PCIDB

KNApSAcK Metabolite C00007758

Metabolite

KNApSAcK Entry

id C00007758
Name Oxymatrine / Ammothamnine / Matrine N-oxide / (+)-Matrine N-oxide / Matrine 1beta-oxide
CAS RN 16837-52-8
Standard InChI InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17+/m0/s1
Standard InChI (Main Layer) InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2

Cluster

Phytochemical cluster No. 3
KCF-S cluster No. 1211

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL458337 CHEMBL1358502

KEGG

By LinkDB C10749

CTD

By CAS RN C037573

Human Protein / Gene in interaction

3 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL458337 CHEMBL2114810 (1)
7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL458337 CHEMBL1794401 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1358502 CHEMBL1614250 (1)
4 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#600274 Frontotemporal dementia; ftd P10636
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (6)

KEGG disease name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003092 C037573 Colitis therapeutic
23568217
D019694 C037573 Hepatitis B, Chronic therapeutic
15340535
D007249 C037573 Inflammation therapeutic
23568217
D008106 C037573 Liver Cirrhosis, Experimental therapeutic
15633229
18395914