Species

KNApSAcK Entry

Organism name Oreophoetes peruana
Genus
Family
Kingdom

NCBI taxonomy

Entry

Linked NCBI taxonomy name Oreophoetes peruana
Linked NCBI taxonomy ID 173814
Linked level species

Family

Family in NCBI taxonomy Diapheromeridae
ID 409189

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Metazoa
ID 33208

Plant class

Plant class
ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00026478 External link 512 Quinoline
CHEMBL14474
C037219
6 / 5 / 2 64 / 4 No. 4717

Human Protein / Gene in interactions

6 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00026478 1 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00026478 0 / 0
P37840 Alpha-synuclein Unclassified protein C00026478 4 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00026478 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00026478 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00026478 0 / 0

64 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
11332 ACOT7, ACH1, ACT, BACH, CTE-II, LACH, LACH1, RP1-120G22.10, hBACH acyl-CoA thioesterase 7 (EC:3.1.2.2) C00026478
199 AIF1, AIF-1, IBA1, IRT-1, IRT1 allograft inflammatory factor 1 C00026478
8125 ANP32A, C15orf1, HPPCn, I1PP2A, LANP, MAPM, PHAP1, PHAPI, PP32 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A C00026478
301 ANXA1, ANX1, LPC1 annexin A1 C00026478
302 ANXA2, ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV annexin A2 C00026478
689 BTF3, BETA-NAC, BTF3a, BTF3b, NACB basic transcription factor 3 C00026478
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00026478
11335 CBX3, HECH, HP1-GAMMA, HP1Hs-gamma chromobox homolog 3 C00026478
891 CCNB1, CCNB cyclin B1 C00026478
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00026478
1029 CDKN2A, ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16 cyclin-dependent kinase inhibitor 2A C00026478
55748 CNDP2, CN2, CPGL, HsT2298, PEPA CNDP dipeptidase 2 (metallopeptidase M20 family) (EC:3.4.13.18) C00026478
7812 CSDE1, D1S155E, RP5-1000E10.3, UNR cold shock domain containing E1, RNA-binding C00026478
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00026478
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00026478
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00026478
1786 DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) C00026478
1869 E2F1, E2F-1, RBAP1, RBBP3, RBP3 E2F transcription factor 1 C00026478
1937 EEF1G, EF1G, GIG35 eukaryotic translation elongation factor 1 gamma C00026478
1938 EEF2, EEF-2, EF-2, EF2, SCA26 eukaryotic translation elongation factor 2 C00026478
2149 F2R, CF2R, HTR, PAR-1, PAR1, TR coagulation factor II (thrombin) receptor C00026478
6624 FSCN1, FAN1, HSN, SNL, p55 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) C00026478
8880 FUBP1, FBP, FUBP far upstream element (FUSE) binding protein 1 C00026478
3191 HNRNPL, HNRPL, hnRNP-L heterogeneous nuclear ribonucleoprotein L C00026478
79256 C00026478
3678 ITGA5, CD49e, FNRA, VLA5A integrin, alpha 5 (fibronectin receptor, alpha polypeptide) C00026478
3690 ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) C00026478
3958 LGALS3, CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2 lectin, galactoside-binding, soluble, 3 C00026478
4000 LMNA, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1 lamin A/C C00026478
4048 LTA4H leukotriene A4 hydrolase (EC:3.3.2.6) C00026478
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00026478
1326 MAP3K8, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT mitogen-activated protein kinase kinase kinase 8 (EC:2.7.11.25) C00026478
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00026478
4292 MLH1, COCA2, FCC2, HNPCC, HNPCC2, hMLH1 mutL homolog 1 C00026478
10797 MTHFD2, NMDMC methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9 1.5.1.15) C00026478
4666 NACA, NACA1 nascent polypeptide-associated complex alpha subunit (EC:5.3.99.3) C00026478
10135 NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN nicotinamide phosphoribosyltransferase (EC:2.4.2.12) C00026478
4831 NME2, NDKB, NDPK-B, NDPKB, NM23-H2, NM23B, PUF NME/NM23 nucleoside diphosphate kinase 2 (EC:2.7.4.6 2.7.13.3) C00026478
29789 OLA1, DOC45, GBP45, GTBP9, GTPBP9 Obg-like ATPase 1 C00026478
10606 PAICS, ADE2, ADE2H1, AIRC, PAIS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (EC:6.3.2.6 4.1.1.21) C00026478
11333 PDAP1, HASPP28, PAP, PAP1 PDGFA associated protein 1 C00026478
5160 PDHA1, PDHA, PDHCE1A, PHE1A pyruvate dehydrogenase (lipoamide) alpha 1 (EC:1.2.4.1) C00026478
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00026478
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00026478
5573 PRKAR1A, ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1 protein kinase, cAMP-dependent, regulatory, type I, alpha (EC:2.7.11.1) C00026478
11212 PROSC proline synthetase co-transcribed homolog (bacterial) C00026478
5684 PSMA3, HC8, PSC3 proteasome (prosome, macropain) subunit, alpha type, 3 (EC:3.4.25.1) C00026478
5700 PSMC1, P26S4, S4, p56 proteasome (prosome, macropain) 26S subunit, ATPase, 1 C00026478
5705 PSMC5, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG proteasome (prosome, macropain) 26S subunit, ATPase, 5 C00026478
5710 PSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 C00026478
5713 PSMD7, MOV34, P40, Rpn8, S12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 C00026478
5902 RANBP1, HTF9A RAN binding protein 1 C00026478
5955 RCN2, E6BP, ERC-55, ERC55, TCBP49 reticulocalbin 2, EF-hand calcium binding domain C00026478
6240 RRM1, R1, RIR1, RR1 ribonucleotide reductase M1 (EC:1.17.4.1) C00026478
1992 SERPINB1, EI, ELANH2, LEI, M/NEI, MNEI, PI-2, PI2 serpin peptidase inhibitor, clade B (ovalbumin), member 1 C00026478
5268 SERPINB5, PI5, maspin serpin peptidase inhibitor, clade B (ovalbumin), member 5 C00026478
7078 TIMP3, HSMRK222, K222, K222TA2, SFD TIMP metallopeptidase inhibitor 3 C00026478
51311 TLR8, CD288 toll-like receptor 8 C00026478
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00026478
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00026478
81567 TXNDC5, ENDOPDI, ERP46, HCC-2, PDIA15, STRF8, UNQ364 thioredoxin domain containing 5 (endoplasmic reticulum) C00026478
9948 WDR1, AIP1, NORI-1 WD repeat domain 1 C00026478
4904 YBX1, BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1 Y box binding protein 1 C00026478
51776 ZAK, AZK, MLK7, MLT, MLTK, MRK, mlklak, pk sterile alpha motif and leucine zipper containing kinase AZK (EC:2.7.11.25) C00026478

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#127750 Dementia, lewy body; dlb P37840
#608902 Drug metabolism, poor, cyp2d6-related P10635
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840

KEGG DISEASE (2)

KEGG name UniProt
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006528 Carcinoma, Hepatocellular C00026478
D006390 Hemangioendothelioma C00026478
D006394 Hemangiosarcoma C00026478
D009362 Neoplasm Metastasis C00026478