PCIDB

KNApSAcK Metabolite C00001409

Metabolite

KNApSAcK Entry

id C00001409
Name Ephedrine / L-Ephedrine / 1(R),2(S)-erythro-(-)-Ephedrine
CAS RN 299-42-3
Standard InChI InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1
Standard InChI (Main Layer) InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3

Cluster

Phytochemical cluster No. 9
KCF-S cluster No. 2149

Link

ChEMBL

By standard InChI CHEMBL211456
By standard InChI Main Layer CHEMBL357080 CHEMBL211456 CHEMBL1590 CHEMBL1620154 CHEMBL2110656 CHEMBL2110905

KEGG

By LinkDB C01575

CTD

By CAS RN D004809

Human Protein / Gene in interaction

13 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1590 CHEMBL1614110 (1)
1 / 0
P14618 Pyruvate kinase PKM Enzyme CHEMBL1590 CHEMBL1614177 (1) CHEMBL1614265 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1590 CHEMBL1614361 (1)
3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1590 CHEMBL1614027 (1)
0 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL1590 CHEMBL1613800 (1)
0 / 0
P06280 Alpha-galactosidase A Enzyme CHEMBL1590 CHEMBL1614130 (1) CHEMBL1613841 (1)
1 / 1
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL1590 CHEMBL1614252 (1)
2 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1590 CHEMBL1613910 (1) CHEMBL1614227 (1)
3 / 3
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL1590 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1590 CHEMBL1614240 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1590 CHEMBL1613777 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1590 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P40225 Thrombopoietin Unclassified protein CHEMBL1590 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1

CTD interaction (7)

compound gene gene name gene description interaction interaction type form reference
pmid
D004809 335 APOA1
apolipoprotein A-I [Ephedrine co-treated with Caffeine] results in increased expression of APOA1 protein affects cotreatment
/ increases expression
protein 16324916
D004809 336 APOA2
Apo-AII
ApoA-II
apoAII
apolipoprotein A-II [Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein affects cotreatment
/ decreases expression
protein 16324916
D004809 338 APOB
FLDB
LDLCQ4
apolipoprotein B [Ephedrine co-treated with Caffeine] results in decreased expression of APOB protein affects cotreatment
/ decreases expression
protein 16324916
D004809 341 APOC1
apolipoprotein C-I [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein affects cotreatment
/ increases expression
protein 16324916
D004809 344 APOC2
APO-CII
APOC-II
apolipoprotein C-II [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein affects cotreatment
/ decreases expression
protein 16324916
D004809 345 APOC3
APOCIII
HALP2
apolipoprotein C-III [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC3 protein affects cotreatment
/ decreases expression
protein 16324916
D004809 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Ephedrine results in increased expression of FOS mRNA increases expression
mRNA 12730611

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#114500 Colorectal cancer; crc P18054
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P18054
#301500 Fabry disease P06280
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#187950 Thrombocythemia 1; thcyt1 P40225

KEGG DISEASE (10)

KEGG disease name UniProt
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

50 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D058186 D004809 Acute Kidney Injury marker/mechanism
12394880
D001249 D004809 Asthma therapeutic
208429
D054537 D004809 Atrioventricular Block marker/mechanism
10407528
14531264
D001763 D004809 Blepharoptosis therapeutic
1819906
D001919 D004809 Bradycardia marker/mechanism
10407528
D002303 D004809 Cardiac Output, Low therapeutic
19957053
D009202 D004809 Cardiomyopathies marker/mechanism
15899737
D002311 D004809 Cardiomyopathy, Dilated marker/mechanism
15899737
D002543 D004809 Cerebral Hemorrhage marker/mechanism
4024187
7081793
D003128 D004809 COMA marker/mechanism
15919169
D003327 D004809 Coronary Disease marker/mechanism
15537744
D003329 D004809 Coronary Vasospasm marker/mechanism
9085987
D056486 D004809 Drug-Induced Liver Injury marker/mechanism
15899737
D004830 D004809 Epilepsy, Tonic-Clonic marker/mechanism
16956868
D005315 D004809 Fetal Diseases marker/mechanism
18806043
D005334 D004809 Fever marker/mechanism
10788568
15653753
D006212 D004809 Hallucinations marker/mechanism
18313019
D006261 D004809 Headache marker/mechanism
2629043
D006323 D004809 Heart Arrest therapeutic
3954116
D006470 D004809 Hemorrhage marker/mechanism
15537744
15653753
D006948 D004809 Hyperkinesis marker/mechanism
3671431
D006967 D004809 Hypersensitivity therapeutic
11028756
D006973 D004809 Hypertension marker/mechanism
therapeutic
2629043
10574509
D020343 D004809 Hypertensive Encephalopathy marker/mechanism
16956868
D007022 D004809 Hypotension marker/mechanism
therapeutic
1801390
3729024
3985392
7716603
8489980
8694167
8728352
8872691
8881615
8956398
9404164
9750602
10407528
10520387
10638892
11251433
11529341
12198065
12439553
12598278
12703073
15766337
15816573
15966388
16226864
18806043
19413828
19957053
20527340
D007024 D004809 Hypotension, Orthostatic therapeutic
2480881
10369619
17901021
D007333 D004809 Insulin Resistance therapeutic
10574509
D007431 D004809 Intraoperative Complications marker/mechanism
10407528
D007669 D004809 Kidney Calculi marker/mechanism
10608519
15673990
D017114 D004809 Liver Failure, Acute marker/mechanism
15899737
D008269 D004809 Macular Edema marker/mechanism
2629043
D015878 D004809 Mydriasis marker/mechanism
15919169
D009203 D004809 Myocardial Infarction marker/mechanism
19413828
D009336 D004809 Necrosis marker/mechanism
15537744
15653753
D019636 D004809 Neurodegenerative Diseases marker/mechanism
11701234
D009765 D004809 Obesity therapeutic
9118819
10574509
D007744 D004809 Obstetric Labor Complications marker/mechanism
18806043
D010146 D004809 Pain therapeutic
12401613
16731324
19232940
D011605 D004809 Psychoses, Substance-Induced marker/mechanism
5706259
D011654 D004809 Pulmonary Edema marker/mechanism
12394880
D012131 D004809 Respiratory Insufficiency marker/mechanism
12394880
D012206 D004809 Rhabdomyolysis marker/mechanism
12394880
D012607 D004809 Scotoma marker/mechanism
2629043
D012640 D004809 Seizures marker/mechanism
65671
2398476
D054138 D004809 Sinus Arrest, Cardiac therapeutic
3954116
D013610 D004809 Tachycardia marker/mechanism
2629043
10520387
D013616 D004809 Tachycardia, Sinus therapeutic
3985392
D017180 D004809 Tachycardia, Ventricular marker/mechanism
15682801
D014549 D004809 Urinary Incontinence therapeutic
8968299
10982206
D014786 D004809 Vision Disorders marker/mechanism
2629043