBL508781		6 / 2 / 3
C00025650	Cheratamine / (+)-Cheratamine
C00025653	Efirine / Cocsulin / (+)-Efirine / Trigilletine / (+)-Cocsuline / (+)-Trigilletine	CHEMBL447886 CHEMBL2063766
C00025656	(+)-Cycleabarbatine		C085398
C00025657	Cycleaneonine / (+)-Cycleanorine / (+)-Cycleaneonine		C058226
C00025660	Epistephanine / (+)-Epistephanine	CHEMBL2063775
C00025662	(+)-Limacine / (+)-Fangchinoline	CHEMBL504256 CHEMBL509803 CHEMBL500614		12 / 6 / 3
C00025663	Kohatamine / (+)-Kohatamine
C00025664	Kohatine / (+)-Kohatine / 5-Hydroxy-(+)-cocsoline
C00025665	Kurramine / (+)-Kurramine / O-Demethyl-1,2-dehydroapateline
C00025668	(+)-Limacusine	CHEMBL507220 CHEMBL503522 CHEMBL509855 CHEMBL1185978
C00025670	O-Methylcocsoline / (+)-Methylcocsoline / (+)-O-Methylcocsoline	CHEMBL1450305 CHEMBL1488591 CHEMBL2063765		28 / 23 / 17
C00025671	(+)-Bisnoraromoline / N,N'-Bisnoraromoline / (+)-N,N-Bisnoraromoline / 2,2'-Didemethylaromoline
C00025672	1'-Epiatherospermoline / (+)-N-Methyl-7-O-demethylpeinamine	CHEMBL500609 CHEMBL452895 CHEMBL492604 CHEMBL1976284
C00025673	1'-Epicocsuline / N-Methylapateline / (+)-N-Methylapateline	CHEMBL447886 CHEMBL2063766
C00025677	(+)-Norpenduline / 2-Demethylpenduline	CHEMBL510273
C00025678	O,O-Dimethylcocsulinine / (+)-O,O-Dimethylcocsulinine
C00025679	(+)-Oxoglaucine	CHEMBL508384 CHEMBL1980630
C00025680	(+)-Pangkoramine
C00025681	Pangkorimine / (+)-Pangkorimine
C00025682	Pendilinine / (+)-Pendilinine / O-Methylpendine / N2-Demethyl-O,O-dimethylpendulinine / O,O-Dimethyl-2'-N-demethylpendulinine
C00025683	Penduline / (+)-Penduline	CHEMBL504323 CHEMBL507540 CHEMBL1198334		4 / 3 / 4
C00025685	(+)-Siddiquamine
C00025686	(+)-Siddiquine
C00025689	Tricordatine / (+)-Tricordatine	CHEMBL443597
C00025700	1,2-Dehydro-2-norlimacusine
C00025701	1,2-Dehydroapateline / (+)-1,2-Dehydroapateline / 1',2'-Didehydroapateline	CHEMBL390616
C00025737	Norobamegine / 2-Norobamegine / (+)-Norobamegine / 2-N-Norobamegine
C00025738	2'-Norfangchinoline / 2'-Demethyl-(+)-limacine / 2'-Demethylfangchinoline	CHEMBL508608
C00025739	2-Norisotetrandrine	CHEMBL450175
C00025740	2'-Norlimacine / (-)-2'-Norlimacine / 2'-Demethyllimacine / 2'-Demethyl-(-)-fangchinoline	CHEMBL508608	C085399
C00025741	Cycleanorin / Cycleanorine / 2'-Nortetrandrine		C015400
C00025742	2'-N-Oxyisotetrandrine	CHEMBL510782
C00025745	3,4-Dehydrocycleanine / 3,4-Didehydrocycleanine / (+)-3,4-Dehydrocycleanine
C00025746	3',4'-Dihydrostephasubine
C00025753	1'-Epikohatine / 5'-Hydroxyapateline / (+)-5-Hydroxyapateline
C00025760	Frangchinoline / 7-O-Demethyltetrandrine	CHEMBL504256 CHEMBL509803 CHEMBL500614		12 / 6 / 3
C00025771	Berbacolorflammine
C00025789	Cepharanoline	CHEMBL496044
C00025813	Coclobine / (+)-Coclobine
C00025815	Cocsilinine / N,N'-Didemethylcocsulinine
C00025816	Cocsoline / (+)-Cocsoline / 2'-Demethylcocsuline
C00025817	Cocsulinine
C00025821	Colorflammine
C00025831	Cycleacurin / Cycleacurine
C00025832	Cycleadrine	CHEMBL504256 CHEMBL509803 CHEMBL500614		12 / 6 / 3
C00025833	Cycleahomine
C00025841	Dehatridine
C00025855	Dihydrowarifteine
C00025856	Dimethyldihydrowarifteine / O,O-Dimethyldihydrowarifteine
C00025857	Dimethylwarifteine / O,O-Dimethylwarifteine / O-Methylcissampareine
C00025873	Fenfangjine A / Tetrandrine 2beta-oxide / Tetrandrine 2beta-N-oxide
C00025874	Fenfangjine B
C00025875	Fenfangjine D / Berbacolorflammine hydroxide / 1,2,3,4-Tetradehydrofangchinolinium hydroxide
C00025876	Funiferine / NSC 189487 / (+)-Funiferine	CHEMBL1969696 CHEMBL2063764
C00025877	Funiferine oxide / Funiferine N-oxide		C015230
C00025878	Gilletine
C00025885	Hayatine / (+/-)-Curine / (+/-)-Bebeerine	CHEMBL1169627		13 / 6 / 5
