KCF-S cluster No. 85 (49 metabolites)

Corresponding Phytochemical cluster No. 3

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (49)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	299
eudicotyledons	14
asterids	4
Spermatophyta	2

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Cumulative family count

class name	count
Fabaceae	298
Berberidaceae	12
Cupressaceae	2
Styracaceae	2
Amaranthaceae	1
Daphniphyllaceae	1
Convolvulaceae	1
Orobanchaceae	1
Euphorbiaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Quinolizidine alkaloids	5

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metabolites link (6)

br08003 Category	KEGG ID	KNApSAcK ID
Quinolizidine alkaloids	C10752	C00002209
Quinolizidine alkaloids	C02621	C00002221
Quinolizidine alkaloids	C10772	C00002225
Quinolizidine alkaloids	C10774	C00002227
Quinolizidine alkaloids	C10776	C00002229
Quinolizidine alkaloids	C10752	C00007692

Metabolite list (49)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002209	Aphylline	CHEMBL509343
C00002213	Cadiamine
C00002221	13-Hydroxylupanine / (+)-13-Hydroxylupanine / (+)-13alpha-Hydroxylupanine	CHEMBL518007	C091205
C00002225	Lupanine / (+)-Lupanine	CHEMBL459396 CHEMBL520093 CHEMBL2008918	C008298
C00002227	Matrine / (+)-Matrine	CHEMBL204860 CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581	C034244	5 / 3 / 7	4 / 5
C00002229	Nuttalline / 7-Hydroxylupanine / 4-beta-Hydroxylupanine		C035706
C00007691	Deoxylupanoline / Anhydrodihydrolupanoline / 10-Oxo-beta-isosparteine / 17-Oxo-beta-isosparteine	CHEMBL509343
C00007692	17-Oxosparteine	CHEMBL509343	C035707
C00007694	alpha-Isolupanine	CHEMBL459396 CHEMBL520093 CHEMBL2008918
C00007698	3alpha-Hydroxylupanine	CHEMBL515231
C00007701	6beta-Hydroxylupanine
C00007704	13beta-Hydroxylupanine	CHEMBL518007
C00007712	13alpha-(Tigloyloxy)lupanine
C00007713	O-Methyljamaidine / 13-Epimethoxylupanine / 13-epi-Methoxylupanine / 13beta-Methoxylupanine / O-Methyl-13-epihydroxylupanine
C00007714	13alpha-Methoxylupanine
C00007716	3beta,13alpha-Dihydroxylupanine
C00007717	4beta,13alpha-Dihydroxyupanine
C00007718	Calpurmenine
C00007720	3beta,4alpha,13alpha-Trihydroxylupanine
C00007744	Virgiline
C00007757	Sophoridine / (-)-Sophoridine	CHEMBL204860 CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581		5 / 3 / 7
C00007761	Sophoranol
C00007762	5alpha-Hydroxysophocarpine
C00007764	9alpha-Hydroxymatrine / (+)-9alpha-Hydroxymatrine	CHEMBL204747
C00007765	5alpha,9alpha-Dihydroxymatrine
C00007781	Camoensidine
C00023313	Allmatrine / 6-Allomatrine / 6beta-Matrine / (+)-Allomatrine / Tetrahydroisosophoramine	CHEMBL204860 CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581		5 / 3 / 7
C00026263	14b-Hydroxymatrine / (-)-14beta-Hydroxymatrine
C00026264	(-)-14beta-Hydroxysophoridine
C00026267	(-)-6alpha-Hydroxylupanine
C00026268	(-)-6alpha-methoxylupanine
C00026280	Pohakuline / (-)-Pohakuline
C00026284	(+)-14alpha-Hydroxymatrine
C00026286	(+)-Albertamine	CHEMBL1672133
C00026287	Chamaetine / Epinuttaline / (+)-Chamaetine
C00026289	(+)-Darvasamine	CHEMBL204860 CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581		5 / 3 / 7
C00026291	(+)-Darvasoline
C00026301	d-Sophoridine / (+)-Sophoridine	CHEMBL204860 CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581		5 / 3 / 7
C00026308	13alpha-Hydroxyisolupanine / 13-Hydroxy-alpha-isolupanine	CHEMBL518007
C00026309	13-Oxolupanine / 13-Ketolupanine / 2,13-Dioxosparteine
C00026311	14beta-Hydroxymatrine / (-)-14beta-Hydroxymatrine
C00026312	Epiaphylline / Dihydromonspessulanine / 0-Oxo-alpha-isosparteine / 17-Oxo-alpha-isosparteine	CHEMBL509343
C00026313	3beta,4alpha-Dihydroxy-13beta-methoxylupanine
C00026314	3-Hydroxylupanine
C00026317	4-Hydroxylupanine
C00026323	Dehydroaphylline	CHEMBL509343
C00026327	Dehydrolupanine	CHEMBL459396 CHEMBL520093 CHEMBL2008918
C00032558	(-)-Camoensidine
C00036283	(-)-Lupanine	CHEMBL459396 CHEMBL520093 CHEMBL2008918

Human Protein / Gene in interactions

5 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P11387	DNA topoisomerase 1	Isomerase	C00002227 C00007757 C00023313 C00026289 C00026301	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002227 C00007757 C00023313 C00026289 C00026301	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00002227 C00007757 C00023313 C00026289 C00026301	0 / 0
O00255	Menin	Unclassified protein	C00002227 C00007757 C00023313 C00026289 C00026301	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002227 C00007757 C00023313 C00026289 C00026301	1 / 2

4 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00002227
4893	NRAS, ALPS4, N-ras, NRAS1, NS6	neuroblastoma RAS viral (v-ras) oncogene homolog	C00002227
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00002227
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00002227

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions