KCF-S cluster No. 24 (122 metabolites)

Corresponding Phytochemical cluster No. 15

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (122)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	297
eudicotyledons	4
asterids	2
Liliopsida	1

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Cumulative family count

class name	count
Fabaceae	180
Calophyllaceae	49
Moraceae	25
Clusiaceae	18
Hypericaceae	14
Rutaceae	8
Berberidaceae	3
Lamiaceae	2
Cyperaceae	1
Euphorbiaceae	1
Proteaceae	1
Burseraceae	1
Ochnaceae	1
Hymenochaetaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Xanthenes	3

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Xanthenes	C10055	C00002945
Xanthenes	C10059	C00002947
Xanthenes	C10074	C00002959

Metabolite list (122)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002945	Dehydrocycloguanandin
C00002947	6-Deoxyjacareubin	CHEMBL457949
C00002959	Jacareubin	CHEMBL1254294
C00004042	6'',6''-Dimethyl-3',4'-methylenedioxypyrano[2'',3'':7,8]flavone
C00004043	5-Hydroxy-6'',6''-dimethylpyrano[2'',3'':7,8]flavone
C00004046	Isopongachromene
C00004047	Isopongaflavone / Candidin (Tephrosia) / 5-Methoxy-8,8-dimethyl-2-phenyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one	CHEMBL454843		10 / 4 / 1
C00004048	5-Methoxy-6'',6''-dimethyl-3',4'-methylenedioxypyrano[2'',3'':7,8]flavone
C00004052	Limonianin / Atalantoflavone	CHEMBL465808
C00004053	Cycloartocarpesin / 8-(2,4-Dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one	CHEMBL221908		2 / 0 / 0
C00004058	Racemoflavone
C00005072	Pongaflavone / Karanjachromene / 3-Methoxy-8,8-dimethyl-2-phenyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one	CHEMBL2204384
C00005074	3,6-Dimethoxy-6'',6''-dimethylpyrano[2,3:7,8]flavone
C00005076	3,5,4'-Trihydroxy-6'',6''-dimethylpyrano[2,3:7,6]flavone
C00005077	Citrusinol	CHEMBL463744
C00005079	4'-Hydroxy-3,6-dimethoxy-6'',6''-dimethylpyrano[2,3:7,8]flavone
C00005080	Sarothranol / 8-(3,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
C00005082	Pongachromene / 2-(1,3-Benzodioxol-5-yl)-3-methoxy-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one / 3-Methoxy-8,8-dimethyl-2-[3,4-(methylenedioxy)phenyl]-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one	CHEMBL573848
C00005085	3,6-Dimethoxy-6'',6''-dimethyl-3',4'-methylenedioxypyrano[2,3:7,8]flavone
C00009430	Corylin	CHEMBL1271888
C00009431	Erythrinin A
C00009433	Calopogoniumisoflavone A
C00009434	Glabrone / Eurycarpin B	CHEMBL600457		1 / 5 / 3
C00009438	Calopogoniumisoflavone B / 6'',6''-Dimethyl-3',4'-methylenedioxypyrano[2'',3'':7,8]isoflavone
C00009440	Jamaicin
C00009441	Durmillone
C00009444	Barbigerone / Lonchocarpusone
C00009445	Ferrugone
C00009446	Ichthynone
C00009492	Alpinumisoflavone	CHEMBL238628	C000154	3 / 1 / 1	1 / 0
C00009493	Derrone	CHEMBL393223
C00009495	4'-O-methylalpinumisoflavone
C00009496	4'-O-Methylderrone
C00009497	Licoisoflavone B	CHEMBL463741
C00009498	Parvisoflavone B	CHEMBL469632
C00009499	Parvisoflavone A	CHEMBL469631
C00009503	Robustone	CHEMBL252722		3 / 11 / 40
C00009504	Alpinumisoflavone dimethyl ether
C00009506	3'-Hydroxyalpinumisoflavone 4'-methyl ether	CHEMBL549827
C00009508	Robustone methyl ether	CHEMBL1403041		11 / 31 / 56
C00009512	Elongatin
C00009517	Toxicarolisoflavone
C00009600	Dehydromillettone / 6beta-Acetylteuscordin / 6a,12a-Didehydromillettone
C00009601	Dehydrodeguelin / 6a,12a-Dehydrodeguelin	CHEMBL465673
C00009605	Dehydrotoxicarol / 7a,13a-Didehydrotoxicarol	CHEMBL122787
C00009808	Neoraufurane
C00009871	Puerarone / 7,2'-Dihydroxy-6'',6''-dimethylpyrano[2'',3'':4',5']isoflavone
C00009873	Isoderrone / 5,7-Dihydroxy-6'',6''-dimethylpyrano[2'',3'':4',3']isoflavone
C00009874	Sophoraisoflavone A / Allolicoisoflavone B
C00009880	Semilicoisoflavone B	CHEMBL1864439		1 / 0 / 0
C00009886	Isojamaicin / 3'-Methoxy-4',5'-methylenedioxy-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavone
C00009893	Pumilaisoflavone D
C00009906	Barpisoflavone C
C00009907	5-Hydroxy-3',4'-methylenedioxy-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavone
C00009913	5-Methoxydurmillone / 5,6-Dimethoxy-3',4'methylenedioxy-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavone
C00009986	6-Hydroxy-6a,12a-dehydro-alpha-toxicarol
C00010025	Anhydrotuberosin / 3-Hydroxy-6'',6''-dimethylpyrano[2'',3'':9,8]pterocarpene
C00010026	3-O-Methylanhydrotuberosin / 3-Methoxy-6'',6''-dimethylpyrano[2'',3'':9,8]pterocarpene
C00011125	Osajaxanthone
C00013394	Muxiangrin II / Muxiangrine II / 5-Hydroxy-2-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-7-methoxy-6-methyl-4H-1-benzopyran-4-one
C00013428	5-Methoxy-2,2-dimethyl-8-phenyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
C00013431	Yinyanghuo C / 2-(2,2-Dimethyl-2H-1-benzopyran-6-yl)-5,7-dihydroxy-4H-1-benzopyran-4-one
C00013432	Carpachromene / 5,4'-Dihidroxy-6'',6''-dimethylpyrano[2'',3'':7,6]flavone / 5-Hydroxy-8-(4-hydroxyphenyl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
C00013434	8,8-Dimethyl-2-phenyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
C00013435	Di-O-methylcarpachromene / Carpachromene dimethyl ether / 5-Methoxy-8-(4-methoxyphenyl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
C00013436	Yinyanghuo E / 5,7-Dihydroxy-2-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-4H-1-benzopyran-4-one
C00013438	5-Hydroxy-8-(4-hydroxy-3-methoxyphenyl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
C00013440	5-Hydroxy-8-(4-hydroxy-3,5-dimethoxyphenyl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
C00013455	Sanaganone / 10,10-Dimethyl-5-phenyl-furo[2',3':5,6]benzo[1,2-b:4,3-b']dipyran-7(10H)-one
C00013532	3,5-Dimethoxy-8,8-dimethyl-2-phenyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
C00019039	Lanceolone / 4'-Hydroxy-5-methoxy-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavone
C00019041	Indicanine C / 5-Methoxy-6'',6''-dimethylpyrano[2'',3'':7,6]isoflavone
C00019054	Norisojamaicin / Griffonianone G / Demethylisojamaicin
C00019055	6,4'-Dimethoxy-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavone
C00019060	Indicanin E / 2'-Hydroxy-5,4'-dimethoxy-6'',6''-dimethylpyrano[2'',3'':7,6]isoflavone
C00019073	Griffonianone B / 6-Hydroxy-5-methoxy-3',4'-methylenedioxy-6'',6''-dimethylpyrano[2'',3'',7,6]isoflavone
C00019075	2',4',5'-Trimethoxy-6'',6''-dimethylpyrano[2'',3'':7,6]isoflavone
C00019078	Scandenal / 3'-Formyl-4',5-dihydroxy-2'',2''-dimethylchromeno[6,7:5'',6'']isoflavone
C00019099	Conrauinone A / 5,6,2'-Trimethoxy-4',5'-methylenedioxy-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavone
C00019217	10,11-Dimethoxy-3,3-dimethyl-3H-pyrano[2',3':7,8][1]benzopyrano[3,2-b][1,5]benzodioxepin-7(14H)-one	CHEMBL464655
C00019254	Hydroxyalpinumisoflavone / (+)-5,4'-Dihydroxy-6''-hydroxymethyl-6''-methylpyrano[2'',3'':7,6]isoflavone
C00019381	Bidwillon C / 4'-Hydroxy-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavone	CHEMBL1214836		1 / 1 / 1
C00019392	Piscidanone / 5,7,4'-Trihydroxy-3'-methoxy-6'',6''-dimethylpyrano[2'',3'':5',6']isoflavone
C00019395	Piscisoflavone B / 7,2'-Dihydroxy-5'-methoxy-6'',6''-dimethylpyrano[2'',3'':4',3']isoflavone
C00019396	Piscisoflavone C / 7-Hydroxy-3'-methoxy-6'',6''-dimethylpyrano[2'',3'':4',5']isoflavone
C00019421	6-Oxo-6a,12a-dehydro-alpha-toxicarol
