PCIDB

KNApSAcK Metabolite C00002218

Metabolite

KNApSAcK Entry

id C00002218
Name Cytisine / (-)-Cytisine
CAS RN 485-35-8
Standard InChI InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2
Standard InChI (Main Layer) InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2

Cluster

Phytochemical cluster No. 3
KCF-S cluster No. 376

Link

ChEMBL

By standard InChI CHEMBL47039
By standard InChI Main Layer CHEMBL47039 CHEMBL497939 CHEMBL1628606

KEGG

By LinkDB C10763

CTD

By CAS RN C004712

Species

Summary

Plant class

class name count
rosids 45
eudicotyledons 1
asterids 1

Family

family name count
Fabaceae 44
Convolvulaceae 1
Viscaceae 1
Anacardiaceae 1

List (47)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Anagyris spp. 49792 Fabaceae rosids Viridiplantae
Baptisia australis 149633 Fabaceae rosids Viridiplantae
Baptisia spp. 49796 Fabaceae rosids Viridiplantae
Baptisia tinctoria R.Br. 49796 Fabaceae rosids Viridiplantae
Bolusanthus specious 53837 Fabaceae rosids Viridiplantae
Chamaecytisus eriocarpus 49803 Fabaceae rosids Viridiplantae
Cladrastis amurensis 38411 Fabaceae rosids Viridiplantae
Clathrotropis glaucophylla 149641 Fabaceae rosids Viridiplantae
Cuscuta platyloba 132262 Convolvulaceae asterids Viridiplantae
Cytisus laburnum L. 49828 Fabaceae rosids Viridiplantae
Cytisus monspessulanus L. 49848 Fabaceae rosids Viridiplantae
Cytisus spp. 3833 Fabaceae rosids Viridiplantae
Euchresta formosana 256638 Fabaceae rosids Viridiplantae
Euchresta horsfieldii 53879 Fabaceae rosids Viridiplantae
Genista libanotica 49818 Fabaceae rosids Viridiplantae
Genista spp. 49818 Fabaceae rosids Viridiplantae
Laburnum anagyroides 49828 Fabaceae rosids Viridiplantae
Maackia tashiroi 256641 Fabaceae rosids Viridiplantae
Petteria ramentacea 49832 Fabaceae rosids Viridiplantae
Piptanthus concolor 70605 Fabaceae rosids Viridiplantae
Piptanthus nepalensis 70606 Fabaceae rosids Viridiplantae
Sophora alopecuroides L. 200492 Fabaceae rosids Viridiplantae
Sophora chrysophylla 171561 Fabaceae rosids Viridiplantae
Sophora griffithii Stocks. 3896 Fabaceae rosids Viridiplantae
Sophora japonica L. 3897 Fabaceae rosids Viridiplantae
Sophora macrophylla 3896 Fabaceae rosids Viridiplantae
Sophora pachycarpa Schrenk. 3896 Fabaceae rosids Viridiplantae
Sophora secundiflora 48122 Fabaceae rosids Viridiplantae
Sophora speciosa 3896 Fabaceae rosids Viridiplantae
Sophora spp. 3896 Fabaceae rosids Viridiplantae
Sophora tomentosa 256637 Fabaceae rosids Viridiplantae
Sophora tonkinensis 714503 Fabaceae rosids Viridiplantae
Sophora viciifolia 1196212 Fabaceae rosids Viridiplantae
Spondias mangifera 43860 Anacardiaceae rosids Viridiplantae
Templetonia retusa 140951 Fabaceae rosids Viridiplantae
Thermopsis alterniflora Rgl.et Schmalh. 49852 Fabaceae rosids Viridiplantae
Thermopsis lanceolata R.Br. 114320 Fabaceae rosids Viridiplantae
Thermopsis rhombifolia 61122 Fabaceae rosids Viridiplantae
Thermopsis spp. 49852 Fabaceae rosids Viridiplantae
Ulex airensis 3901 Fabaceae rosids Viridiplantae
Ulex australis 948848 Fabaceae rosids Viridiplantae
Ulex densus 183289 Fabaceae rosids Viridiplantae
Ulex europaeus 3902 Fabaceae rosids Viridiplantae
Ulex jussiaei 1197277 Fabaceae rosids Viridiplantae
Ulex minor 183318 Fabaceae rosids Viridiplantae
Vexibia pachycarpa 3803 Fabaceae rosids Viridiplantae
Viscum cruciatum 104251 Viscaceae eudicotyledons Viridiplantae

Human Protein / Gene in interaction

27 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL497939 CHEMBL1741321 (2)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL47039 CHEMBL1738312 (1)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL497939 CHEMBL1613818 (1)
6 / 4
P02545 Prelamin-A/C Unclassified protein CHEMBL497939 CHEMBL1614544 (1)
11 / 10
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL497939 CHEMBL1741325 (2)
0 / 1
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta CHEMBL497939 CHEMBL1628606 CHEMBL838764 (1) CHEMBL839749 (1)
CHEMBL826912 (1) CHEMBL826914 (3)
CHEMBL826916 (3) CHEMBL885360 (1)
CHEMBL908428 (1) CHEMBL950042 (1)
CHEMBL1629178 (1) CHEMBL2343668 (1)
0 / 0
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha CHEMBL497939 CHEMBL838764 (1) CHEMBL839749 (1)
CHEMBL839756 (1) CHEMBL826913 (1)
CHEMBL826914 (3) CHEMBL827782 (1)
CHEMBL885360 (1) CHEMBL908428 (1)
CHEMBL950042 (1) CHEMBL2343668 (1)
1 / 0
Q07001 Acetylcholine receptor subunit delta CHRN delta CHEMBL497939 CHEMBL834065 (1) CHEMBL825304 (1)
CHEMBL872144 (1)
3 / 2
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha CHEMBL497939 CHEMBL1628606 CHEMBL754719 (1) CHEMBL838862 (1)
CHEMBL826915 (2) CHEMBL826916 (3)
CHEMBL827784 (1) CHEMBL835515 (1)
CHEMBL835265 (1) CHEMBL838016 (1)
CHEMBL825420 (1) CHEMBL876279 (1)
CHEMBL874315 (1) CHEMBL882470 (1)
CHEMBL883060 (1) CHEMBL883777 (1)
CHEMBL908427 (1) CHEMBL1629209 (1)
CHEMBL1629178 (1)
1 / 1
P07510 Acetylcholine receptor subunit gamma CHRN gamma CHEMBL497939 CHEMBL834065 (1) CHEMBL825304 (1)
CHEMBL872144 (1)
2 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta CHEMBL497939 CHEMBL1628606 CHEMBL754719 (1) CHEMBL838862 (1)
CHEMBL839756 (1) CHEMBL826913 (1)
CHEMBL826915 (2) CHEMBL827782 (1)
CHEMBL827784 (1) CHEMBL835515 (1)
CHEMBL835265 (1) CHEMBL838016 (1)
CHEMBL825420 (1) CHEMBL876279 (1)
CHEMBL874315 (1) CHEMBL882470 (1)
CHEMBL883060 (1) CHEMBL883777 (1)
CHEMBL908427 (1) CHEMBL1629209 (1)
1 / 1
P02708 Acetylcholine receptor subunit alpha CHRN alpha CHEMBL497939 CHEMBL834065 (1) CHEMBL825304 (1)
CHEMBL872144 (1)
3 / 2
P11230 Acetylcholine receptor subunit beta CHRN beta CHEMBL497939 CHEMBL834065 (1) CHEMBL825304 (1)
CHEMBL872144 (1)
2 / 1
O75496 Geminin Unclassified protein CHEMBL47039 CHEMBL2114780 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL47039 CHEMBL1794401 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL497939 CHEMBL1794467 (1)
0 / 0
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha CHEMBL497939 CHEMBL750438 (1) CHEMBL839695 (1)
CHEMBL830100 (1) CHEMBL885367 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL497939 CHEMBL1741322 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL497939 CHEMBL1741323 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL47039 CHEMBL497939 CHEMBL1614108 (3) CHEMBL1613886 (3)
CHEMBL1741324 (2)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL497939 CHEMBL1614250 (1)
4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL47039 CHEMBL497939 CHEMBL1613914 (4)
0 / 0
O00255 Menin Unclassified protein CHEMBL497939 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL497939 CHEMBL1614531 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL47039 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL47039 CHEMBL1613933 (1)
1 / 6
Q15822 Neuronal acetylcholine receptor subunit alpha-2 CHRN alpha CHEMBL497939 CHEMBL826912 (1)
1 / 1

CTD interaction (19)

compound gene gene name gene description interaction interaction type form reference
pmid
C004712 1135 CHRNA2
cholinergic receptor, nicotinic, alpha 2 (neuronal) cytisine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein] affects binding
/ increases activity
protein 9454827
C004712 1136 CHRNA3
LNCR2
NACHRA3
PAOD2
cholinergic receptor, nicotinic, alpha 3 (neuronal) cytisine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein] affects binding
/ increases activity
protein 9454827
C004712 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) cytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] affects binding
/ increases activity
protein 20331614
C004712 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) cytisine binds to [CHRNA4 protein binds to CHRNB2 protein] affects binding
protein 9336329
C004712 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 14645658
C004712 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) cytisine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] affects binding
/ increases activity
protein 14645658
C004712 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) cytisine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein] affects binding
/ increases activity
protein 9454827
C004712 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 9336329
C004712 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) pozanicline inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 9336329
C004712 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) cytisine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein] affects binding
/ decreases reaction
protein 10216184
C004712 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) cytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] affects binding
/ increases activity
protein 20331614
C004712 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) cytisine binds to [CHRNA4 protein binds to CHRNB2 protein] affects binding
protein 9336329
C004712 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 14645658
C004712 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) cytisine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] affects binding
/ increases activity
protein 14645658
C004712 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 9336329
C004712 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) pozanicline inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 9336329
C004712 1143 CHRNB4
cholinergic receptor, nicotinic, beta 4 (neuronal) cytisine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein] affects binding
/ increases activity
protein 9454827
C004712 1143 CHRNB4
cholinergic receptor, nicotinic, beta 4 (neuronal) cytisine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein] affects binding
/ increases activity
protein 9454827
C004712 1143 CHRNB4
cholinergic receptor, nicotinic, beta 4 (neuronal) cytisine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein] affects binding
/ increases activity
protein 9454827

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (36)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#610353 Epilepsy, nocturnal frontal lobe, 4; enfl4 Q15822
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#265000 Multiple pterygium syndrome, escobar variant; evmps P07510
#253290 Multiple pterygium syndrome, lethal type; lmps P02708
P07510
Q07001
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#608931 Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency P11230
#608930 Myasthenic syndrome, congenital, fast-channel P02708
Q07001
#601462 Myasthenic syndrome, congenital, slow-channel; sccms P02708
P11230
Q07001
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#612052 Smoking as a quantitative trait locus 3; sqtl3 P32297
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (33)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00770 Congenital myasthenic syndrome P02708 (related)
P11230 (related)
Q07001 (related)
H00986 Multiple pterygium syndrome P02708 (related)
P07510 (related)
Q07001 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
Q15822 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D012640 C004712 Seizures marker/mechanism
6843794
10942032