KCF-S cluster No. 376 (17 metabolites)

Corresponding Phytochemical cluster No. 3

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (17)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	221
eudicotyledons	6
asterids	3

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Cumulative family count

class name	count
Fabaceae	219
Berberidaceae	5
Convolvulaceae	2
Viscaceae	1
Orobanchaceae	1
Anacardiaceae	1
Rosaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Quinolizidine alkaloids	3

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Quinolizidine alkaloids	C10760	C00002216
Quinolizidine alkaloids	C10763	C00002218
Quinolizidine alkaloids	C10781	C00002234

Metabolite list (17)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002216	Caulophylline / N-Methylcytisine / (-)-N-Methylcytisine	CHEMBL66191 CHEMBL1085045	C034245
C00002218	Cytisine / (-)-Cytisine	CHEMBL47039 CHEMBL497939 CHEMBL1628606	C004712	27 / 36 / 33	6 / 1
C00002234	Rhombifoline / (-)-Rhombifoline	CHEMBL1397610	C119591
C00007725	Sophorasine A
C00007726	Sophorasine B
C00007727	Ethyl 12-cytisineacetate
C00007728	12-Cytisineacetamide	CHEMBL508431
C00007735	N-Formylcytisine / (-)-N-Formylcytisine	CHEMBL1396784 CHEMBL1433686		4 / 6 / 11
C00007736	N-Acetylcytisine	CHEMBL1513538 CHEMBL1553838		2 / 3 / 7
C00007737	Ethyl cytisine-12-carboxylate / 12-Carboxycytisine ethyl ester
C00007738	N-Carbomethoxycytisine / 12-Carboxycytisine methyl ester
C00007742	12-Hydroxycytisine
C00026275	(-)-N-(3-Oxobutyl)cytisine	CHEMBL190851		4 / 3 / 1
C00026276	(-)-N-(N-Acetylaminomethyl)cytisine
C00026325	Dehydrocytisine A / (-)-Dehydrocytisine A	CHEMBL47039 CHEMBL497939 CHEMBL1628606		27 / 36 / 33
C00026326	Dehydrocytisine B / (-)-Dehydrocytisine B	CHEMBL47039 CHEMBL497939 CHEMBL1628606		27 / 36 / 33
C00026339	N-(3-Oxobutyl)cytisine	CHEMBL190851		4 / 3 / 1

Human Protein / Gene in interactions

28 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P32297	Neuronal acetylcholine receptor subunit alpha-3	CHRN alpha	C00002218 C00026275 C00026325 C00026326 C00026339	1 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002218 C00007735 C00007736 C00026325 C00026326	1 / 2
O00255	Menin	Unclassified protein	C00002218 C00007735 C00007736 C00026325 C00026326	2 / 5
P30926	Neuronal acetylcholine receptor subunit beta-4	CHRN beta	C00002218 C00026275 C00026325 C00026326 C00026339	0 / 0
P43681	Neuronal acetylcholine receptor subunit alpha-4	CHRN alpha	C00002218 C00026275 C00026325 C00026326 C00026339	1 / 1
P17787	Neuronal acetylcholine receptor subunit beta-2	CHRN beta	C00002218 C00026275 C00026325 C00026326 C00026339	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002218 C00007735 C00026325 C00026326	0 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00002218 C00026325 C00026326	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002218 C00026325 C00026326	1 / 0
P07510	Acetylcholine receptor subunit gamma	CHRN gamma	C00002218 C00026325 C00026326	2 / 1
P02545	Prelamin-A/C	Unclassified protein	C00002218 C00026325 C00026326	11 / 10
P02708	Acetylcholine receptor subunit alpha	CHRN alpha	C00002218 C00026325 C00026326	3 / 2
P11230	Acetylcholine receptor subunit beta	CHRN beta	C00002218 C00026325 C00026326	2 / 1
O75496	Geminin	Unclassified protein	C00002218 C00026325 C00026326	0 / 0
Q07001	Acetylcholine receptor subunit delta	CHRN delta	C00002218 C00026325 C00026326	3 / 2
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002218 C00026325 C00026326	0 / 0
P36544	Neuronal acetylcholine receptor subunit alpha-7	CHRN alpha	C00002218 C00026325 C00026326	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002218 C00026325 C00026326	0 / 0
Q01196	Runt-related transcription factor 1	Unclassified protein	C00002218 C00026325 C00026326	1 / 4
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002218 C00026325 C00026326	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002218 C00026325 C00026326	0 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00002218 C00026325 C00026326	4 / 3
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002218 C00026325 C00026326	0 / 0
P04062	Glucosylceramidase	Enzyme	C00002218 C00026325 C00026326	6 / 4
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002218 C00026325 C00026326	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00002218 C00026325 C00026326	0 / 1
Q15822	Neuronal acetylcholine receptor subunit alpha-2	CHRN alpha	C00002218 C00026325 C00026326	1 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00007735	3 / 3

6 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1135	CHRNA2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	C00002218
1136	CHRNA3, LNCR2, NACHRA3, PAOD2	cholinergic receptor, nicotinic, alpha 3 (neuronal)	C00002218
1137	CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	C00002218
1139	CHRNA7, CHRNA7-2, NACHRA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	C00002218
1141	CHRNB2, EFNL3, nAChRB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	C00002218
1143	CHRNB4	cholinergic receptor, nicotinic, beta 4 (neuronal)	C00002218

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions