Species

KNApSAcK Entry

Organism name Alangium kurzii
Genus Alangium
Family Cornaceae / Aucubaceae / Garryaceae / Helwingiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Alangium kurzii
Linked NCBI taxonomy ID 161874
Linked level species

Family

Family in NCBI taxonomy Cornaceae
ID 42219

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001798 External link 512 Alangiside
CHEMBL486383
CHEMBL2138751
2 / 0 / 0 No. 577 No. 4
C00028162 External link 512 Demethylalangiside
No. 577 No. 4
C00002015 External link 512 (-)-Anabasine
CHEMBL280963
CHEMBL1496898
CHEMBL1526229
D000691
15 / 18 / 15 0 / 4 No. 2084 No. 1
C00001805 External link 512 Ankorine
No. 2276 No. 4
C00019674 External link 512 Uridine
CHEMBL68846
CHEMBL100259
CHEMBL265701
CHEMBL608294
CHEMBL609651
CHEMBL1092065
CHEMBL2093066
D014529
5 / 0 / 3 7 / 15 No. 2366

Human Protein / Gene in interactions

21 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00001798 C00019674 0 / 0
Q9HA47 Uridine-cytidine kinase 1 Enzyme C00019674 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00019674 0 / 3
P06746 DNA polymerase beta Enzyme C00002015 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002015 0 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00002015 1 / 1
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00002015 1 / 1
P27708 CAD protein Enzyme C00019674 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002015 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002015 1 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002015 4 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002015 7 / 3
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha C00002015 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002015 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002015 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002015 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00019674 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002015 0 / 0
O00255 Menin Unclassified protein C00002015 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002015 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001798 0 / 0

7 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00019674
2993 GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2 glycophorin A (MNS blood group) C00019674
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00019674
9154 SLC28A1, CNT1, HCNT1 solute carrier family 28 (concentrative nucleoside transporter), member 1 C00019674
9153 SLC28A2, CNT2, HCNT2, HsT17153, SPNT1 solute carrier family 28 (concentrative nucleoside transporter), member 2 C00019674
2030 SLC29A1, ENT1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 C00019674
3177 SLC29A2, DER12, ENT2, HNP36 solute carrier family 29 (equilibrative nucleoside transporter), member 2 C00019674

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637

KEGG DISEASE (18)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

19 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001259 Ataxia C00002015
D006948 Hyperkinesis C00002015
D018908 Muscle Weakness C00002015
D014202 Tremor C00002015
D000015 Abnormalities, Multiple C00019674
D000749 Anemia, Megaloblastic C00019674
D001919 Bradycardia C00019674
D002375 Catalepsy C00019674
D004342 Drug Hypersensitivity C00019674
D056486 Drug-Induced Liver Injury C00019674
D064420 Drug-Related Side Effects and Adverse Reactions C00019674
D005234 Fatty Liver C00019674
D007022 Hypotension C00019674
D028361 Mitochondrial Diseases C00019674
C538525 Mitochondrial encephalopathy C00019674
D017240 Mitochondrial Myopathies C00019674
D010523 Peripheral Nervous System Diseases C00019674
D011565 Psoriasis C00019674
D019956 Stereotypic Movement Disorder C00019674