PCIDB

KNApSAcK Metabolite C00001927

Metabolite

KNApSAcK Entry

id C00001927
Name (+)-Tubocurarine
CAS RN 57-95-4
Standard InChI InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1
Standard InChI (Main Layer) InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 10

Link

ChEMBL

By standard InChI CHEMBL339427
By standard InChI Main Layer CHEMBL339427 CHEMBL1616987

KEGG

By LinkDB C07547

CTD

By CAS RN D014403

Species

Summary

Plant class

class name count
eudicotyledons 1

Family

family name count
Menispermaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Chondrodendron tomentosum 461568 Menispermaceae eudicotyledons Viridiplantae

Human Protein / Gene in interaction

5 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O15244 Solute carrier family 22 member 2 Drug uniporter CHEMBL339427 CHEMBL2320303 (1)
0 / 0
Q96FL8 Multidrug and toxin extrusion protein 1 Cation antiporter CHEMBL339427 CHEMBL2320305 (1) CHEMBL2320306 (1)
0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL339427 CHEMBL1794499 (1)
2 / 0
Q86VL8 Multidrug and toxin extrusion protein 2 Cation antiporter CHEMBL339427 CHEMBL2320304 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL339427 CHEMBL2114738 (1)
0 / 0

CTD interaction (70)

compound gene gene name gene description interaction interaction type form reference
pmid
D014403 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2] decreases expression
/ decreases reaction
16644063
D014403 632 BGLAP
BGP
OC
OCN
bone gamma-carboxyglutamate (gla) protein Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP] decreases reaction
/ increases expression
19436947
D014403 730 C7
complement component 7 Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D014403 730 C7
complement component 7 Tubocurarine results in decreased expression of C7 mRNA decreases expression
mRNA 16949557
D014403 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] decreases expression
/ decreases reaction
protein 15231866
D014403 1136 CHRNA3
LNCR2
NACHRA3
PAOD2
cholinergic receptor, nicotinic, alpha 3 (neuronal) Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
/ increases activity
protein 16931985
D014403 1136 CHRNA3
LNCR2
NACHRA3
PAOD2
cholinergic receptor, nicotinic, alpha 3 (neuronal) Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] affects binding
/ decreases reaction
/ increases activity
protein 16931985
D014403 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] affects activity
/ affects binding
/ decreases reaction
protein 11711029
D014403 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
/ increases activity
protein 16931985
D014403 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 14645658
D014403 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]] affects activity
/ affects binding
/ decreases reaction
/ increases reaction
protein 11711029
D014403 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] affects binding
/ decreases activity
protein 14645658
D014403 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Tubocurarine binds to and results in decreased activity of CHRNA7 protein affects binding
/ decreases activity
protein 10082212
D014403 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] decreases reaction
/ increases activity
protein 16931985
D014403 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Tubocurarine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein] affects binding
/ decreases reaction
protein 10216184
D014403 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] affects activity
/ affects binding
/ decreases reaction
protein 11711029
D014403 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
/ increases activity
protein 16931985
D014403 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
/ increases activity
protein 16931985
D014403 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 14645658
D014403 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]] affects activity
/ affects binding
/ decreases reaction
/ increases reaction
protein 11711029
D014403 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] affects binding
/ decreases activity
protein 14645658
D014403 1143 CHRNB4
cholinergic receptor, nicotinic, beta 4 (neuronal) Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] affects binding
/ decreases reaction
/ increases activity
protein 16931985
D014403 1272 CNTN1
F3
GP135
contactin 1 Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D014403 1272 CNTN1
F3
GP135
contactin 1 Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D014403 1272 CNTN1
F3
GP135
contactin 1 Tubocurarine results in decreased expression of CNTN1 mRNA decreases expression
mRNA 16949557
D014403 1272 CNTN1
F3
GP135
contactin 1 Tubocurarine results in increased expression of CNTN1 mRNA increases expression
mRNA 12588870
D014403 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein] decreases reaction
/ increases secretion
protein 9606035
D014403 1719 DHFR
DHFRP1
DYR
dihydrofolate reductase (EC:1.5.1.3) Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D014403 1719 DHFR
DHFRP1
DYR
dihydrofolate reductase (EC:1.5.1.3) Tubocurarine results in decreased expression of DHFR mRNA decreases expression
mRNA 12588870
D014403 27436 EML4
C2orf2
ELP120
EMAP-4
EMAPL4
ROPP120
echinoderm microtubule associated protein like 4 Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D014403 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS] decreases reaction
/ increases expression
16644063
D014403 9638 FEZ1
fasciculation and elongation protein zeta 1 (zygin I) Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA] decreases expression
/ increases reaction
mRNA 12588870
D014403 9638 FEZ1
fasciculation and elongation protein zeta 1 (zygin I) Tubocurarine results in decreased expression of FEZ1 mRNA decreases expression
mRNA 12588870
D014403 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS] decreases reaction
/ increases expression
11425648
D014403 2803 GOLGA4
GCP2
GOLG
MU-RMS-40.18
p230
golgin A4 Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D014403 2803 GOLGA4
GCP2
GOLG
MU-RMS-40.18
p230
golgin A4 Tubocurarine results in decreased expression of GOLGA4 mRNA decreases expression
mRNA 16949557
D014403 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of IL8 mRNA]] decreases reaction
/ increases expression
/ increases reaction
protein 22119045
D014403 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of IL8 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 22119045
D014403 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of IL8 mRNA]] decreases reaction
/ increases expression
/ increases reaction
mRNA 22119045
D014403 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of IL8 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 22119045
D014403 3780 KCNN1
KCa2.1
SK1
SKCA1
hSK1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 Tubocurarine results in decreased activity of KCNN1 protein decreases activity
protein 10696100
D014403 3781 KCNN2
KCa2.2
SK2
SKCA2
SKCa_2
hSK2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 Tubocurarine results in decreased activity of KCNN2 protein decreases activity
protein 10991935
D014403 58508 KMT2C
HALR
MLL3
lysine (K)-specific methyltransferase 2C (EC:2.1.1.43) Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D014403 58508 KMT2C
HALR
MLL3
lysine (K)-specific methyltransferase 2C (EC:2.1.1.43) Tubocurarine results in decreased expression of KMT2C mRNA decreases expression
mRNA 12588870
D014403 9516 LITAF
PIG7
SIMPLE
TP53I7
lipopolysaccharide-induced TNF factor Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D014403 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 22119045
D014403 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 22119045
D014403 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli 026-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 18986645
D014403 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased expression of MMP1 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 18986645
D014403 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA] decreases reaction
/ increases expression
mRNA 17151781
D014403 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein] decreases reaction
/ increases expression
protein 18986645
D014403 51199 NIN
SCKL7
ninein (GSK3B interacting protein) Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA] decreases reaction
/ increases expression
mRNA 16949557
D014403 51199 NIN
SCKL7
ninein (GSK3B interacting protein) Tubocurarine results in decreased expression of NIN mRNA decreases expression
mRNA 16949557
D014403 5071 PARK2
AR-JP
LPRS2
PDJ
PRKN
parkin RBR E3 ubiquitin protein ligase Tubocurarine results in decreased expression of PARK2 mRNA decreases expression
mRNA 16949557
D014403 5757 PTMA
TMSA
prothymosin, alpha Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2] decreases expression
/ decreases reaction
protein 16644063
D014403 5757 PTMA
TMSA
prothymosin, alpha Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS] decreases reaction
/ increases expression
protein 16644063
D014403 5786 PTPRA
HEPTP
HLPR
HPTPA
HPTPalpha
LRP
PTPA
PTPRL2
R-PTP-alpha
RPTPA
protein tyrosine phosphatase, receptor type, A (EC:3.1.3.48) Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D014403 5930 RBBP6
MY038
P2P-R
PACT
RBQ-1
SNAMA
retinoblastoma binding protein 6 Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D014403 6654 SOS1
GF1
GGF1
GINGF
HGF
NS4
son of sevenless homolog 1 (Drosophila) Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D014403 6654 SOS1
GF1
GGF1
GINGF
HGF
NS4
son of sevenless homolog 1 (Drosophila) Tubocurarine results in decreased expression of SOS1 mRNA decreases expression
mRNA 16949557
D014403 6696 SPP1
BNSP
BSPI
ETA-1
OPN
secreted phosphoprotein 1 Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein] decreases reaction
/ increases expression
protein 11425648
D014403 10963 STIP1
HOP
IEF-SSP-3521
P60
STI1
STI1L
stress-induced-phosphoprotein 1 Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA] decreases expression
/ decreases reaction
mRNA 16949557
D014403 10963 STIP1
HOP
IEF-SSP-3521
P60
STI1
STI1L
stress-induced-phosphoprotein 1 Tubocurarine results in decreased expression of STIP1 mRNA decreases expression
mRNA 16949557
D014403 11065 UBE2C
UBCH10
dJ447F3.2
ubiquitin-conjugating enzyme E2C (EC:6.3.2.19) Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA] decreases expression
/ decreases reaction
mRNA 16949557
D014403 11065 UBE2C
UBCH10
dJ447F3.2
ubiquitin-conjugating enzyme E2C (EC:6.3.2.19) Tubocurarine results in decreased expression of UBE2C mRNA decreases expression
mRNA 16949557
D014403 7337 UBE3A
ANCR
AS
E6-AP
EPVE6AP
HPVE6A
ubiquitin protein ligase E3A (EC:6.3.2.19) Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D014403 7337 UBE3A
ANCR
AS
E6-AP
EPVE6AP
HPVE6A
ubiquitin protein ligase E3A (EC:6.3.2.19) Tubocurarine results in increased expression of UBE3A mRNA increases expression
mRNA 12588870
D014403 353174 ZACN
L2
LGICZ
LGICZ1
ZAC
ZAC1
zinc activated ligand-gated ion channel Tubocurarine results in decreased activity of ZACN protein decreases activity
protein 12381728
D014403 51663 ZFR
ZFR1
zinc finger RNA binding protein Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D014403 51663 ZFR
ZFR1
zinc finger RNA binding protein Tubocurarine results in decreased expression of ZFR mRNA decreases expression
mRNA 12588870

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798

Diseases related to CTD interactions

16 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000707 D014403 Anaphylaxis marker/mechanism
7976160
D001049 D014403 Apnea marker/mechanism
4326672
4411993
5690286
D001919 D014403 Bradycardia marker/mechanism
therapeutic
1239221
4247670
8960879
D001986 D014403 Bronchial Spasm marker/mechanism
4104054
D005207 D014403 Fasciculation therapeutic
466933
1167764
1167766
1519714
1978605
2193736
2735177
3158243
3202338
3555877
4250986
6496012
7004273
7910525
8498652
9398951
10680105
12776646
16192781
D006973 D014403 Hypertension therapeutic
686328
D007022 D014403 Hypotension marker/mechanism
1239221
2105067
2429800
4251333
5064013
6166217
D007232 D014403 Infant, Newborn, Diseases marker/mechanism
5690286
D009133 D014403 Muscular Atrophy marker/mechanism
3943663
D009135 D014403 Muscular Diseases therapeutic
143062
1090014
1566986
3158243
7242958
8214718
8498652
D009222 D014403 Myotonia therapeutic
5477651
D010146 D014403 Pain therapeutic
466557
1090014
1566986
6112998
D010149 D014403 Pain, Postoperative therapeutic
143062
3158243
3555877
6496012
7242958
8214718
16192781
D010243 D014403 Paralysis marker/mechanism
2733264
3943663
4255898
4411993
4568132
5690286
D012640 D014403 Seizures marker/mechanism
therapeutic
5690286
6843794
12829730
D014693 D014403 Ventricular Fibrillation marker/mechanism
1239221