KCF-S cluster No. 1211 (8 metabolites)

Corresponding Phytochemical cluster No. 3


Plant Species


Cumulative plant class count

class name count
rosids 22
eudicotyledons 1
asterids 1

Cumulative family count

class name count
Fabaceae 22
Daphniphyllaceae 1
Styracaceae 1

KEGG BRITE br08003 External link 512


Categories (1)

br08003 Category # of metabolite
Quinolizidine alkaloids 1

metabolites link (1)

br08003 Category KEGG ID KNApSAcK ID
Quinolizidine alkaloids C10749 C00007758

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00007695 External link 512 Lupanine N-oxide
C00007751 External link 512 Multiflorine N-oxide
C00007758 External link 512 Oxymatrine
/ Ammothamnine
/ Matrine N-oxide
/ (+)-Matrine N-oxide
/ Matrine 1beta-oxide
CHEMBL458337
CHEMBL1358502
C037573
3 / 11 / 6 0 / 4
C00007760 External link 512 Sophocarpine N-oxide
/ (+)-Sophocarpine N-oxide
CHEMBL380410
C046246
C00007782 External link 512 Camoensidine N-oxide
C00023307 External link 512 (+)-Sophoranol N-oxide
C00026281 External link 512 (-)-Sophoridine N-oxide
CHEMBL458337
CHEMBL1358502
3 / 11 / 6
C00026318 External link 512 5,6-Dehydroisolupanine

Human Protein / Gene in interactions

3 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00007758 C00026281 7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00007758 C00026281 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00007758 C00026281 4 / 3

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#600274 Frontotemporal dementia; ftd P10636
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (6)

KEGG name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003092 Colitis C00007758
D019694 Hepatitis B, Chronic C00007758
D007249 Inflammation C00007758
D008106 Liver Cirrhosis, Experimental C00007758