KCF-S cluster No. 2149 (5 metabolites)

Corresponding Phytochemical cluster No. 9

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (5)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Spermatophyta	20
rosids	2
asterids	1
eudicotyledons	1

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Cumulative family count

class name	count
Ephedraceae	20
Celastraceae	2
Rubiaceae	1
Papaveraceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Phenylalanine derived alkaloids	3

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Phenylalanine derived alkaloids	C08300	C00001405
Phenylalanine derived alkaloids	C01575	C00001409
Phenylalanine derived alkaloids	C02765	C00031097

Metabolite list (5)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001405	D-Cathine	CHEMBL61006 CHEMBL136560 CHEMBL1412041 CHEMBL1574804 CHEMBL1616525 CHEMBL1788114 CHEMBL2092846		13 / 13 / 13
C00001409	Ephedrine / L-Ephedrine / 1(R),2(S)-erythro-(-)-Ephedrine	CHEMBL357080 CHEMBL211456 CHEMBL1590 CHEMBL1620154 CHEMBL2110656 CHEMBL2110905	D004809	13 / 12 / 10	7 / 50
C00031097	Pseudoephedrine / trans-Ephedrine / (+)-Pseudoephedrine	CHEMBL357080 CHEMBL211456 CHEMBL1590 CHEMBL1620154 CHEMBL2110656 CHEMBL2110905	D054199	13 / 12 / 10	0 / 50
C00032016	Methylephedrine / N-Methylephedrine / (-)-Methylephedrine	CHEMBL445001 CHEMBL1589978		3 / 0 / 0
C00032017	Methylpseudoephedrine / (1S,2S)-N-Methylpseudoephedrine	CHEMBL445001 CHEMBL1589978		3 / 0 / 0

Human Protein / Gene in interactions

24 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001405 C00001409 C00031097	1 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001405 C00001409 C00031097	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001405 C00001409 C00031097	0 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001405 C00032016 C00032017	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001405 C00001409 C00031097	0 / 1
P40225	Thrombopoietin	Unclassified protein	C00001409 C00031097	1 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00032016 C00032017	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00001409 C00031097	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00001409 C00031097	3 / 2
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00032016 C00032017	0 / 0
P14618	Pyruvate kinase PKM	Enzyme	C00001409 C00031097	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00001409 C00031097	1 / 1
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00001409 C00031097	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001409 C00031097	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001409 C00031097	3 / 3
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00001409 C00031097	2 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001405	0 / 0
P35348	Alpha-1A adrenergic receptor	Adrenergic receptor	C00001405	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00001405	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00001405	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00001405	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00001405	11 / 10
P35368	Alpha-1B adrenergic receptor	Adrenergic receptor	C00001405	0 / 0
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00001405	0 / 0

7 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
335	APOA1	apolipoprotein A-I	C00001409
336	APOA2, Apo-AII, ApoA-II, apoAII	apolipoprotein A-II	C00001409
338	APOB, FLDB, LDLCQ4	apolipoprotein B	C00001409
341	APOC1	apolipoprotein C-I	C00001409
344	APOC2, APO-CII, APOC-II	apolipoprotein C-II	C00001409
345	APOC3, APOCIII, HALP2	apolipoprotein C-III	C00001409
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00001409

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions