PCIDB

KNApSAcK Metabolite C00001819

Metabolite

KNApSAcK Entry

id C00001819
Name Thalsine / Majarine / Berberine / Umbellatin
CAS RN 2086-83-1
Standard InChI InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1
Standard InChI (Main Layer) InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 155

Link

ChEMBL

By standard InChI CHEMBL295124
By standard InChI Main Layer CHEMBL295124

KEGG

By LinkDB C00757

CTD

By CAS RN D001599

Species

Summary

Plant class

class name count
eudicotyledons 68
rosids 7

Family

family name count
Berberidaceae 25
Ranunculaceae 23
Papaveraceae 18
Rutaceae 7
Menispermaceae 2

List (79)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acangelisia gusanlung 3455 Menispermaceae eudicotyledons Viridiplantae
Archangelicia flava
Archangelisia spp.
Argemone spp. 54795 Papaveraceae eudicotyledons Viridiplantae
Argemone subfusiformia 54795 Papaveraceae eudicotyledons Viridiplantae
Argemone subfusiformis var.subinermis 54795 Papaveraceae eudicotyledons Viridiplantae
Asteropyrum cavaleriei 93606 Ranunculaceae eudicotyledons Viridiplantae
Berberis aemulans 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis brandisiana 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis candidula 258148 Berberidaceae eudicotyledons Viridiplantae
Berberis croatica 435944 Berberidaceae eudicotyledons Viridiplantae
Berberis darwinii 186723 Berberidaceae eudicotyledons Viridiplantae
Berberis densiflora 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis heterobotrys 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis iliensis 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis integerrima 1112794 Berberidaceae eudicotyledons Viridiplantae
Berberis nervosa 258188 Berberidaceae eudicotyledons Viridiplantae
Berberis numularis 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis oblonga 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis poirettii 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis pruinosa 258196 Berberidaceae eudicotyledons Viridiplantae
Berberis pseudanubalata 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis rigidifolia 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis spp. 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis stenophylla 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis turcomanica 22774 Berberidaceae eudicotyledons Viridiplantae
Berberis vulgaris 258209 Berberidaceae eudicotyledons Viridiplantae
Chelidonium majus L. 71251 Papaveraceae eudicotyledons Viridiplantae
Chelidonium spp. 3465 Papaveraceae eudicotyledons Viridiplantae
Chelidonum majus
Coptis chinensis 261450 Ranunculaceae eudicotyledons Viridiplantae
Coptis deltoides 3441 Ranunculaceae eudicotyledons Viridiplantae
Coptis gulinensis 3441 Ranunculaceae eudicotyledons Viridiplantae
Coptis japonica 3442 Ranunculaceae eudicotyledons Viridiplantae
Coptis omeiensis 261451 Ranunculaceae eudicotyledons Viridiplantae
Coptis spp. 3441 Ranunculaceae eudicotyledons Viridiplantae
Corydalis intermedia 54425 Papaveraceae eudicotyledons Viridiplantae
Corydalis ophiocarpa 38929 Papaveraceae eudicotyledons Viridiplantae
Corydalis solida 38914 Papaveraceae eudicotyledons Viridiplantae
Corydalis spp. 3463 Papaveraceae eudicotyledons Viridiplantae
Coscinium fenestratum 483232 Menispermaceae eudicotyledons Viridiplantae
Eschscholtzia california 3465 Papaveraceae eudicotyledons Viridiplantae
Evodia mellifolia 354493 Rutaceae rosids Viridiplantae
Evodia spp. 354493 Rutaceae rosids Viridiplantae
Glaucium arabicum 56852 Papaveraceae eudicotyledons Viridiplantae
Hydrastis canadensis 13569 Ranunculaceae eudicotyledons Viridiplantae
Mahonia aquifolium 203270 Berberidaceae eudicotyledons Viridiplantae
Mahonia japonica 116719 Berberidaceae eudicotyledons Viridiplantae
Mahonia spp. 22774 Berberidaceae eudicotyledons Viridiplantae
Nandina domestica 41776 Berberidaceae eudicotyledons Viridiplantae
Nandina spp. 41775 Berberidaceae eudicotyledons Viridiplantae
Naravelia zeylandica 231672 Ranunculaceae eudicotyledons Viridiplantae
Papaver albiflora 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver confine 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver pinnatifidum 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver radicatum 357475 Papaveraceae eudicotyledons Viridiplantae
Papaver rhoeas chelidonides 3468 Papaveraceae eudicotyledons Viridiplantae
Papaver rhopalothece 3468 Papaveraceae eudicotyledons Viridiplantae
Papver stevenianum
Phellodendron amurense 68554 Rutaceae rosids Viridiplantae
Phellodendron wilsonii 68553 Rutaceae rosids Viridiplantae
Ranunculus serbicus 286994 Ranunculaceae eudicotyledons Viridiplantae
Stylophorum lasiocarpum 72189 Papaveraceae eudicotyledons Viridiplantae
Thalictrum flavum 150094 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum foetidum 1084670 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum foliosum 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum honanense 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum longipedunculatum 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum minus 476039 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum orientale 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum przewalskii 1277786 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum purpurescens 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum spp. 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum symplex 46968 Ranunculaceae eudicotyledons Viridiplantae
Thalictrum wanqii 46968 Ranunculaceae eudicotyledons Viridiplantae
Toddalia aculeata Pers. 159067 Rutaceae rosids Viridiplantae
Toddalia spp. 159067 Rutaceae rosids Viridiplantae
Xanthorhiza simplicissima 13762 Ranunculaceae eudicotyledons Viridiplantae
Zanthoxylum spp. 67937 Rutaceae rosids Viridiplantae

