Species

KNApSAcK Entry

Organism name Sophora tomentosa
Genus Sophora
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Sophora tomentosa
Linked NCBI taxonomy ID 256637
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (19)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002525 External link 512 Formononetin
/ 7-Hydroxy-4'-methoxyisoflavone
CHEMBL242341
C007768
24 / 36 / 58 13 / 0 No. 3 No. 15
C00008274 External link 512 Sophoraflavanone A
/ 8-Geranylnaringenin
CHEMBL490697
1 / 2 / 0 No. 19 No. 14
C00009564 External link 512 Isosophoranone
No. 19 No. 14
C00009803 External link 512 2'-Hydroxy-4'-methoxy-5,6-methylenedioxy-2-phenylbenzofuran
No. 27 No. 15
C00009802 External link 512 2-(2,4-Dihydroxyphenyl)-5,6-methylenedioxybenzofuran
/ 2',4'-Dihydroxy-5,6-methylenedioxy-2-phenylbenzofuran
CHEMBL524490
No. 27 No. 15
C00002573 External link 512 Sophoraisoflavanone A
No. 28 No. 14
C00008245 External link 512 8-Prenylnaringenin
/ Sophoraflavanone B
/ (-)-8-Prenylnaringenin
CHEMBL376915
CHEMBL460647
10 / 8 / 4 No. 28 No. 14
C00008197 External link 512 Isobavachin
CHEMBL491534
C468753
2 / 0 No. 28 No. 14
C00014198 External link 512 Tomentosanol D
/ 5,7,4'-Trihydroxy-8-(2-hydroxy-3-methylbutyl-3-enyl)flavanone
CHEMBL443717
No. 28 No. 14
C00009559 External link 512 Isosophoronol
No. 127 No. 14
C00008635 External link 512 (2S,3S)-3,5,7-Trihydroxy-2'-methoxy-6'',6''-dimethylpyrano[2'',3'':4',3']flavanone
No. 127 No. 14
C00014189 External link 512 Tomentosanol E
/ 5,7,2',4',6'-Pentahydroxy-8-prenyl-6-geranylflavanone
No. 170 No. 14
C00002218 External link 512 Cytisine
/ (-)-Cytisine
CHEMBL47039
CHEMBL497939
CHEMBL1628606
C004712
27 / 36 / 33 6 / 1 No. 376 No. 3
C00002216 External link 512 Caulophylline
/ N-Methylcytisine
/ (-)-N-Methylcytisine
CHEMBL66191
CHEMBL1085045
C034245
No. 376 No. 3
C00002207 External link 512 Anagyrine
/ (-)-Anagyrine
CHEMBL203399
CHEMBL509692
CHEMBL1324708
CHEMBL1454284
C012736
7 / 8 / 11 No. 384 No. 3
C00010010 External link 512 Sophoracarpan A
/ (6R,6aS,11aR)-3-Hydroxy-6,9-dimethoxypterocarpan
No. 1655
C00010011 External link 512 Sophoracarpan B
/ 6-Methoxymaackiain
/ (6R,6aS,11aR)-3-Hydroxy-6-methoxy-8,9-methylenedioxypterocarpan
No. 1655
C00026272 External link 512 (-)-Epilamprolobine
No. 2957 No. 3
C00026292 External link 512 (+)-Epilamprolobine N-oxide
No. 2957 No. 3

Human Protein / Gene in interactions

51 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002207 C00002218 C00002525 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002207 C00002218 C00002525 1 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002207 C00002218 C00002525 1 / 2
O00255 Menin Unclassified protein C00002207 C00002218 C00002525 2 / 5
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002207 C00002218 C00002525 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002218 C00002525 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00002218 C00002525 4 / 3
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002525 C00008245 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00008245 C00008274 2 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002207 C00002525 3 / 3
O75496 Geminin Unclassified protein C00002218 C00008245 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002207 C00002525 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002218 C00002525 0 / 1
Q92731 Estrogen receptor beta NR3A2 C00008245 0 / 1
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta C00002218 0 / 0
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha C00002218 1 / 0
Q07001 Acetylcholine receptor subunit delta CHRN delta C00002218 3 / 2
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00002218 1 / 1
P07510 Acetylcholine receptor subunit gamma CHRN gamma C00002218 2 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00002218 1 / 1
P02708 Acetylcholine receptor subunit alpha CHRN alpha C00002218 3 / 2
P11230 Acetylcholine receptor subunit beta CHRN beta C00002218 2 / 1
P37840 Alpha-synuclein Unclassified protein C00008245 4 / 2
P02545 Prelamin-A/C Unclassified protein C00002218 11 / 10
P38398 Breast cancer type 1 susceptibility protein Enzyme C00002525 4 / 2
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00002525 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00008245 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002218 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00002525 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002218 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00002525 5 / 3
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha C00002218 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002218 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00008245 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002525 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002525 2 / 2
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00008245 0 / 0
P03372 Estrogen receptor NR3A1 C00008245 1 / 1
P04062 Glucosylceramidase Enzyme C00002218 6 / 4
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002218 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002525 4 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002525 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00002525 0 / 0
P31639 Sodium/glucose cotransporter 2 Glucose C00002525 1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00002525 7 / 37
P13866 Sodium/glucose cotransporter 1 Glucose C00002525 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00002218 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002218 1 / 4
Q15822 Neuronal acetylcholine receptor subunit alpha-2 CHRN alpha C00002218 1 / 1
P33527 Multidrug resistance-associated protein 1 drugs C00002525 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00008245 1 / 1

21 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1135 CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) C00002218
1136 CHRNA3, LNCR2, NACHRA3, PAOD2 cholinergic receptor, nicotinic, alpha 3 (neuronal) C00002218
1137 CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) C00002218
1139 CHRNA7, CHRNA7-2, NACHRA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) C00002218
1141 CHRNB2, EFNL3, nAChRB2 cholinergic receptor, nicotinic, beta 2 (neuronal) C00002218
1143 CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) C00002218
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002525
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00002525
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002525
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00002525
2056 EPO, EP, MVCD2 erythropoietin C00002525
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00002525
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00002525
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00002525
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00002525
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002525
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002525
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002525
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00002525
5241 PGR, NR3C3, PR progesterone receptor C00008197
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00008197

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (70)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#610353 Epilepsy, nocturnal frontal lobe, 4; enfl4 Q15822
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 P37231
#606824 Glucose/galactose malabsorption; ggm P13866
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#265000 Multiple pterygium syndrome, escobar variant; evmps P07510
#253290 Multiple pterygium syndrome, lethal type; lmps P02708
P07510
Q07001
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#608931 Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency P11230
#608930 Myasthenic syndrome, congenital, fast-channel P02708
Q07001
#601462 Myasthenic syndrome, congenital, slow-channel; sccms P02708
P11230
Q07001
#601665 Obesity P37231
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#233100 Renal glucosuria; glys1 P31639
#275210 Restrictive dermopathy, lethal P02545
#612052 Smoking as a quantitative trait locus 3; sqtl3 P32297
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0

KEGG DISEASE (77)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00770 Congenital myasthenic syndrome P02708 (related)
P11230 (related)
Q07001 (related)
H00986 Multiple pterygium syndrome P02708 (related)
P07510 (related)
Q07001 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
Q15822 (related)
H01126 Familial renal glucosuria (FRG) P31639 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D012640 Seizures C00002218