Species

KNApSAcK Entry

Organism name Eschscholtzia california
Genus Eschscholtzia
Family Papaveraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Papaveraceae
Linked NCBI taxonomy ID 3465
Linked level family

Family

Family in NCBI taxonomy Papaveraceae
ID 3465

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001819 External link 512 Thalsine
/ Majarine
/ Berberine
/ Umbellatin
CHEMBL295124
D001599
19 / 25 / 26 30 / 19 No. 155 No. 4
C00001917 External link 512 Sanguinarine
/ Pseudochelerythrine
CHEMBL417799
C005705
55 / 55 / 77 23 / 6 No. 254 No. 4

Human Protein / Gene in interactions

57 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001819 C00001917 1 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00001819 C00001917 1 / 4
Q13951 Core-binding factor subunit beta Unclassified protein C00001819 C00001917 0 / 1
Q16637 Survival motor neuron protein Unclassified protein C00001819 C00001917 4 / 1
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00001819 C00001917 1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00001819 C00001917 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001819 C00001917 1 / 2
O00255 Menin Unclassified protein C00001819 C00001917 2 / 5
P10636 Microtubule-associated protein tau Unclassified protein C00001819 C00001917 4 / 3
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001819 C00001917 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001819 C00001917 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001819 C00001917 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00001819 C00001917 1 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001819 C00001917 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001819 C00001917 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001819 C00001917 3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001819 C00001917 0 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00001917 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001917 0 / 0
P37840 Alpha-synuclein Unclassified protein C00001917 4 / 2
O14924 Regulator of G-protein signaling 12 Unclassified protein C00001917 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001917 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001917 0 / 0
P42858 Huntingtin Unclassified protein C00001917 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001917 2 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00001917 0 / 0
P42226 Signal transducer and activator of transcription 6 Unclassified protein C00001917 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001917 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00001917 2 / 3
P02545 Prelamin-A/C Unclassified protein C00001917 11 / 10
P11021 78 kDa glucose-regulated protein Unclassified protein C00001917 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001917 0 / 0
Q99816 Tumor susceptibility gene 101 protein Unclassified protein C00001917 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00001917 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001917 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00001917 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001917 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001917 2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00001917 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001917 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001917 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001917 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001819 2 / 2
P21728 D(1A) dopamine receptor Dopamine receptor C00001917 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001917 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00001917 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001917 0 / 0
Q92934 Bcl2 antagonist of cell death Other cytosolic protein C00001917 0 / 0
O14746 Telomerase reverse transcriptase Enzyme C00001819 5 / 5
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001917 0 / 0
P40225 Thrombopoietin Unclassified protein C00001917 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001917 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001917 2 / 0
Q99700 Ataxin-2 Unclassified protein C00001917 1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00001917 7 / 37
P42345 Serine/threonine-protein kinase mTOR Enzyme C00001917 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001917 0 / 0

44 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
196 AHR, bHLHe76 aryl hydrocarbon receptor C00001819 C00001917
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001819 C00001917
581 BAX, BCL2L4 BCL2-associated X protein C00001819 C00001917
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001819 C00001917
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001819 C00001917
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00001819 C00001917
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001819 C00001917
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00001819 C00001917
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001819 C00001917
1364 CLDN4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R claudin 4 C00001917
7122 CLDN5, AWAL, BEC1, CPETRL1, TMVCF claudin 5 C00001917
1365 CLDN3, C7orf1, CPE-R2, CPETR2, HRVP1, RVP1 claudin 3 C00001917
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00001917
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00001917
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00001917
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00001917
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00001917
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00001917
9075 CLDN2 claudin 2 C00001917
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00001917
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00001917
6615 SNAI1, SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1 snail family zinc finger 1 C00001917
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00001917
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00001819
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00001819
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00001819
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00001819
894 CCND2, KIAK0002 cyclin D2 C00001819
898 CCNE1, CCNE cyclin E1 C00001819
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00001819
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00001819
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00001819
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00001819
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00001819
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00001819
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00001819
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00001819
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00001819
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001819
5027 P2RX7, P2X7 purinergic receptor P2X, ligand-gated ion channel, 7 C00001819
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00001819
6476 SI sucrase-isomaltase (alpha-glucosidase) (EC:3.2.1.10 3.2.1.48) C00001819
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00001819
7185 TRAF1, EBI6, MGC:10353 TNF receptor-associated factor 1 C00001819

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (62)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#609135 Aplastic anemia O14746
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P18054
P84022
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#613989 Dyskeratosis congenita, autosomal dominant, 2; dkca2 O14746
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
P18054
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#615134 Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 O14746
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257220 Niemann-pick disease, type c1; npc1 O15118
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614742 Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 O14746
#178500 Pulmonary fibrosis, idiopathic; ipf O14746
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (83)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00764 Cri du chat syndrome O14746 (related)
H01132 Aplastic anemia (AA) O14746 (related)
H01299 Idiopathic pulmonary fibrosis O14746 (related)
H00022 Bladder cancer O14746 (marker)
P04637 (related)
H00024 Prostate cancer O14746 (marker)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00059 Huntington's disease (HD) P42858 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

24 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009369 Neoplasms C00001917
C00001819
D003924 Diabetes Mellitus, Type 2 C00001819
D009336 Necrosis C00001917
D020964 Embryo Loss C00001917
D009374 Neoplasms, Experimental C00001917
D012878 Skin Neoplasms C00001917
D000647 Amnesia C00001819
D001862 Bone Resorption C00001819
D002471 Cell Transformation, Neoplastic C00001819
D003556 Cystitis C00001819
D003920 Diabetes Mellitus C00001819
D003921 Diabetes Mellitus, Experimental C00001819
D005317 Fetal Growth Retardation C00001917
D004487 Edema C00001819
D006470 Hemorrhage C00001819
D006937 Hypercholesterolemia C00001819
D006943 Hyperglycemia C00001819
D006949 Hyperlipidemias C00001819
D006973 Hypertension C00001819
D007077 Ileal Diseases C00001819
D007333 Insulin Resistance C00001819
D007410 Intestinal Diseases C00001819
D010190 Pancreatic Neoplasms C00001819
D011471 Prostatic Neoplasms C00001819