phytochemical cluster No. 3 (168 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• KCF-S cluster (16)
• Metabolite list (168)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	1016
eudicotyledons	35
asterids	23
Embryophyta	12
Spermatophyta	4
Magnoliophyta	3

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Cumulative family count

class name	count
Fabaceae	1012
Berberidaceae	25
Orobanchaceae	16
Lycopodiaceae	12
Cupressaceae	4
Daphniphyllaceae	4
Convolvulaceae	4
Nymphaeaceae	3
Viscaceae	3
Styracaceae	3
Amaranthaceae	2
Euphorbiaceae	1
Papaveraceae	1
Anacardiaceae	1
Rosaceae	1
Nitrariaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Quinolizidine alkaloids	31

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metabolites link (34)

br08003 Category	KEGG ID	KNApSAcK ID
Quinolizidine alkaloids	C09856	C00001934
Quinolizidine alkaloids	C09860	C00001935
Quinolizidine alkaloids	C09874	C00001943
Quinolizidine alkaloids	C09945	C00001971
Quinolizidine alkaloids	C10747	C00002204
Quinolizidine alkaloids	C10750	C00002207
Quinolizidine alkaloids	C10751	C00002208
Quinolizidine alkaloids	C10752	C00002209
Quinolizidine alkaloids	C10753	C00002210
Quinolizidine alkaloids	C10754	C00002211
Quinolizidine alkaloids	C10755	C00002212
Quinolizidine alkaloids	C10757	C00002214
Quinolizidine alkaloids	C10758	C00002215
Quinolizidine alkaloids	C10760	C00002216
Quinolizidine alkaloids	C10762	C00002217
Quinolizidine alkaloids	C10763	C00002218
Quinolizidine alkaloids	C10764	C00002219
Quinolizidine alkaloids	C10767	C00002220
Quinolizidine alkaloids	C02621	C00002221
Quinolizidine alkaloids	C10769	C00002223
Quinolizidine alkaloids	C10772	C00002225
Quinolizidine alkaloids	C10773	C00002226
Quinolizidine alkaloids	C10774	C00002227
Quinolizidine alkaloids	C10776	C00002229
Quinolizidine alkaloids	C10780	C00002233
Quinolizidine alkaloids	C10781	C00002234
Quinolizidine alkaloids	C10782	C00002235
Quinolizidine alkaloids	C10783	C00002236
Quinolizidine alkaloids	C10789	C00002238
Quinolizidine alkaloids	C10790	C00002239
Quinolizidine alkaloids	C10752	C00007692
Quinolizidine alkaloids	C10764	C00007696
Quinolizidine alkaloids	C10755	C00007722
Quinolizidine alkaloids	C10749	C00007758

KCF-S cluster (16)

KCF-S ID	# of metabolite
No. 85	49
No. 384	19
No. 424	18
No. 376	17
No. 555	15
No. 1023	9
No. 1211	8
No. 1838	6
No. 1636	6
No. 2032	5
No. 1268	5
No. 2957	4
No. 3172	3
No. 5313	2
No. 6163	1
No. 6875	1

Metabolite list (168)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	figure
C00036283	Dimethamine					No. 85
C00032558	11,12-Seco-12,13-didehydromultiflorine		C058266			No. 85
C00007720	N-Acetylcytisine	CHEMBL1513538 CHEMBL1553838		2 / 3 / 7		No. 85
C00026327	Cernuine					No. 85
C00007718	(-)-N-(N-Acetylaminomethyl)cytisine					No. 85
C00007717	Sophorasine B					No. 85
C00026323	4beta-Hydroxyepilupinine					No. 85
C00002209	Dehydrolupanine	CHEMBL459396 CHEMBL520093 CHEMBL2008918				No. 85
C00026317	(+/-)-Epilupinine	CHEMBL459397 CHEMBL1435718		1 / 1 / 1		No. 85
C00026314	2,3-Dehydro-O-(2-pyrrolylcarbonyl)virgiline					No. 85
C00026313	O-(2-Pyrrolylcarbonyl)-virgiline					No. 85
C00002213	(-)-Camoensidine					No. 85
C00026312	Calpaurine					No. 85
C00026311	Calpurnine / Oroboidine		C013362		0 / 3	No. 85
C00007716	Sophorasine A					No. 85
C00026309	Sessilifoline					No. 85
C00007714	N-(3-Oxobutyl)cytisine	CHEMBL190851		4 / 3 / 1		No. 85
C00026308	Digittine / 4beta-Hydroxycalpurnine / 4beta-Hydroxy-13alpha-O-(2'-pyrrolylcarbonyl)lupanine					No. 85
C00026301	Cinegalline					No. 85
C00002221	13alpha-(Tigloyloxy)lupanine					No. 85
C00026291	5,6-Dehydroisolupanine					No. 85
C00026289	Multiflorine N-oxide					No. 85
C00002225	d-Sophoridine / (+)-Sophoridine	CHEMBL204860 CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581		5 / 3 / 7		No. 85
C00026287	Sophocarpine N-oxide / (+)-Sophocarpine N-oxide	CHEMBL380410	C046246			No. 85
C00002227	(+)-Darvasamine	CHEMBL204860 CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581		5 / 3 / 7		No. 85
C00026286	(+)-Sophoranol N-oxide					No. 85
C00002229	9alpha-Hydroxymatrine / (+)-9alpha-Hydroxymatrine	CHEMBL204747				No. 85
C00026284	Camoensidine N-oxide					No. 85
C00007713	(-)-N-(3-Oxobutyl)cytisine	CHEMBL190851		4 / 3 / 1		No. 85
C00026280	Oxymatrine / Ammothamnine / Matrine N-oxide / (+)-Matrine N-oxide / Matrine 1beta-oxide	CHEMBL458337 CHEMBL1358502	C037573	3 / 11 / 6	0 / 4	No. 85
C00007712	Rhombifoline / (-)-Rhombifoline	CHEMBL1397610	C119591			No. 85
C00007704	Cytisine / (-)-Cytisine	CHEMBL47039 CHEMBL497939 CHEMBL1628606	C004712	27 / 36 / 33	6 / 1	No. 85
C00026268	N-(Methoxycarbonyl)angustifoline					No. 85
C00026267	N-Formylangustifoline					No. 85
C00026264	Isoangustifoline	CHEMBL459206				No. 85
C00026263	Dehydroretamine					No. 85
C00023313	5,6-Dehydro-alpha-isolupanine					No. 85
C00007781	2(S)-Hydroxyaphyllidine					No. 85
C00007765	Multiflorine / (-)-Multiflorine	CHEMBL517095				No. 85
C00007764	(-)-13alpha-Hydroxy-4-oxosparteine					No. 85
C00007762	Leontiformine	CHEMBL1476333		2 / 3 / 7		No. 85
C00007761	Schoberine					No. 85
C00007757	10alpha-Hydroxymethylsparteine					No. 85
C00007691	Cadiamine					No. 85
C00007692	5alpha-Hydroxysophocarpine					No. 85
C00007744	11alpha-Allylcytisine					No. 85
C00007694	4beta,13alpha-Dihydroxyupanine					No. 85
C00007701	Dehydrocytisine B / (-)-Dehydrocytisine B	CHEMBL47039 CHEMBL497939 CHEMBL1628606		27 / 36 / 33		No. 85
C00007698	Dehydrocytisine A / (-)-Dehydrocytisine A	CHEMBL47039 CHEMBL497939 CHEMBL1628606		27 / 36 / 33		No. 85
C00007738	7alpha-Hydroxysophoramine					No. 376
C00007742	Isotinctorine					No. 376
C00007725	Baptifoline / (-)-Baptifoline		C106940			No. 376
C00007737	Sophoramine		C055681			No. 376
C00007736	5,6-Dehydromultiflorine					No. 376
C00007735	Thermopsine / (-)-Thermopsine	CHEMBL203399 CHEMBL509692 CHEMBL1324708 CHEMBL1454284	C059560	7 / 8 / 11		No. 376
C00026276	(-)-Sophoridine N-oxide	CHEMBL458337 CHEMBL1358502		3 / 11 / 6		No. 376
C00002234	(+)-14alpha-Hydroxymatrine					No. 376
