KCF-S cluster No. 19 (147 metabolites)

Corresponding Phytochemical cluster No. 14

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (147)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	187
asterids	23
Liliopsida	9
eudicotyledons	2
Magnoliophyta	1

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Cumulative family count

class name	count
Fabaceae	155
Euphorbiaceae	10
Paulowniaceae	8
Moraceae	7
Asteraceae	5
Rutaceae	5
Phrymaceae	5
Zingiberaceae	5
Apiaceae	4
Sarcolaenaceae	4
Velloziaceae	2
Meliaceae	2
Cyperaceae	2
Muntingiaceae	2
Physenaceae	2
Dipterocarpaceae	2
Hernandiaceae	1
Gentianaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Flavanones	2

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metabolites link (2)

br08003 Category	KEGG ID	KNApSAcK ID
Flavanones	C09319	C00000936
Flavanones	C09724	C00000954

Metabolite list (147)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000936	Abyssinone V	CHEMBL255890 CHEMBL454332	C056679	2 / 0 / 0
C00000954	Senegalensein / Lonchocarpol A / 6,8-Diprenylnaringenin	CHEMBL477969 CHEMBL1545584	C068505	16 / 26 / 18
C00008135	Ovaliflavanone A
C00008176	5,7-Dihydroxy-8-C-geranylflavanone
C00008182	5-Hydroxy-7-prenyloxy-8-C-prenylflavanone
C00008184	5-Methoxy-7-prenyloxy-8-C-prenylflavanone
C00008188	5,7-Dihydroxy-6,8-di-C-prenylflavanone
C00008196	7,4'-Dihydroxy-6,8-di-C-prenylflavanone	CHEMBL560504
C00008202	Abyssinone IV	CHEMBL470454		1 / 0 / 0
C00008266	Euchrestaflavanone A	CHEMBL256340
C00008267	Nimbaflavone / 5,7-Dihydroxy-4'-methoxy-8,3'-di-C-prenylflavanone	CHEMBL560530
C00008270	Kushenol A	CHEMBL455679 CHEMBL480280		1 / 0 / 0
C00008273	Mimulone / Bonannione A	CHEMBL374130		1 / 1 / 0
C00008274	Sophoraflavanone A / 8-Geranylnaringenin	CHEMBL490697		1 / 2 / 0
C00008319	Sigmoidin A	CHEMBL229506	C064221	1 / 0 / 0
C00008321	Amoradicin
C00008322	Amoradinin
C00008326	Diplacone	CHEMBL223256		1 / 1 / 0
C00008327	4'-O-Methyldiplacone	CHEMBL2011404		1 / 1 / 0
C00008328	Kuwanon E	CHEMBL1096939
C00008334	Kushenol F
C00008335	Isokurarinone
C00008358	Flemiflavanone A
C00008364	Norkurarinone / Sophoraflavanone G	CHEMBL243148 CHEMBL479477	C064849	3 / 2 / 2
C00008400	Lehmannin
C00008433	Leachianone A	CHEMBL453642 CHEMBL519096		1 / 0 / 0
C00008459	Glabrol	CHEMBL462721		7 / 12 / 6
C00008462	Euchrenone a8
C00008466	Kushenol E / Flemiphilippinin D		C070774
C00008467	Lespedezaflavanone D / Euchrestaflavanone B
C00008468	Gancaonin E
C00008469	Hiravanone / (S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,8-bis(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
C00008492	4'-O-Geranylnaringenin / 5,7-Dihydroxy-4'-geranyloxyflavanone
C00008494	Lespedezaflavanone F
C00008495	Lespedezaflavanone G
C00008496	6,8-Diprenyleriodictyol / 5,7,3',4'-Tetrahydroxy-6,8-di-C-prenylflavanone
C00008498	Sophoraflavanone D
C00008499	Sophoraflavanone E
C00008500	Kenusanone B
C00008508	5,7-Dihydroxy-4'-methoxy-8-C-prenyl-3'-(3-hydroxy-3-methylbutyl)flavanone
C00008511	Lupiniol A1 / Lupiniol A2
C00008512	Lupiniol B
C00008519	Exiguaflavanone A	CHEMBL464368
C00008520	Exiguaflavanone B	CHEMBL465402
C00008521	Leachianone D
C00008522	Leachianone E
C00008531	Exiguaflavanone C
C00008533	Exiguaflavanone E
C00008534	Exiguaflavanone F
C00008536	Exiguaflavanone G
C00008543	Maackiaflavanone
C00008544	5,7,3',4'-Tetrahydroxy-6,5'-di-C-prenylflavanone
C00008545	2'4'-Dihydroxy-5'-(1'',1''-dimethylallyl)-6-C-prenylpinocembrin
C00008611	3-Hydroxyglabrol	CHEMBL463947
C00008622	Lespedezaflavanone C	CHEMBL463256		1 / 2 / 2
C00008627	Kushenol L
C00008646	(2R,3S)-3,5,7-Trihydroxy-6-geranylflavanone
C00008647	Bonanniol A	CHEMBL220418
C00008648	3,5,4'-Trihydroxy-7-geranyloxyflavanone
C00008649	Bonanniol B
C00008650	Kushenol I	CHEMBL243147 CHEMBL480281 CHEMBL1972376		2 / 2 / 2
C00008651	Kushenol N	CHEMBL243147 CHEMBL480281 CHEMBL1972376		2 / 2 / 2
C00008652	Kushenol H	CHEMBL77703 CHEMBL440494 CHEMBL388661 CHEMBL516688		2 / 2 / 2
C00008653	Kushenol K	CHEMBL77703 CHEMBL440494 CHEMBL388661 CHEMBL516688		2 / 2 / 2
C00008654	Diplacol	CHEMBL411385
C00008655	Diplacol 4'-methylether	CHEMBL2011402		1 / 1 / 0
C00009562	Lespedeol A
C00009564	Isosophoranone
C00009565	Sophoraisoflavanone B / 5,7,2'-Trihydroxy-4'-methoxy-6,5'-diprenylisoflavanone
C00009970	3'-Dimethylallylkievitone / 5,7,2',4'-Tetrahydroxy-8,3'-diprenylisoflavanone	CHEMBL1711925		7 / 10 / 4
C00013590	Sophoraflavanone C
C00014172	5-Hydroxy-7-O-nerylflavanone
C00014173	Paratocarpin L / Macarangaflavanone B / 5,7,4'-Trihydroxy-6,3'-diprenylflavanone	CHEMBL471799
C00014174	Burttinonedehydrate / (S)-5,7-Dihydroxy-4'-methoxy-3'-(3-methylbutadienyl)-5'-(3-methylbut-2-enyl)flavanone	CHEMBL513969		1 / 0 / 0
C00014175	Abyssinone V 4'-methyl ether / 5,7-Dihydroxy-4'-methoxy-3',5'-diprenylflavanone	CHEMBL470249 CHEMBL1425525		20 / 20 / 13
C00014176	Abyssinin III / Abyssinoflavanone III / 5,7,3',4'-Tetrahydroxy-5',6'-diprenylflavanone
C00014177	Monotesone B / 5,7,3',5'-Tetrahydroxy-6,8-diprenylflavanone	CHEMBL1689341		1 / 2 / 0
C00014183	(2S)-5,7,2',4'-Tetrahydroxy-8-prenyl-5'-(1,1-dimethylallyl)flavanone	CHEMBL516671
C00014184	(2S)-5,7,4'-Trihydroxy-2'-methoxy-8-prenyl-5'-(1,1-dimethylallyl)flavanone
C00014185	Prostratol F / (2S)-7,4'-Dihydroxy-8-geranylflavanone
C00014186	Macarangaflavanone A / 5,7,4'-Trihydroxy-3'-geranylflavanone
C00014187	Sanggenol A / 5,7,2',4'-Tetrahydroxy-3'-geranylflavanone
C00014190	Remangiflavanone A / 5,7,4'-Trihydroxy-8-(2-isopropyl-5-methyl-5-hexenyl)flavanone	CHEMBL517168
C00014191	Kushenol R / (2S)-7,2'-Dihydroxy-8-lavandulyl-5-methoxyflavanone	CHEMBL520605
C00014192	Kushenol U / (2S)-7,4'-Dihydroxy-8-lavandulyl-5-methoxyflavanone	CHEMBL519440
C00014193	Alopecurone G / 7,4'-Dihydroxy-8-lavandulyl-2'-methoxyflavanone
C00014194	Remangiflavanone B / 5,7,2',4'-Tetrahydroxy-8-(2-isopropyl-5-methyl-5-hexenyl)flavanone	CHEMBL464195
C00014195	Kurarinone / 7,2',4'-Trihydroxy-8-lavandulyl-5-methoxyflavanone	CHEMBL243796		6 / 3 / 3
C00014196	(2S)-2'-Methoxykurarinone / (2S)-7,4'-Dihydroxy-8-lavandulyl-5,2'-dimethoxyflavanone	CHEMBL480469 CHEMBL496451		1 / 0 / 0
C00014199	Kushenol T / (2S)-5,7,2'-Trihydroxy-8-(5-hydroxy-2-isopropenyl-5-methylhexyl)flavanone	CHEMBL509486		1 / 0 / 0
C00014200	Burttinone / 5,7-Dihydroxy-4'-methoxy-3'-prenyl-5'-[(3-methyl-2-butenyl)phenyl]flavanone	CHEMBL515837 CHEMBL1977731		1 / 0 / 0
C00014202	Dorsmanin H / 5,7,3',4'-Tetrahydroxy-6-prenyl-8-(2-hydroxy-3-methylbut-3-enyl)flavanone
C00014203	Kushenol Q / 5,7,2',4'-Tetrahydroxy-8-[2-(2-hydroxyisopropyl)-5-methyl-4-hexenyl]flavanone
C00014204	Kushenol P / (2S)-5,7,4'-Trihydroxy-2'-methoxy-8-(5-hydroxy-5-methyl-2-isopropenylhexyl)flavanone	CHEMBL519277
C00014383	3,5,7,4'-Tetrahydroxy-6,8-diprenylflavanone	CHEMBL479131
C00014385	Kushenol X / (2R,3R)-3,5,7,2',4'-Pentahydroxy-8-lavandulylflavanone	CHEMBL517073
C00018903	(+)-3-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-2,3-dihydro-7-hydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
C00018922	Eryzerin A / (+/-)-7,2',4'-Trihydroxy-8,3'-diprenylisoflavanone
C00018923	Eryzerin B / (3R)-7,4'-Dihydroxy-2'-methoxy,6,8-diprenylisoflavanone
C00018971	7,4'-Dihydroxy-2'-methoxy-6-geranylisoflavanone
C00018974	Tetrapterol G / 5,7,2',4'-Tetrahydroxy-6,5'-diprenylisoflavanone
C00018975	Tetrapterol H / 5,7,2'-Trihydroxy-4'-methoxy-8,5'-diprenylisoflavanone
C00018976	Tetrapterol I / 7,4'-Dihydroxy-6,3'-diprenylisoflavanone
C00018981	(-)-Bidwillon A / 7,2',4'-Trihydroxy-6,8-diprenylisoflavanone
C00018982	Orientanol D / 3,7,2',4'-Tetrahydroxy-6,8-diprenylisoflavanone
C00018983	Orientanol E / 5,7,2',4'-Tetrahydroxy-6,8-diprenylisoflavanone
C00018986	Dalversinol A / 5,7,2',4'-Tetrahydroxy-8-prenyl-3'-(1,1-dimethyl-2-propenyl)isoflavanone	CHEMBL463094
C00018991	Glisoflavanone / 5,7,2',4'-Tetrahydroxy-6,3'-diprenylisoflavanone
C00018995	Erysengalensein B / 5,7,2',4',5'-Pentahydroxy-6,8-di-(gamma,gamma-dimethylallyl)isoflavanone
C00019042	Vogelin D / (3R)-5,7-Dihydroxy-4'-methoxy-6,3'-diprenylisoflavanone	CHEMBL514443
C00019181	Neokurarinol
C00019182	Norkurarinol	CHEMBL454647 CHEMBL479294
C00019183	Kurarinol	CHEMBL455667 CHEMBL517832		1 / 0 / 0
C00019291	Bolusanthin II / 3,5,7,2',4'-Pentahydroxy-8,3'-diprenylisoflavanone
C00019297	Bolusanthol C / 5,7,4'-Trihydroxy-6,3'-diprenylisoflavanone
C00019333	Kanzonol G / (3S)-5,2',4'-Trihydroxy-7-methoxy-6,3'-diprenylisoflavanone
C00019364	Kenusanone A / 5,7,2',4'-Tetrahydroxy-5'-[(2E)-3,7-dimethyl-2,6-octadienyl]isoflavanone
C00019510	Desmodianone C / (R)-5,7,2',4'-Tetrahydroxy-6-methyl-5'-(3,7-dimethylocata-2,6-dienyl)isoflavanone
C00019520	Tetrapterol C
C00019521	Tetrapterol D / 5,7,4'-Trihydroxy-3'-((2E)-3,7-dimethyl-2,6-octadienyl)isoflavanone
C00019522	Tetrapterol E / 7,4'-Dihydroxy-3'-((2E)-3,7-dimethyl-2,6-octadienyl)isoflavanone
C00019534	Prostratol A / 7,2',4'-Trihydroxy-5'-((2E)-3,7-dimethyl-2,6-octadienyl)isoflavanone
C00019535	Prostratol B / 7,2',4'-Trihydroxy-6,5'-diprenylisoflavanone
C00019646	Kenusanone H / 5,7,2',4'-Tetrahydroxy-8-[(2E)-3,7-dimethyl-2,6-octadienyl]isoflavanone
C00019719	Lupinol A / (2S,3S)-3,5,7,4'-Tetrahydroxy-6,3'-diprenylcoumaranochroman-5-one
C00019720	Lupinol B / (2S,3S)-5,7,4'-Trihydroxy-3-methoxy-6,3'-diprenylcoumaranochroman-4-one
C00029591	7-Methoxy-5-hydroxy-8-geranylflavanone	CHEMBL252728
C00035119	Isonymphaeol B
C00038046	(-)-6-Geranylpinocembrin	CHEMBL254612
C00038094	(-)-(2R)-8-Geranylpinostrobin	CHEMBL252728
C00038097	(2S)-6-Geranylpinostrobin	CHEMBL399909
C00038266	3'-O-Methyl-5'-hydroxydiplacone	CHEMBL463675
C00038267	3'-O-Methyl-5'-methoxydiplacol	CHEMBL463842 CHEMBL2011406		1 / 1 / 0
C00038268	3'-O-Methyldiplacol	CHEMBL459258		1 / 1 / 0
C00038269	3'-O-Methyldiplacone	CHEMBL253152		1 / 1 / 0
C00038344	Abyssinoflavanone VII	CHEMBL229220		1 / 0 / 0
C00038409	Alnifoliol
C00040495	Tomentodiplacol	CHEMBL253151
C00040496	Tomentodiplacone B	CHEMBL517927
C00041874	Sophoraflavanone K / (+)-Sophoraflavanone K (Sophora flavescens)
C00041875	Sophoraflavanone L	CHEMBL463940
C00042145	4'-O-Methylbonannione A / (-)-4'-O-Methylbonannione A	CHEMBL479870
C00042798	Nymphaeol B	CHEMBL464364
C00043053	Tanariflavanone D / (-)-Tanariflavanone D	CHEMBL499116
C00047145	Paratocarpin L / Macarangaflavanone B / 3',6-di(gamma,gamma-Dimethylallyl)-4',5,7-trihydroxyflavanone	CHEMBL471799
C00048132	Sophoronol E / (+)-Sophoronol E	CHEMBL557704
C00048133	Sophoronol F / (+)-Sophoronol F	CHEMBL558301

Human Protein / Gene in interactions

37 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P22303	Acetylcholinesterase	Hydrolase	C00008273 C00008326 C00008327 C00008655 C00038267 C00038268 C00038269	1 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00000936 C00008202 C00008319 C00014174 C00014175 C00014200 C00038344	0 / 0
P56817	Beta-secretase 1	A1A	C00008270 C00008364 C00008433 C00014195 C00014196 C00014199 C00019183	0 / 0
P31639	Sodium/glucose cotransporter 2	Glucose	C00008364 C00008650 C00008651 C00008652 C00008653 C00014195	1 / 1
P13866	Sodium/glucose cotransporter 1	Glucose	C00008364 C00008650 C00008651 C00008652 C00008653 C00014195	1 / 1
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000954 C00008459 C00009970 C00014175	2 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00000954 C00008459 C00009970 C00014175	0 / 0
O75496	Geminin	Unclassified protein	C00000954 C00008459 C00009970 C00014175	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00000954 C00008459 C00014175	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00000954 C00008459 C00014175	1 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00000954 C00009970 C00014175	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00000954 C00009970 C00014175	1 / 1
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00000954 C00009970 C00014175	7 / 3
P39748	Flap endonuclease 1	Enzyme	C00000954 C00014175	0 / 0
P17861	X-box-binding protein 1	Unclassified protein	C00000954 C00014175	1 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000954 C00014175	4 / 3
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00008274 C00014177	2 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000954 C00014175	1 / 2
P03372	Estrogen receptor	NR3A1	C00014195	1 / 1
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00014175	1 / 4
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00008622	2 / 2
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00008459	5 / 3
P04062	Glucosylceramidase	Enzyme	C00000954	6 / 4
P37840	Alpha-synuclein	Unclassified protein	C00008459	4 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00014175	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00014175	0 / 0
P06746	DNA polymerase beta	Enzyme	C00000954	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00014175	1 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00000954	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00014195	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00014175	0 / 0
P07900	Heat shock protein HSP 90-alpha	Other cytosolic protein	C00009970	0 / 0
P04054	Phospholipase A2	Enzyme	C00000936	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00014175	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00014175	0 / 0
O00255	Menin	Unclassified protein	C00000954	2 / 5
P35610	Sterol O-acyltransferase 1	Enzyme	C00014195	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions