Species

KNApSAcK Entry

Organism name Piptanthus nepalensis
Genus Piptanthus
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Piptanthus nepalensis
Linked NCBI taxonomy ID 70606
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00010106 External link 512 Genistein 7,4'-O-diglucoside
/ Genistein 7,4'-di-O-glucoside
/ Genistein-7,4'-di-O-beta-glucopyranoside
No. 1 No. 15
C00010080 External link 512 Daidzein 7,4'-di-O-glucoside
C047425
No. 1 No. 15
C00010105 External link 512 Sophoricoside
/ Genistein 4'-O-glucoside
CHEMBL486626
3 / 0 / 0 No. 2 No. 15
C00010079 External link 512 Daidzein 4'-O-glucoside
CHEMBL1209148
No. 2 No. 15
C00002553 External link 512 Ononin
/ Formononetin 7-O-glucoside
CHEMBL465980
11 / 14 / 40 No. 2 No. 15
C00002525 External link 512 Formononetin
/ 7-Hydroxy-4'-methoxyisoflavone
CHEMBL242341
C007768
24 / 36 / 58 13 / 0 No. 3 No. 15
C00009380 External link 512 Daidzein
/ 7,4'-Dihydroxyisoflavone
CHEMBL8145
C004742
60 / 68 / 76 113 / 12 No. 71 No. 15
C00002225 External link 512 Lupanine
/ (+)-Lupanine
CHEMBL459396
CHEMBL520093
CHEMBL2008918
C008298
No. 85 No. 3
C00002216 External link 512 Caulophylline
/ N-Methylcytisine
/ (-)-N-Methylcytisine
CHEMBL66191
CHEMBL1085045
C034245
No. 376 No. 3
C00002218 External link 512 Cytisine
/ (-)-Cytisine
CHEMBL47039
CHEMBL497939
CHEMBL1628606
C004712
27 / 36 / 33 6 / 1 No. 376 No. 3
C00002207 External link 512 Anagyrine
/ (-)-Anagyrine
CHEMBL203399
CHEMBL509692
CHEMBL1324708
CHEMBL1454284
C012736
7 / 8 / 11 No. 384 No. 3

Human Protein / Gene in interactions

85 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002207 C00002218 C00002525 C00009380 C00010105 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002207 C00002218 C00002525 C00009380 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002207 C00002218 C00002525 C00009380 1 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00002207 C00002525 C00009380 C00010105 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002207 C00002218 C00002525 1 / 2
P04637 Cellular tumor antigen p53 Transcription Factor C00002525 C00002553 C00009380 7 / 37
O00255 Menin Unclassified protein C00002207 C00002218 C00002525 2 / 5
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002207 C00002525 C00009380 3 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002218 C00002525 C00009380 0 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002218 C00002525 C00009380 0 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002525 C00002553 C00009380 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002218 C00002525 C00009380 4 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002553 C00009380 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00002525 C00009380 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00002525 C00009380 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002553 C00009380 1 / 1
P02545 Prelamin-A/C Unclassified protein C00002218 C00009380 11 / 10
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00009380 C00010105 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00002553 C00009380 1 / 1
P05091 Aldehyde dehydrogenase, mitochondrial Oxidoreductase C00002553 C00009380 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002525 C00009380 2 / 2
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00002553 C00009380 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002525 C00009380 4 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002218 C00009380 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00002525 C00009380 5 / 3
P11021 78 kDa glucose-regulated protein Unclassified protein C00002525 C00009380 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00002525 C00002553 4 / 2
P51151 Ras-related protein Rab-9A Unclassified protein C00002553 C00009380 0 / 0
O75496 Geminin Unclassified protein C00002218 C00009380 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002525 C00009380 0 / 0
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme C00009380 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00009380 1 / 8
P11387 DNA topoisomerase 1 Isomerase C00009380 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00009380 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00009380 0 / 0
P11230 Acetylcholine receptor subunit beta CHRN beta C00002218 2 / 1
P02708 Acetylcholine receptor subunit alpha CHRN alpha C00002218 3 / 2
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00002218 1 / 1
P07510 Acetylcholine receptor subunit gamma CHRN gamma C00002218 2 / 1
P41143 Delta-type opioid receptor Opioid receptor C00009380 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00009380 0 / 1
P15121 Aldose reductase Enzyme C00002553 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002218 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00009380 1 / 0
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00002218 1 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002218 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00009380 0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00009380 2 / 2
Q07001 Acetylcholine receptor subunit delta CHRN delta C00002218 3 / 2
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha C00002218 0 / 0
P04745 Alpha-amylase 1 Enzyme C00009380 0 / 0
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha C00002218 1 / 0
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta C00002218 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00009380 2 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00002525 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00009380 3 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein C00009380 5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00009380 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00009380 1 / 1
P03372 Estrogen receptor NR3A1 C00009380 1 / 1
P35372 Mu-type opioid receptor Opioid receptor C00009380 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00009380 0 / 0
P04062 Glucosylceramidase Enzyme C00002218 6 / 4
P54132 Bloom syndrome protein Enzyme C00009380 1 / 2
P14618 Pyruvate kinase PKM Enzyme C00009380 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002553 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00009380 2 / 0
Q99700 Ataxin-2 Unclassified protein C00009380 1 / 1
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00009380 0 / 0
P10275 Androgen receptor NR3C4 C00009380 3 / 4
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002218 0 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor C00009380 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00009380 1 / 0
P40225 Thrombopoietin Unclassified protein C00009380 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00009380 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00009380 1 / 1
P31639 Sodium/glucose cotransporter 2 Glucose C00002525 1 / 1
P13866 Sodium/glucose cotransporter 1 Glucose C00002525 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00002218 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002218 1 / 4
Q15822 Neuronal acetylcholine receptor subunit alpha-2 CHRN alpha C00002218 1 / 1
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00009380 3 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme C00009380 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002525 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00009380 0 / 0

122 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00002525 C00009380
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00002525 C00009380
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002525 C00009380
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002525 C00009380
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002525 C00009380
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00002525 C00009380
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00002525 C00009380
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00002525 C00009380
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00002525 C00009380
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002525 C00009380
11098 PRSS23, SIG13, SPUVE, ZSIG13 protease, serine, 23 C00009380
196 AHR, bHLHe76 aryl hydrocarbon receptor C00009380
249 ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) C00009380
251 ALPPL2, ALPG, ALPPL, GCAP alkaline phosphatase, placental-like 2 (EC:3.1.3.1) C00009380
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00009380
396 ARHGDIA, GDIA1, NPHS8, RHOGDI, RHOGDI-1 Rho GDP dissociation inhibitor (GDI) alpha C00009380
23545 ATP6V0A2, A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS ATPase, H+ transporting, lysosomal V0 subunit a2 (EC:3.6.3.6) C00009380
11177 BAZ1A, ACF1, WALp1, WCRF180, hACF1 bromodomain adjacent to zinc finger domain, 1A C00009380
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00009380
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00009380
632 BGLAP, BGP, OC, OCN bone gamma-carboxyglutamate (gla) protein C00009380
672 BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53 breast cancer 1, early onset C00009380
103993 C00009380
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00009380
890 CCNA2, CCN1, CCNA cyclin A2 C00009380
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00009380
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00009380
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00009380
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00009380
1103 CHAT, CHOACTASE, CMS1A, CMS1A2 choline O-acetyltransferase (EC:2.3.1.6) C00009380
1152 CKB, B-CK, CKBB creatine kinase, brain (EC:2.7.3.2) C00009380
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00009380
9167 COX7A2L, COX7AR, COX7RP, EB1, SIG81 cytochrome c oxidase subunit VIIa polypeptide 2 like C00009380
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00009380
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00009380
6387 CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B chemokine (C-X-C motif) ligand 12 C00009380
1588 CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) C00009380
10057 ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 C00009380
10257 ABCC4, EST170205, MOAT-B, MOATB, MRP4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 C00009380
1589 CYP21A2, CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10) C00009380
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00009380
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00009380
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00009380
1795 DOCK3, MOCA, PBP dedicator of cytokinesis 3 C00009380
1846 DUSP4, HVH2, MKP-2, MKP2, TYP dual specificity phosphatase 4 (EC:3.1.3.16 3.1.3.48) C00009380
9166 EBAG9, EB9, PDAF estrogen receptor binding site associated, antigen, 9 C00009380
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00009380
2027 ENO3, GSD13, MSE enolase 3 (beta, muscle) (EC:4.2.1.11) C00009380
2041 EPHA1, EPH, EPHT, EPHT1 EPH receptor A1 (EC:2.7.10.1) C00009380
83715 ESPN, DFNB36 espin C00009380
1135 CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) C00002218
19 ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD ATP-binding cassette, sub-family A (ABC1), member 1 C00009380
2101 ESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1 estrogen-related receptor alpha C00009380
2103 ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2 estrogen-related receptor beta C00009380
2104 ESRRG, ERR3, ERRgamma, NR3B3 estrogen-related receptor gamma C00009380
56776 FMN2 formin 2 C00009380
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00009380
9687 GREB1 growth regulation by estrogen in breast cancer 1 C00009380
3284 HSD3B2, HSD3B, HSDB, SDR11E2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) C00009380
7866 IFRD2, IFNRP, SKMc15, SM15 interferon-related developmental regulator 2 C00009380
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC:2.7.10.1) C00009380
3487 IGFBP4, BP-4, HT29-IGFBP, IBP4, IGFBP-4 insulin-like growth factor binding protein 4 C00009380
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00009380
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00009380
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00009380
26145 IRF2BP1 interferon regulatory factor 2 binding protein 1 C00009380
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00009380
26251 KCNG2, KCNF2, KV6.2 potassium voltage-gated channel, subfamily G, member 2 C00009380
354 KLK3, APS, KLK2A1, PSA, hK3 kallikrein-related peptidase 3 (EC:3.4.21.77) C00009380
27074 LAMP3, CD208, DC_LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403 lysosomal-associated membrane protein 3 C00009380
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00009380
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00009380
4199 ME1, HUMNDME, MES malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) C00009380
4502 MT2A, MT2 metallothionein 2A C00009380
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00009380
10499 NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75 nuclear receptor coactivator 2 C00009380
4824 NKX3-1, BAPX2, NKX3, NKX3.1, NKX3A NK3 homeobox 1 C00009380
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00009380
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00009380
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00009380
8204 NRIP1, RIP140 nuclear receptor interacting protein 1 C00009380
56944 OLFML3, HNOEL-iso, OLF44 olfactomedin-like 3 C00009380
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00009380
5111 PCNA proliferating cell nuclear antigen C00009380
64236 PDLIM2, MYSTIQUE, SLIM PDZ and LIM domain 2 (mystique) C00009380
5174 PDZK1, CAP70, CLAMP, NHERF-3, NHERF3, PDZD1 PDZ domain containing 1 C00009380
5241 PGR, NR3C3, PR progesterone receptor C00009380
5411 PNN, DRS, DRSP, SDK3, memA pinin, desmosome associated protein C00009380
10957 PNRC1, B4-2, PNAS-145, PROL2, PRR2 proline-rich nuclear receptor coactivator 1 C00009380
5458 POU4F2, BRN3.2, BRN3B, Brn-3b POU class 4 homeobox 2 C00009380
5580 PRKCD, MAY1, PKCD, nPKC-delta protein kinase C, delta (EC:2.7.10.2 2.7.11.13) C00009380
119 ADD2, ADDB adducin 2 (beta) C00009380
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00009380
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC:2.7.10.2) C00009380
5932 RBBP8, COM1, CTIP, JWDS, RIM, SAE2, SCKL2 retinoblastoma binding protein 8 C00009380
6197 RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2 ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1) C00009380
81537 SGPP1, SPPase1 sphingosine-1-phosphate phosphatase 1 C00009380
6558 SLC12A2, BSC, BSC2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 C00009380
6513 SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED solute carrier family 2 (facilitated glucose transporter), member 1 C00009380
8140 SLC7A5, 4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1 solute carrier family 7 (amino acid transporter light chain, L system), member 5 C00009380
6781 STC1, STC stanniocalcin 1 C00009380
27347 STK39, DCHT, PASK, SPAK serine threonine kinase 39 (EC:2.7.11.1) C00009380
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00009380
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00009380
6870 TACR3, HH11, NK-3R, NK3R, NKR, TAC3RL tachykinin receptor 3 C00009380
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00009380
7041 TGFB1I1, ARA55, HIC-5, HIC5, TSC-5 transforming growth factor beta 1 induced transcript 1 C00009380
7130 TNFAIP6, TSG-6, TSG6 tumor necrosis factor, alpha-induced protein 6 C00009380
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00009380
9537 TP53I11, PIG11 tumor protein p53 inducible protein 11 C00009380
7164 TPD52L1, D53, hD53 tumor protein D52-like 1 C00009380
7345 UCHL1, NDGOA, PARK5, PGP_9.5, PGP9.5, PGP95, Uch-L1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (EC:3.4.19.12) C00009380
1143 CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) C00002218
1141 CHRNB2, EFNL3, nAChRB2 cholinergic receptor, nicotinic, beta 2 (neuronal) C00002218
1139 CHRNA7, CHRNA7-2, NACHRA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) C00002218
1137 CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) C00002218
1136 CHRNA3, LNCR2, NACHRA3, PAOD2 cholinergic receptor, nicotinic, alpha 3 (neuronal) C00002218
7367 UGT2B17, BMND12, UDPGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 (EC:2.4.1.17) C00009380
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00009380
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002525
2056 EPO, EP, MVCD2 erythropoietin C00002525
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00002525

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (93)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#610251 Alcohol sensitivity, acute P05091
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#218800 Crigler-najjar syndrome, type i P22310
#606785 Crigler-najjar syndrome, type ii P22310
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#610353 Epilepsy, nocturnal frontal lobe, 4; enfl4 Q15822
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22310
#137800 Glioma susceptibility 1; glm1 P37231
#606824 Glucose/galactose malabsorption; ggm P13866
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#211980 Lung cancer P00533
P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#265000 Multiple pterygium syndrome, escobar variant; evmps P07510
#253290 Multiple pterygium syndrome, lethal type; lmps P02708
P07510
Q07001
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#608931 Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency P11230
#608930 Myasthenic syndrome, congenital, fast-channel P02708
Q07001
#601462 Myasthenic syndrome, congenital, slow-channel; sccms P02708
P11230
Q07001
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#233100 Renal glucosuria; glys1 P31639
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#612052 Smoking as a quantitative trait locus 3; sqtl3 P32297
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989

KEGG DISEASE (93)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
H00018 Gastric cancer P00533 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00770 Congenital myasthenic syndrome P02708 (related)
P11230 (related)
Q07001 (related)
H00986 Multiple pterygium syndrome P02708 (related)
P07510 (related)
Q07001 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H01071 Acute alcohol sensitivity P05091 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
Q15822 (related)
H00548 Brunner syndrome P21397 (related)
H01126 Familial renal glucosuria (FRG) P31639 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

13 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D012640 Seizures C00002218
D000230 Adenocarcinoma C00009380
D000647 Amnesia C00009380
D002318 Cardiovascular Diseases C00009380
D003924 Diabetes Mellitus, Type 2 C00009380
D004487 Edema C00009380
D016889 Endometrial Neoplasms C00009380
D007172 Erectile Dysfunction C00009380
D006965 Hyperplasia C00009380
D006973 Hypertension C00009380
D017254 Leukemic Infiltration C00009380
D008569 Memory Disorders C00009380
D014693 Ventricular Fibrillation C00009380