KCF-S cluster No. 4717 (2 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| asterids | 1 |
Cumulative family count
| class name | count |
|---|---|
| Diapheromeridae | 1 |
| Solanaceae | 1 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00026478
|
Quinoline
|
CHEMBL14474
|
C037219
|
6 / 5 / 2 | 64 / 4 |
|
|
C00034433
|
alpha,beta-Dipyridyl
|
CHEMBL178348
|
1 / 0 / 0 |
|
Human Protein / Gene in interactions
7 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00026478 | 1 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00026478 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00026478 | 4 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00026478 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00034433 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00026478 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00026478 | 0 / 0 |
64 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 11332 | ACOT7, ACH1, ACT, BACH, CTE-II, LACH, LACH1, RP1-120G22.10, hBACH | acyl-CoA thioesterase 7 (EC:3.1.2.2) |
C00026478
|
| 199 | AIF1, AIF-1, IBA1, IRT-1, IRT1 | allograft inflammatory factor 1 |
C00026478
|
| 8125 | ANP32A, C15orf1, HPPCn, I1PP2A, LANP, MAPM, PHAP1, PHAPI, PP32 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A |
C00026478
|
| 301 | ANXA1, ANX1, LPC1 | annexin A1 |
C00026478
|
| 302 | ANXA2, ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV | annexin A2 |
C00026478
|
| 689 | BTF3, BETA-NAC, BTF3a, BTF3b, NACB | basic transcription factor 3 |
C00026478
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00026478
|
| 11335 | CBX3, HECH, HP1-GAMMA, HP1Hs-gamma | chromobox homolog 3 |
C00026478
|
| 891 | CCNB1, CCNB | cyclin B1 |
C00026478
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00026478
|
| 1029 | CDKN2A, ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16 | cyclin-dependent kinase inhibitor 2A |
C00026478
|
| 55748 | CNDP2, CN2, CPGL, HsT2298, PEPA | CNDP dipeptidase 2 (metallopeptidase M20 family) (EC:3.4.13.18) |
C00026478
|
| 7812 | CSDE1, D1S155E, RP5-1000E10.3, UNR | cold shock domain containing E1, RNA-binding |
C00026478
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00026478
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00026478
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00026478
|
| 1786 | DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT | DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) |
C00026478
|
| 1869 | E2F1, E2F-1, RBAP1, RBBP3, RBP3 | E2F transcription factor 1 |
C00026478
|
| 1937 | EEF1G, EF1G, GIG35 | eukaryotic translation elongation factor 1 gamma |
C00026478
|
| 1938 | EEF2, EEF-2, EF-2, EF2, SCA26 | eukaryotic translation elongation factor 2 |
C00026478
|
| 2149 | F2R, CF2R, HTR, PAR-1, PAR1, TR | coagulation factor II (thrombin) receptor |
C00026478
|
| 6624 | FSCN1, FAN1, HSN, SNL, p55 | fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) |
C00026478
|
| 8880 | FUBP1, FBP, FUBP | far upstream element (FUSE) binding protein 1 |
C00026478
|
| 3191 | HNRNPL, HNRPL, hnRNP-L | heterogeneous nuclear ribonucleoprotein L |
C00026478
|
| 79256 |
C00026478
|
||
| 3678 | ITGA5, CD49e, FNRA, VLA5A | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
C00026478
|
| 3690 | ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
C00026478
|
| 3958 | LGALS3, CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2 | lectin, galactoside-binding, soluble, 3 |
C00026478
|
| 4000 | LMNA, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1 | lamin A/C |
C00026478
|
| 4048 | LTA4H | leukotriene A4 hydrolase (EC:3.3.2.6) |
C00026478
|
| 5604 | MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 | mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) |
C00026478
|
| 1326 | MAP3K8, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT | mitogen-activated protein kinase kinase kinase 8 (EC:2.7.11.25) |
C00026478
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00026478
|
| 4292 | MLH1, COCA2, FCC2, HNPCC, HNPCC2, hMLH1 | mutL homolog 1 |
C00026478
|
| 10797 | MTHFD2, NMDMC | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9 1.5.1.15) |
C00026478
|
| 4666 | NACA, NACA1 | nascent polypeptide-associated complex alpha subunit (EC:5.3.99.3) |
C00026478
|
| 10135 | NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN | nicotinamide phosphoribosyltransferase (EC:2.4.2.12) |
C00026478
|
| 4831 | NME2, NDKB, NDPK-B, NDPKB, NM23-H2, NM23B, PUF | NME/NM23 nucleoside diphosphate kinase 2 (EC:2.7.4.6 2.7.13.3) |
C00026478
|
| 29789 | OLA1, DOC45, GBP45, GTBP9, GTPBP9 | Obg-like ATPase 1 |
C00026478
|
| 10606 | PAICS, ADE2, ADE2H1, AIRC, PAIS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (EC:6.3.2.6 4.1.1.21) |
C00026478
|
| 11333 | PDAP1, HASPP28, PAP, PAP1 | PDGFA associated protein 1 |
C00026478
|
| 5160 | PDHA1, PDHA, PDHCE1A, PHE1A | pyruvate dehydrogenase (lipoamide) alpha 1 (EC:1.2.4.1) |
C00026478
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00026478
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00026478
|
| 5573 | PRKAR1A, ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1 | protein kinase, cAMP-dependent, regulatory, type I, alpha (EC:2.7.11.1) |
C00026478
|
| 11212 | PROSC | proline synthetase co-transcribed homolog (bacterial) |
C00026478
|
| 5684 | PSMA3, HC8, PSC3 | proteasome (prosome, macropain) subunit, alpha type, 3 (EC:3.4.25.1) |
C00026478
|
| 5700 | PSMC1, P26S4, S4, p56 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 |
C00026478
|
| 5705 | PSMC5, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG | proteasome (prosome, macropain) 26S subunit, ATPase, 5 |
C00026478
|
| 5710 | PSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 |
C00026478
|
| 5713 | PSMD7, MOV34, P40, Rpn8, S12 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 |
C00026478
|
| 5902 | RANBP1, HTF9A | RAN binding protein 1 |
C00026478
|
| 5955 | RCN2, E6BP, ERC-55, ERC55, TCBP49 | reticulocalbin 2, EF-hand calcium binding domain |
C00026478
|
| 6240 | RRM1, R1, RIR1, RR1 | ribonucleotide reductase M1 (EC:1.17.4.1) |
C00026478
|
| 1992 | SERPINB1, EI, ELANH2, LEI, M/NEI, MNEI, PI-2, PI2 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 |
C00026478
|
| 5268 | SERPINB5, PI5, maspin | serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
C00026478
|
| 7078 | TIMP3, HSMRK222, K222, K222TA2, SFD | TIMP metallopeptidase inhibitor 3 |
C00026478
|
| 51311 | TLR8, CD288 | toll-like receptor 8 |
C00026478
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00026478
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00026478
|
| 81567 | TXNDC5, ENDOPDI, ERP46, HCC-2, PDIA15, STRF8, UNQ364 | thioredoxin domain containing 5 (endoplasmic reticulum) |
C00026478
|
| 9948 | WDR1, AIP1, NORI-1 | WD repeat domain 1 |
C00026478
|
| 4904 | YBX1, BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1 | Y box binding protein 1 |
C00026478
|
| 51776 | ZAK, AZK, MLK7, MLT, MLTK, MRK, mlklak, pk | sterile alpha motif and leucine zipper containing kinase AZK (EC:2.7.11.25) |
C00026478
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (5)
| OMIM | preferred title | UniProt |
|---|---|---|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|