C00002218	13-Oxolupanine / 13-Ketolupanine / 2,13-Dioxosparteine					No. 376
C00002216	Virgiline					No. 376
C00026325	Anhydrolycocernuine					No. 376
C00026326	Carolinianine					No. 376
C00007728	(-)-Argentamine / (-)-13-Hydroxythermopsine					No. 376
C00026339	(+)-Epilamprolobine N-oxide					No. 376
C00007727	Epibaptifoline / (-)-Epibaptifoline					No. 376
C00007726	13beta-Hydroxythermopsine					No. 376
C00026275	Deoxoangustifoline					No. 376
C00007724	Dehydrobaptifoline					No. 384
C00007723	Ethyl 12-cytisineacetate					No. 384
C00007722	N-Carbomethoxycytisine / 12-Carboxycytisine methyl ester					No. 384
C00023310	(+)-5,6-Dehydrolupanine					No. 384
C00026337	9beta-Hydroxylamprolobine					No. 384
C00007729	(-)-9alpha-Hydroxysophoramine					No. 384
C00025370	5,6-Dehydro-alpha-isosparteine					No. 384
C00002207	4-Hydroxylupanine					No. 384
C00026324	Epilupinine acetate					No. 384
C00026320	Tashiromine					No. 384
C00026319	(-)-Lupinine	CHEMBL459397 CHEMBL1435718	C015971	1 / 1 / 1		No. 384
C00002212	Lupanine / (+)-Lupanine	CHEMBL459396 CHEMBL520093 CHEMBL2008918	C008298			No. 384
C00002215	3alpha-Hydroxylupanine	CHEMBL515231				No. 384
C00002239	Dehydroaphylline	CHEMBL509343				No. 384
C00007750	Retamine					No. 384
C00026270	Virgiboidine					No. 384
C00026271	Tetrahydrorhombifoline	CHEMBL460224				No. 384
C00002235	14b-Hydroxymatrine / (-)-14beta-Hydroxymatrine					No. 384
C00002238	Epiaphylline / Dihydromonspessulanine / 0-Oxo-alpha-isosparteine / 17-Oxo-alpha-isosparteine	CHEMBL509343				No. 384
C00007693	3beta,13alpha-Dihydroxylupanine					No. 424
C00002236	14beta-Hydroxymatrine / (-)-14beta-Hydroxymatrine					No. 424
C00002233	(-)-14beta-Hydroxysophoridine					No. 424
C00002228	(+)-Albertamine	CHEMBL1672133				No. 424
C00026269	N-(Ethoxycarbonyl)angustifoline					No. 424
C00002224	Sophoridine / (-)-Sophoridine	CHEMBL204860 CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581		5 / 3 / 7		No. 424
C00026302	13alpha-Cinnamoyloxylupanine					No. 424
C00007752	beta-Isosparteine	CHEMBL412873 CHEMBL44625 CHEMBL172633 CHEMBL1328708 CHEMBL1492771 CHEMBL1740920 CHEMBL1908847 CHEMBL2010478		93 / 50 / 48		No. 424
C00026265	Angustifoline	CHEMBL459206	C101930			No. 424
C00007681	17-Oxosparteine	CHEMBL509343	C035707			No. 424
C00007685	6beta-Hydroxylupanine					No. 424
C00026260	11,12-Dehydrosparteine					No. 424
C00026329	Dihydrodeoxycernuine					No. 424
C00007684	(-)-6alpha-Hydroxylupanine					No. 424
C00028974	Griffithine					No. 424
C00007687	(-)-6alpha-methoxylupanine					No. 424
C00007686	(+)-Darvasoline					No. 424
C00007682	Aphylline	CHEMBL509343				No. 424
C00026328	Lycocernuine					No. 555
C00032562	Deoxynupharidine	CHEMBL140239 CHEMBL140758	C010908			No. 555
C00007743	Tinctorine / (-)-Tinctorine					No. 555
C00026330	(-)-Epilamprolobine					No. 555
C00026306	13alpha-Benzoyloxylupanine					No. 555
C00007688	Sophoranol					No. 555
C00007689	5alpha,9alpha-Dihydroxymatrine					No. 555
C00002219	O-Methyljamaidine / 13-Epimethoxylupanine / 13-epi-Methoxylupanine / 13beta-Methoxylupanine / O-Methyl-13-epihydroxylupanine					No. 555
C00025365	11,12-Dehydrolupanine / 1,12-Didehydrolupanine					No. 555
C00007696	3beta,4alpha,13alpha-Trihydroxylupanine					No. 555
C00007747	Thermopsamine / (+)-Thermopsamine					No. 555
C00007748	13-Hydroxysparteine					No. 555
C00007749	14alpha-Hydroxysparteine					No. 555
C00002211	(-)-Lupanine	CHEMBL459396 CHEMBL520093 CHEMBL2008918				No. 555
C00007690	Pohakuline / (-)-Pohakuline					No. 555
