Nicotiana tabacum (L.)
Species
KNApSAcK Entry
| Organism name | Nicotiana tabacum (L.) |
|---|---|
| Genus | Nicotiana |
| Family | Solanaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Nicotiana tabacum |
|---|---|
| Linked NCBI taxonomy ID | 4097 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Solanaceae |
|---|---|
| ID | 4070 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001384
|
L-Ornithine
|
CHEMBL446143
CHEMBL103686 CHEMBL2009502 |
6 / 5 / 6 | No. 1538 |
|
|||
|
C00001340
|
L-Arginine
|
CHEMBL212301
CHEMBL1485 |
22 / 12 / 16 | No. 1782 |
|
|||
|
C00002015
|
(-)-Anabasine
|
CHEMBL280963
CHEMBL1496898 CHEMBL1526229 |
D000691
|
15 / 18 / 15 | 0 / 4 | No. 2084 | No. 1 |
|
|
C00001403
|
Cadaverine
|
CHEMBL119296
|
D002103
|
12 / 3 / 5 | No. 3767 |
|
||
|
C00034433
|
alpha,beta-Dipyridyl
|
CHEMBL178348
|
1 / 0 / 0 | No. 4717 |
|
|||
|
C00034470
|
Cotinine
/ (-)-Cotinine |
CHEMBL664
CHEMBL365343 CHEMBL578211 |
D003367
|
21 / 28 / 26 | 17 / 5 | No. 6660 |
|
|
|
C00001400
|
Agmatine
|
CHEMBL58343
|
D000376
|
11 / 2 / 3 | 0 / 9 | No. 7327 | No. 78 |
|
|
C00001404
|
N-Carbamoylputrescine
|
C024563
|
No. 7764 | No. 78 |
|
Human Protein / Gene in interactions
56 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001340 C00001384 C00001400 C00002015 C00034470 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001340 C00001384 C00001400 C00002015 C00034470 | 0 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001340 C00001384 C00001400 C00002015 C00034470 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001340 C00001384 C00001400 C00002015 C00034470 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001340 C00001384 C00001400 C00002015 C00034470 | 1 / 1 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001340 C00002015 C00034470 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001340 C00001400 C00034470 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001340 C00002015 C00034470 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00001340 C00002015 C00034470 | 2 / 5 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001340 C00002015 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00034433 C00034470 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00001340 C00001400 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001340 C00034470 | 3 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001340 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001403 | 1 / 2 |
| Q15661 | Tryptase alpha/beta-1 | S1A | C00001340 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00034470 | 11 / 10 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00002015 | 1 / 1 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00002015 | 1 / 1 |
| O94760 | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | Enzyme | C00001340 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00001403 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00001403 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00001403 | 1 / 2 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | C00001400 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00001403 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00034470 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00001403 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002015 | 7 / 3 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00034470 | 3 / 1 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00002015 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00001340 | 1 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00034470 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00001403 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00001403 | 0 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001384 | 3 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00034470 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00001403 | 0 / 0 |
| P29474 | Nitric oxide synthase, endothelial | Enzyme | C00001340 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001400 | 0 / 0 |
| P35228 | Nitric oxide synthase, inducible | Enzyme | C00001340 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00002015 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00034470 | 2 / 2 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001340 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00034470 | 1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00034470 | 2 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00001403 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00001403 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001403 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00034470 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00034470 | 1 / 1 |
| O15244 | Solute carrier family 22 member 2 | Drug uniporter | C00001400 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002015 | 4 / 1 |
| P29475 | Nitric oxide synthase, brain | Enzyme | C00001340 | 0 / 0 |
| Q9H015 | Solute carrier family 22 member 4 | Unclassified protein | C00001340 | 1 / 1 |
| O75751 | Solute carrier family 22 member 3 | Unclassified protein | C00001400 | 0 / 0 |
| O76082 | Solute carrier family 22 member 5 | Unclassified protein | C00001340 | 1 / 2 |
17 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 57491 | AHRR, AHH, AHHR, bHLHe77 | aryl-hydrocarbon receptor repressor |
C00034470
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00034470
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00034470
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00034470
|
| 1139 | CHRNA7, CHRNA7-2, NACHRA7 | cholinergic receptor, nicotinic, alpha 7 (neuronal) |
C00034470
|
| 26047 | CNTNAP2, AUTS15, CASPR2, CDFE, NRXN4, PTHSL1 | contactin associated protein-like 2 |
C00034470
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00034470
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00034470
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00034470
|
| 1555 | CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 | cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) |
C00034470
|
| 2672 | GFI1, GFI-1, GFI1A, SCN2, ZNF163 | growth factor independent 1 transcription repressor |
C00034470
|
| 3116 | HLA-DPB2, DP2B, DPB2, DPbeta2, HLA-DP2B | major histocompatibility complex, class II, DP beta 2 (pseudogene) |
C00034470
|
| 64005 | MYO1G, HA2, MHAG | myosin IG |
C00034470
|
| 861 | RUNX1, AML1, AML1-EVI-1, AMLCR1, CBFA2, EVI-1, PEBP2aB | runt-related transcription factor 1 |
C00034470
|
| 145567 | TTC7B, TTC7L1, c14_5685 | tetratricopeptide repeat domain 7B |
C00034470
|
| 54657 | UGT1A4, HUG-BR2, UDPGT, UDPGT_1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D | UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) |
C00034470
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00034470
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (51)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #212140 | Carnitine deficiency, systemic primary; cdsp |
O76082
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #301500 | Fabry disease |
P06280
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #611162 | Malaria, susceptibility to |
P35228
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #180300 | Rheumatoid arthritis; ra |
Q9H015
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
KEGG DISEASE (43)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00286 | Crohn's disease |
O76082
(related)
Q9H015 (related) |
| H00525 | Disorders of fatty-acid oxidation |
O76082
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) |
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35228
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
16 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D013375 | Substance Withdrawal Syndrome |
C00001400
C00034470 |
| D006948 | Hyperkinesis |
C00002015
C00034470 |
| D013610 | Tachycardia |
C00001400
|
| D007022 | Hypotension |
C00001400
|
| D009021 | Morphine Dependence |
C00001400
|
| D009293 | Opioid-Related Disorders |
C00001400
|
| D010146 | Pain |
C00001400
|
| D001919 | Bradycardia |
C00001400
|
| D006973 | Hypertension |
C00001400
|
| D001259 | Ataxia |
C00002015
|
| D006930 | Hyperalgesia |
C00001400
|
| D018908 | Muscle Weakness |
C00002015
|
| D014202 | Tremor |
C00002015
|
| D008175 | Lung Neoplasms |
C00034470
|
| D009784 | Occupational Diseases |
C00034470
|
| D014029 | Tobacco Use Disorder |
C00034470
|