C00019465	Kanzonol U / 5,4'-Dihydroxy-6'',6''-dimethylpyrano[2'',3'':2',3']-2-arylbenzofuran	CHEMBL233147		1 / 0 / 0
C00019489	3',4'-Methlenedioxy-8-methoxy-5-hydroxy-6'',6''-dimethylchromeno-[2'',3'':7,6]-isoflavone
C00019499	Durallone / 6,3',4'-Trimethoxy-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavone
C00019500	6-Demethyldurallone / 6-Hydroxy-3',4'-dimethoxy-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavone
C00019527	Glyinflanin H / 6,2'-Dihydroxy-6'',6''-dimethylpyrano[2'',3'':4',3']-2-arylbenzofuran	CHEMBL233766		1 / 0 / 0
C00019592	Lupinalbin H / 5,4'-Dihydroxy-6'',6''-dimethylpyrano[2'',3'':7,6]coumaronochromone
C00019600	Piscisoflavone D / 7,4'-Dihydroxy-5'-methoxy-6'',6''-dimethylpyrano[2'',3'':3',2']isoflavone
C00019668	4'-Demethyltoxicarol / 5,4'-Dihydroxy-2',5'-dimethoxy-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavone	CHEMBL250439
C00019708	Erysubin B / (-)-5,4'-Dihydroxy-6''-hydroxymethyl-6''-methylpyrano[2'',3'':7,6]isoflavone
C00030503	Hyperxanthone
C00032117	Paxanthone
C00032368	Toxicarol isoflavone
C00032369	Toxyloxanthone B	CHEMBL482997
C00033957	Isojacareubin
C00034917	Vogelin J
C00034926	6-Deoxyisojacareubin
C00035169	Erylatissin B
C00036150	Moracin D	CHEMBL463241		1 / 2 / 2
C00036151	Moracin E
C00036155	Moracin K
C00036163	Moracin U
C00036164	Morusignin C
C00036181	Nigrolineaxanthone F	CHEMBL469411
C00036183	Nigrolineaxanthone H
C00036232	Tovoxanthone
C00037159	Forbexanthone
C00037183	Globulixanthone C
C00037728	Rheediachromenoxanthone
C00038633	Brandisianin D / (-)-Brandisianin D	CHEMBL400360
C00041560	Glycyrrhizol B	CHEMBL495062
C00043286	Artochamin C	CHEMBL445760
C00044577	Brasixanthone F
C00046642	Caledonixanthone B
C00047319	Oblongixanthone A
C00049039	Atroviridin
C00049717	Clusiparalicoline C	CHEMBL446307

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00009492 C00019465 C00019527	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00009503 C00009508	0 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00009503 C00009508	7 / 37
P10636	Microtubule-associated protein tau	Unclassified protein	C00009503 C00009508	4 / 3
P03372	Estrogen receptor	NR3A1	C00009492 C00019381	1 / 1
O75496	Geminin	Unclassified protein	C00004047 C00009880	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00004047 C00009508	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00004047	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00004047	2 / 0
P02545	Prelamin-A/C	Unclassified protein	C00009508	11 / 10
Q92731	Estrogen receptor beta	NR3A2	C00009492	0 / 1
O75908	Sterol O-acyltransferase 2	Enzyme	C00004053	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00004047	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00004047	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00009508	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00036150	2 / 2
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00009434	5 / 3
P28482	Mitogen-activated protein kinase 1	Erk	C00009508	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00009508	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00009508	2 / 2
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00004047	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00009508	4 / 1
P35610	Sterol O-acyltransferase 1	Enzyme	C00004053	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00004047	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00009508	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00004047	1 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00004047	1 / 1

1 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00009492

Related Diseases

Diseases related to proteins in ChEMBL interactions