KCF-S cluster No. 28 (117 metabolites)

Corresponding Phytochemical cluster No. 14

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (117)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	188
asterids	28
Magnoliophyta	3
eudicotyledons	2
Euphyllophyta	1

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Cumulative family count

class name	count
Fabaceae	163
Asteraceae	26
Moraceae	9
Rutaceae	6
Dipterocarpaceae	4
Annonaceae	3
Platanaceae	2
Euphorbiaceae	2
Cannabaceae	2
Meliaceae	2
Apiaceae	2
Ophioglossaceae	1

KEGG BRITE br08003

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Categories (2)

br08003 Category	# of metabolite
Flavanones	2
Isoflavanones	3

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metabolites link (5)

br08003 Category	KEGG ID	KNApSAcK ID
Flavanones	C09752	C00000965
Flavanones	C09831	C00000996
Isoflavanones	C10418	C00002523
Isoflavanones	C01590	C00002541
Isoflavanones	C10530	C00002573

Metabolite list (117)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000965	Glabranin	CHEMBL253998 CHEMBL488888		5 / 2 / 3
C00000996	Abyssinin II / Abyssinoflavanone II / 5'-Prenylhomoeriodictyol	CHEMBL388722		1 / 0 / 0
C00000997	6-Prenylnaringenin	CHEMBL1537093		14 / 16 / 16
C00002523	(+-)-5-Deoxykievitone
C00002541	Kievitone		C094208
C00002573	Sophoraisoflavanone A
C00008131	Isoderricidin
C00008136	Ovaliflavanone B
C00008171	Isoglabranin / 6-Prenylpinocembrin / 5,7-Dihydroxy-6-C-prenylflavanone	CHEMBL2143430 CHEMBL2165236		1 / 0 / 0
C00008172	5-Hydroxy-7-methoxy-6-C-prenylflavanone	CHEMBL1088927
C00008174	5,7-Dihydroxy-8-C-(4-hydroxy-3-methyl-2-butenyl)flavanone
C00008175	5,7-Dihydroxy-8-C-(gamma-methyl-gamma-formylallyl)flavanone
C00008177	Tephrinone / 7-O-Methylglabranine / 5-Hydroxy-7-methoxy-8-prenylflavanone	CHEMBL1089227
C00008183	5-Methoxy-7-prenyloxyflavanone
C00008187	6-C-Prenyl-8-C-methylpinocembrin
C00008189	7-O-Prenylpinocembrin
C00008190	7-O-Prenylcryptostrobin
C00008197	Isobavachin	CHEMBL491534	C468753		2 / 0
C00008201	Abyssinone II	CHEMBL389924 CHEMBL558103 CHEMBL1688178		2 / 2 / 2
C00008235	Selinone
C00008245	8-Prenylnaringenin / Sophoraflavanone B / (-)-8-Prenylnaringenin	CHEMBL376915 CHEMBL460647		10 / 8 / 4
C00008246	Isoxanthohumol(Sophora)	CHEMBL492828		4 / 0 / 1
C00008247	Bavachin	CHEMBL469444		1 / 2 / 2
C00008248	Bavachinin	CHEMBL1551302	C468752	5 / 4 / 8
C00008263	5,4'-Dihydroxy-7-methoxy-6-C-prenylflavanone
C00008265	5,4'-Dihydroxy-7-O-prenylflavanone
C00008316	6-Prenyleriodictyol
C00008317	8-Prenyleriodictyol
C00008318	Sigmoidin B	CHEMBL229454	C064222	1 / 0 / 0
C00008350	Eriodictyol 7,3'-dimethyl ether 4'-prenyl ether
C00008357	5,3',4'-Trihydroxy-7-methoxy-8-C-prenylflavanone
C00008385	Candidone	CHEMBL454844
C00008393	Isoderricin A
C00008448	8-Methoxypinocembrin 7-O-prenyl ether
C00008451	Licoflavanone	CHEMBL457680	C060400	1 / 2 / 2
C00008452	Euchrenone a7 / (2S)-Euchrenone a7 / (-)-(2S)-Euchrenone a7	CHEMBL457686		1 / 2 / 2
C00008453	5,7-Dihydroxy-4'-methoxy-8-C-prenylflavanone	CHEMBL556429		1 / 2 / 0
C00008454	2'-Prenyleriodictyol
C00008456	4'-Methylsigmoidin B		C055273
C00008491	Crotaramosmin
C00008493	5-Hydroxy-7-methoxy-4'-prenyloxyflavanone
C00008497	Kenusanone I
C00008502	Kenusanone D
C00008507	5,7-Dihydroxy-4'-methoxy-8-C-(2-hydroxy-3-methyl-3-butenyl)flavanone
C00008540	Exiguaflavanone K	CHEMBL486858
C00009552	Secundifloran
C00009957	Diphysolone / 5,7,2',4'-Tetrahydroxy-6-prenylisoflavanone
C00009958	Diphysolidone / 5,7,2'-Trihydroxy-4'-methoxy-6-prenylisoflavanone
C00009959	4'-O-Methylkievitone / 5,7,2'-Trihydroxy-4'-methoxy-8-prenylisoflavanone
C00009962	Echinoisosophoranone / 5,4'-Dihydroxy-7,2'-dimethoxy-5'-(1''',1'''-dimethylallyl)isoflavanone
C00009963	3S-5,7,3'-Trihydroxy-4'-methoxy-5'-prenylisoflavanone
C00009965	5-Deoxykievitol
C00009966	(+)-Dihydrowighteone / (+)-5,7,4'-Trihydroxy-6-prenylisoflavanone
C00009967	Kievitol
C00009972	(+)-Echinoisoflavanone
C00014154	5,7-Dihydroxy-6-methyl-8-prenylflavanone
C00014155	Mundulea flavanone A / 4'-Hydroxyisoderricin / 4'-Hydroxy-7-methoxy-8-prenylflavanone
C00014156	Kushenol S / 5,7,2'-Trihydroxy-8-prenylflavanone	CHEMBL482042
C00014157	5,7,4'-Trihydroxy-6-methyl-8-prenylflavanone
C00014158	5,7,4'-Trihydroxy-8-methyl-6-prenylflavanone
C00014159	Agrandol / 5,7-Dihydroxy-6-methoxy-8-prenylflavanone	CHEMBL491588		2 / 1 / 1
C00014160	Microfolione / (2R)-5,7-Dihydroxy-8-methoxy-6-prenylflavanone	CHEMBL498989		2 / 1 / 1
C00014161	Mundulea flavanone B / 7-Methyl-4'-hydroxyglabranin / 7-O-Methyl-8-prenylnaringenin	CHEMBL521792
C00014162	Flowerine / 5-Hydroxy-7,4'-dimethoxy-8-prenylflavanone
C00014163	Flowerone / 5,7,8,4'-Tetrahydroxy-3'-prenylflavanone
C00014164	Leachianone G / 5,7,2',4'-Tetrahydroxy-8-prenylflavanone	CHEMBL516930 CHEMBL1783937
C00014165	Monotesone A / 5,7,3'-Trihydroxy-4'-O-prenylflavanone
C00014166	Dioflorin / (2R)-5,7,2'-Trihydroxy-8-methoxy-6-prenylflavanone
C00014168	5,7-Dihydroxy-3',4'-dimethoxy-5'-prenylflavanone
C00014169	Kushenol V / 5,7,2',4'-Tetrahydroxy-5'-methoxy-6-prenylflavanone	CHEMBL480869
C00014170	Kushenol W / 5,7,2',4'-Tetrahydroxy-5'-methoxy-8-prenylflavanone	CHEMBL479476
C00014171	Laxiflorin / 5,7,4'-Trihydroxy-3'-methoxy-6-(beta-hydroxyethyl)-8-prenylflavanone
C00014179	(2S)-5,7,4'-Trihydroxy-6-(1,1-dimethylallyl)flavanone	CHEMBL478765
C00014180	Ugonin E / 5,7,4'-Trihydroxy-8-(1,1-dimethylallyl)flavanone
C00014181	(2S)-5,7,3',4'-Tetrahydroxy-6-(1,1-dimethylallyl)flavanone
C00014182	(2S)-5,7,4'-Trihydroxy-3'-methoxy-6-(1,1-dimethylallyl)flavanone
C00014198	Tomentosanol D / 5,7,4'-Trihydroxy-8-(2-hydroxy-3-methylbutyl-3-enyl)flavanone	CHEMBL443717
C00014201	Licoleafol / (2S)-5,7,3',4'-Tetrahydroxy-8-[(E)-3-hydroxymethyl-2-butenyl]flavanone
C00014213	Abyssinoflavanone IV / 5,7,3'-Trihydroxy-2'-prenyl-[2'',3'':4',5']furanoflavanone
C00014380	Dioclenol / 3,5,7-Trihydroxy-8-methoxy-6-prenylflavanone
C00018904	2,3-Dihydro-2'-hydroxyneobavaisoflavanone
C00018913	Arizonicanol C / 5,7,3'-Trihydroxy-2',4'-dimethoxy-6-prenylisoflavanone
C00018914	Arizonicanol D / 5,7,3'-Trihydroxy-4'-methoxy-2'-prenylisoflavanone
C00018917	Secundiflorol A
C00018933	Vogelin B / Erypoegin C / 5,7,4'-Trihydroxy-2'-methoxy-5'-prenylisoflavanone
C00018934	Erypoegin D / 5,4'-Dihydroxy-7,2'-dimethoxy-5'-prenylisoflavanone
C00018951	Dihydrolicoisoflavone / (S)-5,7,2',4'-Tetrahydroxy-3'-prenylisoflavanone
C00018957	(3R)-5,7,2',3'-Tetrahydroxy-4'-methoxy-5'-prenylisoflavanone
C00018958	(3R)-7,2,3'-Trihydroxy-4'-methoxy-5'-prenylisoflavanone / (+)-(3R)-7,2,3'-Trihydroxy-4'-methoxy-5'-prenylisoflavanone
C00018959	(3S)-3,7,2',3'-Tetrahydroxy-4'-methoxy-5'-prenylisoflavanone
C00018968	Sigmoidin J / 7,4'-Dihydroxy-2',5'-dimethoxy-6-prenylisoflavanone		C090619
C00019058	Vogelin A / 5,7,2'-Trihydroxy-4'-methoxy-5'-prenylisoflavone
C00019148	Pervilleanone	CHEMBL1973510
C00019149	3'-O-Demethylpervilleanone	CHEMBL1987286
C00019296	Bolusanthol B / 5,7,3',4'-Tetrahydroxy-5-prenylisoflavanone
C00019464	Eryvellutinone / 2',4'-Dihydroxy-6-prenyl-7-methoxyisoflavanone
C00019509	Desmodianone B / (R)-5,2',4'-Trihydroxy-7-methoxy-6-methyl-8-prenylisoflavanone
C00019536	Prostratol C / 7,2'-Dihydroxy-4'-methoxy-5'-prenylisoflavanone	CHEMBL1811967		1 / 0 / 0
C00019595	Sigmoidin I / 7,4'-Dihydroxy-2'-methoxy-5'-prenylisoflavanone
C00019620	Glyasperin K / (S)-5,2'-Dihydroxy-7,4'-dimethoxy-6-prenylisoflavanone
C00019631	Fraserinone A / 5,7,4'-Trihydroxy-2'-methoxy-5'-(1,1-dimethyl-2-propenyl)isoflavanone
C00019644	Kenusanone F / 3,5,7,4'-Tetrahydroxy-2'-methoxy-3'-prenylisoflavanone
C00019718	Piscerythrol / (2S,3S)-3,5,7,4'-Tetrahydroxy-5'-methoxy-3'-prenylcoumaranochroman-4-one
C00019721	Lupinol C / (2R,3S)-3,5,7,4'-Tetrahydroxy-6-prenylcoumaranochroman-4-one
C00019752	Glyasperin B / 5,2',4'-Trihydroxy-7-methoxy-6-prenylisoflavanone
C00021677	Secundiflorol D	CHEMBL1987286
C00021678	Secundiflorol E
C00021679	Secundiflorol F
C00033000	Glicoisoflavanone
C00033902	Helichrysone C / (+)-Helichrysone C
C00034739	Uncinanone D / (-)-Uncinanone D
C00035170	Erylatissin C / (-)-Erylatissin C
C00036234	Uncinanone A
C00036586	5,7,3'-Trihydroxy-4'-methoxy-5'-gamma,gamma-dimethylallylisoflavanone
C00037154	Flavescenone A
C00038874	Cudraflavanone B	CHEMBL460437
C00048131	Sophoronol D / (+)-Sophoronol D	CHEMBL549957