C00025886	Hayatinine / (+)-Hayatinine	CHEMBL454476
C00025900	Insulanoline
C00025901	Insularine / O-Methylinsulanoline
C00025902	Insularine 2beta-N-oxide
C00025906	Isocycleaneonine
C00025907	Isogilletine N-oxide
C00025914	Isotrilobin / Homotrilobin / Homotrilobine / (+)-Isotrilobine / N,O-Dimethylcocsoline	CHEMBL503241 CHEMBL448550
C00025927	Limacusine / (+)-Limacusine	CHEMBL507220 CHEMBL503522 CHEMBL509855 CHEMBL1185978
C00025928	Limacusine 2'-beta-N-oxide / (+)-Limacusine 2'-beta-N-oxide / (+)-Limacusine 2-alpha-N-oxide
C00025936	Macolidine	CHEMBL504525 CHEMBL508781		6 / 2 / 3
C00025938	Menisarine / (+)-Menisarine
C00025942	Methyldihydrowarifteine / O-Methyldihydrowarifteine
C00025943	NSC 79640 / Methylwarifteine / O-Methylwarifteine	CHEMBL2063771
C00025946	(+)-Bisnoraromoline / N,N'-Bisnoraromoline / 2,2'-Didemethylaromoline
C00025951	N-Acetylnortiliacorinine A
C00025957	O7-Demethyl-N-methylpeinamine / N-Methyl-7-O-demethylpeinamine	CHEMBL500609 CHEMBL452895 CHEMBL492604 CHEMBL1976284
C00025958	N-Methylpachygonamine
C00025959	N-Methyltiliamosine / N'-Methyltiliamosine
C00025964	Nortiliacorine A	CHEMBL2017490
C00025965	Nortrilobine / N2'-Demethyltrilobine
C00025981	Obamegine / Stepholine / (+)-Obamegine	CHEMBL500609 CHEMBL452895 CHEMBL492604 CHEMBL1976284	C034784
C00025985	O-Methylcocsoline	CHEMBL1450305 CHEMBL1488591 CHEMBL2063765		28 / 23 / 17
C00025986	O-Methylcocsulinine
C00025994	Oxofangchirine / (+)-Oxofangchirine		C049410
C00025999	Pachygonamine
C00026001	Pachyovatamine
C00026007	Peinamine / (-)-2-Demethylberbamine	CHEMBL510273
C00026008	Pendine / (+)-Pendine
C00026012	Phaeanthine / O,O-Dimethylkrukovine	CHEMBL176045 CHEMBL367260 CHEMBL445477 CHEMBL449690 CHEMBL504958 CHEMBL504757		26 / 23 / 48
C00026027	Sciadenine
C00026028	Sciadoferine / 2,3-Dihydrosciadoline
C00026029	Sciadoline
C00026063	Aromoline / Thalicrine / (+)-Aromoline	CHEMBL504525 CHEMBL508781	C066341	6 / 2 / 3
C00026065	Tiliafunimine
C00026066	Tiliamosine
C00026067	Tiliaresine
C00026068	Tiliarine		C468758
C00026069	Tilitriandrine		C058264
C00026071	Trigilletimine
C00026082	Warifteine
C00026147	Stepinonine
C00027134	Cissacapine
C00027240	(-)-Antioquine
C00027312	Cavanine
C00027324	Chondrofoline	CHEMBL1172569
C00027359	Fastrine
C00027360	Fenfangjine C
C00027372	Guatteboline
C00027396	Isothalmidine / (+)-Isothalmidine
C00027482	Sepeerine / Ocoteamine
C00027490	Thalfine
C00027494	Thalmine
C00027496	Tiliacosine
C00027497	Tiliasine
C00027507	2-Norcepharanoline
C00027513	Angchibangkine / (+)-Angchibangkine	CHEMBL524668
C00027514	Aquifoline
C00027577	O,O-Dimethylcurine / (-)-O,O-Dimethylcurine
C00027579	O-Methylisothalicberine	CHEMBL2005418
C00027596	Thalrugosinone
C00027676	12-O-Demethyllauberine
C00027728	2'-Norisotetrandrine
C00028113	Cycleanine N-oxide / Cycleanine, 2-oxide
C00028114	Cycleatjehenine / (+)-Cycleatjehenine	CHEMBL487904
C00028135	Dehatrine		C082415
C00028657	N-Demethylcycleanine
C00028699	N-Methylfangchinoline / (+)-2-N-Methylfangchinoline
C00028734	Nortenuipine
C00028735	Nortrilobine
C00028750	O,N-Dimethylapateline	CHEMBL503241 CHEMBL448550
C00028769	O-Methylrepandine	CHEMBL464525
C00029096	Thalfinine
C00029097	Thalfoetidine
C00029098	Thalicberine
C00029102	Thalidezine / Thalidesine
C00029107	Thalifortine
C00029108	Thaligosine	CHEMBL443881
C00029109	Thaligosinine	CHEMBL503002
C00029112	Thalisopidine
C00041991	(+)-10-Hydroxyisotrilobine
C00049465	Longiberine
C00049505	O-Methyllongiberine

Human Protein / Gene in interactions

