PCIDB

KNApSAcK Metabolite C00026478

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00026478
Name	Quinoline
CAS RN	91-22-5
Standard InChI	InChI=1S/C9H7N/c1-2-6-9-8(4-1)5-3-7-10-9/h1-7H
Standard InChI (Main Layer)	InChI=1S/C9H7N/c1-2-6-9-8(4-1)5-3-7-10-9/h1-7H

Cluster

Phytochemical cluster
KCF-S cluster	No. 4717

Link

ChEMBL

By standard InChI	CHEMBL14474
By standard InChI Main Layer	CHEMBL14474

KEGG

By LinkDB	C06413

CTD

By CAS RN	C037219

Species

Summary

Plant class

class name	count

Family

family name	count
Diapheromeridae	1

List (1)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Oreophoetes peruana	173814	Diapheromeridae		Metazoa

Human Protein / Gene in interaction

6 ChEMBL Protein in interactions

accession	description	class description	compound	assay ID (# of activities)	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	CHEMBL14474	CHEMBL729206 (1)	1 / 0
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	CHEMBL14474	CHEMBL1908087 (1)	0 / 0
P37840	Alpha-synuclein	Unclassified protein	CHEMBL14474	CHEMBL2354282 (1)	4 / 2
P00352	Retinal dehydrogenase 1	Enzyme	CHEMBL14474	CHEMBL1614458 (1)	0 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	CHEMBL14474	CHEMBL1908085 (1)	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	CHEMBL14474	CHEMBL1794483 (1)	0 / 0

CTD interaction (76)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
C037219	11332	ACOT7 ACH1 ACT BACH CTE-II LACH LACH1 RP1-120G22.10 hBACH	acyl-CoA thioesterase 7 (EC:3.1.2.2)	quinoline analog results in increased expression of ACOT7 protein	increases expression	protein	18645022
C037219	199	AIF1 AIF-1 IBA1 IRT-1 IRT1	allograft inflammatory factor 1	quinoline analog results in increased activity of AIF1 protein	increases activity	protein	18645022
C037219	8125	ANP32A C15orf1 HPPCn I1PP2A LANP MAPM PHAP1 PHAPI PP32	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	quinoline analog results in decreased expression of ANP32A protein	decreases expression	protein	18645022
C037219	301	ANXA1 ANX1 LPC1	annexin A1	quinoline analog results in increased expression of ANXA1 protein	increases expression	protein	18645022
C037219	302	ANXA2 ANX2 ANX2L4 CAL1H LIP2 LPC2 LPC2D P36 PAP-IV	annexin A2	quinoline analog results in increased expression of ANXA2 protein	increases expression	protein	18645022
C037219	689	BTF3 BETA-NAC BTF3a BTF3b NACB	basic transcription factor 3	quinoline analog results in decreased expression of BTF3 protein	decreases expression	protein	18645022
C037219	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	quinoline analog results in increased cleavage of and results in increased activity of CASP3 protein	increases activity / increases cleavage	protein	18645022
C037219	11335	CBX3 HECH HP1-GAMMA HP1Hs-gamma	chromobox homolog 3	quinoline analog results in decreased expression of CBX3 protein	decreases expression	protein	18645022
C037219	891	CCNB1 CCNB	cyclin B1	quinoline analog results in increased expression of CCNB1 protein	increases expression	protein	18645022
C037219	1026	CDKN1A CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	quinoline analog results in increased expression of CDKN1A protein	increases expression	protein	18645022
C037219	1026	CDKN1A CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	[quinoline analog results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein	increases expression	protein	18645022
C037219	1029	CDKN2A ARF CDK4I CDKN2 CMM2 INK4 INK4A MLM MTS-1 MTS1 P14 P14ARF P16 P16-INK4A P16INK4 P16INK4A P19 P19ARF TP16	cyclin-dependent kinase inhibitor 2A	quinoline analog results in decreased methylation of CDKN2A promoter	decreases methylation	promoter	19417133
C037219	1029	CDKN2A ARF CDK4I CDKN2 CMM2 INK4 INK4A MLM MTS-1 MTS1 P14 P14ARF P16 P16-INK4A P16INK4 P16INK4A P19 P19ARF TP16	cyclin-dependent kinase inhibitor 2A	quinoline analog results in increased expression of CDKN2A mRNA	increases expression	mRNA	19417133
C037219	1029	CDKN2A ARF CDK4I CDKN2 CMM2 INK4 INK4A MLM MTS-1 MTS1 P14 P14ARF P16 P16-INK4A P16INK4 P16INK4A P19 P19ARF TP16	cyclin-dependent kinase inhibitor 2A	quinoline analog results in increased expression of CDKN2A protein	increases expression	protein	19417133
C037219	55748	CNDP2 CN2 CPGL HsT2298 PEPA	CNDP dipeptidase 2 (metallopeptidase M20 family) (EC:3.4.13.18)	quinoline analog results in increased expression of CNDP2 protein	increases expression	protein	18645022
C037219	7812	CSDE1 D1S155E RP5-1000E10.3 UNR	cold shock domain containing E1, RNA-binding	quinoline analog results in increased expression of CSDE1 protein	increases expression	protein	18645022
C037219	1544	CYP1A2 CP12 P3-450 P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	quinoline analog results in decreased activity of CYP1A2 protein	decreases activity	protein	15916432
C037219	1548	CYP2A6 CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB	cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1)	CYP2A6 protein results in increased metabolism of quinoline	increases metabolic processing	protein	8824525
C037219	1571	CYP2E1 CPE1 CYP2E P450-J P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	CYP2E1 protein results in increased hydroxylation of quinoline	increases hydroxylation	protein	8824525
C037219	1786	DNMT1 ADCADN AIM CXXC9 DNMT HSN1E MCMT	DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37)	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [quinoline analog results in increased degradation of DNMT1 protein]	decreases reaction / increases degradation	protein	19417133
C037219	1786	DNMT1 ADCADN AIM CXXC9 DNMT HSN1E MCMT	DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37)	quinoline analog results in increased degradation of DNMT1 protein	increases degradation	protein	19417133
C037219	1869	E2F1 E2F-1 RBAP1 RBBP3 RBP3	E2F transcription factor 1	quinoline analog affects the expression of E2F1 protein	affects expression	protein	15450938
C037219	1937	EEF1G EF1G GIG35	eukaryotic translation elongation factor 1 gamma	quinoline analog results in increased expression of EEF1G protein	increases expression	protein	18645022
C037219	1938	EEF2 EEF-2 EF-2 EF2 SCA26	eukaryotic translation elongation factor 2	quinoline analog results in decreased expression of EEF2 protein	decreases expression	protein	18645022
C037219	2149	F2R CF2R HTR PAR-1 PAR1 TR	coagulation factor II (thrombin) receptor	quinoline analog binds to and results in decreased activity of F2R protein	affects binding / decreases activity	protein	16380251
C037219	6624	FSCN1 FAN1 HSN SNL p55	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	quinoline analog results in increased expression of FSCN1 protein	increases expression	protein	18645022
C037219	8880	FUBP1 FBP FUBP	far upstream element (FUSE) binding protein 1	quinoline analog results in decreased expression of FUBP1 protein	decreases expression	protein	18645022
C037219	3191	HNRNPL HNRPL hnRNP-L	heterogeneous nuclear ribonucleoprotein L	quinoline analog results in decreased expression of HNRNPL protein	decreases expression	protein	18645022
C037219	79256			quinoline analog results in decreased expression of HNRPD protein	decreases expression	protein	18645022
C037219	3678	ITGA5 CD49e FNRA VLA5A	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	quinoline analog binds to and results in decreased activity of [ITGA5 protein binds to ITGB3 protein]	affects binding / decreases activity	protein	16984141
C037219	3690	ITGB3 BDPLT16 BDPLT2 CD61 GP3A GPIIIa GT	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	quinoline analog binds to and results in decreased activity of [ITGA5 protein binds to ITGB3 protein]	affects binding / decreases activity	protein	16984141
C037219	3958	LGALS3 CBP35 GAL3 GALBP GALIG L31 LGALS2 MAC2	lectin, galactoside-binding, soluble, 3	quinoline analog results in increased expression of LGALS3 protein	increases expression	protein	18645022
C037219	4000	LMNA CDCD1 CDDC CMD1A CMT2B1 EMD2 FPL FPLD FPLD2 HGPS IDC LDP1 LFP LGMD1B LMN1 LMNC LMNL1 PRO1	lamin A/C	quinoline analog results in decreased expression of LMNA protein	decreases expression	protein	18645022
C037219	4000	LMNA CDCD1 CDDC CMD1A CMT2B1 EMD2 FPL FPLD FPLD2 HGPS IDC LDP1 LFP LGMD1B LMN1 LMNC LMNL1 PRO1	lamin A/C	quinoline analog results in increased expression of LMNA protein	increases expression	protein	18645022
C037219	4048	LTA4H	leukotriene A4 hydrolase (EC:3.3.2.6)	quinoline analog results in increased expression of LTA4H protein	increases expression	protein	18645022
C037219	5604	MAP2K1 CFC3 MAPKK1 MEK1 MKK1 PRKMK1	mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)	quinoline results in decreased activity of MAP2K1 protein	decreases activity	protein	18393446
C037219	1326	MAP3K8 COT EST ESTF MEKK8 TPL2 Tpl-2 c-COT	mitogen-activated protein kinase kinase kinase 8 (EC:2.7.11.25)	quinoline analog results in decreased activity of MAP3K8 protein	decreases activity	protein	16973359
C037219	5599	MAPK8 JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	quinoline analog inhibits the reaction [ZAK protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]]	decreases reaction / increases activity / increases phosphorylation / increases reaction	protein	15737997
C037219	5599	MAPK8 JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	quinoline analog results in decreased phosphorylation of and results in decreased activity of MAPK8 protein	decreases activity / decreases phosphorylation	protein	15737997
C037219	4292	MLH1 COCA2 FCC2 HNPCC HNPCC2 hMLH1	mutL homolog 1	quinoline analog results in increased expression of MLH1 mRNA	increases expression	mRNA	19417133
C037219	10797	MTHFD2 NMDMC	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9 1.5.1.15)	quinoline analog results in decreased expression of MTHFD2 protein	decreases expression	protein	18645022
C037219	4666	NACA NACA1	nascent polypeptide-associated complex alpha subunit (EC:5.3.99.3)	quinoline analog results in decreased expression of NACA protein	decreases expression	protein	18645022
C037219	10135	NAMPT 1110035O14Rik PBEF PBEF1 VF VISFATIN	nicotinamide phosphoribosyltransferase (EC:2.4.2.12)	quinoline analog results in increased expression of NAMPT protein	increases expression	protein	18645022
C037219	4831	NME2 NDKB NDPK-B NDPKB NM23-H2 NM23B PUF	NME/NM23 nucleoside diphosphate kinase 2 (EC:2.7.4.6 2.7.13.3)	quinoline analog results in increased expression of NME2 protein	increases expression	protein	18645022
C037219	29789	OLA1 DOC45 GBP45 GTBP9 GTPBP9	Obg-like ATPase 1	quinoline analog results in decreased expression of OLA1 protein	decreases expression	protein	18645022
C037219	10606	PAICS ADE2 ADE2H1 AIRC PAIS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (EC:6.3.2.6 4.1.1.21)	quinoline analog results in increased expression of PAICS protein	increases expression	protein	18645022
C037219	11333	PDAP1 HASPP28 PAP PAP1	PDGFA associated protein 1	quinoline analog results in decreased expression of PDAP1 protein	decreases expression	protein	18645022
C037219	5160	PDHA1 PDHA PDHCE1A PHE1A	pyruvate dehydrogenase (lipoamide) alpha 1 (EC:1.2.4.1)	quinoline analog results in increased expression of PDHA1 protein	increases expression	protein	18645022
C037219	5465	PPARA NR1C1 PPAR PPARalpha hPPAR	peroxisome proliferator-activated receptor alpha	quinoline analog binds to and affects the activity of PPARA protein	affects activity / affects binding	protein	17610302
C037219	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	quinoline analog binds to and affects the activity of PPARG protein	affects activity / affects binding	protein	17610302
C037219	5573	PRKAR1A ACRDYS1 ADOHR CAR CNC CNC1 PKR1 PPNAD1 PRKAR1 TSE1	protein kinase, cAMP-dependent, regulatory, type I, alpha (EC:2.7.11.1)	quinoline analog results in increased expression of PRKAR1A protein	increases expression	protein	18645022
C037219	11212	PROSC	proline synthetase co-transcribed homolog (bacterial)	quinoline analog results in increased expression of PROSC protein	increases expression	protein	18645022
C037219	5684	PSMA3 HC8 PSC3	proteasome (prosome, macropain) subunit, alpha type, 3 (EC:3.4.25.1)	quinoline analog results in decreased expression of PSMA3 protein	decreases expression	protein	18645022
C037219	5700	PSMC1 P26S4 S4 p56	proteasome (prosome, macropain) 26S subunit, ATPase, 1	quinoline analog results in increased expression of PSMC1 protein	increases expression	protein	18645022
C037219	5705	PSMC5 S8 SUG-1 SUG1 TBP10 TRIP1 p45 p45/SUG	proteasome (prosome, macropain) 26S subunit, ATPase, 5	quinoline analog results in increased expression of PSMC5 protein	increases expression	protein	18645022
C037219	5710	PSMD4 AF AF-1 ASF MCB1 Rpn10 S5A pUB-R5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	quinoline analog results in decreased expression of PSMD4 protein	decreases expression	protein	18645022
C037219	5713	PSMD7 MOV34 P40 Rpn8 S12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	quinoline analog results in increased expression of PSMD7 protein	increases expression	protein	18645022
C037219	5902	RANBP1 HTF9A	RAN binding protein 1	quinoline analog results in decreased expression of RANBP1 protein	decreases expression	protein	18645022
C037219	5955	RCN2 E6BP ERC-55 ERC55 TCBP49	reticulocalbin 2, EF-hand calcium binding domain	quinoline analog results in decreased expression of RCN2 protein	decreases expression	protein	18645022
C037219	6240	RRM1 R1 RIR1 RR1	ribonucleotide reductase M1 (EC:1.17.4.1)	quinoline analog results in decreased expression of RRM1 protein	decreases expression	protein	18645022
C037219	1992	SERPINB1 EI ELANH2 LEI M/NEI MNEI PI-2 PI2	serpin peptidase inhibitor, clade B (ovalbumin), member 1	quinoline analog results in increased expression of SERPINB1 protein	increases expression	protein	18645022
C037219	5268	SERPINB5 PI5 maspin	serpin peptidase inhibitor, clade B (ovalbumin), member 5	quinoline analog results in increased expression of SERPINB5 protein	increases expression	protein	18645022
C037219	7078	TIMP3 HSMRK222 K222 K222TA2 SFD	TIMP metallopeptidase inhibitor 3	quinoline analog results in decreased methylation of TIMP3 promoter	decreases methylation	promoter	19417133
C037219	7078	TIMP3 HSMRK222 K222 K222TA2 SFD	TIMP metallopeptidase inhibitor 3	quinoline analog results in increased expression of TIMP3 mRNA	increases expression	mRNA	19417133
C037219	7078	TIMP3 HSMRK222 K222 K222TA2 SFD	TIMP metallopeptidase inhibitor 3	quinoline analog results in increased expression of TIMP3 protein	increases expression	protein	19417133
C037219	51311	TLR8 CD288	toll-like receptor 8	quinoline analog results in increased phosphorylation of and results in increased activity of TLR8 protein	increases activity / increases phosphorylation	protein	17868034
C037219	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	quinoline analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]	decreases reaction / increases expression	protein	16973359
C037219	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	quinoline analog results in increased activity of TP53 protein	increases activity	protein	12082016
C037219	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	quinoline analog results in increased expression of TP53 protein	increases expression	protein	18645022
C037219	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	quinoline analog results in increased expression of TP53 protein mutant form	increases expression	protein	18645022
C037219	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	[quinoline analog results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein	increases expression	protein	18645022
C037219	81567	TXNDC5 ENDOPDI ERP46 HCC-2 PDIA15 STRF8 UNQ364	thioredoxin domain containing 5 (endoplasmic reticulum)	quinoline analog results in decreased expression of TXNDC5 protein	decreases expression	protein	18645022
C037219	9948	WDR1 AIP1 NORI-1	WD repeat domain 1	quinoline analog results in increased expression of WDR1 protein	increases expression	protein	18645022
C037219	4904	YBX1 BP-8 CSDA2 CSDB DBPB MDR-NF1 NSEP-1 NSEP1 YB-1 YB1	Y box binding protein 1	quinoline analog results in decreased expression of YBX1 protein	decreases expression	protein	18645022
C037219	51776	ZAK AZK MLK7 MLT MLTK MRK mlklak pk	sterile alpha motif and leucine zipper containing kinase AZK (EC:2.7.11.25)	quinoline analog inhibits the reaction [ZAK protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]]	decreases reaction / increases activity / increases phosphorylation / increases reaction	protein	15737997
C037219	51776	ZAK AZK MLK7 MLT MLTK MRK mlklak pk	sterile alpha motif and leucine zipper containing kinase AZK (EC:2.7.11.25)	quinoline analog results in decreased activity of ZAK protein	decreases activity	protein	15737997

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM	preferred title	UniProt
#127750	Dementia, lewy body; dlb	P37840
#608902	Drug metabolism, poor, cyp2d6-related	P10635
#168601	Parkinson disease 1, autosomal dominant; park1	P37840
#605543	Parkinson disease 4, autosomal dominant; park4	P37840
#168600	Parkinson disease, late-onset; pd	P37840

KEGG DISEASE (2)

KEGG	disease name	UniProt
H00057	Parkinson's disease (PD)	P37840 (related)
H00066	Lewy body dementia (LBD)	P37840 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease	compound	disease name	evidence type	reference pmid
D006528	C037219	Carcinoma, Hepatocellular	marker/mechanism	598648
D006390	C037219	Hemangioendothelioma	marker/mechanism	598648
D006394	C037219	Hemangiosarcoma	marker/mechanism	598648
D009362	C037219	Neoplasm Metastasis	marker/mechanism	598648

KNApSAcK Metabolite C00026478

Index Metabolite Species Human Protein / Gene in interactions Related Diseases

Metabolite

KNApSAcK Entry

Cluster

Link

ChEMBL

KEGG

CTD

Species

Summary

Plant class

Family

List (1)

* NCBI

Human Protein / Gene in interaction

6 ChEMBL Protein in interactions

CTD interaction (76)

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (5)

KEGG DISEASE (2)

Diseases related to CTD interactions

4 disease from interactions of metabolites

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases