PCIDB

KNApSAcK Metabolite C00002015

Metabolite

KNApSAcK Entry

id C00002015
Name (-)-Anabasine
CAS RN 494-52-0
Standard InChI InChI=1S/C10H14N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h3-4,6,8,10,12H,1-2,5,7H2/t10-/m0/s1
Standard InChI (Main Layer) InChI=1S/C10H14N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h3-4,6,8,10,12H,1-2,5,7H2

Cluster

Phytochemical cluster No. 1
KCF-S cluster No. 2084

Link

ChEMBL

By standard InChI CHEMBL1526229
By standard InChI Main Layer CHEMBL280963 CHEMBL1496898 CHEMBL1526229

KEGG

By LinkDB C06180

CTD

By CAS RN D000691

Human Protein / Gene in interaction

15 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1496898 CHEMBL1526229 CHEMBL1614110 (2) CHEMBL1741321 (2)
1 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL280963 CHEMBL1613842 (1)
4 / 2
P06746 DNA polymerase beta Enzyme CHEMBL280963 CHEMBL1614079 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1496898 CHEMBL1526229 CHEMBL1614027 (1) CHEMBL1741325 (2)
0 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta CHEMBL280963 CHEMBL751862 (1)
1 / 1
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha CHEMBL280963 CHEMBL751862 (1)
1 / 1
P39748 Flap endonuclease 1 Enzyme CHEMBL280963 CHEMBL1794486 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL280963 CHEMBL2114810 (1)
7 / 3
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha CHEMBL280963 CHEMBL751838 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1526229 CHEMBL1741322 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1496898 CHEMBL1526229 CHEMBL1613777 (2) CHEMBL1741323 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1526229 CHEMBL1741324 (2)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1526229 CHEMBL1614211 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL1496898 CHEMBL1526229 CHEMBL1614531 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1496898 CHEMBL1526229 CHEMBL1614531 (2)
1 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637

KEGG DISEASE (15)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001259 D000691 Ataxia marker/mechanism
23219611
D006948 D000691 Hyperkinesis marker/mechanism
19366487
D018908 D000691 Muscle Weakness marker/mechanism
23219611
D014202 D000691 Tremor marker/mechanism
23219611