KCF-S cluster No. 2578 (4 metabolites)

Corresponding Phytochemical cluster No. 9

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (4)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	8
asterids	1
eudicotyledons	1

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Cumulative family count

class name	count
Celastraceae	2
Cistaceae	2
Salicaceae	1
Euphorbiaceae	1
Cyprinidae	1
Convolvulaceae	1
Proteaceae	1
Urticaceae	1
Apidae	1
Rutaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Phenylalanine derived alkaloids	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Phenylalanine derived alkaloids	C08301	C00001406

Metabolite list (4)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000211	Phenylglyoxal	CHEMBL233632	D010658	5 / 1 / 1	3 / 0
C00001406	D-Cathinone	CHEMBL1124 CHEMBL2104047		1 / 0 / 0
C00002685	Acetophenone	CHEMBL274467	C038699	2 / 0 / 0	2 / 0
C00042277	Benzamide	CHEMBL267373		19 / 19 / 15

Human Protein / Gene in interactions

25 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000211 C00042277	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000211 C00042277	1 / 1
P28482	Mitogen-activated protein kinase 1	Erk	C00000211	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00042277	3 / 2
P54132	Bloom syndrome protein	Enzyme	C00042277	1 / 2
Q13464	Rho-associated protein kinase 1	Rock	C00002685	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00000211	0 / 0
O75496	Geminin	Unclassified protein	C00042277	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00002685	0 / 0
P09874	Poly [ADP-ribose] polymerase 1	Enzyme	C00042277	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00042277	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00042277	0 / 0
Q86W56	Poly(ADP-ribose) glycohydrolase	Enzyme	C00042277	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00042277	3 / 3
Q01453	Peripheral myelin protein 22	Unclassified protein	C00042277	5 / 2
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00000211	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00042277	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00042277	0 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00042277	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00042277	4 / 3
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00042277	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00042277	1 / 1
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00042277	0 / 0
P06746	DNA polymerase beta	Enzyme	C00042277	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001406	0 / 0

5 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
217	ALDH2, ALDH-E2, ALDHI, ALDM	aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)	C00002685
250	ALPP, ALP, PALP, PLAP, PLAP-1	alkaline phosphatase, placental (EC:3.1.3.1)	C00002685
10327	AKR1A1, ALDR1, ALR, ARM, DD3	aldo-keto reductase family 1, member A1 (aldehyde reductase) (EC:1.1.1.2)	C00000211
231	AKR1B1, ADR, ALDR1, ALR2, AR	aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)	C00000211
2530	FUT8	fucosyltransferase 8 (alpha (1,6) fucosyltransferase) (EC:2.4.1.68)	C00000211

Related Diseases

Diseases related to proteins in ChEMBL interactions