KCF-S cluster No. 424 (18 metabolites)

Corresponding Phytochemical cluster No. 3


Plant Species


Cumulative plant class count

class name count
rosids 105
eudicotyledons 3
asterids 1
Spermatophyta 1

Cumulative family count

class name count
Fabaceae 104
Viscaceae 1
Convolvulaceae 1
Berberidaceae 1
Papaveraceae 1
Cupressaceae 1
Nitrariaceae 1

KEGG BRITE br08003 External link 512


Categories (1)

br08003 Category # of metabolite
Quinolizidine alkaloids 2

metabolites link (2)

br08003 Category KEGG ID KNApSAcK ID
Quinolizidine alkaloids C10780 C00002233
Quinolizidine alkaloids C10783 C00002236

Metabolite list (18)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00002224 External link 512 Leontiformine
CHEMBL1476333
2 / 3 / 7
C00002228 External link 512 Multiflorine
/ (-)-Multiflorine
CHEMBL517095
C00002233 External link 512 Retamine
C00002236 External link 512 Spartein
/ (-)-Spartein
CHEMBL412873
CHEMBL44625
CHEMBL172633
CHEMBL1328708
CHEMBL1492771
CHEMBL1740920
CHEMBL1908847
CHEMBL2010478
D013034
93 / 50 / 48 1 / 2
C00007681 External link 512 alpha-Isosparteine
CHEMBL412873
CHEMBL44625
CHEMBL172633
CHEMBL1328708
CHEMBL1492771
CHEMBL1740920
CHEMBL1908847
CHEMBL2010478
93 / 50 / 48
C00007682 External link 512 beta-Isosparteine
CHEMBL412873
CHEMBL44625
CHEMBL172633
CHEMBL1328708
CHEMBL1492771
CHEMBL1740920
CHEMBL1908847
CHEMBL2010478
93 / 50 / 48
C00007684 External link 512 7-Hydroxysparteine
C00007685 External link 512 13-Hydroxysparteine
C00007686 External link 512 13-Epihydroxysparteine
/ 13beta-Hydroxysparteine
/ 13-Epi-hydroxysparteine
C00007687 External link 512 14alpha-Hydroxysparteine
C00007693 External link 512 10alpha-Hydroxymethylsparteine
C00007752 External link 512 13alpha-Hydroxymultiflorine
C00026260 External link 512 (-)-13alpha-Hydroxy-4-oxosparteine
C00026265 External link 512 Deoxonuttaline
/ 4alpha-Hydroxysparteine
/ (-)-4alpha-Hydroxysparteine
C00026269 External link 512 7-Hydroxypusilline
/ (-)-7-Hydroxy-beta-isosparteine
C00026302 External link 512 Thermopsamine
/ (+)-Thermopsamine
C00026329 External link 512 Dehydrosparteine
/ (-)-Dehydrosparteine
CHEMBL412873
CHEMBL44625
CHEMBL172633
CHEMBL1328708
CHEMBL1492771
CHEMBL1740920
CHEMBL1908847
CHEMBL2010478
93 / 50 / 48
C00028974 External link 512 Schoberine

Human Protein / Gene in interactions

93 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002224 C00002236 C00007681 C00007682 C00026329 1 / 2
O00255 Menin Unclassified protein C00002224 C00002236 C00007681 C00007682 C00026329 2 / 5
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002236 C00007681 C00007682 C00026329 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002236 C00007681 C00007682 C00026329 2 / 2
P08246 Neutrophil elastase S1A C00002236 C00007681 C00007682 C00026329 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00002236 C00007681 C00007682 C00026329 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00002236 C00007681 C00007682 C00026329 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P29466 Caspase-1 C14 C00002236 C00007681 C00007682 C00026329 0 / 0
P17252 Protein kinase C alpha type Alpha C00002236 C00007681 C00007682 C00026329 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00002236 C00007681 C00007682 C00026329 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002236 C00007681 C00007682 C00026329 2 / 2
P02545 Prelamin-A/C Unclassified protein C00002236 C00007681 C00007682 C00026329 11 / 10
P00918 Carbonic anhydrase 2 Lyase C00002236 C00007681 C00007682 C00026329 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00002236 C00007681 C00007682 C00026329 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002236 C00007681 C00007682 C00026329 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00002236 C00007681 C00007682 C00026329 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00002236 C00007681 C00007682 C00026329 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00002236 C00007681 C00007682 C00026329 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00002236 C00007681 C00007682 C00026329 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002236 C00007681 C00007682 C00026329 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002236 C00007681 C00007682 C00026329 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00002236 C00007681 C00007682 C00026329 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002236 C00007681 C00007682 C00026329 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00002236 C00007681 C00007682 C00026329 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00002236 C00007681 C00007682 C00026329 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00002236 C00007681 C00007682 C00026329 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00002236 C00007681 C00007682 C00026329 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00002236 C00007681 C00007682 C00026329 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002236 C00007681 C00007682 C00026329 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00002236 C00007681 C00007682 C00026329 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00002236 C00007681 C00007682 C00026329 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00002236 C00007681 C00007682 C00026329 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00002236 C00007681 C00007682 C00026329 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00002236 C00007681 C00007682 C00026329 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P08311 Cathepsin G S1A C00002236 C00007681 C00007682 C00026329 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00002236 C00007681 C00007682 C00026329 1 / 0
P03956 Interstitial collagenase M10A C00002236 C00007681 C00007682 C00026329 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00002236 C00007681 C00007682 C00026329 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00002236 C00007681 C00007682 C00026329 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00002236 C00007681 C00007682 C00026329 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00002236 C00007681 C00007682 C00026329 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00002236 C00007681 C00007682 C00026329 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00002236 C00007681 C00007682 C00026329 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00002236 C00007681 C00007682 C00026329 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002236 C00007681 C00007682 C00026329 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00002236 C00007681 C00007682 C00026329 2 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002236 C00007681 C00007682 C00026329 0 / 3
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00002236 C00007681 C00007682 C00026329 0 / 0
P03372 Estrogen receptor NR3A1 C00002236 C00007681 C00007682 C00026329 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00002236 C00007681 C00007682 C00026329 1 / 0
P22303 Acetylcholinesterase Hydrolase C00002236 C00007681 C00007682 C00026329 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002236 C00007681 C00007682 C00026329 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002236 C00007681 C00007682 C00026329 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00002236 C00007681 C00007682 C00026329 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00002236 C00007681 C00007682 C00026329 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00002236 C00007681 C00007682 C00026329 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00002236 C00007681 C00007682 C00026329 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00002236 C00007681 C00007682 C00026329 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002236 C00007681 C00007682 C00026329 1 / 0

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00002236

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (50)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (48)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001145 Arrhythmias, Cardiac C00002236
D054537 Atrioventricular Block C00002236