Chelidonium majus L.
Species
KNApSAcK Entry
| Organism name | Chelidonium majus L. |
|---|---|
| Genus | Chelidonium |
| Family | Papaveraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Chelidonium majus |
|---|---|
| Linked NCBI taxonomy ID | 71251 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Papaveraceae |
|---|---|
| ID | 3465 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Natural Activity
List (48)
| Species | Activity |
|---|---|
| Chelidonium majus L. | 12-Lipoxygenase-Inhibitor |
| Chelidonium majus L. | 5-Lipoxygenase Inhibitor |
| Chelidonium majus L. | Abortifacient |
| Chelidonium majus L. | Alterative |
| Chelidonium majus L. | Analgesic |
| Chelidonium majus L. | Anthelminthic |
| Chelidonium majus L. | Antiaggregant |
| Chelidonium majus L. | Antianaphylactic |
| Chelidonium majus L. | Antibacterial |
| Chelidonium majus L. | Anticancer |
| Chelidonium majus L. | Antiherpetic |
| Chelidonium majus L. | Antiinflammatory |
| Chelidonium majus L. | Antileukotriene |
| Chelidonium majus L. | Antimutagenic |
| Chelidonium majus L. | Antisarcomic |
| Chelidonium majus L. | Antiseptic |
| Chelidonium majus L. | Antispasmodic |
| Chelidonium majus L. | Antithromboxane |
| Chelidonium majus L. | Antitumor |
| Chelidonium majus L. | Antitussive |
| Chelidonium majus L. | Antiviral |
| Chelidonium majus L. | Aphrodisiac |
| Chelidonium majus L. | Candidicide |
| Chelidonium majus L. | Cholagogue |
| Chelidonium majus L. | Cholekinetic |
| Chelidonium majus L. | Choleretic |
| Chelidonium majus L. | CNS-Depressant |
| Chelidonium majus L. | Collyrium |
| Chelidonium majus L. | Cytotoxic |
| Chelidonium majus L. | Deobstruent |
| Chelidonium majus L. | Diaphoretic |
| Chelidonium majus L. | Diuretic |
| Chelidonium majus L. | Expectorant |
| Chelidonium majus L. | Fungicide |
| Chelidonium majus L. | Hepatoprotective |
| Chelidonium majus L. | Hepatotoxic |
| Chelidonium majus L. | Hypoglycemic |
| Chelidonium majus L. | Hypotensive |
| Chelidonium majus L. | Immunostimulant |
| Chelidonium majus L. | Keratopreventive |
| Chelidonium majus L. | Laxative |
| Chelidonium majus L. | Myocontractant |
| Chelidonium majus L. | Myorelaxant |
| Chelidonium majus L. | Protisticide |
| Chelidonium majus L. | Sedative |
| Chelidonium majus L. | Trichomonicide |
| Chelidonium majus L. | Uterocontractant |
| Chelidonium majus L. | Vulnerary |
Metabolite list (11)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00026095
|
Stylopine
/ (-)-Stylopine / l-Tetrahydrocoptisine / (-)-Tetrahydrocoptisine |
CHEMBL1922602
|
No. 37 | No. 4 |
|
|||
|
C00001819
|
Thalsine
/ Majarine / Berberine / Umbellatin |
CHEMBL295124
|
D001599
|
19 / 25 / 26 | 30 / 19 | No. 155 | No. 4 |
|
|
C00024668
|
YHL II
/ Coptisine |
CHEMBL362071
|
C034384
|
No. 155 | No. 4 |
|
||
|
C00026118
|
Corysamine
|
No. 155 | No. 4 |
|
||||
|
C00026083
|
(-)-(alpha)-Stylopine methiodide
|
No. 234 |
|
|||||
|
C00024636
|
Chelirubine
|
C033476
|
No. 254 | No. 4 |
|
|||
|
C00024663
|
Sanguinarin
/ Sanguinarine / Sanguinarium / Pseudochelerythrine |
CHEMBL417799
|
C005705
|
55 / 55 / 77 | 23 / 6 | No. 254 | No. 4 |
|
|
C00002236
|
Spartein
/ (-)-Spartein |
CHEMBL412873
CHEMBL44625 CHEMBL172633 CHEMBL1328708 CHEMBL1492771 CHEMBL1740920 CHEMBL1908847 CHEMBL2010478 |
D013034
|
93 / 50 / 48 | 1 / 2 | No. 424 | No. 3 |
|
|
C00001799
|
Thalictrimine
/ Allocryptopine / alpha-Fagarine / beta-Homochelidonine / alpha-Allocryptopine |
CHEMBL520043
|
C109505
|
3 / 2 / 3 | 2 / 0 | No. 820 | No. 4 |
|
|
C00001906
|
Fumarin
/ Biflorine / Protopine / Fumarine / Corydinine |
CHEMBL453019
|
C009093
|
5 / 5 / 4 | 2 / 0 | No. 820 | No. 4 |
|
|
C00028040
|
Chelidimerine
|
C000467
|
No. 1563 |
|
Human Protein / Gene in interactions
139 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001819 C00001906 C00002236 C00024663 | 1 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001799 C00001819 C00002236 C00024663 | 1 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001819 C00001906 C00002236 C00024663 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001819 C00001906 C00002236 C00024663 | 0 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001819 C00001906 C00024663 | 3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001819 C00002236 C00024663 | 0 / 1 |
| O00255 | Menin | Unclassified protein | C00001819 C00002236 C00024663 | 2 / 5 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001819 C00002236 C00024663 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001819 C00024663 | 4 / 3 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002236 C00024663 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001799 C00024663 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00001819 C00002236 | 2 / 2 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001819 C00024663 | 4 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001819 C00024663 | 0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001906 C00024663 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002236 C00024663 | 0 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00001819 C00024663 | 1 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001819 C00024663 | 1 / 4 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002236 C00024663 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001819 C00024663 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001819 C00024663 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002236 C00024663 | 11 / 10 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00001819 C00024663 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00001819 C00024663 | 1 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00002236 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002236 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00002236 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002236 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00002236 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00002236 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00002236 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00002236 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00002236 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00002236 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00002236 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00002236 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00002236 | 0 / 0 |