C00007756	Dehydrosparteine / (-)-Dehydrosparteine	CHEMBL412873 CHEMBL44625 CHEMBL172633 CHEMBL1328708 CHEMBL1492771 CHEMBL1740920 CHEMBL1908847 CHEMBL2010478		93 / 50 / 48		No. 1023
C00007740	O-Acetylbaptifolin					No. 1023
C00007739	Acetylepibaptifoline / O-Acetylepibaptifoline					No. 1023
C00007741	(-)-Clathrotropine					No. 1023
C00007730	Leontidine					No. 1023
C00002208	Nuttalline / 7-Hydroxylupanine / 4-beta-Hydroxylupanine		C035706			No. 1023
C00007734	Anagyrine / (-)-Anagyrine	CHEMBL203399 CHEMBL509692 CHEMBL1324708 CHEMBL1454284	C012736	7 / 8 / 11		No. 1023
C00007732	Camoensine					No. 1023
C00026334	Lamprolobine					No. 1023
C00023307	Aphyllidine					No. 1211
C00007782	(-)-Argyrolobine / 2-(R)-Hydroxyaphyllidine					No. 1211
C00007760	7-Hydroxysparteine					No. 1211
C00007695	3beta,4alpha-Dihydroxy-13beta-methoxylupanine					No. 1211
C00007751	Spartein / (-)-Spartein	CHEMBL412873 CHEMBL44625 CHEMBL172633 CHEMBL1328708 CHEMBL1492771 CHEMBL1740920 CHEMBL1908847 CHEMBL2010478	D013034	93 / 50 / 48	1 / 2	No. 1211
C00007758	7-Hydroxypusilline / (-)-7-Hydroxy-beta-isosparteine					No. 1211
C00026318	(+)-Epilupinine	CHEMBL459397 CHEMBL1435718		1 / 1 / 1		No. 1211
C00026281	Lupanine N-oxide					No. 1211
C00025362	5,6-Dehydrolupanine					No. 1268
C00007705	12-Hydroxycytisine					No. 1268
C00007709	Caulophylline / N-Methylcytisine / (-)-N-Methylcytisine	CHEMBL66191 CHEMBL1085045	C034245			No. 1268
C00007707	N-Formylcytisine / (-)-N-Formylcytisine	CHEMBL1396784 CHEMBL1433686		4 / 6 / 11		No. 1268
C00002217	Calpurmenine					No. 1268
C00007746	13-Epihydroxysparteine / 13beta-Hydroxysparteine / 13-Epi-hydroxysparteine					No. 1636
C00007745	Deoxonuttaline / 4alpha-Hydroxysparteine / (-)-4alpha-Hydroxysparteine					No. 1636
C00007721	Ethyl cytisine-12-carboxylate / 12-Carboxycytisine ethyl ester					No. 1636
C00007719	12-Cytisineacetamide	CHEMBL508431				No. 1636
C00002214	Camoensidine					No. 1636
C00025367	(2R,9R)-Dihydroxyaphyllidine					No. 1636
C00007779	Argyrolobine / 2(R)-Hydroxyaphyllidine					No. 1838
C00025366	(2S,9R)-Dihydroxyaphyllidine					No. 1838
C00026303	13alpha-(Cinnamoyloxy)-lupanine					No. 1838
C00002226	Matrine / (+)-Matrine	CHEMBL204860 CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581	C034244	5 / 3 / 7	4 / 5	No. 1838
C00025369	5,6-Dehydrosparteine		C044693			No. 1838
C00007678	Deoxylupanoline / Anhydrodihydrolupanoline / 10-Oxo-beta-isosparteine / 17-Oxo-beta-isosparteine	CHEMBL509343				No. 1838
C00028194	Argentine					No. 2032
C00001943	13-Hydroxylupanine / (+)-13-Hydroxylupanine / (+)-13alpha-Hydroxylupanine	CHEMBL518007	C091205			No. 2032
C00001935	13beta-Hydroxylupanine	CHEMBL518007				No. 2032
C00027863	(-)-12,12'-Methylenedicytisine					No. 2032
C00001934	13alpha-Hydroxyisolupanine / 13-Hydroxy-alpha-isolupanine	CHEMBL518007				No. 2032
C00026292	Cinevanine					No. 2957
C00007775	13alpha-Hydroxymultiflorine					No. 2957
C00002223	Allmatrine / 6-Allomatrine / 6beta-Matrine / (+)-Allomatrine / Tetrahydroisosophoramine	CHEMBL204860 CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581		5 / 3 / 7		No. 2957
C00026272	11-Oxotetrahydrorhombifoline					No. 2957
C00032557	Albine	CHEMBL514884				No. 3172
C00002210	alpha-Isolupanine	CHEMBL459396 CHEMBL520093 CHEMBL2008918				No. 3172
C00007784	Epiaphyllidine / 11-Epiaphyllidine					No. 3172
C00002204	Chamaetine / Epinuttaline / (+)-Chamaetine					No. 5313
C00007754	alpha-Isosparteine	CHEMBL412873 CHEMBL44625 CHEMBL172633 CHEMBL1328708 CHEMBL1492771 CHEMBL1740920 CHEMBL1908847 CHEMBL2010478		93 / 50 / 48		No. 5313
C00001971	3-Hydroxylupanine					No. 6163
C00002220	13alpha-Methoxylupanine					No. 6875

Human Protein / Gene in interactions

117 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002207 C00002218 C00002224 C00002227 C00002236 C00002238 C00007681 C00007682 C00007735 C00007736 C00007757 C00023313 C00026289 C00026301 C00026325 C00026326 C00026329	1 / 2
O00255	Menin	Unclassified protein	C00002207 C00002218 C00002224 C00002227 C00002236 C00002238 C00007681 C00007682 C00007735 C00007736 C00007757 C00023313 C00026289 C00026301 C00026325 C00026326 C00026329	2 / 5
P28482	Mitogen-activated protein kinase 1	Erk	C00002227 C00002236 C00007681 C00007682 C00007757 C00023313 C00026289 C00026301 C00026329	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002207 C00002218 C00002236 C00002238 C00007681 C00007682 C00026325 C00026326 C00026329	1 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002227 C00002236 C00007681 C00007682 C00007757 C00023313 C00026289 C00026301 C00026329	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002207 C00002218 C00002236 C00002238 C00007681 C00007682 C00026325 C00026326 C00026329	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002218 C00002236 C00007681 C00007682 C00007735 C00026325 C00026326 C00026329	0 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002218 C00002236 C00007681 C00007682 C00026325 C00026326 C00026329	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002218 C00002236 C00007681 C00007682 C00026325 C00026326 C00026329	0 / 1
P02545	Prelamin-A/C	Unclassified protein	C00002218 C00002236 C00007681 C00007682 C00026325 C00026326 C00026329	11 / 10
P83916	Chromobox protein homolog 1	Unclassified protein	C00002218 C00007758 C00026281 C00026325 C00026326	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00002227 C00007757 C00023313 C00026289 C00026301	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00002218 C00007758 C00026281 C00026325 C00026326	4 / 3
P43681	Neuronal acetylcholine receptor subunit alpha-4	CHRN alpha	C00002218 C00026275 C00026325 C00026326 C00026339	1 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002207 C00002218 C00002238 C00026325 C00026326	0 / 0
P32297	Neuronal acetylcholine receptor subunit alpha-3	CHRN alpha	C00002218 C00026275 C00026325 C00026326 C00026339	1 / 0
P30926	Neuronal acetylcholine receptor subunit beta-4	CHRN beta	C00002218 C00026275 C00026325 C00026326 C00026339	0 / 0
P17787	Neuronal acetylcholine receptor subunit beta-2	CHRN beta	C00002218 C00026275 C00026325 C00026326 C00026339	1 / 1
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00002236 C00007681 C00007682 C00026329	5 / 9
P35367	Histamine H1 receptor	Histamine receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00002236 C00007681 C00007682 C00026329	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00002236 C00007681 C00007682 C00026329	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00002236 C00007681 C00007682 C00026329	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00002236 C00007681 C00007682 C00026329	1 / 1
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00002236 C00007681 C00007682 C00026329	0 / 1
P00918	Carbonic anhydrase 2	Lyase	C00002236 C00007681 C00007682 C00026329	1 / 2
P33765	Adenosine receptor A3	Adenosine receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00002236 C00007681 C00007682 C00026329	2 / 2
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00002236 C00007681 C00007682 C00026329	0 / 0
P06239	Tyrosine-protein kinase Lck	Src	C00002236 C00007681 C00007682 C00026329	0 / 1
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00002236 C00007681 C00007682 C00026329	1 / 1
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00002236 C00007681 C00007682 C00026329	1 / 8
P17252	Protein kinase C alpha type	Alpha	C00002236 C00007681 C00007682 C00026329	0 / 0
P14416	D(2) dopamine receptor	Dopamine receptor	C00002236 C00007681 C00007682 C00026329	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00002236 C00007681 C00007682 C00026329	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00002236 C00007681 C00007682 C00026329	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00002236 C00007681 C00007682 C00026329	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00002236 C00007681 C00007682 C00026329	1 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00002236 C00007681 C00007682 C00026329	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00002236 C00007681 C00007682 C00026329	2 / 2
P30542	Adenosine receptor A1	Adenosine receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00002236 C00007681 C00007682 C00026329	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00002236 C00007681 C00007682 C00026329	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P29466	Caspase-1	C14	C00002236 C00007681 C00007682 C00026329	0 / 0
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00002236 C00007681 C00007682 C00026329	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P08311	Cathepsin G	S1A	C00002236 C00007681 C00007682 C00026329	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00002236 C00007681 C00007682 C00026329	1 / 0
P03956	Interstitial collagenase	M10A	C00002236 C00007681 C00007682 C00026329	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P08246	Neutrophil elastase	S1A	C00002236 C00007681 C00007682 C00026329	2 / 1
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00002236 C00007681 C00007682 C00026329	1 / 1
P04150	Glucocorticoid receptor	NR3C1	C00002236 C00007681 C00007682 C00026329	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00002236 C00007681 C00007682 C00026329	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00002236 C00007681 C00007682 C00026329	0 / 3
P25021	Histamine H2 receptor	Histamine receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00002236 C00007681 C00007682 C00026329	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00002236 C00007681 C00007682 C00026329	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00002236 C00007681 C00007682 C00026329	1 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00002236 C00007681 C00007682 C00026329	2 / 1
Q16539	Mitogen-activated protein kinase 14	p38	C00002236 C00007681 C00007682 C00026329	0 / 0
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00002236 C00007681 C00007682 C00026329	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00002236 C00007681 C00007682 C00026329	0 / 0
P03372	Estrogen receptor	NR3A1	C00002236 C00007681 C00007682 C00026329	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00002236 C00007681 C00007682 C00026329	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00002236 C00007681 C00007682 C00026329	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00002236 C00007681 C00007682 C00026329	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00002236 C00007681 C00007682 C00026329	2 / 0
Q92731	Estrogen receptor beta	NR3A2	C00002236 C00007681 C00007682 C00026329	0 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002207 C00002238 C00007735	3 / 3
P36544	Neuronal acetylcholine receptor subunit alpha-7	CHRN alpha	C00002218 C00026325 C00026326	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002218 C00026325 C00026326	0 / 0
Q15822	Neuronal acetylcholine receptor subunit alpha-2	CHRN alpha	C00002218 C00026325 C00026326	1 / 1
O75496	Geminin	Unclassified protein	C00002218 C00026325 C00026326	0 / 0
Q01196	Runt-related transcription factor 1	Unclassified protein	C00002218 C00026325 C00026326	1 / 4
P11230	Acetylcholine receptor subunit beta	CHRN beta	C00002218 C00026325 C00026326	2 / 1
P02708	Acetylcholine receptor subunit alpha	CHRN alpha	C00002218 C00026325 C00026326	3 / 2
Q13951	Core-binding factor subunit beta	Unclassified protein	C00002218 C00026325 C00026326	0 / 1
Q07001	Acetylcholine receptor subunit delta	CHRN delta	C00002218 C00026325 C00026326	3 / 2
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002226 C00007678 C00026303	1 / 1
P04062	Glucosylceramidase	Enzyme	C00002218 C00026325 C00026326	6 / 4
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002218 C00026325 C00026326	0 / 0
P07510	Acetylcholine receptor subunit gamma	CHRN gamma	C00002218 C00026325 C00026326	2 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00002207 C00002238	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00007758 C00026281	7 / 3

11 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1135	CHRNA2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	C00002218
1136	CHRNA3, LNCR2, NACHRA3, PAOD2	cholinergic receptor, nicotinic, alpha 3 (neuronal)	C00002218
1137	CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	C00002218
1139	CHRNA7, CHRNA7-2, NACHRA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	C00002218
1141	CHRNB2, EFNL3, nAChRB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	C00002218
1143	CHRNB4	cholinergic receptor, nicotinic, beta 4 (neuronal)	C00002218
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00002227
4893	NRAS, ALPS4, N-ras, NRAS1, NS6	neuroblastoma RAS viral (v-ras) oncogene homolog	C00002227
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00002227
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00002227
1565	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	C00002236

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions