PCIDB

KNApSAcK Metabolite C00002227

Metabolite

KNApSAcK Entry

id C00002227
Name Matrine / (+)-Matrine
CAS RN 519-02-8
Standard InChI InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1
Standard InChI (Main Layer) InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2

Cluster

Phytochemical cluster No. 3
KCF-S cluster No. 85

Link

ChEMBL

By standard InChI CHEMBL204860
By standard InChI Main Layer CHEMBL204860 CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581

KEGG

By LinkDB C10774

CTD

By CAS RN C034244

Human Protein / Gene in interaction

5 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P11387 DNA topoisomerase 1 Isomerase CHEMBL1824581 CHEMBL1826307 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1733145 CHEMBL1738606 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL1396816 CHEMBL1613808 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL1396816 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1396816 CHEMBL1614531 (1)
1 / 3

CTD interaction (4)

compound gene gene name gene description interaction interaction type form reference
pmid
C034244 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog matrine results in decreased expression of MYC mRNA decreases expression
mRNA 11489473
C034244 4893 NRAS
ALPS4
N-ras
NRAS1
NS6
neuroblastoma RAS viral (v-ras) oncogene homolog matrine results in increased expression of NRAS mRNA increases expression
mRNA 11489473
C034244 7150 TOP1
TOPI
topoisomerase (DNA) I (EC:5.99.1.2) matrine analog results in decreased activity of TOP1 protein decreases activity
protein 21194615
C034244 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 matrine results in increased expression of TP53 mRNA increases expression
mRNA 11489473

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (3)

OMIM preferred title UniProt
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255

KEGG DISEASE (7)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

5 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D002289 C034244 Carcinoma, Non-Small-Cell Lung therapeutic
21312072
D002779 C034244 Cholestasis therapeutic
19619254
D056487 C034244 Drug-Induced Liver Injury, Chronic therapeutic
19426721
D006331 C034244 Heart Diseases therapeutic
20604842
D008113 C034244 Liver Neoplasms therapeutic
19426721