Sophora tonkinensis
Species
KNApSAcK Entry
| Organism name | Sophora tonkinensis |
|---|---|
| Genus | Sophora |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Sophora tonkinensis |
|---|---|
| Linked NCBI taxonomy ID | 714503 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (18)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00020221
|
2-(2',4'-Dihydroxyphenyl)-8,8-dimethyl-10-(3-methyl-2-butenyl)-8H-pyrano[2,3-d]chroman-4-one
|
No. 39 |
|
|||||
|
C00020675
|
2,3-Dihydro-7-hydroxy-2-(7-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-8-(3-methyl-7-butenyl)-4H-1-benzopyran-4-one
|
No. 39 |
|
|||||
|
C00023313
|
Allmatrine
/ 6-Allomatrine / 6beta-Matrine / (+)-Allomatrine / Tetrahydroisosophoramine |
CHEMBL204860
CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581 |
5 / 3 / 7 | No. 85 | No. 3 |
|
||
|
C00002227
|
Matrine
/ (+)-Matrine |
CHEMBL204860
CHEMBL383443 CHEMBL525227 CHEMBL1396816 CHEMBL1733145 CHEMBL1824581 |
C034244
|
5 / 3 / 7 | 4 / 5 | No. 85 | No. 3 |
|
|
C00026263
|
14b-Hydroxymatrine
/ (-)-14beta-Hydroxymatrine |
No. 85 | No. 3 |
|
||||
|
C00007761
|
Sophoranol
|
No. 85 | No. 3 |
|
||||
|
C00007092
|
2,4,2'-Trihydroxy-6'',6''-dimethyl-3'-prenylpyrano[2'',3'':4',5']chalcone
|
No. 186 |
|
|||||
|
C00007075
|
Sophoradochromene
|
No. 186 |
|
|||||
|
C00020676
|
2-[2,3-Dihydro-2-(1-hydroxy-1-methylethyl)-7-(3-methyl-2-butenyl)-5-benzofuranyl]-2,3-dihydro-7-hydroxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
|
No. 235 |
|
|||||
|
C00002216
|
Caulophylline
/ N-Methylcytisine / (-)-N-Methylcytisine |
CHEMBL66191
CHEMBL1085045 |
C034245
|
No. 376 | No. 3 |
|
||
|
C00002218
|
Cytisine
/ (-)-Cytisine |
CHEMBL47039
CHEMBL497939 CHEMBL1628606 |
C004712
|
27 / 36 / 33 | 6 / 1 | No. 376 | No. 3 |
|
|
C00002207
|
Anagyrine
/ (-)-Anagyrine |
CHEMBL203399
CHEMBL509692 CHEMBL1324708 CHEMBL1454284 |
C012736
|
7 / 8 / 11 | No. 384 | No. 3 |
|
|
|
C00002235
|
Sophoramine
|
C055681
|
No. 384 | No. 3 |
|
|||
|
C00026262
|
(-)-14beta-Acetoxymatrine
|
No. 712 |
|
|||||
|
C00007760
|
Sophocarpine N-oxide
/ (+)-Sophocarpine N-oxide |
CHEMBL380410
|
C046246
|
No. 1211 | No. 3 |
|
||
|
C00007758
|
Oxymatrine
/ Ammothamnine / Matrine N-oxide / (+)-Matrine N-oxide / Matrine 1beta-oxide |
CHEMBL458337
CHEMBL1358502 |
C037573
|
3 / 11 / 6 | 0 / 4 | No. 1211 | No. 3 |
|
|
C00023309
|
Lemannine
/ Lehmannine / (+)-Lehmannine |
CHEMBL205311
|
No. 1721 |
|
||||
|
C00026296
|
(+)-Leontalbinine
|
No. 2607 |
|
Human Protein / Gene in interactions
33 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002207 C00002218 C00002227 C00023313 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00002207 C00002218 C00002227 C00023313 | 2 / 5 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002207 C00002218 | 1 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002207 C00002218 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002218 C00007758 | 4 / 3 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002207 C00002218 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002227 C00023313 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002218 C00007758 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002227 C00023313 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002227 C00023313 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002218 | 0 / 0 |
| P02708 | Acetylcholine receptor subunit alpha | CHRN alpha | C00002218 | 3 / 2 |
| P11230 | Acetylcholine receptor subunit beta | CHRN beta | C00002218 | 2 / 1 |
| P07510 | Acetylcholine receptor subunit gamma | CHRN gamma | C00002218 | 2 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002207 | 0 / 0 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00002218 | 1 / 1 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00002218 | 1 / 1 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00007758 | 7 / 3 |
| Q07001 | Acetylcholine receptor subunit delta | CHRN delta | C00002218 | 3 / 2 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002218 | 0 / 0 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00002218 | 0 / 0 |
| P32297 | Neuronal acetylcholine receptor subunit alpha-3 | CHRN alpha | C00002218 | 1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002218 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002207 | 3 / 3 |
| P30926 | Neuronal acetylcholine receptor subunit beta-4 | CHRN beta | C00002218 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002218 | 0 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002218 | 0 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002218 | 11 / 10 |
| P04062 | Glucosylceramidase | Enzyme | C00002218 | 6 / 4 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002218 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002218 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002218 | 1 / 4 |
| Q15822 | Neuronal acetylcholine receptor subunit alpha-2 | CHRN alpha | C00002218 | 1 / 1 |
10 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1135 | CHRNA2 | cholinergic receptor, nicotinic, alpha 2 (neuronal) |
C00002218
|
| 1136 | CHRNA3, LNCR2, NACHRA3, PAOD2 | cholinergic receptor, nicotinic, alpha 3 (neuronal) |
C00002218
|
| 1137 | CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 | cholinergic receptor, nicotinic, alpha 4 (neuronal) |
C00002218
|
| 1139 | CHRNA7, CHRNA7-2, NACHRA7 | cholinergic receptor, nicotinic, alpha 7 (neuronal) |
C00002218
|
| 1141 | CHRNB2, EFNL3, nAChRB2 | cholinergic receptor, nicotinic, beta 2 (neuronal) |
C00002218
|
| 1143 | CHRNB4 | cholinergic receptor, nicotinic, beta 4 (neuronal) |
C00002218
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00002227
|
| 4893 | NRAS, ALPS4, N-ras, NRAS1, NS6 | neuroblastoma RAS viral (v-ras) oncogene homolog |
C00002227
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00002227
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002227
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (46)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #610353 | Epilepsy, nocturnal frontal lobe, 4; enfl4 |
Q15822
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #265000 | Multiple pterygium syndrome, escobar variant; evmps |
P07510
|
| #253290 | Multiple pterygium syndrome, lethal type; lmps |
P02708
P07510 Q07001 |
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #608931 | Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency |
P11230
|
| #608930 | Myasthenic syndrome, congenital, fast-channel |
P02708
Q07001 |
| #601462 | Myasthenic syndrome, congenital, slow-channel; sccms |
P02708
P11230 Q07001 |
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #612052 | Smoking as a quantitative trait locus 3; sqtl3 |
P32297
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (39)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00770 | Congenital myasthenic syndrome |
P02708
(related)
P11230 (related) Q07001 (related) |
| H00986 | Multiple pterygium syndrome |
P02708
(related)
P07510 (related) Q07001 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) Q15822 (related) |
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
10 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D012640 | Seizures |
C00002218
|
| D002289 | Carcinoma, Non-Small-Cell Lung |
C00002227
|
| D002779 | Cholestasis |
C00002227
|
| D056487 | Drug-Induced Liver Injury, Chronic |
C00002227
|
| D006331 | Heart Diseases |
C00002227
|
| D008113 | Liver Neoplasms |
C00002227
|
| D003092 | Colitis |
C00007758
|
| D019694 | Hepatitis B, Chronic |
C00007758
|
| D007249 | Inflammation |
C00007758
|
| D008106 | Liver Cirrhosis, Experimental |
C00007758
|