62 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O75164	Lysine-specific demethylase 4A	Enzyme	C00001816 C00001836 C00001897 C00001919 C00025278 C00025306 C00025313 C00025320 C00025602 C00025604 C00025624 C00025662 C00025670 C00025760 C00025832 C00025885 C00025985 C00026012	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00001816 C00001836 C00001897 C00001919 C00025278 C00025306 C00025313 C00025320 C00025602 C00025604 C00025624 C00025662 C00025670 C00025760 C00025832 C00025885 C00025985 C00026012	1 / 1
O75496	Geminin	Unclassified protein	C00001816 C00001836 C00001919 C00025278 C00025306 C00025313 C00025320 C00025602 C00025604 C00025662 C00025670 C00025760 C00025832 C00025885 C00025985 C00026012	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00001836 C00001897 C00001919 C00025278 C00025306 C00025313 C00025320 C00025624 C00025662 C00025670 C00025760 C00025832 C00025985 C00026012	1 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00001836 C00001897 C00001919 C00025278 C00025306 C00025313 C00025320 C00025624 C00025662 C00025670 C00025760 C00025832 C00025985 C00026012	2 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001811 C00001817 C00001836 C00001909 C00001919 C00025278 C00025313 C00025649 C00025670 C00025683 C00025936 C00025985 C00026012 C00026063	0 / 1
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00001836 C00001919 C00025278 C00025306 C00025313 C00025320 C00025604 C00025662 C00025670 C00025760 C00025832 C00025985 C00026012	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00001836 C00001919 C00025278 C00025306 C00025313 C00025320 C00025662 C00025670 C00025760 C00025832 C00025985 C00026012	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00001811 C00001817 C00001836 C00001909 C00001919 C00025278 C00025313 C00025649 C00025683 C00025936 C00026012 C00026063	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001811 C00001919 C00025278 C00025313 C00025649 C00025670 C00025936 C00025985 C00026012 C00026063	1 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001811 C00001919 C00025278 C00025313 C00025649 C00025670 C00025936 C00025985 C00026012 C00026063	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001811 C00001919 C00025278 C00025313 C00025649 C00025670 C00025936 C00025985 C00026012 C00026063	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001811 C00001919 C00025278 C00025313 C00025649 C00025670 C00025936 C00025985 C00026012 C00026063	1 / 1
P08183	Multidrug resistance protein 1	drug	C00001919 C00025278 C00025306 C00025313 C00025320 C00025662 C00025760 C00025832 C00026012	1 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00001816 C00001919 C00025278 C00025313 C00025602 C00025670 C00025885 C00025985 C00026012	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001836 C00001919 C00025278 C00025313 C00025670 C00025985 C00026012	1 / 2
P10636	Microtubule-associated protein tau	Unclassified protein	C00001816 C00001836 C00025602 C00025670 C00025885 C00025985	4 / 3
Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	Enzyme	C00025306 C00025320 C00025604 C00025662 C00025760 C00025832	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001919 C00025278 C00025313 C00025670 C00025985 C00026012	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00001836 C00001866 C00001919 C00025278 C00025313 C00026012	1 / 1
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00001919 C00025278 C00025313 C00025604 C00026012	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00025306 C00025320 C00025662 C00025760 C00025832	1 / 1
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00025306 C00025320 C00025662 C00025760 C00025832	0 / 0
P42858	Huntingtin	Unclassified protein	C00001816 C00025602 C00025670 C00025885 C00025985	1 / 1
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00001836 C00001919 C00025278 C00025313 C00026012	0 / 0
O00255	Menin	Unclassified protein	C00001836 C00001919 C00025278 C00025313 C00026012	2 / 5
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00025306 C00025320 C00025662 C00025760 C00025832	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00001919 C00025278 C00025313 C00025604 C00026012	0 / 0
P43351	DNA repair protein RAD52 homolog	Unclassified protein	C00001816 C00001897 C00025602 C00025624 C00025885	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00001919 C00025278 C00025313 C00026012	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001816 C00001836 C00025602 C00025885	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00001919 C00025278 C00025313 C00026012	4 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00001919 C00025278 C00025313 C00026012	7 / 37
P06280	Alpha-galactosidase A	Enzyme	C00001919 C00025278 C00025313 C00026012	1 / 1
P35372	Mu-type opioid receptor	Opioid receptor	C00001816 C00025602 C00025885	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00001816 C00025602 C00025885	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001817 C00001909 C00025683	3 / 3
Q01196	Runt-related transcription factor 1	Unclassified protein	C00001866 C00025670 C00025985	1 / 4
Q13951	Core-binding factor subunit beta	Unclassified protein	C00001866 C00025670 C00025985	0 / 1
O43603	Galanin receptor type 2	Galanin receptor	C00001816 C00025602 C00025885	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00001836 C00025670 C00025985	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00001836 C00025670 C00025985	0 / 0
P47898	5-hydroxytryptamine receptor 5A	Serotonin receptor	C00001816 C00025602 C00025885	0 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00001816 C00025602 C00025885	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00001836 C00025670 C00025985	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001836 C00025670 C00025985	0 / 0
P54750	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE_1A	C00001817 C00001909 C00025683	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00025670 C00025985	1 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00025670 C00025985	1 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00025670 C00025985	2 / 1
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00025670 C00025985	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00025670 C00025985	7 / 3
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00001927	2 / 0
Q96FL8	Multidrug and toxin extrusion protein 1	Cation antiporter	C00001927	0 / 0
O15244	Solute carrier family 22 member 2	Drug uniporter	C00001927	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001866	0 / 0
Q86VL8	Multidrug and toxin extrusion protein 2	Cation antiporter	C00001927	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00001866	2 / 3
O15118	Niemann-Pick C1 protein	Unclassified protein	C00001836	1 / 1
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001927	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00001836	0 / 0
P04062	Glucosylceramidase	Enzyme	C00001836	6 / 4

51 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00001836 C00001919 C00025278
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00001919 C00001927 C00025278
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00001817 C00001919 C00025278
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00001919 C00025278
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00001919 C00025278
1577	CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3	cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1)	C00001919 C00025278
27436	EML4, C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120	echinoderm microtubule associated protein like 4	C00001927
637	BID, FP497	BH3 interacting domain death agonist	C00001817
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00001817
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00001817
1147	CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	C00001817
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00001817
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00001817
7128	TNFAIP3, A20, OTUD7C, TNFA1P2	tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12)	C00001817
632	BGLAP, BGP, OC, OCN	bone gamma-carboxyglutamate (gla) protein	C00001927
730	C7	complement component 7	C00001927
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00001927
1136	CHRNA3, LNCR2, NACHRA3, PAOD2	cholinergic receptor, nicotinic, alpha 3 (neuronal)	C00001927
1137	CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	C00001927
1139	CHRNA7, CHRNA7-2, NACHRA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	C00001927
1141	CHRNB2, EFNL3, nAChRB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	C00001927
1143	CHRNB4	cholinergic receptor, nicotinic, beta 4 (neuronal)	C00001927
1272	CNTN1, F3, GP135	contactin 1	C00001927
1437	CSF2, GMCSF	colony stimulating factor 2 (granulocyte-macrophage)	C00001927
1719	DHFR, DHFRP1, DYR	dihydrofolate reductase (EC:1.5.1.3)	C00001927
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00001817
355	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6	Fas cell surface death receptor	C00001927
9638	FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	C00001927
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00001927
2803	GOLGA4, GCP2, GOLG, MU-RMS-40.18, p230	golgin A4	C00001927
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00001927
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00001927
3780	KCNN1, KCa2.1, SK1, SKCA1, hSK1	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1	C00001927
3781	KCNN2, KCa2.2, SK2, SKCA2, SKCa_2, hSK2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	C00001927
58508	KMT2C, HALR, MLL3	lysine (K)-specific methyltransferase 2C (EC:2.1.1.43)	C00001927
9516	LITAF, PIG7, SIMPLE, TP53I7	lipopolysaccharide-induced TNF factor	C00001927
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00001927
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00001927
4312	MMP1, CLG, CLGN	matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)	C00001927
51199	NIN, SCKL7	ninein (GSK3B interacting protein)	C00001927
5071	PARK2, AR-JP, LPRS2, PDJ, PRKN	parkin RBR E3 ubiquitin protein ligase	C00001927
5757	PTMA, TMSA	prothymosin, alpha	C00001927
5786	PTPRA, HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA	protein tyrosine phosphatase, receptor type, A (EC:3.1.3.48)	C00001927
5930	RBBP6, MY038, P2P-R, PACT, RBQ-1, SNAMA	retinoblastoma binding protein 6	C00001927
6654	SOS1, GF1, GGF1, GINGF, HGF, NS4	son of sevenless homolog 1 (Drosophila)	C00001927
6696	SPP1, BNSP, BSPI, ETA-1, OPN	secreted phosphoprotein 1	C00001927
10963	STIP1, HOP, IEF-SSP-3521, P60, STI1, STI1L	stress-induced-phosphoprotein 1	C00001927
11065	UBE2C, UBCH10, dJ447F3.2	ubiquitin-conjugating enzyme E2C (EC:6.3.2.19)	C00001927
7337	UBE3A, ANCR, AS, E6-AP, EPVE6AP, HPVE6A	ubiquitin protein ligase E3A (EC:6.3.2.19)	C00001927
353174	ZACN, L2, LGICZ, LGICZ1, ZAC, ZAC1	zinc activated ligand-gated ion channel	C00001927
51663	ZFR, ZFR1	zinc finger RNA binding protein	C00001927

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions