PCIDB

Roemeria refracta

Species

KNApSAcK Entry

Organism name Roemeria refracta
Genus Roemeria
Family Papaveraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Roemeria refracta
Linked NCBI taxonomy ID 72192
Linked level species

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00027641 External link 512 (14S)-Reframidine N-oxide
/ (-)-(5R,11S,14S)-Reframidine N-oxide
C00025625 External link 512 Roemerine
/ (-)-Remerine
/ (-)-Aporheine
/ (-)-Roemerine
CHEMBL36654
CHEMBL483825
C030169
23 / 10 / 13 No. 20 No. 4
C00028941 External link 512 Roelactamine
No. 233 No. 4
C00025812 External link 512 Coclaurine
/ (S)-Coclaurine
/ (-)-Coclaurine
CHEMBL256448
CHEMBL453291
CHEMBL446211
C004690
8 / 17 / 10 No. 253 No. 4
C00028938 External link 512 Roefractine
No. 345 No. 4
C00001810 External link 512 Armepavine
/ (-)-Armepavine
/ (R)-(-)-Armepavine
CHEMBL451722
CHEMBL1186477
CHEMBL1186510
7 / 5 / 3 No. 345 No. 4
C00028871 External link 512 Pseudolaudanine
No. 345 No. 4
C00001802 External link 512 Amurine
/ (+)-Amurine
No. 426 No. 4
C00027366 External link 512 Flavinantine
/ (-)-Flavinantine
CHEMBL463084
1 / 4 / 2 No. 426 No. 4
C00028711 External link 512 Noramurine
No. 426 No. 4
C00027640 External link 512 (14R)-Reframidine N-oxide
/ (-)-(5R,11S,14R)-Reframidine N-oxide
No. 526
C00026023 External link 512 Remrefidine
/ (+)-Remrefidine
No. 553
C00028943 External link 512 Roemeridine
CHEMBL1985228
CHEMBL1994960
No. 776
C00031097 External link 512 Pseudoephedrine
/ trans-Ephedrine
/ (+)-Pseudoephedrine
CHEMBL357080
CHEMBL211456
CHEMBL1590
CHEMBL1620154
CHEMBL2110656
CHEMBL2110905
D054199
13 / 12 / 10 0 / 50 No. 2149 No. 9
C00026134 External link 512 Mecambridine
/ (-)-Oreophiline
/ (-)-Mecambridine
C051429
No. 3042

Human Protein / Gene in interactions

43 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001810 C00025625 C00025812 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001810 C00025812 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00025812 C00031097 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001810 C00025812 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001810 C00031097 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001810 C00025625 2 / 0
O75496 Geminin Unclassified protein C00025625 C00025812 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001810 C00031097 3 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00031097 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025625 1 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00025625 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00031097 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001810 0 / 0
P39748 Flap endonuclease 1 Enzyme C00025625 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00031097 3 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025625 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00025625 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00025812 7 / 3
P00734 Prothrombin S1A C00027366 4 / 2
P06280 Alpha-galactosidase A Enzyme C00031097 1 / 1
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00031097 2 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00025625 1 / 1
O15118 Niemann-Pick C1 protein Unclassified protein C00025625 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00025625 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00031097 0 / 0
P04062 Glucosylceramidase Enzyme C00025812 6 / 4
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00031097 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00031097 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00025625 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025625 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00025625 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00025812 4 / 3
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00025625 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00025625 0 / 0
P06746 DNA polymerase beta Enzyme C00025625 0 / 0
P40225 Thrombopoietin Unclassified protein C00031097 1 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025625 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00025625 1 / 1
O00255 Menin Unclassified protein C00025625 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00025625 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00025625 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00025625 1 / 4
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00031097 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (42)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#114500 Colorectal cancer; crc P18054
P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P18054
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (35)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

50 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D054058 Acute Coronary Syndrome C00031097
D058186 Acute Kidney Injury C00031097
D000787 Angina Pectoris C00031097
D000799 Angioedema C00031097
D001146 Arrhythmia, Sinus C00031097
D001259 Ataxia C00031097
D001714 Bipolar Disorder C00031097
D001929 Brain Edema C00031097
D009202 Cardiomyopathies C00031097
D002543 Cerebral Hemorrhage C00031097
D017091 Colitis, Ischemic C00031097
D003139 Common Cold C00031097
D003329 Coronary Vasospasm C00031097
D003873 Dermatitis, Exfoliative C00031097
D006970 Disorders of Excessive Somnolence C00031097
D004244 Dizziness C00031097
D004342 Drug Hypersensitivity C00031097
D062787 Drug Overdose C00031097
D006261 Headache C00031097
D006333 Heart Failure C00031097
D006967 Hypersensitivity C00031097
D006973 Hypertension C00031097
D020343 Hypertensive Encephalopathy C00031097
D007251 Influenza, Human C00031097
D053609 Lethargy C00031097
D009203 Myocardial Infarction C00031097
D009207 Myoclonus C00031097
D009668 Nose Diseases C00031097
D010554 Personality Disorders C00031097
D010612 Pharyngitis C00031097
D011605 Psychoses, Substance-Induced C00031097
D011644 Puerperal Disorders C00031097
D012220 Rhinitis C00031097
D012221 Rhinitis, Allergic, Perennial C00031097
D006255 Rhinitis, Allergic, Seasonal C00031097
D012640 Seizures C00031097
D012852 Sinusitis C00031097
D020521 Stroke C00031097
D013575 Syncope C00031097
D013614 Tachycardia, Paroxysmal C00031097
D013617 Tachycardia, Supraventricular C00031097
D017180 Tachycardia, Ventricular C00031097
D014202 Tremor C00031097
D014545 Urinary Calculi C00031097
D016055 Urinary Retention C00031097
D052878 Urolithiasis C00031097
D014581 Urticaria C00031097
D018879 Ventricular Premature Complexes C00031097
D014839 Vomiting C00031097
D014987 Xerostomia C00031097