Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
C00001405 External link 512 Pseudoephedrine
/ trans-Ephedrine
/ (+)-Pseudoephedrine
13 / 12 / 10 0 / 50 No. 2149
C00032017 External link 512 Benzamide
19 / 19 / 15 No. 2149
C00032016 External link 512 Phenylglyoxal
5 / 1 / 1 3 / 0 No. 2149
C00001409 External link 512 Methylephedrine
/ N-Methylephedrine
/ (-)-Methylephedrine
3 / 0 / 0 No. 2149
C00031097 External link 512 Acetophenone
2 / 0 / 0 2 / 0 No. 2149
C00002685 External link 512 Methylpseudoephedrine
/ (1S,2S)-N-Methylpseudoephedrine
3 / 0 / 0 No. 2578
C00001406 External link 512 D-Cathine
13 / 13 / 13 No. 2578
C00000211 External link 512 Ephedrine
/ L-Ephedrine
/ 1(R),2(S)-erythro-(-)-Ephedrine
13 / 12 / 10 7 / 50 No. 2578
C00042277 External link 512 D-Cathinone
1 / 0 / 0 No. 2578

Human Protein / Gene in interactions

44 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001405 C00001409 C00031097 C00042277 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001405 C00001409 C00031097 C00042277 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001405 C00001409 C00031097 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000211 C00032016 C00032017 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001409 C00031097 C00042277 3 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001405 C00032016 C00032017 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001409 C00031097 C00042277 3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001405 C00001409 C00031097 0 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000211 C00042277 0 / 0
P40225 Thrombopoietin Unclassified protein C00001409 C00031097 1 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001409 C00031097 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00032016 C00032017 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00001409 C00031097 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001409 C00031097 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001409 C00031097 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000211 C00042277 1 / 1
P06280 Alpha-galactosidase A Enzyme C00001409 C00031097 1 / 1
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00001409 C00031097 2 / 0
P09874 Poly [ADP-ribose] polymerase 1 Enzyme C00042277 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00042277 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00042277 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00002685 0 / 0
P35348 Alpha-1A adrenergic receptor Adrenergic receptor C00001405 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000211 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001405 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001405 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00042277 5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000211 0 / 0
O75496 Geminin Unclassified protein C00042277 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001405 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001405 0 / 0
Q13464 Rho-associated protein kinase 1 Rock C00002685 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00042277 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00042277 4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein C00042277 0 / 0
P54132 Bloom syndrome protein Enzyme C00042277 1 / 2
Q86W56 Poly(ADP-ribose) glycohydrolase Enzyme C00042277 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00042277 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001405 11 / 10
P06746 DNA polymerase beta Enzyme C00042277 0 / 0
Q99700 Ataxin-2 Unclassified protein C00042277 1 / 1
P35368 Alpha-1B adrenergic receptor Adrenergic receptor C00001405 0 / 0
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00001405 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001406 0 / 0

12 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
217 ALDH2, ALDH-E2, ALDHI, ALDM aldehyde dehydrogenase 2 family (mitochondrial) (EC: C00002685
250 ALPP, ALP, PALP, PLAP, PLAP-1 alkaline phosphatase, placental (EC: C00002685
335 APOA1 apolipoprotein A-I C00001409
336 APOA2, Apo-AII, ApoA-II, apoAII apolipoprotein A-II C00001409
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00001409
341 APOC1 apolipoprotein C-I C00001409
344 APOC2, APO-CII, APOC-II apolipoprotein C-II C00001409
345 APOC3, APOCIII, HALP2 apolipoprotein C-III C00001409
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00001409
10327 AKR1A1, ALDR1, ALR, ARM, DD3 aldo-keto reductase family 1, member A1 (aldehyde reductase) (EC: C00000211
231 AKR1B1, ADR, ALDR1, ALR2, AR aldo-keto reductase family 1, member B1 (aldose reductase) (EC: C00000211
2530 FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) (EC: C00000211

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (35)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P18054
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P18054
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#139393 Guillain-barre syndrome, familial; gbs Q01453
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225


KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

88 disease in interactions with metabolites

D058186 Acute Kidney Injury C00001409
D017180 Tachycardia, Ventricular C00001409
D012640 Seizures C00001409
D011605 Psychoses, Substance-Induced C00001409
D009203 Myocardial Infarction C00001409
D020343 Hypertensive Encephalopathy C00001409
D009202 Cardiomyopathies C00001409
D006973 Hypertension C00001409
D002543 Cerebral Hemorrhage C00001409
D006967 Hypersensitivity C00001409
D006261 Headache C00001409
D003329 Coronary Vasospasm C00001409
D053609 Lethargy C00031097
D004830 Epilepsy, Tonic-Clonic C00001409
D005315 Fetal Diseases C00001409
D005334 Fever C00001409
D006212 Hallucinations C00001409
D003327 Coronary Disease C00001409
D006323 Heart Arrest C00001409
D006470 Hemorrhage C00001409
D006948 Hyperkinesis C00001409
D003128 COMA C00001409
D002311 Cardiomyopathy, Dilated C00001409
D002303 Cardiac Output, Low C00001409
D007022 Hypotension C00001409
D007024 Hypotension, Orthostatic C00001409
D007333 Insulin Resistance C00001409
D007431 Intraoperative Complications C00001409
D007669 Kidney Calculi C00001409
D017114 Liver Failure, Acute C00001409
D008269 Macular Edema C00001409
D015878 Mydriasis C00001409
D001919 Bradycardia C00001409
D009336 Necrosis C00001409
D019636 Neurodegenerative Diseases C00001409
D009765 Obesity C00001409
D007744 Obstetric Labor Complications C00001409
D010146 Pain C00001409
D001763 Blepharoptosis C00001409
D011654 Pulmonary Edema C00001409
D012131 Respiratory Insufficiency C00001409
D012206 Rhabdomyolysis C00001409
D012607 Scotoma C00001409
D054537 Atrioventricular Block C00001409
D054138 Sinus Arrest, Cardiac C00001409
D013610 Tachycardia C00001409
D013616 Tachycardia, Sinus C00001409
D001249 Asthma C00001409
D014549 Urinary Incontinence C00001409
D014786 Vision Disorders C00001409
D054058 Acute Coronary Syndrome C00031097
D000787 Angina Pectoris C00031097
D000799 Angioedema C00031097
D001146 Arrhythmia, Sinus C00031097
D001259 Ataxia C00031097
D001714 Bipolar Disorder C00031097
D001929 Brain Edema C00031097
D017091 Colitis, Ischemic C00031097
D003139 Common Cold C00031097
D003873 Dermatitis, Exfoliative C00031097
D006970 Disorders of Excessive Somnolence C00031097
D004244 Dizziness C00031097
D004342 Drug Hypersensitivity C00031097
D062787 Drug Overdose C00031097
D006333 Heart Failure C00031097
D007251 Influenza, Human C00031097
D056486 Drug-Induced Liver Injury C00001409
D009207 Myoclonus C00031097
D009668 Nose Diseases C00031097
D010554 Personality Disorders C00031097
D010612 Pharyngitis C00031097
D011644 Puerperal Disorders C00031097
D012220 Rhinitis C00031097
D012221 Rhinitis, Allergic, Perennial C00031097
D006255 Rhinitis, Allergic, Seasonal C00031097
D012852 Sinusitis C00031097
D020521 Stroke C00031097
D013575 Syncope C00031097
D013614 Tachycardia, Paroxysmal C00031097
D013617 Tachycardia, Supraventricular C00031097
D014202 Tremor C00031097
D014545 Urinary Calculi C00031097
D016055 Urinary Retention C00031097
D052878 Urolithiasis C00031097
D014581 Urticaria C00031097
D018879 Ventricular Premature Complexes C00031097
D014839 Vomiting C00031097
D014987 Xerostomia C00031097