Ephedra equisetina
Species
KNApSAcK Entry
| Organism name | Ephedra equisetina |
|---|---|
| Genus | Ephedra |
| Family | Ephedraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Ephedra equisetina |
|---|---|
| Linked NCBI taxonomy ID | 173280 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Ephedraceae |
|---|---|
| ID | 3386 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Spermatophyta |
|---|---|
| ID | 58024 |
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005356
|
Sexangularetin 3-glucoside
|
No. 2 | No. 15 |
|
||||
|
C00001409
|
Ephedrine
/ L-Ephedrine / 1(R),2(S)-erythro-(-)-Ephedrine |
CHEMBL357080
CHEMBL211456 CHEMBL1590 CHEMBL1620154 CHEMBL2110656 CHEMBL2110905 |
D004809
|
13 / 12 / 10 | 7 / 50 | No. 2149 | No. 9 |
|
Human Protein / Gene in interactions
13 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001409 | 1 / 0 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00001409 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001409 | 3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001409 | 0 / 1 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00001409 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00001409 | 1 / 1 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00001409 | 2 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001409 | 3 / 3 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00001409 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001409 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001409 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001409 | 0 / 1 |
| P40225 | Thrombopoietin | Unclassified protein | C00001409 | 1 / 1 |
7 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 335 | APOA1 | apolipoprotein A-I |
C00001409
|
| 336 | APOA2, Apo-AII, ApoA-II, apoAII | apolipoprotein A-II |
C00001409
|
| 338 | APOB, FLDB, LDLCQ4 | apolipoprotein B |
C00001409
|
| 341 | APOC1 | apolipoprotein C-I |
C00001409
|
| 344 | APOC2, APO-CII, APOC-II | apolipoprotein C-II |
C00001409
|
| 345 | APOC3, APOCIII, HALP2 | apolipoprotein C-III |
C00001409
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00001409
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (12)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #114500 | Colorectal cancer; crc |
P18054
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P18054
|
| #301500 | Fabry disease |
P06280
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
KEGG DISEASE (10)
| KEGG | name | UniProt |
|---|---|---|
| H00125 | Fabry disease |
P06280
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
50 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D058186 | Acute Kidney Injury |
C00001409
|
| D001249 | Asthma |
C00001409
|
| D054537 | Atrioventricular Block |
C00001409
|
| D001763 | Blepharoptosis |
C00001409
|
| D001919 | Bradycardia |
C00001409
|
| D002303 | Cardiac Output, Low |
C00001409
|
| D009202 | Cardiomyopathies |
C00001409
|
| D002311 | Cardiomyopathy, Dilated |
C00001409
|
| D002543 | Cerebral Hemorrhage |
C00001409
|
| D003128 | COMA |
C00001409
|
| D003327 | Coronary Disease |
C00001409
|
| D003329 | Coronary Vasospasm |
C00001409
|
| D056486 | Drug-Induced Liver Injury |
C00001409
|
| D004830 | Epilepsy, Tonic-Clonic |
C00001409
|
| D005315 | Fetal Diseases |
C00001409
|
| D005334 | Fever |
C00001409
|
| D006212 | Hallucinations |
C00001409
|
| D006261 | Headache |
C00001409
|
| D006323 | Heart Arrest |
C00001409
|
| D006470 | Hemorrhage |
C00001409
|
| D006948 | Hyperkinesis |
C00001409
|
| D006967 | Hypersensitivity |
C00001409
|
| D006973 | Hypertension |
C00001409
|
| D020343 | Hypertensive Encephalopathy |
C00001409
|
| D007022 | Hypotension |
C00001409
|
| D007024 | Hypotension, Orthostatic |
C00001409
|
| D007333 | Insulin Resistance |
C00001409
|
| D007431 | Intraoperative Complications |
C00001409
|
| D007669 | Kidney Calculi |
C00001409
|
| D017114 | Liver Failure, Acute |
C00001409
|
| D008269 | Macular Edema |
C00001409
|
| D015878 | Mydriasis |
C00001409
|
| D009203 | Myocardial Infarction |
C00001409
|
| D009336 | Necrosis |
C00001409
|
| D019636 | Neurodegenerative Diseases |
C00001409
|
| D009765 | Obesity |
C00001409
|
| D007744 | Obstetric Labor Complications |
C00001409
|
| D010146 | Pain |
C00001409
|
| D011605 | Psychoses, Substance-Induced |
C00001409
|
| D011654 | Pulmonary Edema |
C00001409
|
| D012131 | Respiratory Insufficiency |
C00001409
|
| D012206 | Rhabdomyolysis |
C00001409
|
| D012607 | Scotoma |
C00001409
|
| D012640 | Seizures |
C00001409
|
| D054138 | Sinus Arrest, Cardiac |
C00001409
|
| D013610 | Tachycardia |
C00001409
|
| D013616 | Tachycardia, Sinus |
C00001409
|
| D017180 | Tachycardia, Ventricular |
C00001409
|
| D014549 | Urinary Incontinence |
C00001409
|
| D014786 | Vision Disorders |
C00001409
|