Species

KNApSAcK Entry

Organism name Ephedra intermedia
Genus Ephedra
Family Ephedraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ephedra intermedia
Linked NCBI taxonomy ID 173278
Linked level species

Family

Family in NCBI taxonomy Ephedraceae
ID 3386

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001409 External link 512 Ephedrine
/ L-Ephedrine
/ 1(R),2(S)-erythro-(-)-Ephedrine
CHEMBL357080
CHEMBL211456
CHEMBL1590
CHEMBL1620154
CHEMBL2110656
CHEMBL2110905
D004809
13 / 12 / 10 7 / 50 No. 2149 No. 9
C00031097 External link 512 Pseudoephedrine
/ trans-Ephedrine
/ (+)-Pseudoephedrine
CHEMBL357080
CHEMBL211456
CHEMBL1590
CHEMBL1620154
CHEMBL2110656
CHEMBL2110905
D054199
13 / 12 / 10 0 / 50 No. 2149 No. 9
C00032016 External link 512 Methylephedrine
/ N-Methylephedrine
/ (-)-Methylephedrine
CHEMBL445001
CHEMBL1589978
3 / 0 / 0 No. 2149 No. 9
C00032017 External link 512 Methylpseudoephedrine
/ (1S,2S)-N-Methylpseudoephedrine
CHEMBL445001
CHEMBL1589978
3 / 0 / 0 No. 2149 No. 9

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001409 C00031097 1 / 0
P14618 Pyruvate kinase PKM Enzyme C00001409 C00031097 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001409 C00031097 3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001409 C00031097 0 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001409 C00031097 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00032016 C00032017 0 / 0
P06280 Alpha-galactosidase A Enzyme C00001409 C00031097 1 / 1
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00001409 C00031097 2 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001409 C00031097 3 / 3
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001409 C00031097 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001409 C00031097 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001409 C00031097 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001409 C00031097 0 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00032016 C00032017 0 / 0
P40225 Thrombopoietin Unclassified protein C00001409 C00031097 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00032016 C00032017 0 / 0

7 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
335 APOA1 apolipoprotein A-I C00001409
336 APOA2, Apo-AII, ApoA-II, apoAII apolipoprotein A-II C00001409
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00001409
341 APOC1 apolipoprotein C-I C00001409
344 APOC2, APO-CII, APOC-II apolipoprotein C-II C00001409
345 APOC3, APOCIII, HALP2 apolipoprotein C-III C00001409
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00001409

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#114500 Colorectal cancer; crc P18054
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P18054
#301500 Fabry disease P06280
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#187950 Thrombocythemia 1; thcyt1 P40225

KEGG DISEASE (10)

KEGG name UniProt
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

88 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D058186 Acute Kidney Injury C00001409
C00031097
D017180 Tachycardia, Ventricular C00001409
C00031097
D012640 Seizures C00001409
C00031097
D011605 Psychoses, Substance-Induced C00001409
C00031097
D009203 Myocardial Infarction C00001409
C00031097
D020343 Hypertensive Encephalopathy C00001409
C00031097
D009202 Cardiomyopathies C00001409
C00031097
D006973 Hypertension C00001409
C00031097
D002543 Cerebral Hemorrhage C00001409
C00031097
D006967 Hypersensitivity C00001409
C00031097
D006261 Headache C00001409
C00031097
D003329 Coronary Vasospasm C00001409
C00031097
D053609 Lethargy C00031097
D004830 Epilepsy, Tonic-Clonic C00001409
D005315 Fetal Diseases C00001409
D005334 Fever C00001409
D006212 Hallucinations C00001409
D003327 Coronary Disease C00001409
D006323 Heart Arrest C00001409
D006470 Hemorrhage C00001409
D006948 Hyperkinesis C00001409
D003128 COMA C00001409
D002311 Cardiomyopathy, Dilated C00001409
D002303 Cardiac Output, Low C00001409
D007022 Hypotension C00001409
D007024 Hypotension, Orthostatic C00001409
D007333 Insulin Resistance C00001409
D007431 Intraoperative Complications C00001409
D007669 Kidney Calculi C00001409
D017114 Liver Failure, Acute C00001409
D008269 Macular Edema C00001409
D015878 Mydriasis C00001409
D001919 Bradycardia C00001409
D009336 Necrosis C00001409
D019636 Neurodegenerative Diseases C00001409
D009765 Obesity C00001409
D007744 Obstetric Labor Complications C00001409
D010146 Pain C00001409
D001763 Blepharoptosis C00001409
D011654 Pulmonary Edema C00001409
D012131 Respiratory Insufficiency C00001409
D012206 Rhabdomyolysis C00001409
D012607 Scotoma C00001409
D054537 Atrioventricular Block C00001409
D054138 Sinus Arrest, Cardiac C00001409
D013610 Tachycardia C00001409
D013616 Tachycardia, Sinus C00001409
D001249 Asthma C00001409
D014549 Urinary Incontinence C00001409
D014786 Vision Disorders C00001409
D054058 Acute Coronary Syndrome C00031097
D000787 Angina Pectoris C00031097
D000799 Angioedema C00031097
D001146 Arrhythmia, Sinus C00031097
D001259 Ataxia C00031097
D001714 Bipolar Disorder C00031097
D001929 Brain Edema C00031097
D017091 Colitis, Ischemic C00031097
D003139 Common Cold C00031097
D003873 Dermatitis, Exfoliative C00031097
D006970 Disorders of Excessive Somnolence C00031097
D004244 Dizziness C00031097
D004342 Drug Hypersensitivity C00031097
D062787 Drug Overdose C00031097
D006333 Heart Failure C00031097
D007251 Influenza, Human C00031097
D056486 Drug-Induced Liver Injury C00001409
D009207 Myoclonus C00031097
D009668 Nose Diseases C00031097
D010554 Personality Disorders C00031097
D010612 Pharyngitis C00031097
D011644 Puerperal Disorders C00031097
D012220 Rhinitis C00031097
D012221 Rhinitis, Allergic, Perennial C00031097
D006255 Rhinitis, Allergic, Seasonal C00031097
D012852 Sinusitis C00031097
D020521 Stroke C00031097
D013575 Syncope C00031097
D013614 Tachycardia, Paroxysmal C00031097
D013617 Tachycardia, Supraventricular C00031097
D014202 Tremor C00031097
D014545 Urinary Calculi C00031097
D016055 Urinary Retention C00031097
D052878 Urolithiasis C00031097
D014581 Urticaria C00031097
D018879 Ventricular Premature Complexes C00031097
D014839 Vomiting C00031097
D014987 Xerostomia C00031097