Species

KNApSAcK Entry

Organism name Porcelia macrocarpa
Genus Porcelia
Family Annonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Porcelia
Linked NCBI taxonomy ID 306974
Linked level genus

Family

Family in NCBI taxonomy Annonaceae
ID 22140

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005428 External link 512 Quercetin 3-glucoside-7-rhamnoside
/ Quercetin 3-O-glucoside-7-O-rhamnoside
/ Quercetin 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside
CHEMBL592361
CHEMBL1774171
No. 1 No. 15
C00005373 External link 512 Hirsutrin
/ Isoquercetin
/ Isoquercetrin
/ (-)-Isoquercetrin
/ Quercetin 3-glucoside
/ Quercetin 3-O-beta-D-glucoside
/ Quercetin-3-O-beta-D-glucopyranoside
/ Quercetin 3-O-beta-D-glucopyranoside
/ (-)-Quercetin-3-O-beta-D-glucopyranoside
CHEMBL33027
CHEMBL309323
CHEMBL250450
CHEMBL251254
CHEMBL457304
CHEMBL1098724
CHEMBL2337335
CHEMBL2337336
38 / 43 / 34 No. 2 No. 15
C00025231 External link 512 Asimilobine
/ (-)-Asimilobine
CHEMBL389271
CHEMBL469423
C054614
1 / 1 / 0 No. 20 No. 4
C00001878 External link 512 Liriodenine
/ Oxoushinsunine
/ Spermatheridine
CHEMBL37736
C026980
5 / 3 / 1 No. 74
C00025812 External link 512 Coclaurine
/ (S)-Coclaurine
/ (-)-Coclaurine
CHEMBL256448
CHEMBL453291
CHEMBL446211
C004690
8 / 17 / 10 No. 253 No. 4
C00027440 External link 512 Norjuziphine
/ (-)-Norjusiphine
/ (-)-Norjuziphine
CHEMBL462757
No. 253 No. 4
C00001910 External link 512 Reticuline
/ (+)-Reticuline
CHEMBL235212
CHEMBL401501
CHEMBL464734
C003298
1 / 0 / 0 No. 345 No. 4
C00025272 External link 512 Stepharine
/ (+)-Stepharine
CHEMBL463957
CHEMBL1975436
C009320
No. 688
C00045581 External link 512 6-Methoxyonychine
No. 3623
C00046241 External link 512 Onychine
CHEMBL181614
C054955
No. 3644

Human Protein / Gene in interactions

46 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005373 C00025812 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00005373 C00025812 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005373 C00025812 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00005373 C00025812 4 / 3
P35372 Mu-type opioid receptor Opioid receptor C00001910 C00005373 0 / 0
O75496 Geminin Unclassified protein C00005373 C00025812 0 / 0
P04062 Glucosylceramidase Enzyme C00005373 C00025812 6 / 4
P15121 Aldose reductase Enzyme C00005373 0 / 0
P02545 Prelamin-A/C Unclassified protein C00005373 11 / 10
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005373 1 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005373 0 / 0
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta C00001878 0 / 0
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha C00001878 1 / 0
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00001878 1 / 1
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00001878 1 / 1
P07237 Protein disulfide-isomerase Enzyme C00005373 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005373 1 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00005373 0 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00001878 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00005373 1 / 1
P39748 Flap endonuclease 1 Enzyme C00005373 0 / 0
P06746 DNA polymerase beta Enzyme C00005373 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00005373 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005373 1 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00025812 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00005373 1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00005373 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00005373 3 / 1
P14679 Tyrosinase Oxidoreductase C00005373 4 / 2
P06280 Alpha-galactosidase A Enzyme C00005373 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00005373 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00005373 0 / 1
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005373 2 / 0
P22303 Acetylcholinesterase Hydrolase C00025231 1 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00005373 0 / 3
Q9UNA4 DNA polymerase iota Enzyme C00005373 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005373 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00025812 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00005373 1 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00005373 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00005373 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005373 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00005373 4 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00005373 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005373 1 / 4
Q9NPH5 NADPH oxidase 4 Enzyme C00005373 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (54)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#614490 Blood group, junior system; jr Q9UNQ0
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#601626 Leukemia, acute myeloid; aml P36888
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#612052 Smoking as a quantitative trait locus 3; sqtl3 P32297
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (38)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00213 Hypophosphatasia P05186 (related)
H00125 Fabry disease P06280 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00192 Xanthinuria P47989 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)