Species

KNApSAcK Entry

Organism name Euchresta horsfeldii
Genus Euchresta
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Euchresta
Linked NCBI taxonomy ID 53878
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00009943 External link 512 Euchrenone b8
No. 18 No. 15
C00009948 External link 512 Euchrenone b9
No. 18 No. 15
C00009944 External link 512 Euchrenone b6
No. 18 No. 15
C00009949 External link 512 Euchrenone b7
No. 18 No. 15
C00008466 External link 512 Kushenol E
/ Flemiphilippinin D
C070774
No. 19 No. 14
C00008462 External link 512 Euchrenone a8
No. 19 No. 14
C00008459 External link 512 Glabrol
CHEMBL462721
7 / 12 / 6 No. 19 No. 14
C00008452 External link 512 Euchrenone a7
/ (2S)-Euchrenone a7
/ (-)-(2S)-Euchrenone a7
CHEMBL457686
1 / 2 / 2 No. 28 No. 14
C00008463 External link 512 Euchrenone a9
CHEMBL550385
No. 39
C00009950 External link 512 Euchrenone b10
/ 8-Prenylerythrinin C
CHEMBL2159049
C109428
1 / 0 / 0 No. 47 No. 15
C00002227 External link 512 Matrine
/ (+)-Matrine
CHEMBL204860
CHEMBL383443
CHEMBL525227
CHEMBL1396816
CHEMBL1733145
CHEMBL1824581
C034244
5 / 3 / 7 4 / 5 No. 85 No. 3
C00010011 External link 512 Sophoracarpan B
/ 6-Methoxymaackiain
/ (6R,6aS,11aR)-3-Hydroxy-6-methoxy-8,9-methylenedioxypterocarpan
No. 1655

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00009950 0 / 0
Q99700 Ataxin-2 Unclassified protein C00008459 1 / 1
P37840 Alpha-synuclein Unclassified protein C00008459 4 / 2
P11387 DNA topoisomerase 1 Isomerase C00002227 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002227 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00008459 2 / 0
O75496 Geminin Unclassified protein C00008459 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00008452 2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00008459 5 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00002227 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00008459 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00008459 1 / 0
O00255 Menin Unclassified protein C00002227 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002227 1 / 2

4 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00002227
4893 NRAS, ALPS4, N-ras, NRAS1, NS6 neuroblastoma RAS viral (v-ras) oncogene homolog C00002227
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00002227
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00002227

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#601665 Obesity P37231
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (15)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002289 Carcinoma, Non-Small-Cell Lung C00002227
D002779 Cholestasis C00002227
D056487 Drug-Induced Liver Injury, Chronic C00002227
D006331 Heart Diseases C00002227
D008113 Liver Neoplasms C00002227