Species

KNApSAcK Entry

Organism name Stephania pierrei Diels(=S.erecta Craib)
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025593 External link 512 (-)-2-Norisocepharanthine
/ 2'-Nor-1-epicepharanthine
CHEMBL476777
CHEMBL505900
No. 10 No. 4
C00025604 External link 512 Cycleanine
/ (-)-Cycleanine
CHEMBL1711244
CHEMBL1983719
C037098
7 / 1 / 1 No. 10 No. 4
C00025634 External link 512 1,2-Dehydroapateline
/ (+)-1,2-Dehydroapateline
CHEMBL390616
No. 10 No. 4
C00025841 External link 512 Dehatridine
No. 10 No. 4
C00025623 External link 512 Phanostenine
/ (-)-Phanostenine
CHEMBL515639
No. 20 No. 4
C00025622 External link 512 (-)-Nordicentrine
CHEMBL518744
No. 20 No. 4
C00025612 External link 512 (-)-Isolaureline
CHEMBL389270
CHEMBL510954
CHEMBL600966
No. 20 No. 4
C00025626 External link 512 Remeroline
/ (R)-Roemeroline
/ (-)-Roemeroline
/ N-Methylanolobine
CHEMBL499835
No. 20 No. 4
C00025812 External link 512 Coclaurine
/ (S)-Coclaurine
/ (-)-Coclaurine
CHEMBL256448
CHEMBL453291
CHEMBL446211
C004690
8 / 17 / 10 No. 253 No. 4
C00025654 External link 512 Codamine
/ (+)-Codamine
/ L-(+)-Codamine
/ (S)-(+)-Codamine
CHEMBL251624
No. 345 No. 4

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00025604 C00025812 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00025604 0 / 0
P04062 Glucosylceramidase Enzyme C00025812 6 / 4
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025604 0 / 0
Q99700 Ataxin-2 Unclassified protein C00025604 1 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00025604 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00025812 7 / 3
P14618 Pyruvate kinase PKM Enzyme C00025812 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025604 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00025812 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00025812 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00025812 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00025604 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00025812 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (11)

KEGG name UniProt
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)