Human Protein / Gene in interactions

37 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00008201 C00008247 C00008451 C00008452	2 / 2
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00000996 C00008201 C00008318 C00019536	0 / 0
P03372	Estrogen receptor	NR3A1	C00008245 C00014159 C00014160	1 / 1
Q92731	Estrogen receptor beta	NR3A2	C00008245 C00014159 C00014160	0 / 1
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00000997 C00008171 C00008245	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000997 C00008248	1 / 2
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00008245 C00008453	2 / 0
O75496	Geminin	Unclassified protein	C00000997 C00008245	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000965	1 / 0
P11309	Serine/threonine-protein kinase pim-1	Pim	C00000965	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000965	0 / 1
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000997	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000997	2 / 0
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00000997	1 / 4
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00008245	0 / 0
Q04759	Protein kinase C theta type	Delta	C00008246	0 / 1
P17252	Protein kinase C alpha type	Alpha	C00008246	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00008248	0 / 0
P37840	Alpha-synuclein	Unclassified protein	C00008245	4 / 2
P28482	Mitogen-activated protein kinase 1	Erk	C00000997	0 / 0
P56817	Beta-secretase 1	A1A	C00008246	0 / 0
P04062	Glucosylceramidase	Enzyme	C00000997	6 / 4
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00008245	0 / 0
O15530	3-phosphoinositide-dependent protein kinase 1	Pdk1	C00008246	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000965	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000965	0 / 1
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00000997	1 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00000997	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000997	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000997	4 / 3
Q9UBT6	DNA polymerase kappa	Enzyme	C00008248	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00008248	1 / 1
O00255	Menin	Unclassified protein	C00008248	2 / 5
Q13951	Core-binding factor subunit beta	Unclassified protein	C00000997	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00000997	1 / 4
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00008245	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00008245	1 / 1

2 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5241	PGR, NR3C3, PR	progesterone receptor	C00008197
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00008197

Related Diseases

Diseases related to proteins in ChEMBL interactions