Sophora flavescens
Species
KNApSAcK Entry
| Organism name | Sophora flavescens |
|---|---|
| Genus | Sophora |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Sophora flavescens |
|---|---|
| Linked NCBI taxonomy ID | 49840 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (84)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00010158
|
Kushenol O
/ Formononetin 7-O-xylosyl-(1->6)-glucoside |
No. 1 | No. 15 |
|
||||
|
C00009389
|
Cyclosin
/ Calycosin / 3'-Hydroxyformononetin |
CHEMBL241608
|
10 / 9 / 6 | No. 3 | No. 15 |
|
||
|
C00002525
|
Formononetin
/ 7-Hydroxy-4'-methoxyisoflavone |
CHEMBL242341
|
C007768
|
24 / 36 / 58 | 13 / 0 | No. 3 | No. 15 |
|
|
C00041297
|
8-Lavandulylkaempferol
|
CHEMBL463941
|
No. 14 | No. 15 |
|
|||
|
C00005021
|
Kushenol C
|
No. 14 | No. 15 |
|
||||
|
C00009515
|
Lupalbigenin
/ 5,7,4'-Trihydroxy-6,3'-diprenylisoflavone |
CHEMBL463936
|
No. 14 | No. 15 |
|
|||
|
C00013518
|
Sophoflavescenol
/ 3,7-Dihydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one |
CHEMBL77651
|
No. 15 | No. 15 |
|
|||
|
C00037155
|
Flavescenone B
|
No. 15 | No. 15 |
|
||||
|
C00037156
|
Flavescenone C
|
No. 15 | No. 15 |
|
||||
|
C00002545
|
Luteone
/ Luteone(isoflavone) |
CHEMBL549617
|
No. 15 | No. 15 |
|
|||
|
C00002586
|
Wighteone
/ Erythrinin B / 5,7,4'-Trihydroxy-6-prenylisoflavone |
CHEMBL393222
|
2 / 1 / 1 | No. 15 | No. 15 |
|
||
|
C00014196
|
(2S)-2'-Methoxykurarinone
/ (2S)-7,4'-Dihydroxy-8-lavandulyl-5,2'-dimethoxyflavanone |
CHEMBL480469
CHEMBL496451 |
1 / 0 / 0 | No. 19 | No. 14 |
|
||
|
C00019182
|
Norkurarinol
|
CHEMBL454647
CHEMBL479294 |
No. 19 | No. 14 |
|
|||
|
C00014385
|
Kushenol X
/ (2R,3R)-3,5,7,2',4'-Pentahydroxy-8-lavandulylflavanone |
CHEMBL517073
|
No. 19 | No. 14 |
|
|||
|
C00014204
|
Kushenol P
/ (2S)-5,7,4'-Trihydroxy-2'-methoxy-8-(5-hydroxy-5-methyl-2-isopropenylhexyl)flavanone |
CHEMBL519277
|
No. 19 | No. 14 |
|
|||
|
C00014203
|
Kushenol Q
/ 5,7,2',4'-Tetrahydroxy-8-[2-(2-hydroxyisopropyl)-5-methyl-4-hexenyl]flavanone |
No. 19 | No. 14 |
|
||||
|
C00014199
|
Kushenol T
/ (2S)-5,7,2'-Trihydroxy-8-(5-hydroxy-2-isopropenyl-5-methylhexyl)flavanone |
CHEMBL509486
|
1 / 0 / 0 | No. 19 | No. 14 |
|
||
|
C00019181
|
Neokurarinol
|
No. 19 | No. 14 |
|
||||
|
C00014195
|
Kurarinone
/ 7,2',4'-Trihydroxy-8-lavandulyl-5-methoxyflavanone |
CHEMBL243796
|
6 / 3 / 3 | No. 19 | No. 14 |
|
||
|
C00014192
|
Kushenol U
/ (2S)-7,4'-Dihydroxy-8-lavandulyl-5-methoxyflavanone |
CHEMBL519440
|
No. 19 | No. 14 |
|
|||
|
C00014191
|
Kushenol R
/ (2S)-7,2'-Dihydroxy-8-lavandulyl-5-methoxyflavanone |
CHEMBL520605
|
No. 19 | No. 14 |
|
|||
|
C00019183
|
Kurarinol
|
CHEMBL455667
CHEMBL517832 |
1 / 0 / 0 | No. 19 | No. 14 |
|
||
|
C00008650
|
Kushenol I
|
CHEMBL243147
CHEMBL480281 CHEMBL1972376 |
2 / 2 / 2 | No. 19 | No. 14 |
|
||
|
C00008270
|
Kushenol A
|
CHEMBL455679
CHEMBL480280 |
1 / 0 / 0 | No. 19 | No. 14 |
|
||
|
C00008335
|
Isokurarinone
|
No. 19 | No. 14 |
|
||||
|
C00041874
|
Sophoraflavanone K
/ (+)-Sophoraflavanone K (Sophora flavescens) |
No. 19 | No. 14 |
|
||||
|
C00008364
|
Norkurarinone
/ Sophoraflavanone G |
CHEMBL243148
CHEMBL479477 |
C064849
|
3 / 2 / 2 | No. 19 | No. 14 |
|
|
|
C00008400
|
Lehmannin
|
No. 19 | No. 14 |
|
||||
|
C00008433
|
Leachianone A
|
CHEMBL453642
CHEMBL519096 |
1 / 0 / 0 | No. 19 | No. 14 |
|
||
|
C00008653
|
Kushenol K
|
CHEMBL77703
CHEMBL440494 CHEMBL388661 CHEMBL516688 |
2 / 2 / 2 | No. 19 | No. 14 |
|
||
|
C00008466
|
Kushenol E
/ Flemiphilippinin D |
C070774
|
No. 19 | No. 14 |
|
|||
|
C00008652
|
Kushenol H
|
CHEMBL77703
CHEMBL440494 CHEMBL388661 CHEMBL516688 |
2 / 2 / 2 | No. 19 | No. 14 |
|
||
|
C00008627
|
Kushenol L
|
No. 19 | No. 14 |
|
||||
|
C00008651
|
Kushenol N
|
CHEMBL243147
CHEMBL480281 CHEMBL1972376 |
2 / 2 / 2 | No. 19 | No. 14 |
|
||
|
C00041875
|
Sophoraflavanone L
|
CHEMBL463940
|
No. 19 | No. 14 |
|
|||
|
C00009492
|
Alpinumisoflavone
|
CHEMBL238628
|
C000154
|
3 / 1 / 1 | 1 / 0 | No. 24 | No. 15 |
|
|
C00014170
|
Kushenol W
/ 5,7,2',4'-Tetrahydroxy-5'-methoxy-8-prenylflavanone |
CHEMBL479476
|
No. 28 | No. 14 |
|
|||
|
C00008452
|
Euchrenone a7
/ (2S)-Euchrenone a7 / (-)-(2S)-Euchrenone a7 |
CHEMBL457686
|
1 / 2 / 2 | No. 28 | No. 14 |
|
||
|
C00014164
|
Leachianone G
/ 5,7,2',4'-Tetrahydroxy-8-prenylflavanone |
CHEMBL516930
CHEMBL1783937 |
No. 28 | No. 14 |
|
|||
|
C00008497
|
Kenusanone I
|
No. 28 | No. 14 |
|
||||
|
C00014169
|
Kushenol V
/ 5,7,2',4'-Tetrahydroxy-5'-methoxy-6-prenylflavanone |
CHEMBL480869
|
No. 28 | No. 14 |
|
|||
|
C00037154
|
Flavescenone A
|
No. 28 | No. 14 |
|
||||
|
C00014156
|
Kushenol S
/ 5,7,2'-Trihydroxy-8-prenylflavanone |
CHEMBL482042
|
No. 28 | No. 14 |
|
|||
|
C00008245
|
8-Prenylnaringenin
/ Sophoraflavanone B / (-)-8-Prenylnaringenin |
CHEMBL376915
CHEMBL460647 |
10 / 8 / 4 | No. 28 | No. 14 |
|
||
|
C00008197
|
Isobavachin
|
CHEMBL491534
|
C468753
|
2 / 0 | No. 28 | No. 14 |
|
|
|
C00008668
|
Kushenol J
|
No. 48 | No. 14 |
|
||||
|
C00002546
|
Inermin
/ Maackiain / (-)-Maackiain / Demethylpterocarpin / 3-Hydroxy-8,9-methylenedioxypterocarpan |
CHEMBL334918
CHEMBL239047 CHEMBL445279 |
3 / 2 / 3 | No. 66 | No. 15 |
|
||
|
C00009994
|
Kushenin
/ Lespedezol D1 / 3,9-Dihydroxy-8-methoxypterocarpan |
No. 66 | No. 15 |
|
||||
|
C00026263
|
14b-Hydroxymatrine
/ (-)-14beta-Hydroxymatrine |
No. 85 | No. 3 |
|
||||
|
C00002227
|
Matrine
/ (+)-Matrine |
CHEMBL204860
CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581 |
C034244
|
5 / 3 / 7 | 4 / 5 | No. 85 | No. 3 |
|
|
C00026264
|
(-)-14beta-Hydroxysophoridine
|
No. 85 | No. 3 |
|
||||
|
C00007761
|
Sophoranol
|
No. 85 | No. 3 |
|
||||
|
C00007757
|
Sophoridine
/ (-)-Sophoridine |
CHEMBL204860
CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581 |
5 / 3 / 7 | No. 85 | No. 3 |
|
||
|
C00002225
|
Lupanine
/ (+)-Lupanine |
CHEMBL459396
CHEMBL520093 CHEMBL2008918 |
C008298
|
No. 85 | No. 3 |
|
||
|
C00023313
|
Allmatrine
/ 6-Allomatrine / 6beta-Matrine / (+)-Allomatrine / Tetrahydroisosophoramine |
CHEMBL204860
CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581 |
5 / 3 / 7 | No. 85 | No. 3 |
|
||
|
C00008336
|
Kushenol B
|
No. 170 | No. 14 |
|
||||
|
C00008644
|
Kushenol M
|
No. 170 | No. 14 |
|
||||
|
C00007139
|
Kushenol D
|
No. 190 | No. 13 |
|
||||
|
C00007149
|
Kuraridinol
|
No. 190 | No. 13 |
|
||||
|
C00005022
|
Kushenol G
|
No. 240 |
|
|||||
|
C00002234
|
Rhombifoline
/ (-)-Rhombifoline |
CHEMBL1397610
|
C119591
|
No. 376 | No. 3 |
|
||
|
C00002216
|
Caulophylline
/ N-Methylcytisine / (-)-N-Methylcytisine |
CHEMBL66191
CHEMBL1085045 |
C034245
|
No. 376 | No. 3 |
|
||
|
C00002235
|
Sophoramine
|
C055681
|
No. 384 | No. 3 |
|
|||
|
C00002212
|
Baptifoline
/ (-)-Baptifoline |
C106940
|
No. 384 | No. 3 |
|
|||
|
C00023310
|
(-)-9alpha-Hydroxysophoramine
|
No. 384 | No. 3 |
|
||||
|
C00002207
|
Anagyrine
/ (-)-Anagyrine |
CHEMBL203399
CHEMBL509692 CHEMBL1324708 CHEMBL1454284 |
C012736
|
7 / 8 / 11 | No. 384 | No. 3 |
|
|
|
C00022314
|
Isomatrine
/ (+)-Isomatrine |
No. 408 |
|
|||||
|
C00002219
|
5,6-Dehydrolupanine
|
No. 555 | No. 3 |
|
||||
|
C00019473
|
Trifolirhizin 6'-O-malonate
/ Maackiain 3-O-glucosyl-6''-malonate |
No. 557 | No. 15 |
|
||||
|
C00010186
|
Trifolirhizin
/ Sophojaponicin B1 / (-)-Maackiain 3-O-glucoside |
CHEMBL454878
|
No. 557 | No. 15 |
|
|||
|
C00007758
|
Oxymatrine
/ Ammothamnine / Matrine N-oxide / (+)-Matrine N-oxide / Matrine 1beta-oxide |
CHEMBL458337
CHEMBL1358502 |
C037573
|
3 / 11 / 6 | 0 / 4 | No. 1211 | No. 3 |
|
|
C00023307
|
(+)-Sophoranol N-oxide
|
No. 1211 | No. 3 |
|
||||
|
C00023309
|
Lemannine
/ Lehmannine / (+)-Lehmannine |
CHEMBL205311
|
No. 1721 |
|
||||
|
C00007759
|
Sophocarpine
/ (-)-Sophocarpine |
CHEMBL377725
CHEMBL380909 |
C035933
|
0 / 1 | No. 1721 |
|
||
|
C00023308
|
9alpha-Hydroxysophocarpine
/ (-)-9alpha-Hydroxysophocarpine |
CHEMBL382625
|
No. 1721 |
|
||||
|
C00019180
|
Kushecarpin C
/ (6S,6aS,11aR,11bS)-3-Keto-11b-hydroxy-8,9-dimethoxy-1,2-dihydropterocarpan |
No. 2023 |
|
|||||
|
C00019178
|
Kushecarpin A
/ (6S,6aS,11aR,11bS)-3-Keto-11b-hydroxy-6,9-dimethoxy-1,2-dihydropterocarpan |
No. 2023 |
|
|||||
|
C00019179
|
Kushecarpin B
/ (6S,6aS,11aR,11bR)-3-Keto-6,11b-dimethoxy-8,9-methylenedioxy-1,2-dihydropterocarpan |
No. 2023 |
|
|||||
|
C00007776
|
Mamanine
|
CHEMBL1970238
|
C055675
|
No. 2186 |
|
|||
|
C00022315
|
5-Episophocarpine
|
No. 2357 |
|
|||||
|
C00023312
|
(-)-Leontalbinine N-oxide
|
C080544
|
No. 2607 |
|
||||
|
C00023311
|
7,8-Didehydrosophoramine
|
No. 6013 |
|
|||||
|
C00041469
|
Cyclokuraridin
/ (-)-Cyclokuraridin |
CHEMBL498464
|
No. 6769 |
|
||||
|
C00014389
|
Kosamol A
/ 3,5,7,2',4'-Pentahydroxy-6-(3-hydroxy-3-methylbutyl)-8-lavandulylflavanone |
No. 8309 |
|
Human Protein / Gene in interactions
50 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P31639 | Sodium/glucose cotransporter 2 | Glucose | C00002525 C00002546 C00008364 C00008650 C00008651 C00008652 C00008653 C00014195 | 1 / 1 |
| P13866 | Sodium/glucose cotransporter 1 | Glucose | C00002525 C00002546 C00008364 C00008650 C00008651 C00008652 C00008653 C00014195 | 1 / 1 |
| P56817 | Beta-secretase 1 | A1A | C00008270 C00008364 C00008433 C00014195 C00014196 C00014199 C00019183 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00002207 C00002227 C00002525 C00007757 C00023313 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002207 C00002227 C00002525 C00007757 C00023313 | 1 / 2 |
| P03372 | Estrogen receptor | NR3A1 | C00002586 C00008245 C00009492 C00014195 | 1 / 1 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002227 C00007757 C00023313 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002586 C00008245 C00009492 | 0 / 1 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002227 C00007757 C00023313 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002227 C00007757 C00023313 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002207 C00002525 C00009389 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002525 C00007758 C00009389 | 4 / 3 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002207 C00002525 | 1 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002207 C00002525 | 3 / 3 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002525 C00002546 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002207 C00002525 | 1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002207 C00002525 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002525 C00008245 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002525 C00009389 | 4 / 2 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00002525 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00008245 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00014195 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00008245 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00007758 | 7 / 3 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00007758 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00009389 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00008452 | 2 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00002525 | 5 / 3 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002525 | 0 / 1 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00002525 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00008245 | 4 / 2 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00008245 | 2 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002525 | 2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00009389 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00009389 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00008245 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00008245 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00002525 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00009389 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00009389 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00009389 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002525 | 4 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002525 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00002525 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00009389 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002525 | 7 / 37 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00009492 | 0 / 0 |
| P35610 | Sterol O-acyltransferase 1 | Enzyme | C00014195 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00002525 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00008245 | 1 / 1 |
19 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00002525
C00009492
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002525
|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00002525
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002525
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00002525
|
| 2056 | EPO, EP, MVCD2 | erythropoietin |
C00002525
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00002525
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00002525
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00002525
|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002525
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002525
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002525
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002525
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00002227
|
| 4893 | NRAS, ALPS4, N-ras, NRAS1, NS6 | neuroblastoma RAS viral (v-ras) oncogene homolog |
C00002227
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00002227
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002227
|
| 5241 | PGR, NR3C3, PR | progesterone receptor |
C00008197
|
| 7031 | TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 | trefoil factor 1 |
C00008197
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (54)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #606824 | Glucose/galactose malabsorption; ggm |
P13866
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #211980 | Lung cancer |
P04637
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #233100 | Renal glucosuria; glys1 |
P31639
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
KEGG DISEASE (66)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) Q92731 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01261 | Congenital glucose-galactose malabsorption (GGM) |
P13866
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01126 | Familial renal glucosuria (FRG) |
P31639
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
9 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D007249 | Inflammation |
C00007759
C00007758 |
| D008113 | Liver Neoplasms |
C00002227
|
| D056487 | Drug-Induced Liver Injury, Chronic |
C00002227
|
| D006331 | Heart Diseases |
C00002227
|
| D002779 | Cholestasis |
C00002227
|
| D002289 | Carcinoma, Non-Small-Cell Lung |
C00002227
|
| D003092 | Colitis |
C00007758
|
| D019694 | Hepatitis B, Chronic |
C00007758
|
| D008106 | Liver Cirrhosis, Experimental |
C00007758
|