PCIDB

Chondrodendron tomentosum

Species

KNApSAcK Entry

Organism name Chondrodendron tomentosum
Genus Chondrodendron
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Chondrodendron tomentosum
Linked NCBI taxonomy ID 461568
Linked level species

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Natural Activity

List (32)

Species Activity
Chondrodendron tomentosum Ruiz & Pav. Analgesic
Chondrodendron tomentosum Ruiz & Pav. Anesthetic
Chondrodendron tomentosum Ruiz & Pav. Anesthetic
Chondrodendron tomentosum Ruiz & Pav. Anticonvulsant
Chondrodendron tomentosum Ruiz & Pav. Anticonvulsant
Chondrodendron tomentosum Ruiz & Pav. Antiedemic
Chondrodendron tomentosum Ruiz & Pav. Antipyretic
Chondrodendron tomentosum Ruiz & Pav. Antiseptic
Chondrodendron tomentosum Ruiz & Pav. Antiseptic
Chondrodendron tomentosum Ruiz & Pav. Aperient
Chondrodendron tomentosum Ruiz & Pav. Aperient
Chondrodendron tomentosum Ruiz & Pav. Bitter
Chondrodendron tomentosum Ruiz & Pav. Bitter
Chondrodendron tomentosum Ruiz & Pav. Curare
Chondrodendron tomentosum Ruiz & Pav. Curare
Chondrodendron tomentosum Ruiz & Pav. Diuretic
Chondrodendron tomentosum Ruiz & Pav. Diuretic
Chondrodendron tomentosum Ruiz & Pav. Emmenagogue
Chondrodendron tomentosum Ruiz & Pav. Emmenagogue
Chondrodendron tomentosum Ruiz & Pav. Febrifuge
Chondrodendron tomentosum Ruiz & Pav. Hypotensive
Chondrodendron tomentosum Ruiz & Pav. Hypotensive
Chondrodendron tomentosum Ruiz & Pav. Laxative
Chondrodendron tomentosum Ruiz & Pav. Litholytic
Chondrodendron tomentosum Ruiz & Pav. Litholytic
Chondrodendron tomentosum Ruiz & Pav. Myoparalytic
Chondrodendron tomentosum Ruiz & Pav. Myoparalytic
Chondrodendron tomentosum Ruiz & Pav. Myorelaxant
Chondrodendron tomentosum Ruiz & Pav. Myorelaxant
Chondrodendron tomentosum Ruiz & Pav. Tonic
Chondrodendron tomentosum Ruiz & Pav. toxic
Chondrodendron tomentosum Ruiz & Pav. toxic

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001816 External link 512 (+)-Bebeerine
CHEMBL1169627
C066405
13 / 6 / 5 No. 10 No. 4
C00001870 External link 512 Isobebeerin
/ Isobebeerine
/ Isochondodendrine
CHEMBL509310
CHEMBL1169628
No. 10 No. 4
C00001927 External link 512 (+)-Tubocurarine
CHEMBL339427
CHEMBL1616987
D014403
5 / 2 / 0 38 / 16 No. 10 No. 4
C00025602 External link 512 l-Curine
/ (-)-Curine
/ l-Bebeerine
/ Aristolochine
/ (-)-Bebeerine
/ Aristolochine(C36 alkaloid)
CHEMBL1169627
13 / 6 / 5 No. 10 No. 4

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001816 C00025602 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001816 C00025602 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001816 C00025602 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001816 C00025602 1 / 1
O43603 Galanin receptor type 2 Galanin receptor C00001816 C00025602 0 / 0
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor C00001816 C00025602 0 / 0
P42858 Huntingtin Unclassified protein C00001816 C00025602 1 / 1
O75496 Geminin Unclassified protein C00001816 C00025602 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00001816 C00025602 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001816 C00025602 4 / 3
P35372 Mu-type opioid receptor Opioid receptor C00001816 C00025602 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001816 C00025602 0 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein C00001816 C00025602 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001927 2 / 0
Q96FL8 Multidrug and toxin extrusion protein 1 Cation antiporter C00001927 0 / 0
O15244 Solute carrier family 22 member 2 Drug uniporter C00001927 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001927 0 / 0
Q86VL8 Multidrug and toxin extrusion protein 2 Cation antiporter C00001927 0 / 0

38 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001927
632 BGLAP, BGP, OC, OCN bone gamma-carboxyglutamate (gla) protein C00001927
730 C7 complement component 7 C00001927
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00001927
1136 CHRNA3, LNCR2, NACHRA3, PAOD2 cholinergic receptor, nicotinic, alpha 3 (neuronal) C00001927
1137 CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) C00001927
1139 CHRNA7, CHRNA7-2, NACHRA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) C00001927
1141 CHRNB2, EFNL3, nAChRB2 cholinergic receptor, nicotinic, beta 2 (neuronal) C00001927
1143 CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) C00001927
1272 CNTN1, F3, GP135 contactin 1 C00001927
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00001927
1719 DHFR, DHFRP1, DYR dihydrofolate reductase (EC:1.5.1.3) C00001927
27436 EML4, C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120 echinoderm microtubule associated protein like 4 C00001927
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00001927
9638 FEZ1 fasciculation and elongation protein zeta 1 (zygin I) C00001927
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00001927
2803 GOLGA4, GCP2, GOLG, MU-RMS-40.18, p230 golgin A4 C00001927
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00001927
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001927
3780 KCNN1, KCa2.1, SK1, SKCA1, hSK1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 C00001927
3781 KCNN2, KCa2.2, SK2, SKCA2, SKCa_2, hSK2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 C00001927
58508 KMT2C, HALR, MLL3 lysine (K)-specific methyltransferase 2C (EC:2.1.1.43) C00001927
9516 LITAF, PIG7, SIMPLE, TP53I7 lipopolysaccharide-induced TNF factor C00001927
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00001927
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00001927
4312 MMP1, CLG, CLGN matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) C00001927
51199 NIN, SCKL7 ninein (GSK3B interacting protein) C00001927
5071 PARK2, AR-JP, LPRS2, PDJ, PRKN parkin RBR E3 ubiquitin protein ligase C00001927
5757 PTMA, TMSA prothymosin, alpha C00001927
5786 PTPRA, HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA protein tyrosine phosphatase, receptor type, A (EC:3.1.3.48) C00001927
5930 RBBP6, MY038, P2P-R, PACT, RBQ-1, SNAMA retinoblastoma binding protein 6 C00001927
6654 SOS1, GF1, GGF1, GINGF, HGF, NS4 son of sevenless homolog 1 (Drosophila) C00001927
6696 SPP1, BNSP, BSPI, ETA-1, OPN secreted phosphoprotein 1 C00001927
10963 STIP1, HOP, IEF-SSP-3521, P60, STI1, STI1L stress-induced-phosphoprotein 1 C00001927
11065 UBE2C, UBCH10, dJ447F3.2 ubiquitin-conjugating enzyme E2C (EC:6.3.2.19) C00001927
7337 UBE3A, ANCR, AS, E6-AP, EPVE6AP, HPVE6A ubiquitin protein ligase E3A (EC:6.3.2.19) C00001927
353174 ZACN, L2, LGICZ, LGICZ1, ZAC, ZAC1 zinc activated ligand-gated ion channel C00001927
51663 ZFR, ZFR1 zinc finger RNA binding protein C00001927

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#600274 Frontotemporal dementia; ftd P10636
#143100 Huntington disease; hd P42858
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (5)

KEGG name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

16 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000707 Anaphylaxis C00001927
D001049 Apnea C00001927
D001919 Bradycardia C00001927
D001986 Bronchial Spasm C00001927
D005207 Fasciculation C00001927
D006973 Hypertension C00001927
D007022 Hypotension C00001927
D007232 Infant, Newborn, Diseases C00001927
D009133 Muscular Atrophy C00001927
D009135 Muscular Diseases C00001927
D009222 Myotonia C00001927
D010146 Pain C00001927
D010149 Pain, Postoperative C00001927
D010243 Paralysis C00001927
D012640 Seizures C00001927
D014693 Ventricular Fibrillation C00001927