Leontice albertii
Species
KNApSAcK Entry
| Organism name | Leontice albertii |
|---|---|
| Genus | Leontice |
| Family | Berberidaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Leontice |
|---|---|
| Linked NCBI taxonomy ID | 168832 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Berberidaceae |
|---|---|
| ID | 41773 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (3)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002227
|
Matrine
/ (+)-Matrine |
CHEMBL204860
CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581 |
C034244
|
5 / 3 / 7 | 4 / 5 | No. 85 | No. 3 |
|
|
C00025370
|
Leontidine
|
No. 384 | No. 3 |
|
||||
|
C00002015
|
(-)-Anabasine
|
CHEMBL280963
CHEMBL1496898 CHEMBL1526229 |
D000691
|
15 / 18 / 15 | 0 / 4 | No. 2084 | No. 1 |
|
Human Protein / Gene in interactions
18 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002015 C00002227 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00002015 C00002227 | 2 / 5 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002015 | 7 / 3 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002015 | 0 / 1 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00002015 | 1 / 1 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00002015 | 1 / 1 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002227 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002015 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002227 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00002015 | 0 / 0 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00002015 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002227 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002015 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002015 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002015 | 0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002015 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002015 | 4 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002015 | 1 / 0 |
4 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00002227
|
| 4893 | NRAS, ALPS4, N-ras, NRAS1, NS6 | neuroblastoma RAS viral (v-ras) oncogene homolog |
C00002227
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00002227
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002227
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (18)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
KEGG DISEASE (15)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) |
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
Diseases related to CTD interactions
9 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
C00002227
|
| D002779 | Cholestasis |
C00002227
|
| D056487 | Drug-Induced Liver Injury, Chronic |
C00002227
|
| D006331 | Heart Diseases |
C00002227
|
| D008113 | Liver Neoplasms |
C00002227
|
| D001259 | Ataxia |
C00002015
|
| D006948 | Hyperkinesis |
C00002015
|
| D018908 | Muscle Weakness |
C00002015
|
| D014202 | Tremor |
C00002015
|