Human Protein / Gene in interaction

19 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL295124 CHEMBL1614110 (1) CHEMBL1741321 (1)
1 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL295124 CHEMBL1613842 (1)
4 / 2
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL295124 CHEMBL2169429 (1)
1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL295124 CHEMBL2169431 (1)
0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL295124 CHEMBL1676103 (1)
2 / 2
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL295124 CHEMBL1614361 (1)
3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL295124 CHEMBL1741325 (1)
0 / 1
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL295124 CHEMBL1614458 (1)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL295124 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL295124 CHEMBL2169430 (1)
1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL295124 CHEMBL1741322 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL295124 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL295124 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL295124 CHEMBL1614421 (1)
4 / 3
O14746 Telomerase reverse transcriptase Enzyme CHEMBL295124 CHEMBL1958529 (1)
5 / 5
O00255 Menin Unclassified protein CHEMBL295124 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL295124 CHEMBL1614531 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL295124 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL295124 CHEMBL1613933 (1)
1 / 6

CTD interaction (55)

compound gene gene name gene description interaction interaction type form reference
pmid
D001599 196 AHR
bHLHe76
aryl hydrocarbon receptor Berberine results in increased activity of AHR protein increases activity
protein 16046213
D001599 581 BAX
BCL2L4
BCL2-associated X protein Berberine results in increased expression of BAX mRNA increases expression
mRNA 20656010
D001599 581 BAX
BCL2L4
BCL2-associated X protein Berberine results in increased expression of BAX protein increases expression
protein 16505103
20656010
D001599 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Berberine results in decreased expression of BCL2 mRNA decreases expression
mRNA 20656010
D001599 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Berberine results in decreased expression of BCL2 protein decreases expression
protein 16505103
20656010
D001599 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Berberine results in decreased expression of BCL2L1 protein decreases expression
protein 16505103
D001599 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 Berberine binds to BIRC5 promoter affects binding
promoter 17968851
D001599 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Berberine results in increased activity of CASP3 protein increases activity
protein 20656010
D001599 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Berberine results in increased cleavage of and results in increased activity of CASP3 protein increases activity
/ increases cleavage
protein 16505103
D001599 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Berberine results in increased expression of CASP3 mRNA increases expression
mRNA 20656010
D001599 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Berberine results in increased activity of CASP8 protein increases activity
protein 20656010
D001599 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Berberine results in increased cleavage of CASP9 protein increases cleavage
protein 16505103
D001599 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA] decreases reaction
/ increases expression
mRNA 16391493
D001599 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] decreases reaction
/ increases secretion
protein 16391493
D001599 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] decreases reaction
/ increases expression
mRNA 16391493
D001599 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein] decreases reaction
/ increases secretion
protein 16391493
D001599 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Berberine results in decreased expression of CCND1 protein decreases expression
protein 16505103
D001599 894 CCND2
KIAK0002
cyclin D2 Berberine results in decreased expression of CCND2 protein decreases expression
protein 16505103
D001599 898 CCNE1
CCNE
cyclin E1 Berberine results in decreased expression of CCNE1 protein decreases expression
protein 16505103
D001599 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) Berberine results in decreased expression of CDK2 protein decreases expression
protein 16505103
D001599 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) Berberine results in decreased expression of CDK4 protein decreases expression
protein 16505103
D001599 1021 CDK6
PLSTIRE
cyclin-dependent kinase 6 (EC:2.7.11.22) Berberine results in decreased expression of CDK6 protein decreases expression
protein 16505103
D001599 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Berberine results in increased expression of CDKN1A protein increases expression
protein 16505103
D001599 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Berberine results in increased expression of CDKN1B protein increases expression
protein 16505103
D001599 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic Berberine affects the localization of CYCS protein affects localization
protein 16505103
D001599 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Berberine results in decreased activity of CYP1A1 protein decreases activity
protein 16046213
D001599 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Berberine results in increased expression of CYP1A1 mRNA increases expression
mRNA 16046213
D001599 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor Berberine results in increased expression of FAS mRNA increases expression
mRNA 20656010
D001599 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor Berberine results in increased expression of FAS protein increases expression
protein 20656010
D001599 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) Berberine results in increased expression of FASLG mRNA increases expression
mRNA 20656010
D001599 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) Berberine results in increased expression of FASLG protein increases expression
protein 20656010
D001599 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA] decreases reaction
/ increases expression
protein 16391493
D001599 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Berberine inhibits the reaction [IL1B protein results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
protein 16391493
D001599 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] decreases reaction
/ increases secretion
protein 16391493
D001599 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Berberine inhibits the reaction [IL1B protein results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 16391493
D001599 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Berberine inhibits the reaction [IL1B protein results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 16391493
D001599 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Berberine inhibits the reaction [IL1B protein results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 16391493
D001599 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Berberine inhibits the reaction [TNF protein results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 16391493
D001599 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Berberine inhibits the reaction [TNF protein results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 16391493
D001599 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) arsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein] decreases activity
/ increases reaction
protein 18294404
D001599 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein] decreases activity
/ increases reaction
protein 18294404
D001599 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Berberine results in decreased activity of MMP2 protein decreases activity
protein 18294404
D001599 5027 P2RX7
P2X7
purinergic receptor P2X, ligand-gated ion channel, 7 Berberine affects the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] affects reaction
/ increases activity
protein 21320518
D001599 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Berberine results in increased cleavage of PARP1 protein increases cleavage
protein 16505103
D001599 6476 SI
sucrase-isomaltase (alpha-glucosidase) (EC:3.2.1.10 3.2.1.48) Berberine results in decreased expression of SI mRNA decreases expression
mRNA 20229011
D001599 6476 SI
sucrase-isomaltase (alpha-glucosidase) (EC:3.2.1.10 3.2.1.48) N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Berberine results in decreased expression of SI mRNA] decreases expression
/ decreases reaction
mRNA 20229011
D001599 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] decreases reaction
/ increases expression
protein 16391493
D001599 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Berberine inhibits the reaction [TNF protein results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
protein 16391493
D001599 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein] decreases reaction
/ increases secretion
protein 16391493
D001599 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Berberine inhibits the reaction [TNF protein results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 16391493
D001599 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Berberine results in increased expression of TNF mRNA increases expression
mRNA 20656010
D001599 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Berberine results in increased secretion of TNF protein increases secretion
protein 20656010
D001599 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Berberine results in increased expression of TP53 mRNA increases expression
mRNA 20656010
D001599 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Berberine results in increased expression of TP53 protein increases expression
protein 20656010
D001599 7185 TRAF1
EBI6
MGC:10353
TNF receptor-associated factor 1 Berberine results in increased expression of TRAF1 protein increases expression
protein 20656010

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (25)

OMIM preferred title UniProt
#609135 Aplastic anemia O14746
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#613989 Dyskeratosis congenita, autosomal dominant, 2; dkca2 O14746
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#613688 Long qt syndrome 2; lqt2 Q12809
#615134 Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 O14746
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614742 Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 O14746
#178500 Pulmonary fibrosis, idiopathic; ipf O14746
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (26)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00764 Cri du chat syndrome O14746 (related)
H01132 Aplastic anemia (AA) O14746 (related)
H01299 Idiopathic pulmonary fibrosis O14746 (related)
H00022 Bladder cancer O14746 (marker)
H00024 Prostate cancer O14746 (marker)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)

Diseases related to CTD interactions

19 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000647 D001599 Amnesia therapeutic
9268086
D001862 D001599 Bone Resorption therapeutic
9881647
D002471 D001599 Cell Transformation, Neoplastic therapeutic
18951886
D003556 D001599 Cystitis therapeutic
11393582
D003920 D001599 Diabetes Mellitus therapeutic
22342832
D003921 D001599 Diabetes Mellitus, Experimental therapeutic
20229011
D003924 D001599 Diabetes Mellitus, Type 2 therapeutic
19080170
D004487 D001599 Edema therapeutic
11393582
D006470 D001599 Hemorrhage therapeutic
11393582
D006937 D001599 Hypercholesterolemia therapeutic
22342832
D006943 D001599 Hyperglycemia therapeutic
22342832
D006949 D001599 Hyperlipidemias therapeutic
20656010
D006973 D001599 Hypertension therapeutic
22342832
D007077 D001599 Ileal Diseases therapeutic
21963898
D007333 D001599 Insulin Resistance therapeutic
18563319
D007410 D001599 Intestinal Diseases therapeutic
20656010
21073932
D009369 D001599 Neoplasms therapeutic
12415430
D010190 D001599 Pancreatic Neoplasms therapeutic
21491092
D011471 D001599 Prostatic Neoplasms therapeutic
16505103