KCF-S cluster No. 18 (151 metabolites)

Corresponding Phytochemical cluster No. 15

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (151)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	250
asterids	2
eudicotyledons	1

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Cumulative family count

class name	count
Fabaceae	103
Moraceae	67
Clusiaceae	49
Calophyllaceae	16
Hypericaceae	11
Euphorbiaceae	2
Lamiaceae	2
Combretaceae	2
Berberidaceae	1

KEGG BRITE br08003

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Categories (2)

br08003 Category	# of metabolite
Isoflavones	1
Xanthenes	1

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metabolites link (2)

br08003 Category	KEGG ID	KNApSAcK ID
Isoflavones	C10519	C00002562
Xanthenes	C10076	C00002961

Metabolite list (151)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001070	Morusin / Mulberrochromene / 2-(2,4-Dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methyl-2-butenyl)-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one	CHEMBL464006	C057451	16 / 17 / 10
C00002555	Osajin	CHEMBL238188		36 / 50 / 70
C00002562	Pomiferin	CHEMBL393136		37 / 43 / 61
C00002961	Macluraxanthone / 3-Hydroxyblancoxanthone	CHEMBL478960		5 / 11 / 11
C00004021	Brosimone I / (E)-(+)-3,8,10-Trihydroxy-9-(3-methyl-1-butenyl)-6-(2-methyl-1-propenyl)-6H,7H-[1]benzopyrano[4,3-b][1]benzopyran-7-one
C00004029	Cyclomorusin / Cyclomulberrochromene / 6,11-Dihydroxy-3,3-dimethyl-8-(2-methyl-1-propenyl)-3H,7H,8H-bis[1]benzopyrano[4,3-b:6',5'-e]pyran-7-one	CHEMBL1770313		1 / 0 / 0
C00004038	Brosimone G
C00004044	Fulvinervin B / (E)-5-Hydroxy-8,8-dimethyl-6-(3-methyl-1,3-butadienyl)-2-phenyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one / 5-Hydroxy-8,8-dimethyl-6-[(1E)-3-methyl-1,3-butadienyl]-2-phenyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
C00004045	Fulvinervin C / (E)-5-Hydroxy-6-(3-hydroxy-3-methyl-1-butenyl)-8,8-dimethyl-2-phenyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one / 5-Hydroxy-6-[(1E)-3-hydroxy-3-methyl-1-butenyl]-8,8-dimethyl-2-phenyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
C00004055	Cycloartomunin / 6,12-Dihydroxy-11-methoxy-3,3-dimethyl-8-(2-methyl-1-propenyl)-3H,7H,8H-bis[1]benzopyrano[4,3-b:6',5'-e]pyran-7-one
C00004056	Kuwanon B
C00004057	Kuwanon A	CHEMBL1770312		1 / 0 / 0
C00004059	Morusinol / Oxydihydromorusin / 2-(2,4-Dihydroxyphenyl)-5-hydroxy-3-(3-hydroxy-3-methylbutyl)-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one	CHEMBL1719948		10 / 5 / 2
C00004063	Desmodol
C00004066	Artobilichromene
C00004092	Kanzonol E / 2-(2,2-Dimethyl-2H-1-benzopyran-6-yl)-7-hydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
C00004093	Laxifolin / 5-Hydroxy-2-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methyl-2-butenyl)-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
C00004094	Isolaxifolin / 5-Hydroxy-8-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methyl-2-butenyl)-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
C00004098	Isocyclomorusin / (+)-3,8-Dihydroxy-11,11-dimethyl-6-(2-methyl-1-propenyl)-6H,7H,11H-bis[1]benzopyrano[4,3-b:6',7'-e]pyran-7-one	CHEMBL230558
C00004101	Cycloartocarpin A	CHEMBL463093
C00004105	KB-2 / 5,2',4',5'-Tetrahydroxy-3-(3-hydroxy-3-methylbutyl)-6'',6''-dimethylpyrano[2'',3'':7,8]flavone
C00004106	KB 3 / Artonin E / 5-Hydroxy-8,8-dimethyl-3-(3-methyl-2-butenyl)-2-(2,4,5-trihydroxyphenyl)-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one	CHEMBL463106	C066727
C00005075	Sericetin	CHEMBL1495541		2 / 0 / 1
C00005083	Macaflavone I
C00005084	Macaflavone II