| O14924 | Regulator of G-protein signaling 12 | Unclassified protein | C00024663 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002236 | 1 / 8 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00024663 | 2 / 3 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00002236 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002236 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00002236 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00002236 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00002236 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00002236 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00002236 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00002236 | 1 / 1 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00024663 | 0 / 0 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00002236 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00002236 | 1 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00024663 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00002236 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002236 | 2 / 2 |
| P39748 | Flap endonuclease 1 | Enzyme | C00024663 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00002236 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00024663 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00024663 | 2 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00024663 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00002236 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00002236 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00002236 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00002236 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00002236 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00002236 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002236 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00002236 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00002236 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00002236 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00002236 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00002236 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002236 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00002236 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002236 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00002236 | 0 / 0 |
| P42226 | Signal transducer and activator of transcription 6 | Unclassified protein | C00024663 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00002236 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00024663 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00024663 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002236 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00024663 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00024663 | 0 / 0 |
| Q99816 | Tumor susceptibility gene 101 protein | Unclassified protein | C00024663 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002236 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00002236 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00002236 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00002236 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00002236 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00002236 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00002236 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00002236 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00002236 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00002236 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00002236 | 0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00024663 | 2 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00002236 | 1 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00002236 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00002236 | 2 / 1 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00002236 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00024663 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00024663 | 2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00024663 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00024663 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00024663 | 4 / 2 |
| P03372 | Estrogen receptor | NR3A1 | C00002236 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00002236 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002236 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00002236 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00002236 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00002236 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00002236 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00002236 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00002236 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00002236 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00024663 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00024663 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00002236 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00002236 | 2 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00002236 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002236 | 0 / 3 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00024663 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00024663 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00002236 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00002236 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00002236 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00002236 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00002236 | 1 / 1 |
| Q92934 | Bcl2 antagonist of cell death | Other cytosolic protein | C00024663 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002236 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00002236 | 0 / 0 |
| O14746 | Telomerase reverse transcriptase | Enzyme | C00001819 | 5 / 5 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00024663 | 2 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00024663 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00024663 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00024663 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00024663 | 7 / 37 |
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | C00024663 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00024663 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00001799 | 1 / 1 |
46 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001799
C00001819
C00001906
C00024663
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001819
C00024663
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001819
C00024663
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001819
C00024663
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00001819
C00024663
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00001819
C00024663
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00001819
C00024663
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001819
C00024663
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00001819
C00024663
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001799
C00001906
|
| 7122 | CLDN5, AWAL, BEC1, CPETRL1, TMVCF | claudin 5 |
C00024663
|
| 1364 | CLDN4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R | claudin 4 |
C00024663
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00024663
|
| 2950 | GSTP1, DFN7, FAEES3, GST3, GSTP, PI | glutathione S-transferase pi 1 (EC:2.5.1.18) |
C00024663
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00024663
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00024663
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00024663
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00024663
|
| 1365 | CLDN3, C7orf1, CPE-R2, CPETR2, HRVP1, RVP1 | claudin 3 |
C00024663
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00024663
|
| 1728 | NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 | NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) |
C00024663
|
| 6615 | SNAI1, SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1 | snail family zinc finger 1 |
C00024663
|
| 9075 | CLDN2 | claudin 2 |
C00024663
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00024663
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00001819
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00001819
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00001819
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00001819
|
| 894 | CCND2, KIAK0002 | cyclin D2 |
C00001819
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00001819
|
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) |
C00001819
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00001819
|
| 1021 | CDK6, PLSTIRE | cyclin-dependent kinase 6 (EC:2.7.11.22) |
C00001819
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00001819
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00001819
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00001819
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00001819
|
| 356 | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) |
C00001819
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00001819
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001819
|
| 5027 | P2RX7, P2X7 | purinergic receptor P2X, ligand-gated ion channel, 7 |
C00001819
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00001819
|
| 6476 | SI | sucrase-isomaltase (alpha-glucosidase) (EC:3.2.1.10 3.2.1.48) |
C00001819
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00001819
|
| 7185 | TRAF1, EBI6, MGC:10353 | TNF receptor-associated factor 1 |
C00001819
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00002236
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (94)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #609135 | Aplastic anemia |
O14746
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
P84022 |
| #162800 | Cyclic neutropenia |
P08246
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #613989 | Dyskeratosis congenita, autosomal dominant, 2; dkca2 |
O14746
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #615134 | Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 |
O14746
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614742 | Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 |
O14746
|
| #178500 | Pulmonary fibrosis, idiopathic; ipf |
O14746
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (95)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00764 | Cri du chat syndrome |
O14746
(related)
|
| H01132 | Aplastic anemia (AA) |
O14746
(related)
|
| H01299 | Idiopathic pulmonary fibrosis |
O14746
(related)
|
| H00022 | Bladder cancer |
O14746
(marker)
P00533 (related) P04626 (related) P04637 (related) |
| H00024 | Prostate cancer |
O14746
(marker)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
26 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D009369 | Neoplasms |
C00024663
C00001819 |
| D004487 | Edema |
C00001819
|
| D009336 | Necrosis |
C00024663
|
| D020964 | Embryo Loss |
C00024663
|
| D009374 | Neoplasms, Experimental |
C00024663
|
| D012878 | Skin Neoplasms |
C00024663
|
| D000647 | Amnesia |
C00001819
|
| D001862 | Bone Resorption |
C00001819
|
| D002471 | Cell Transformation, Neoplastic |
C00001819
|
| D003556 | Cystitis |
C00001819
|
| D003920 | Diabetes Mellitus |
C00001819
|
| D003921 | Diabetes Mellitus, Experimental |
C00001819
|
| D003924 | Diabetes Mellitus, Type 2 |
C00001819
|
| D005317 | Fetal Growth Retardation |
C00024663
|
| D006470 | Hemorrhage |
C00001819
|
| D006937 | Hypercholesterolemia |
C00001819
|
| D006943 | Hyperglycemia |
C00001819
|
| D006949 | Hyperlipidemias |
C00001819
|
| D006973 | Hypertension |
C00001819
|
| D007077 | Ileal Diseases |
C00001819
|
| D007333 | Insulin Resistance |
C00001819
|
| D007410 | Intestinal Diseases |
C00001819
|
| D010190 | Pancreatic Neoplasms |
C00001819
|
| D011471 | Prostatic Neoplasms |
C00001819
|
| D001145 | Arrhythmias, Cardiac |
C00002236
|
| D054537 | Atrioventricular Block |
C00002236
|