KNApSAcK Metabolite C00034470
Metabolite
KNApSAcK Entry
| id | C00034470 |
|---|---|
| Name | Cotinine / (-)-Cotinine |
| CAS RN | 486-56-6 |
| Standard InChI | InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 6660 |
Link
ChEMBL
| By standard InChI | CHEMBL578211 |
|---|---|
| By standard InChI Main Layer | CHEMBL664 CHEMBL365343 CHEMBL578211 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | D003367 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| asterids | 1 |
Family
| family name | count |
|---|---|
| Solanaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Nicotiana tabacum (L.) | 4097 | Solanaceae | asterids | Viridiplantae |
Human Protein / Gene in interaction
21 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL365343 |
CHEMBL1741321
(2)
|
1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | CHEMBL578211 |
CHEMBL1794499
(2)
|
2 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | CHEMBL664 |
CHEMBL1794573
(1)
|
2 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL365343 |
CHEMBL1614544
(1)
|
11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | CHEMBL365343 |
CHEMBL1614361
(1)
|
3 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | CHEMBL365343 |
CHEMBL1613776
(1)
|
3 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL365343 |
CHEMBL1741325
(2)
|
0 / 1 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | CHEMBL664 CHEMBL578211 |
CHEMBL832816
(1)
CHEMBL1023677
(1)
|
0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | CHEMBL578211 |
CHEMBL1794486
(1)
|
0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | CHEMBL365343 |
CHEMBL1738606
(1)
|
0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL664 |
CHEMBL1613808
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL365343 CHEMBL578211 |
CHEMBL830921
(1)
CHEMBL1741322
(2)
|
0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL578211 |
CHEMBL1738675
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL365343 |
CHEMBL1741323
(2)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL365343 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
CHEMBL1741324 (2) |
0 / 1 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | CHEMBL664 |
CHEMBL1614052
(1)
|
1 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL664 CHEMBL365343 |
CHEMBL1613914
(2)
|
0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | CHEMBL365343 |
CHEMBL1614086
(1)
CHEMBL1614034
(1)
|
1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL664 |
CHEMBL1738442
(1)
|
0 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL664 |
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL664 |
CHEMBL1614531
(1)
|
1 / 3 |
CTD interaction (22)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D003367 | 57491 |
AHRR
AHH AHHR bHLHe77 |
aryl-hydrocarbon receptor repressor | Cotinine affects the methylation of AHRR gene |
affects methylation
|
gene |
22851337
|
| D003367 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cotinine results in increased phosphorylation of AKT1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
22687995
|
| D003367 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | Cotinine results in increased phosphorylation of AKT1 protein |
increases phosphorylation
|
protein |
22687995
|
| D003367 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Cotinine inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
22687995
|
| D003367 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | Cotinine inhibits the reaction [Doxorubicin results in increased activity of CASP7 protein] |
decreases reaction
/ increases activity |
protein |
22687995
|
| D003367 | 1139 |
CHRNA7
CHRNA7-2 NACHRA7 |
cholinergic receptor, nicotinic, alpha 7 (neuronal) | CHRNA7 protein mutant form results in increased susceptibility to Cotinine |
increases response to substance
|
protein |
10082212
|
| D003367 | 1139 |
CHRNA7
CHRNA7-2 NACHRA7 |
cholinergic receptor, nicotinic, alpha 7 (neuronal) | Cotinine binds to and results in increased activity of CHRNA7 protein |
affects binding
/ increases activity |
protein |
10082212
|
| D003367 | 26047 |
CNTNAP2
AUTS15 CASPR2 CDFE NRXN4 PTHSL1 |
contactin associated protein-like 2 | Cotinine affects the methylation of CNTNAP2 gene |
affects methylation
|
gene |
22851337
|
| D003367 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | Cotinine affects the methylation of CYP1A1 gene |
affects methylation
|
gene |
22851337
|
| D003367 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | Cotinine results in decreased activity of CYP1A2 protein |
decreases activity
|
protein |
15916432
|
| D003367 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | Cotinine results in increased activity of CYP1A2 protein |
increases activity
|
protein |
16203240
|
| D003367 | 1548 |
CYP2A6
CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB |
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) | CYP2A6 gene mutant form results in decreased abundance of Cotinine |
decreases abundance
|
gene |
10668854
|
| D003367 | 1548 |
CYP2A6
CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB |
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) | CYP2A6 protein results in increased chemical synthesis of Cotinine |
increases chemical synthesis
|
protein |
10999944
11259349 11805739 12024803 12487152 12488541 12504349 12844137 15225612 15735609 16141602 16402086 16636685 17035386 17979512 18041664 18360915 |
| D003367 | 1548 |
CYP2A6
CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB |
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) | CYP2A6 protein results in increased metabolism of Cotinine |
increases metabolic processing
|
protein |
12024803
12406643 12464242 16141602 17035386 |
| D003367 | 1555 |
CYP2B6
CPB6 CYP2B CYP2B7 CYP2B7P CYPIIB6 EFVM IIB1 P450 |
cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) | CYP2B6 protein results in increased chemical synthesis of Cotinine |
increases chemical synthesis
|
protein |
12488541
|
| D003367 | 2672 |
GFI1
GFI-1 GFI1A SCN2 ZNF163 |
growth factor independent 1 transcription repressor | Cotinine affects the methylation of GFI1 gene |
affects methylation
|
gene |
22851337
|
| D003367 | 3116 |
HLA-DPB2
DP2B DPB2 DPbeta2 HLA-DP2B |
major histocompatibility complex, class II, DP beta 2 (pseudogene) | Cotinine affects the methylation of HLA-DPB2 gene |
affects methylation
|
gene |
22851337
|
| D003367 | 64005 |
MYO1G
HA2 MHAG |
myosin IG | Cotinine affects the methylation of MYO1G gene |
affects methylation
|
gene |
22851337
|
| D003367 | 861 |
RUNX1
AML1 AML1-EVI-1 AMLCR1 CBFA2 EVI-1 PEBP2aB |
runt-related transcription factor 1 | Cotinine affects the methylation of RUNX1 gene |
affects methylation
|
gene |
22851337
|
| D003367 | 145567 |
TTC7B
TTC7L1 c14_5685 |
tetratricopeptide repeat domain 7B | Cotinine affects the methylation of TTC7B gene |
affects methylation
|
gene |
22851337
|
| D003367 | 54657 |
UGT1A4
HUG-BR2 UDPGT UDPGT_1-4 UGT-1D UGT1-04 UGT1.4 UGT1D |
UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) | UGT1A4 protein results in increased glucuronidation of Cotinine |
increases glucuronidation
|
protein |
14570768
16141602 |
| D003367 | 54600 |
UGT1A9
HLUGP4 LUGP4 UDPGT UDPGT_1-9 UGT-1I UGT1-09 UGT1-9 UGT1.9 UGT1AI UGT1I |
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) | UGT1A9 protein results in increased glucuronidation of Cotinine |
increases glucuronidation
|
protein |
16141602
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (28)
| OMIM | preferred title | UniProt |
|---|---|---|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
KEGG DISEASE (26)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
Diseases related to CTD interactions
5 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D006948 | D003367 | Hyperkinesis |
marker/mechanism
|
19366487
|
|
| D008175 | D003367 | Lung Neoplasms |
marker/mechanism
|
22687995
|
|
| D009784 | D003367 | Occupational Diseases |
marker/mechanism
|
17444052
|
|
| D013375 | D003367 | Substance Withdrawal Syndrome |
marker/mechanism
|
4091074
|
|
| D014029 | D003367 | Tobacco Use Disorder |
marker/mechanism
|
519268
|