C00005086	Broussoflavonol A / 8-(3,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-2,2-dimethyl-10-(3-methyl-2-butenyl)-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
C00009447	Munetone	CHEMBL463492
C00009448	Cajaisoflavone
C00009449	Mundulone	CHEMBL465339		11 / 19 / 44
C00009513	Chandalone
C00009514	Scandenone / Warangalone	CHEMBL458134	C105205
C00009518	Nallanin / Scandinone
C00009519	Isoauriculatin
C00009520	Isoauriculasin
C00009521	Auriculatin
C00009522	Auriculasin / Cudraisoflavone A	CHEMBL459129
C00009525	Auriculin / Auriculatin 4'-methyl ether
C00009532	Millettin
C00009836	4'-O-Prenylalpinumisoflavone	CHEMBL1970103
C00009915	Isochandalone / 5,7-Dihydroxy-6-prenyl-6'',6''-dimethylpyrano[2'',3'':4',3']isoflavone	CHEMBL460441
C00009919	Angustone B / 5,7,2'-Trihydroxy-6-prenyl-6'',6''-dimethylpyrano[2'',3'':4',3']isoflavone
C00009923	Gancaonin H / 5,7,3'-Trihydroxy-6-prenyl-6'',6''-dimethylpyrano[2'',3'':4',5']isoflavone
C00009929	Angustone C / 5,2',4'-Trihydroxy-3'-prenyl-6'',6''-dimethylpyrano[2'',3'':7,6]isoflavone
C00009930	Lupinisoflavone L
C00009934	Lupinisoflavone K
C00009935	Ulexone A / 5,7-Dihydroxy-8-prenyl-6'',6''-dimethylpyrano[2'',3'':4',3']isoflavone	CHEMBL461062
C00009937	Ulexone B
C00009938	Ulexone D
C00009939	Ulexone C
C00009943	Euchrenone b8
C00009944	Euchrenone b6
C00009947	Euchrenone b3 / 5-Hydroxy-2'-methoxy-4',5'-methylenedioxy-6-prenyl-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavone
C00009948	Euchrenone b9
C00009949	Euchrenone b7
C00011150	Ulexin C	CHEMBL517608
C00011151	Ulexin D	CHEMBL517314
C00013393	Muxiangrin III / Muxiangrine III / 2-[3,4-Dihydroxy-5-(3-methyl-2-butenyl)phenyl]-5-hydroxy-7-methoxy-6,8-dimethyl-4H-1-benzopyran-4-one
C00013395	Muxiangrin I / Muxiangrine I / 5-Hydroxy-2-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-7-methoxy-6,8-dimethyl-4H-1-benzopyran-4-one
C00013442	Australone A / 2H,(-)-8-(2,4-Dihydroxyphenyl)-5-hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-6H-benzo[1,2-b:5,4-b']dipyran-6-one
C00013456	Yinyanghuo A / (-)-5,7-Dihydroxy-2-[8-(2-hydroxy-3-methyl-3-butenyl)-2,2-dimethyl-2H-1-benzopyran-6-yl]-4H-1-benzopyran-4-one	CHEMBL462969
C00013459	Morusignin L
C00013485	Cycloartobiloxanthone / 5a,6-Dihydro-1,3,8-trihydroxy-5,5,11,11-tetramethyl-5H,7H,11H-benzofuro[3,4-bc]pyrano[3,2-h]xanthen-7-one	CHEMBL516519		2 / 0 / 0
C00013488	Cycloartomunoxanthone / 5a,6-Dihydro-1,8-dihydroxy-3-methoxy-5,5,11,11-tetramethyl-5H,7H,11H-benzofuro[3,4-bc]pyrano[3,2-h]xanthen-7-one
C00013499	Artocommunol CA / (+)-6-Hydroxy-11-methoxy-3,3-dimethyl-8-(2-methyl-1-propenyl)-3H,7H,8H-bis[1]benzopyrano[4,3-b:6',5'-e]pyran-7-one
C00013536	Broussonol B / 8,9-Dihydro-3,5-dihydroxy-2-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-8,9,9-trimethyl-4H-furo[2,3-h]-1-benzopyran-4-one	CHEMBL457086
C00013538	Broussonol A / 8-(1,1-Dimethyl-2-propenyl)-3,5,7-trihydroxy-2-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-4H-1-benzopyran-4-one	CHEMBL457085
C00018940	Lespedezol A3 / 3,8-Dihydroxy-6'-methyl-6'-(4-methyl-3-pentenyl)pyrano[2',3':9,10]pterocarpene
C00019079	Scanderone / 4',5-Dihydroxy-3'-prenyl-2'',2''-dimethylchromeno[7,8:6'',5'']isoflavone
C00019080	Ulexin B
C00019084	Kraussianone 1 / 5,2'-Dihydroxy-(2'',3'':7,6),(2''',3''':4',3')-bis(6,6-dimethylpyrano)isoflavone
C00019085	Kraussianone 2 / 5,7,2'-Trihydroxy-6-prenyl-6'',6''-dimethylpyrano[2'',3'':4',5']isoflavone
C00019086	Kraussianone 3 / 5,7,2'-Trihydroxy-6-(3-hydroxy-3-methyl-3-butyl)-6'',6''-dimethylpyrano[2'',3'':4',3']isoflavone
C00019097	Kraussianone 6 / 5,2',5''-Trihydroxy-4'',5''-dihydro-(2'',3'':7,6),(2''',3''':4',3')-bis(6,6-dimethylpyrano)isoflavone
C00019098	Kraussianone 7 / 5,7,2'-Trihydroxy-6-(2-hydroxy-3-methyl-3-butenyl)-6'',6''-dimethylpyrano[2'',3'':4',3']isoflavone
C00019156	5-O-Methyl-4'-O-(3-methylbut-2-enyl)alpinumisoflavone
C00019168	Formosanatin D
C00019170	Euchretin G
C00019247	Artoindonesianin Y / 3',5'-Dihydroxy-2',6'-diprenyl-6'',6''-dimethylpyrano[2'',3'':6,7]-2-arylbenzofuran
C00019317	2-(1-Hydroxy-1-methylethyl)-3-hydroxy-2,3-dihydrofuranoalpinumisoflavone
C00019370	Ulexin A / 5,7-Dihydroxy-6-(2-hydroxy-3-methyl-3-butenyl)-6'',6''-dimethylpyrano[2'',3'':4',3']isoflavone
C00019414	Euchretin H
C00019466	Kanzonol V / 5,4'-Dihydroxy-6-prenyl-6'',6''-dimethylpyrano[2'',3'':2',3']-2-arylbenzofuran
C00019474	Kanzonol T / 5,7,2'-Trihydroxy-6-(3-hydroxy-3-methylbutyl)-6'',6''-dimethylpyrano[2'',3'':4',3']isoflavone
C00019502	Isoerythrin-A 4'-(3-methylbut-2-enyl)ether
C00019514	Erysenegalensein L / 5,2',4'-Trihydroxy-8-(2'''-hydroxy-3'''-methyl-3'''-butenyl)-6'',6''-dimethylpyrano[2'',3'':7,6]isoflavone
C00019538	Ormosidin / 7,4'-Dihydroxy-6'',6''-dimethylpyrano[2'',3'':5,6]-8-(3-methyl-1,3-butadienyl)isoflavone
C00019540	Eturunagarone / 5,4'-Dihydroxy-8-(3-methoxy-3-methylbutyl)-6'',6''-dimethylpyrano[2'',3'':7,6]-isoflavone
C00019623	Glyasperin N / 5,7,4'-Trihydroxy-8-prenyl-6'',6''-dimethylpyrano[2'',3'':2',3']isoflavone
C00019626	7,6]isoflavone / Erysenegalensein F / 5,2',4'-Trihydroxy-8-(2,3-epoxy-3-methylbutyl)-6'',6''-dimethylpyrano[2'',3''
C00019669	2'-O-Methylisoauriculatin
C00020492	Flemiphilippinin C		C070776
C00024193	Gerontoxanthone A	CHEMBL517514		7 / 10 / 6
C00024194	Gerontoxanthone B	CHEMBL478938
C00029567	5'-Hydroxycudraflavone A
C00029729	Artoindonesianin D
C00030035	Cudraflavone A	CHEMBL230558
C00030107	Demethylcalabaxanthone	CHEMBL564653
C00030356	Garcinone B	CHEMBL560332
C00030897	Osajin 4'-methyl ether
C00031562	Acetyl blancoxanthone
C00032105	Padiaxanthone / Brasilixanthone B
C00032355	Thwaitesixanthone	CHEMBL2006383
C00032505	Warangalone 4'-methyl ether
C00032517	Xanthone V1
C00034827	Cowaxanthone D / Dulcisxanthone F
C00034842	Formoxanthone A	CHEMBL1254112
C00034875	Morusignin J	CHEMBL2147812
C00034889	Rheediaxanthone A
C00034916	Vogelin I / (+)-Vogelin I
C00035249	Bangangxanthone A
C00035818	Caloxanthone A
C00035841	Inoxanthone
C00036131	Latisxanthone D	CHEMBL469412
C00036177	Nigrolineaxanthone B
C00036182	Nigrolineaxanthone G
C00036184	Nigrolineaxanthone I
C00036836	Brasilixanthone A
C00036862	Caloxanthone D
C00036963	Cudraxanthone B
C00036966	Cudraxanthone K
C00037370	Kayeaxanthone
C00037472	Manglexanthone
C00037494	Merguenone
C00037602	Paxanthone B
C00037708	Pyranojacareubin
C00037861	Subelliptenone H
C00037919	Tovopyrifolin A
C00039430	Isocudraxanthone K	CHEMBL390040
C00040462	Termicalcicolanone A	CHEMBL224141
C00040463	Termicalcicolanone B
C00040543	Trapezifolixanthone		C401852
C00040963	Garciniaxanthone B	CHEMBL481243
C00041222	(-)-Cudraflavone A	CHEMBL230558
C00041223	(-)-Cycloartocarpin	CHEMBL525350
C00042227	Ananixanthone	CHEMBL460547
C00042432	Cycloartelastoxanthendiol / (-)-Cycloartelastoxanthendiol	CHEMBL464517
C00042749	Morusignin I
C00042772	Nigrolineaxanthone V
C00044541	Artocommunol CE / (+)-Artocommunol CE
C00044572	Brasixanthone A
C00044573	Brasixanthone B
C00044574	Brasixanthone C
C00044575	Brasixanthone D
C00044576	Brasixanthone E
C00044782	Globulixanthone B / (+)-Globulixanthone B	CHEMBL464752
C00044959	Nigrolineaxanthone K	CHEMBL462457
C00044961	Nigrolineaxanthone M	CHEMBL518394
C00045814	Cudraxanthone Q / Brasixanthone B
C00045960	Garcimangosone B
C00047431	Dehydrolupinifolinol	CHEMBL557501
C00047788	Cathafuran C	CHEMBL550963

Human Protein / Gene in interactions

59 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00001070 C00002555 C00002562 C00004059 C00024193	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00001070 C00002555 C00002562 C00004059 C00024193	2 / 0
Q99700	Ataxin-2	Unclassified protein	C00001070 C00002555 C00002562 C00004059 C00024193	1 / 1
O75496	Geminin	Unclassified protein	C00002555 C00002562 C00004059 C00024193	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00002555 C00002562 C00002961 C00009449	4 / 1
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00001070 C00002555 C00002562 C00004059	1 / 1
P56817	Beta-secretase 1	A1A	C00001070 C00004029 C00004057 C00004059	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00001070 C00002555 C00002562 C00004059	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002555 C00002562 C00005075 C00009449	0 / 1
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00001070 C00002555 C00002562 C00004059	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00001070 C00002555 C00002562 C00004059	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00002555 C00002562 C00009449	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00002555 C00002562 C00009449	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00002555 C00002562 C00024193	1 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00001070 C00002555 C00002562	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00002555 C00002562 C00002961	4 / 3
P04637	Cellular tumor antigen p53	Transcription Factor	C00002555 C00002562 C00009449	7 / 37
P00352	Retinal dehydrogenase 1	Enzyme	C00002555 C00002562 C00009449	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00002555 C00002562 C00024193	2 / 2
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00002555 C00002562 C00024193	4 / 2
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002555 C00002562 C00002961	1 / 2
O00255	Menin	Unclassified protein	C00002555 C00002562 C00002961	2 / 5
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002555 C00005075 C00009449	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00001070 C00002562	0 / 0
P04062	Glucosylceramidase	Enzyme	C00002555 C00009449	6 / 4
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00002555 C00002562	0 / 3
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00001070 C00002562	7 / 3
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002562 C00002961	0 / 0
P37840	Alpha-synuclein	Unclassified protein	C00001070 C00002562	4 / 2
Q9UBT6	DNA polymerase kappa	Enzyme	C00002555 C00002562	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00002555 C00009449	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00002555 C00002562	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002562	0 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00001070	2 / 0
Q04206	Transcription factor p65	Transcription Factor	C00013485	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002562	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00009449	2 / 2
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00013485	0 / 0
P42858	Huntingtin	Unclassified protein	C00002555	1 / 1
P55210	Caspase-7	C14	C00002562	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002562	1 / 1
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00002562	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00002562	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00002555	1 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00009449	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002555	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00001070	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002562	0 / 1
P07900	Heat shock protein HSP 90-alpha	Other cytosolic protein	C00002562	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00002555	11 / 10
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00002555	1 / 1
O00167	Eyes absent homolog 2	Enzyme	C00002555	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002555	0 / 0
P06746	DNA polymerase beta	Enzyme	C00002555	0 / 0
Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	Enzyme	C00004059	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00001070	0 / 3
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00001070	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002555	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002562	1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions