PCIDB

KNApSAcK Metabolite C00004362

Metabolite

KNApSAcK Entry

id C00004362
Name Diosmin / Luteolin 4'-methyl ether 7-rutinoside / 5,7,3'-Trihydroxy-4'-methoxyflavone 7-O-rutinoside
CAS RN 520-27-4
Standard InChI InChI=1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10?,19?,21-,22+,23-,24-,25?,26?,27+,28+/m0/s1
Standard InChI (Main Layer) InChI=1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 1

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL231884 CHEMBL1512770 CHEMBL1707291

KEGG

By LinkDB C10039

CTD

By CAS RN D004145

Human Protein / Gene in interaction

20 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme CHEMBL231884 CHEMBL1614079 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL231884 CHEMBL1707291 CHEMBL1794585 (2)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL1707291 CHEMBL1794311 (1)
2 / 3
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL1512770 CHEMBL1614458 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL231884 CHEMBL1707291 CHEMBL1794486 (2)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL231884 CHEMBL1738606 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL231884 CHEMBL2114780 (1)
0 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor CHEMBL231884 CHEMBL1696939 (1)
1 / 2
Q9Y253 DNA polymerase eta Enzyme CHEMBL231884 CHEMBL1707291 CHEMBL1794569 (2)
1 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL231884 CHEMBL1512770 CHEMBL1614257 (2) CHEMBL1614410 (1)
1 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1512770 CHEMBL1794467 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL231884 CHEMBL1707291 CHEMBL1738588 (2)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL231884 CHEMBL1707291 CHEMBL1794483 (2)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL231884 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1512770 CHEMBL1614211 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1512770 CHEMBL1707291 CHEMBL1794536 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1512770 CHEMBL1613914 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL1512770 CHEMBL1614364 (1) CHEMBL1738394 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL231884 CHEMBL1512770 CHEMBL1614257 (2)
2 / 5
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL1512770 CHEMBL2114738 (1)
0 / 0

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
D004145 196 AHR
bHLHe76
aryl hydrocarbon receptor Diosmin binds to and results in increased activity of AHR protein affects binding
/ increases activity
protein 14644660

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (14)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00016 Oral cancer P40763 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

5 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003921 D004145 Diabetes Mellitus, Experimental therapeutic
22056647
D003924 D004145 Diabetes Mellitus, Type 2 therapeutic
22056647
D056486 D004145 Drug-Induced Liver Injury marker/mechanism
2563116
D006501 D004145 Hepatic Encephalopathy marker/mechanism
2563116
D007565 D004145 Jaundice marker/mechanism
2563116