phytochemical cluster No. 9 (9 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• KCF-S cluster (2)
• Metabolite list (9)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Spermatophyta	20
rosids	10
asterids	2
eudicotyledons	2

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Cumulative family count

class name	count
Ephedraceae	20
Celastraceae	4
Cistaceae	2
Cyprinidae	1
Convolvulaceae	1
Euphorbiaceae	1
Rubiaceae	1
Salicaceae	1
Proteaceae	1
Urticaceae	1
Apidae	1
Papaveraceae	1
Rutaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Phenylalanine derived alkaloids	4

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Phenylalanine derived alkaloids	C08300	C00001405
Phenylalanine derived alkaloids	C08301	C00001406
Phenylalanine derived alkaloids	C01575	C00001409
Phenylalanine derived alkaloids	C02765	C00031097

KCF-S cluster (2)

KCF-S ID	# of metabolite
No. 2149	5
No. 2578	4

Metabolite list (9)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	figure
C00001405	Pseudoephedrine / trans-Ephedrine / (+)-Pseudoephedrine	CHEMBL357080 CHEMBL211456 CHEMBL1590 CHEMBL1620154 CHEMBL2110656 CHEMBL2110905	D054199	13 / 12 / 10	0 / 50	No. 2149
C00032017	Benzamide	CHEMBL267373		19 / 19 / 15		No. 2149
C00032016	Phenylglyoxal	CHEMBL233632	D010658	5 / 1 / 1	3 / 0	No. 2149
C00001409	Methylephedrine / N-Methylephedrine / (-)-Methylephedrine	CHEMBL445001 CHEMBL1589978		3 / 0 / 0		No. 2149
C00031097	Acetophenone	CHEMBL274467	C038699	2 / 0 / 0	2 / 0	No. 2149
C00002685	Methylpseudoephedrine / (1S,2S)-N-Methylpseudoephedrine	CHEMBL445001 CHEMBL1589978		3 / 0 / 0		No. 2578
C00001406	D-Cathine	CHEMBL61006 CHEMBL136560 CHEMBL1412041 CHEMBL1574804 CHEMBL1616525 CHEMBL1788114 CHEMBL2092846		13 / 13 / 13		No. 2578
C00000211	Ephedrine / L-Ephedrine / 1(R),2(S)-erythro-(-)-Ephedrine	CHEMBL357080 CHEMBL211456 CHEMBL1590 CHEMBL1620154 CHEMBL2110656 CHEMBL2110905	D004809	13 / 12 / 10	7 / 50	No. 2578
C00042277	D-Cathinone	CHEMBL1124 CHEMBL2104047		1 / 0 / 0		No. 2578

Human Protein / Gene in interactions

44 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001405 C00001409 C00031097 C00042277	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001405 C00001409 C00031097 C00042277	1 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001405 C00001409 C00031097	1 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00000211 C00032016 C00032017	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001409 C00031097 C00042277	3 / 3
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001405 C00032016 C00032017	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00001409 C00031097 C00042277	3 / 2
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001405 C00001409 C00031097	0 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000211 C00042277	0 / 0
P40225	Thrombopoietin	Unclassified protein	C00001409 C00031097	1 / 1
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00001409 C00031097	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00032016 C00032017	0 / 0
P14618	Pyruvate kinase PKM	Enzyme	C00001409 C00031097	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001409 C00031097	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00001409 C00031097	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000211 C00042277	1 / 1
P06280	Alpha-galactosidase A	Enzyme	C00001409 C00031097	1 / 1
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00001409 C00031097	2 / 0
P09874	Poly [ADP-ribose] polymerase 1	Enzyme	C00042277	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00042277	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00042277	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00002685	0 / 0
P35348	Alpha-1A adrenergic receptor	Adrenergic receptor	C00001405	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000211	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001405	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00001405	0 / 0
Q01453	Peripheral myelin protein 22	Unclassified protein	C00042277	5 / 2
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00000211	0 / 0
O75496	Geminin	Unclassified protein	C00042277	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00001405	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00001405	0 / 0
Q13464	Rho-associated protein kinase 1	Rock	C00002685	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00042277	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00042277	4 / 3
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00042277	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00042277	1 / 2
Q86W56	Poly(ADP-ribose) glycohydrolase	Enzyme	C00042277	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00042277	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00001405	11 / 10
P06746	DNA polymerase beta	Enzyme	C00042277	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00042277	1 / 1
P35368	Alpha-1B adrenergic receptor	Adrenergic receptor	C00001405	0 / 0
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00001405	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001406	0 / 0

12 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
217	ALDH2, ALDH-E2, ALDHI, ALDM	aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)	C00002685
250	ALPP, ALP, PALP, PLAP, PLAP-1	alkaline phosphatase, placental (EC:3.1.3.1)	C00002685
335	APOA1	apolipoprotein A-I	C00001409
336	APOA2, Apo-AII, ApoA-II, apoAII	apolipoprotein A-II	C00001409
338	APOB, FLDB, LDLCQ4	apolipoprotein B	C00001409
341	APOC1	apolipoprotein C-I	C00001409
344	APOC2, APO-CII, APOC-II	apolipoprotein C-II	C00001409
345	APOC3, APOCIII, HALP2	apolipoprotein C-III	C00001409
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00001409
10327	AKR1A1, ALDR1, ALR, ARM, DD3	aldo-keto reductase family 1, member A1 (aldehyde reductase) (EC:1.1.1.2)	C00000211
231	AKR1B1, ADR, ALDR1, ALR2, AR	aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)	C00000211
2530	FUT8	fucosyltransferase 8 (alpha (1,6) fucosyltransferase) (EC:2.4.1.68)	C00000211

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions