PCIDB

Sophora davidii

Species

KNApSAcK Entry

Organism name Sophora davidii
Genus Sophora
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Sophora davidii
Linked NCBI taxonomy ID 49839
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (14)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00004362 External link 512 Diosmin
/ Luteolin 4'-methyl ether 7-rutinoside
/ 5,7,3'-Trihydroxy-4'-methoxyflavone 7-O-rutinoside
CHEMBL231884
CHEMBL1512770
CHEMBL1707291
D004145
20 / 8 / 14 1 / 5 No. 1 No. 15
C00008364 External link 512 Norkurarinone
/ Sophoraflavanone G
CHEMBL243148
CHEMBL479477
C064849
3 / 2 / 2 No. 19 No. 14
C00008433 External link 512 Leachianone A
CHEMBL453642
CHEMBL519096
1 / 0 / 0 No. 19 No. 14
C00002227 External link 512 Matrine
/ (+)-Matrine
CHEMBL204860
CHEMBL383443
CHEMBL525227
CHEMBL1396816
CHEMBL1733145
CHEMBL1824581
C034244
5 / 3 / 7 4 / 5 No. 85 No. 3
C00002209 External link 512 Aphylline
CHEMBL509343
No. 85 No. 3
C00037006 External link 512 Davidiol C
No. 93
C00002905 External link 512 epsilon-Viniferin
/ (-)-epsilon-Viniferin
CHEMBL498439
CHEMBL1224875
CHEMBL1224889
C091891
9 / 0 No. 108 No. 30
C00015825 External link 512 Miyabenol C
/ trans-Miyabenol
No. 163 No. 30
C00015693 External link 512 lpha-Viniferin
/ (+)-alpha-Viniferin
CHEMBL443463
CHEMBL1997745
C064176
1 / 0 / 3 1 / 2 No. 163 No. 30
C00032889 External link 512 Davidiol A
/ (-)-Davidiol A
CHEMBL466300
No. 163 No. 30
C00037005 External link 512 Davidiol B
No. 163 No. 30
C00002219 External link 512 5,6-Dehydrolupanine
No. 555 No. 3
C00015872 External link 512 Sophoraflavanone H
No. 669
C00008525 External link 512 Sophoraflavanone I
No. 669

Human Protein / Gene in interactions

26 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002227 C00004362 1 / 2
O00255 Menin Unclassified protein C00002227 C00004362 2 / 5
P56817 Beta-secretase 1 A1A C00008364 C00008433 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002227 C00004362 0 / 0
P13866 Sodium/glucose cotransporter 1 Glucose C00008364 1 / 1
P11387 DNA topoisomerase 1 Isomerase C00002227 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00004362 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00004362 0 / 0
P39748 Flap endonuclease 1 Enzyme C00004362 0 / 0
P06746 DNA polymerase beta Enzyme C00004362 0 / 0
O75496 Geminin Unclassified protein C00004362 0 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00004362 1 / 2
Q9Y253 DNA polymerase eta Enzyme C00004362 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00004362 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00004362 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002227 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00015693 0 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00004362 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00004362 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00004362 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00004362 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00004362 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00004362 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00004362 1 / 1
P31639 Sodium/glucose cotransporter 2 Glucose C00008364 1 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00004362 0 / 0

14 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00002905 C00015693
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00002905
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00002227
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00002227
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00002227
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002905
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00002905
4893 NRAS, ALPS4, N-ras, NRAS1, NS6 neuroblastoma RAS viral (v-ras) oncogene homolog C00002227
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00002905
1555 CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) C00002905
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00002905
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00002905
3949 LDLR, FH, FHC, LDLCQ2 low density lipoprotein receptor C00002905
196 AHR, bHLHe76 aryl hydrocarbon receptor C00004362

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#606824 Glucose/galactose malabsorption; ggm P13866
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#233100 Renal glucosuria; glys1 P31639
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (19)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H01126 Familial renal glucosuria (FRG) P31639 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00016 Oral cancer P40763 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

12 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002289 Carcinoma, Non-Small-Cell Lung C00002227
D002779 Cholestasis C00002227
D056487 Drug-Induced Liver Injury, Chronic C00002227
D006331 Heart Diseases C00002227
D008113 Liver Neoplasms C00002227
D004487 Edema C00015693
D007249 Inflammation C00015693
D003921 Diabetes Mellitus, Experimental C00004362
D003924 Diabetes Mellitus, Type 2 C00004362
D056486 Drug-Induced Liver Injury C00004362
D006501 Hepatic Encephalopathy C00004362
D007565 Jaundice C00004362